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The map label for this gene is mprA [H]

Identifier: 86609935

GI number: 86609935

Start: 2595567

End: 2596268

Strand: Direct

Name: mprA [H]

Synonym: CYB_2501

Alternate gene names: 86609935

Gene position: 2595567-2596268 (Clockwise)

Preceding gene: 86609934

Following gene: 86609937

Centisome position: 85.19

GC content: 62.39

Gene sequence:

>702_bases
ATGGCACGGATTTTATTGGTGGACGATGAAGTGGAGTTGGCCGATTCTCTGGCCCAGCAACTGAGGCGAGAGGGCTACAC
GGTGGACGTGGCCTACACGGGGGGGCGAGCCTGGGAACTGCTGCAAAAGACGGGATCCCTGCCCTACAATCTGCTGGTCT
TGGATTGGATGTTGCCGGAGCTCTCCGGGCTTTCCCTCTGTCAGCGGGTACGGCAGGTGGATTGCACCACCCCTATCCTG
TTTCTGACGGCCAAAGATACCCTAGACGACCGGGTGGAAGGGCTGGATGCCGGGGCAGATGATTACTTGGTGAAGCCGTT
CGAGCTGCGGGAACTGCTGGCGCGGGTGCGGGCCCTCTTGCGGCGAACCACAGGTACTGGAGAAGGGATCCCTCGCCTAC
AGATAGGGGATTTGGAGCTGGATCGGGAGAACCAGGTGGCCTACCGGCAGGGGCGGATGATCCACCTCTCCCAAAAAGAG
TTTCGCCTGCTGGAGTACTTCATGACCCACCCCGGCCAGTTGCTCACCCACGACCAGATCTACGAGCAGGTGTGGGCCGG
AGAGGATCCCCCCAGCAGCAACGTCTTGGCAGCCCAGGTGCGCCTGCTGCGGCGCCGCCTCAGGTTGCCCGGGGCAGCAG
AATTGATCCACGCCGTCTACGGCAAGGGCTATCGCTTCGGGCCTGTCGCCGGGGATCCCTAG

Upstream 100 bases:

>100_bases
GGGACGGAGTCCTTTTCTGAGTACGTCAGCGCTCCACATTGTTTCCAAGACAACAGCGAGACCGAGTCCTGAGGTGTTCG
CGTTAGCGGGACGGAGTCCT

Downstream 100 bases:

>100_bases
CAGCCGTCCCACCTGTAGATAAAACCAAGGCTCCCCCGAAAAGAAGGAGCCCTGCCGGGTCTGGGGAGCGCTTTCAGTCA
GCAATGCCACCAGGGCGTTC

Product: DNA-binding response regulator

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 233; Mature: 232

Protein sequence:

>233_residues
MARILLVDDEVELADSLAQQLRREGYTVDVAYTGGRAWELLQKTGSLPYNLLVLDWMLPELSGLSLCQRVRQVDCTTPIL
FLTAKDTLDDRVEGLDAGADDYLVKPFELRELLARVRALLRRTTGTGEGIPRLQIGDLELDRENQVAYRQGRMIHLSQKE
FRLLEYFMTHPGQLLTHDQIYEQVWAGEDPPSSNVLAAQVRLLRRRLRLPGAAELIHAVYGKGYRFGPVAGDP

Sequences:

>Translated_233_residues
MARILLVDDEVELADSLAQQLRREGYTVDVAYTGGRAWELLQKTGSLPYNLLVLDWMLPELSGLSLCQRVRQVDCTTPIL
FLTAKDTLDDRVEGLDAGADDYLVKPFELRELLARVRALLRRTTGTGEGIPRLQIGDLELDRENQVAYRQGRMIHLSQKE
FRLLEYFMTHPGQLLTHDQIYEQVWAGEDPPSSNVLAAQVRLLRRRLRLPGAAELIHAVYGKGYRFGPVAGDP
>Mature_232_residues
ARILLVDDEVELADSLAQQLRREGYTVDVAYTGGRAWELLQKTGSLPYNLLVLDWMLPELSGLSLCQRVRQVDCTTPILF
LTAKDTLDDRVEGLDAGADDYLVKPFELRELLARVRALLRRTTGTGEGIPRLQIGDLELDRENQVAYRQGRMIHLSQKEF
RLLEYFMTHPGQLLTHDQIYEQVWAGEDPPSSNVLAAQVRLLRRRLRLPGAAELIHAVYGKGYRFGPVAGDP

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=223, Percent_Identity=39.9103139013453, Blast_Score=146, Evalue=1e-36,
Organism=Escherichia coli, GI1789402, Length=225, Percent_Identity=37.3333333333333, Blast_Score=137, Evalue=6e-34,
Organism=Escherichia coli, GI1790552, Length=222, Percent_Identity=39.1891891891892, Blast_Score=136, Evalue=1e-33,
Organism=Escherichia coli, GI87082012, Length=227, Percent_Identity=35.6828193832599, Blast_Score=132, Evalue=2e-32,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=34.051724137931, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI1786599, Length=229, Percent_Identity=32.3144104803493, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1788394, Length=229, Percent_Identity=34.9344978165939, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1790860, Length=205, Percent_Identity=34.1463414634146, Blast_Score=118, Evalue=4e-28,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=31.6964285714286, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1786911, Length=227, Percent_Identity=34.3612334801762, Blast_Score=112, Evalue=3e-26,
Organism=Escherichia coli, GI2367329, Length=213, Percent_Identity=36.150234741784, Blast_Score=110, Evalue=8e-26,
Organism=Escherichia coli, GI1790863, Length=231, Percent_Identity=30.3030303030303, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1787229, Length=228, Percent_Identity=32.8947368421053, Blast_Score=102, Evalue=2e-23,
Organism=Escherichia coli, GI145693140, Length=242, Percent_Identity=27.6859504132231, Blast_Score=71, Evalue=7e-14,
Organism=Escherichia coli, GI1790437, Length=128, Percent_Identity=29.6875, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788550, Length=112, Percent_Identity=31.25, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26371; Mature: 26239

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARILLVDDEVELADSLAQQLRREGYTVDVAYTGGRAWELLQKTGSLPYNLLVLDWMLPE
CEEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHC
LSGLSLCQRVRQVDCTTPILFLTAKDTLDDRVEGLDAGADDYLVKPFELRELLARVRALL
CCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHH
RRTTGTGEGIPRLQIGDLELDRENQVAYRQGRMIHLSQKEFRLLEYFMTHPGQLLTHDQI
HHCCCCCCCCCCEEECCEEECCCCCHHHHCCCEEEECHHHHHHHHHHHHCCCCCCHHHHH
YEQVWAGEDPPSSNVLAAQVRLLRRRLRLPGAAELIHAVYGKGYRFGPVAGDP
HHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCCCCC
>Mature Secondary Structure 
ARILLVDDEVELADSLAQQLRREGYTVDVAYTGGRAWELLQKTGSLPYNLLVLDWMLPE
EEEEEECCHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHCCCCCHHHHHHHHHHC
LSGLSLCQRVRQVDCTTPILFLTAKDTLDDRVEGLDAGADDYLVKPFELRELLARVRALL
CCHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHCCCCCCCCCEECCHHHHHHHHHHHHHH
RRTTGTGEGIPRLQIGDLELDRENQVAYRQGRMIHLSQKEFRLLEYFMTHPGQLLTHDQI
HHCCCCCCCCCCEEECCEEECCCCCHHHHCCCEEEECHHHHHHHHHHHHCCCCCCHHHHH
YEQVWAGEDPPSSNVLAAQVRLLRRRLRLPGAAELIHAVYGKGYRFGPVAGDP
HHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA