Click here to switch to the map view.

The map label for this gene is ptrB [C]

Identifier: 86609965

GI number: 86609965

Start: 2634102

End: 2636165

Strand: Direct

Name: ptrB [C]

Synonym: CYB_2532

Alternate gene names: 86609965

Gene position: 2634102-2636165 (Clockwise)

Preceding gene: 86609963

Following gene: 86609968

Centisome position: 86.46

GC content: 60.47

Gene sequence:

>2064_bases
ATGCTCAACTACCCGCCCAGCTATCCGGATCCCACCGTTGTCGACATCTACCACGGGCAGGCGGTACCGGATCCCTACCG
CTGGCTAGAGGATCTAGATTCGGAGCAGACGCGGGCCTGGATTGAGGCGCAAAACCACCTTACCTTTAACTACTTGCAGC
AGATCCCAGCCCGGCAGCGGATCCGAGAACGCCTGACCCAGCTCTGGAACTATGAAAAATACAGCCAGCCCTTCAAAGAA
GGGGGCCGCTACTTCTATTTCAAGAACGACGGCCTGCAAAACCAAAGTGTTCTCTATACCCAAGAAAGCCTGGAGGCTGA
GGCCAGGGTCTTGCTGGATCCCAACACCTTCTCCGAAGACGGTACGGTGGCTCTAGCGGGCATTGCCATCAGCCGTGATG
GGCGGTATCTGGCCTATGGTCTCTCCCGCTCCGGCTCCGACTGGCAAGAATGGAAGGTGCGGGACATCGAAACCGGCGAG
GATTTGCCGGATCACCTCCGCTGGGTCAAGTTTTCCGGGGCGAGCTGGACGCTGGATGGGCAAGGATTTTTCTACAGCCG
CTACGACGAACCGGCCCCCGGCAGCGAATACGAAAGCGTCAACTACTTCCAGAAGCTCTACTACCACCGCCTGGGCACCT
CCCAGTCAGAAGATGTTTTGGTCTATCACCGCCCCGACCAAAAAGAGTGGGGCTTTGCCGGCGGGGTTACTGAAGATGGG
AATTACCTCATCATCTCCGTCTGGCGGGGCACGGATCCCAAAAACCTCATCTTCTACAAAGACTTGCGGGATCCCCAGTC
TCCTGTAGTAGAGCTCATCCGCGAGTTTGAGGCCGAATACAGCTTCGTGGGCAACGACGGATCCCGCTTTTGGCTGTTGA
CGGACTGCCAAGCTCCTCGGCGGCGACTGGTGGCCATCGACTTGGAGCAGCCTGACCGGGTGCAGGAGGTGATCCCCGAG
GCGGAGGAGACCCTGCAGGGGGTTAGCTTGATCAACAATCAGTTTGTGGCCTTCTACCTCAAAGACGCCCACACCCAGAT
CAAGACCTTTGCTTTAGACGGCACCTACCTAGGAGAAATCCCGCTGCCCGGGCTGGGATCCGCCAGCGGCTTTGGCGGCA
AGCGCTACGACACCGAGACCTTCTACACCTTCACCAGCTTCACCACCCCGCCCACCATCTACCGCTACGATTTCACCAGC
GGCACCAGCACCCTGTTCCGTCAGCCCCAGGTGGATTTCGATCCCCAGGCCTACGAGGTGCAGCAGGTGTTCTACACCAG
CAAAGATGGCACCCGCATCCCCATGTTTCTCGTCCACCGCCGCGGCCTGACTCGGACAGGGGATCACCCCACCCTGCTGT
ATGGCTACGGTGGCTTTGGCATCTCACTTACCCCCAGCTTTTCAGTGGGTCTGGTGGCCTGGCTGGAAATGGGAGGGGTT
TACGCCCAGCCCAATTTGCGCGGCGGCGGCGAGTACGGAGAAGAGTGGCACCAGGCGGGCACCAAGCTCAACAAGCAAAA
GGTGTTCGACGACTTTATTGCCGCTGCCGAGTGGCTGATAGCCCATGGCTACACCAACCCCGCCAAGTTGGCCATCTCCG
GCGGCAGCAACGGCGGCCTGCTGGTGGGGGCCTGCCTGGTTCAGAGGCCGGAGCTGTTTGCAGCGGCCCTGCCGGCAGTG
GGGGTGTTCGACATGCTGCGCTTTCATAAGTTCACCATCGGCTGGGCCTGGATCTCCGAGTACGGATCCCCGGAGAACCC
GGAGGAATTCAAGGCCCTCTACGCCTATTCCCCTCTGCACAACCTCAAGCCCGGCACTGCCTATCCCGCCACCCTGATCA
CCACCGCAGATCACGACGACCGGGTGGTGCCCGCCCACAGCTTCAAGTTTGCCGCTGCCCTGCAGGTAGCCCAGGGGGGA
TCCCAGCCCATCCTCATCCGCATCGACACCAAGGCAGGGCACGGGGCCGGCAAGCCCACCAGCAAGCTGATTGAGGAAGC
TGCCGACCGCTGGGCCTTTTTGGTGCAGGTGCTAGGGATCCCCTGGGACGGAACGGGAAGTTAG

Upstream 100 bases:

>100_bases
CTCGGCTTCCACTATAGCGAGCATGCCTGGCAAAGGCCGGAGAGTGGGTTTTTGGCTTCTCCTCTGCCATAGTGGAATGG
GTCTCTAGCGCTTAGGTCTC

Downstream 100 bases:

>100_bases
CGAGCTCTAGGACCCAGGCCCACCCGACCGGCATAAACTGCCGCTTCCCCCAGCTCGTCTTCGATGCGCAGCAGTTGGTT
GTACTTGGCAATGCGCTCGC

Product: prolyl oligopeptidase

Products: NA

Alternate protein names: PE; Post-proline cleaving enzyme [H]

Number of amino acids: Translated: 687; Mature: 687

Protein sequence:

>687_residues
MLNYPPSYPDPTVVDIYHGQAVPDPYRWLEDLDSEQTRAWIEAQNHLTFNYLQQIPARQRIRERLTQLWNYEKYSQPFKE
GGRYFYFKNDGLQNQSVLYTQESLEAEARVLLDPNTFSEDGTVALAGIAISRDGRYLAYGLSRSGSDWQEWKVRDIETGE
DLPDHLRWVKFSGASWTLDGQGFFYSRYDEPAPGSEYESVNYFQKLYYHRLGTSQSEDVLVYHRPDQKEWGFAGGVTEDG
NYLIISVWRGTDPKNLIFYKDLRDPQSPVVELIREFEAEYSFVGNDGSRFWLLTDCQAPRRRLVAIDLEQPDRVQEVIPE
AEETLQGVSLINNQFVAFYLKDAHTQIKTFALDGTYLGEIPLPGLGSASGFGGKRYDTETFYTFTSFTTPPTIYRYDFTS
GTSTLFRQPQVDFDPQAYEVQQVFYTSKDGTRIPMFLVHRRGLTRTGDHPTLLYGYGGFGISLTPSFSVGLVAWLEMGGV
YAQPNLRGGGEYGEEWHQAGTKLNKQKVFDDFIAAAEWLIAHGYTNPAKLAISGGSNGGLLVGACLVQRPELFAAALPAV
GVFDMLRFHKFTIGWAWISEYGSPENPEEFKALYAYSPLHNLKPGTAYPATLITTADHDDRVVPAHSFKFAAALQVAQGG
SQPILIRIDTKAGHGAGKPTSKLIEEAADRWAFLVQVLGIPWDGTGS

Sequences:

>Translated_687_residues
MLNYPPSYPDPTVVDIYHGQAVPDPYRWLEDLDSEQTRAWIEAQNHLTFNYLQQIPARQRIRERLTQLWNYEKYSQPFKE
GGRYFYFKNDGLQNQSVLYTQESLEAEARVLLDPNTFSEDGTVALAGIAISRDGRYLAYGLSRSGSDWQEWKVRDIETGE
DLPDHLRWVKFSGASWTLDGQGFFYSRYDEPAPGSEYESVNYFQKLYYHRLGTSQSEDVLVYHRPDQKEWGFAGGVTEDG
NYLIISVWRGTDPKNLIFYKDLRDPQSPVVELIREFEAEYSFVGNDGSRFWLLTDCQAPRRRLVAIDLEQPDRVQEVIPE
AEETLQGVSLINNQFVAFYLKDAHTQIKTFALDGTYLGEIPLPGLGSASGFGGKRYDTETFYTFTSFTTPPTIYRYDFTS
GTSTLFRQPQVDFDPQAYEVQQVFYTSKDGTRIPMFLVHRRGLTRTGDHPTLLYGYGGFGISLTPSFSVGLVAWLEMGGV
YAQPNLRGGGEYGEEWHQAGTKLNKQKVFDDFIAAAEWLIAHGYTNPAKLAISGGSNGGLLVGACLVQRPELFAAALPAV
GVFDMLRFHKFTIGWAWISEYGSPENPEEFKALYAYSPLHNLKPGTAYPATLITTADHDDRVVPAHSFKFAAALQVAQGG
SQPILIRIDTKAGHGAGKPTSKLIEEAADRWAFLVQVLGIPWDGTGS
>Mature_687_residues
MLNYPPSYPDPTVVDIYHGQAVPDPYRWLEDLDSEQTRAWIEAQNHLTFNYLQQIPARQRIRERLTQLWNYEKYSQPFKE
GGRYFYFKNDGLQNQSVLYTQESLEAEARVLLDPNTFSEDGTVALAGIAISRDGRYLAYGLSRSGSDWQEWKVRDIETGE
DLPDHLRWVKFSGASWTLDGQGFFYSRYDEPAPGSEYESVNYFQKLYYHRLGTSQSEDVLVYHRPDQKEWGFAGGVTEDG
NYLIISVWRGTDPKNLIFYKDLRDPQSPVVELIREFEAEYSFVGNDGSRFWLLTDCQAPRRRLVAIDLEQPDRVQEVIPE
AEETLQGVSLINNQFVAFYLKDAHTQIKTFALDGTYLGEIPLPGLGSASGFGGKRYDTETFYTFTSFTTPPTIYRYDFTS
GTSTLFRQPQVDFDPQAYEVQQVFYTSKDGTRIPMFLVHRRGLTRTGDHPTLLYGYGGFGISLTPSFSVGLVAWLEMGGV
YAQPNLRGGGEYGEEWHQAGTKLNKQKVFDDFIAAAEWLIAHGYTNPAKLAISGGSNGGLLVGACLVQRPELFAAALPAV
GVFDMLRFHKFTIGWAWISEYGSPENPEEFKALYAYSPLHNLKPGTAYPATLITTADHDDRVVPAHSFKFAAALQVAQGG
SQPILIRIDTKAGHGAGKPTSKLIEEAADRWAFLVQVLGIPWDGTGS

Specific function: Cleaves peptide bonds on the C-terminal side of prolyl residues within peptides that are up to approximately 30 amino acids long. Has an absolute requirement for an X-Pro bond in the trans configuration immediately preceding the Pro-Y scissible bond [H]

COG id: COG1505

COG function: function code E; Serine proteases of the peptidase family S9A

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9A family [H]

Homologues:

Organism=Homo sapiens, GI41349456, Length=707, Percent_Identity=49.7878359264498, Blast_Score=675, Evalue=0.0,
Organism=Homo sapiens, GI108860686, Length=247, Percent_Identity=29.1497975708502, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI284172420, Length=247, Percent_Identity=29.1497975708502, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI284172413, Length=247, Percent_Identity=29.1497975708502, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI70778815, Length=247, Percent_Identity=29.1497975708502, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI284172438, Length=247, Percent_Identity=29.1497975708502, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI284172431, Length=247, Percent_Identity=29.1497975708502, Blast_Score=99, Evalue=1e-20,
Organism=Homo sapiens, GI108860692, Length=199, Percent_Identity=29.6482412060301, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1788150, Length=676, Percent_Identity=27.0710059171598, Blast_Score=218, Evalue=1e-57,
Organism=Drosophila melanogaster, GI24583414, Length=708, Percent_Identity=47.7401129943503, Blast_Score=629, Evalue=1e-180,
Organism=Drosophila melanogaster, GI221510989, Length=706, Percent_Identity=44.3342776203966, Blast_Score=573, Evalue=1e-163,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002471
- InterPro:   IPR001375
- InterPro:   IPR002470
- InterPro:   IPR004106 [H]

Pfam domain/function: PF00326 Peptidase_S9; PF02897 Peptidase_S9_N [H]

EC number: =3.4.21.26 [H]

Molecular weight: Translated: 77401; Mature: 77401

Theoretical pI: Translated: 4.92; Mature: 4.92

Prosite motif: PS00708 PRO_ENDOPEP_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.6 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNYPPSYPDPTVVDIYHGQAVPDPYRWLEDLDSEQTRAWIEAQNHLTFNYLQQIPARQR
CCCCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHCCCEEHHHHHHCCHHHH
IRERLTQLWNYEKYSQPFKEGGRYFYFKNDGLQNQSVLYTQESLEAEARVLLDPNTFSED
HHHHHHHHHCCHHHCCHHHHCCCEEEEECCCCCCCEEEEEHHHCCCCEEEEECCCCCCCC
GTVALAGIAISRDGRYLAYGLSRSGSDWQEWKVRDIETGEDLPDHLRWVKFSGASWTLDG
CCEEEEEEEEECCCCEEEEECCCCCCCHHHCEEEECCCCCCCHHHCEEEEECCCEEEECC
QGFFYSRYDEPAPGSEYESVNYFQKLYYHRLGTSQSEDVLVYHRPDQKEWGFAGGVTEDG
CCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCC
NYLIISVWRGTDPKNLIFYKDLRDPQSPVVELIREFEAEYSFVGNDGSRFWLLTDCQAPR
CEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCC
RRLVAIDLEQPDRVQEVIPEAEETLQGVSLINNQFVAFYLKDAHTQIKTFALDGTYLGEI
CEEEEEECCCCHHHHHHCCHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEECCEEECCC
PLPGLGSASGFGGKRYDTETFYTFTSFTTPPTIYRYDFTSGTSTLFRQPQVDFDPQAYEV
CCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHCCCCCCCCCCHHEE
QQVFYTSKDGTRIPMFLVHRRGLTRTGDHPTLLYGYGGFGISLTPSFSVGLVAWLEMGGV
EEEEEECCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCEEECCCCHHHHHHHHHHCCE
YAQPNLRGGGEYGEEWHQAGTKLNKQKVFDDFIAAAEWLIAHGYTNPAKLAISGGSNGGL
EECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCE
LVGACLVQRPELFAAALPAVGVFDMLRFHKFTIGWAWISEYGSPENPEEFKALYAYSPLH
EEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHCCCCCCHHHHHEEEEECCHH
NLKPGTAYPATLITTADHDDRVVPAHSFKFAAALQVAQGGSQPILIRIDTKAGHGAGKPT
CCCCCCCCCEEEEEECCCCCCEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCH
SKLIEEAADRWAFLVQVLGIPWDGTGS
HHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MLNYPPSYPDPTVVDIYHGQAVPDPYRWLEDLDSEQTRAWIEAQNHLTFNYLQQIPARQR
CCCCCCCCCCCCEEEEECCCCCCCHHHHHHHCCCHHHHHHHHHCCCEEHHHHHHCCHHHH
IRERLTQLWNYEKYSQPFKEGGRYFYFKNDGLQNQSVLYTQESLEAEARVLLDPNTFSED
HHHHHHHHHCCHHHCCHHHHCCCEEEEECCCCCCCEEEEEHHHCCCCEEEEECCCCCCCC
GTVALAGIAISRDGRYLAYGLSRSGSDWQEWKVRDIETGEDLPDHLRWVKFSGASWTLDG
CCEEEEEEEEECCCCEEEEECCCCCCCHHHCEEEECCCCCCCHHHCEEEEECCCEEEECC
QGFFYSRYDEPAPGSEYESVNYFQKLYYHRLGTSQSEDVLVYHRPDQKEWGFAGGVTEDG
CCEEEECCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCCCCCCC
NYLIISVWRGTDPKNLIFYKDLRDPQSPVVELIREFEAEYSFVGNDGSRFWLLTDCQAPR
CEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHCCCEEEECCCCCEEEEEECCCCCC
RRLVAIDLEQPDRVQEVIPEAEETLQGVSLINNQFVAFYLKDAHTQIKTFALDGTYLGEI
CEEEEEECCCCHHHHHHCCHHHHHHHHHHHHCCCEEEEEEECCCCEEEEEEECCEEECCC
PLPGLGSASGFGGKRYDTETFYTFTSFTTPPTIYRYDFTSGTSTLFRQPQVDFDPQAYEV
CCCCCCCCCCCCCCCCCCCEEEEEEECCCCCEEEEEECCCCCHHHHCCCCCCCCCCHHEE
QQVFYTSKDGTRIPMFLVHRRGLTRTGDHPTLLYGYGGFGISLTPSFSVGLVAWLEMGGV
EEEEEECCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCEEECCCCHHHHHHHHHHCCE
YAQPNLRGGGEYGEEWHQAGTKLNKQKVFDDFIAAAEWLIAHGYTNPAKLAISGGSNGGL
EECCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCE
LVGACLVQRPELFAAALPAVGVFDMLRFHKFTIGWAWISEYGSPENPEEFKALYAYSPLH
EEEHHHHCCCHHHHHHHHHHHHHHHHHHHHHEEEEHHHHHCCCCCCHHHHHEEEEECCHH
NLKPGTAYPATLITTADHDDRVVPAHSFKFAAALQVAQGGSQPILIRIDTKAGHGAGKPT
CCCCCCCCCEEEEEECCCCCCEECCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCH
SKLIEEAADRWAFLVQVLGIPWDGTGS
HHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8370677 [H]