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The map label for this gene is proA [H]

Identifier: 86608045

GI number: 86608045

Start: 563050

End: 564351

Strand: Reverse

Name: proA [H]

Synonym: CYB_0553

Alternate gene names: 86608045

Gene position: 564351-563050 (Counterclockwise)

Preceding gene: 86608046

Following gene: 86608044

Centisome position: 18.52

GC content: 59.75

Gene sequence:

>1302_bases
GTGACAGATTTCGGTTCAGACTTTGACTTAGGTACCACTCTGCGACAGGTACGCCGCTTACTACCGCAGATGCAGCGGTT
GAGCAGCCAAACCAAGCGCCAGGCCCTGCTGGCTCTCTCGCGGTGTTTGTTGGAGCGCTCCGATCTGCTCCTGGAAGCCA
ATACCCTCGACCTGGAAAGTTGCCGCGAGCAAACCGTACCGGAGTGGATCCTCAACGGCCTGAAGCTCACCCCCGAGCGC
CTACAGCGATCCGCCCAGTTGCTGACTCTCCTGGCCCAGCAGCCGGATCCCATTGGCAAGCTGGAGAAAGGGCACCGCCA
GGAGAACGGCCTGTTTATTGGCCGCTACCGCGTCCCGTTGGGGTTGATCGCTCTGGTCTATGAAATCTACCCCGAGTTTG
CCCTAAATGGCATTGGCATGTGCTTAAAAGCGGGAAACGGCGTGATTTTGGCCAGCAGCGGTCCCATCCAGAAAACCCAC
CAGGCTATGGTCAACCTGTTGGCAGAGACGGCTTACGAGCACGGGATCCCGGAAGGAGCCATTCAAACCTTGCCCGCCCA
AGACCGAACCGCAGATCCCCAAGTAGATTCCCCACTATTGCCGTTGTTACAGCAAACCCGCTACCTAGACCTGGTGATTC
CCTGCGGTCGCCCCGGCTGGGTGGAGTTCCTGTTGCAGGCCAGCAAAGTGCCGACTCTGGCTACCCATTTGGGCTACGGC
CACATCTATCTGGATCGCACCGCCCCTTGGCCTTTGGTCAAGTCGGTTTTGTTGGATCCCCTCGCCCAGTATGGCTCAGA
AGGGATCCCTATCTATCAGCCCCTCACCCTTTGGCTGCTGATCCACACCGATTGGGCCGCCAACCATCTGACCGCCTTGG
TGGAGGACTTGCTGGGTCACGGGATCGCTGTACAGGCAGCAGCACCCATCCTAGAGCAGTTCCCGCAGCTCCAGCCGCTT
GGGCAAGGCTTTGACTCGACAGAACGACCTCATCTGCGCCTGCAGCCCATTGCCGACCTGACGGAGGCGATCGCCTGGAT
TAACAAAAATGGTTGCCGTCAATCGGAGACGATCCTCACCGATAGCCAATCGGCGGCCCAGCGCTTTCTCCAGGAAGTAG
ATGCCGCCCTGATCCACATCAACACTTCCCCCCTCTCGGCAGGCCGGGGAGCTGGGATCCCCACGTTGGGAGCGTTTCGC
GACCTGTCTTTGGGCATTTCTACCCAGCGGCTGCACGTGCGCGGGCCCATCGACGTGGAAGCCCTGACAACGGTGAAGGT
GGTGGCTCAGGGCGATCTGTAG

Upstream 100 bases:

>100_bases
TTGGCAGCCCCAGCACTTGTGGATCCAACCATTTCTTGTTAGCAGTGGTCTGGAGAACGCAGCGGGTCTGTCTCTAATGG
GCTAGGCGGGAGAAGTTCAA

Downstream 100 bases:

>100_bases
AGCCGGGCAGCAACCCAACTGATGCGCCAAGGTTGGCCGGTCTGCCCAAGATCCAAGAGCTGGGATGAGGCTGGAGAATG
AGAATGTAGATCGCCATCAG

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 433; Mature: 432

Protein sequence:

>433_residues
MTDFGSDFDLGTTLRQVRRLLPQMQRLSSQTKRQALLALSRCLLERSDLLLEANTLDLESCREQTVPEWILNGLKLTPER
LQRSAQLLTLLAQQPDPIGKLEKGHRQENGLFIGRYRVPLGLIALVYEIYPEFALNGIGMCLKAGNGVILASSGPIQKTH
QAMVNLLAETAYEHGIPEGAIQTLPAQDRTADPQVDSPLLPLLQQTRYLDLVIPCGRPGWVEFLLQASKVPTLATHLGYG
HIYLDRTAPWPLVKSVLLDPLAQYGSEGIPIYQPLTLWLLIHTDWAANHLTALVEDLLGHGIAVQAAAPILEQFPQLQPL
GQGFDSTERPHLRLQPIADLTEAIAWINKNGCRQSETILTDSQSAAQRFLQEVDAALIHINTSPLSAGRGAGIPTLGAFR
DLSLGISTQRLHVRGPIDVEALTTVKVVAQGDL

Sequences:

>Translated_433_residues
MTDFGSDFDLGTTLRQVRRLLPQMQRLSSQTKRQALLALSRCLLERSDLLLEANTLDLESCREQTVPEWILNGLKLTPER
LQRSAQLLTLLAQQPDPIGKLEKGHRQENGLFIGRYRVPLGLIALVYEIYPEFALNGIGMCLKAGNGVILASSGPIQKTH
QAMVNLLAETAYEHGIPEGAIQTLPAQDRTADPQVDSPLLPLLQQTRYLDLVIPCGRPGWVEFLLQASKVPTLATHLGYG
HIYLDRTAPWPLVKSVLLDPLAQYGSEGIPIYQPLTLWLLIHTDWAANHLTALVEDLLGHGIAVQAAAPILEQFPQLQPL
GQGFDSTERPHLRLQPIADLTEAIAWINKNGCRQSETILTDSQSAAQRFLQEVDAALIHINTSPLSAGRGAGIPTLGAFR
DLSLGISTQRLHVRGPIDVEALTTVKVVAQGDL
>Mature_432_residues
TDFGSDFDLGTTLRQVRRLLPQMQRLSSQTKRQALLALSRCLLERSDLLLEANTLDLESCREQTVPEWILNGLKLTPERL
QRSAQLLTLLAQQPDPIGKLEKGHRQENGLFIGRYRVPLGLIALVYEIYPEFALNGIGMCLKAGNGVILASSGPIQKTHQ
AMVNLLAETAYEHGIPEGAIQTLPAQDRTADPQVDSPLLPLLQQTRYLDLVIPCGRPGWVEFLLQASKVPTLATHLGYGH
IYLDRTAPWPLVKSVLLDPLAQYGSEGIPIYQPLTLWLLIHTDWAANHLTALVEDLLGHGIAVQAAAPILEQFPQLQPLG
QGFDSTERPHLRLQPIADLTEAIAWINKNGCRQSETILTDSQSAAQRFLQEVDAALIHINTSPLSAGRGAGIPTLGAFRD
LSLGISTQRLHVRGPIDVEALTTVKVVAQGDL

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361368, Length=410, Percent_Identity=26.5853658536585, Blast_Score=112, Evalue=6e-25,
Organism=Homo sapiens, GI62912457, Length=410, Percent_Identity=26.5853658536585, Blast_Score=112, Evalue=6e-25,
Organism=Escherichia coli, GI1786438, Length=433, Percent_Identity=29.7921478060046, Blast_Score=180, Evalue=1e-46,
Organism=Caenorhabditis elegans, GI17569967, Length=417, Percent_Identity=26.8585131894484, Blast_Score=133, Evalue=2e-31,
Organism=Caenorhabditis elegans, GI17569969, Length=417, Percent_Identity=26.8585131894484, Blast_Score=133, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6324899, Length=451, Percent_Identity=24.6119733924612, Blast_Score=131, Evalue=2e-31,
Organism=Drosophila melanogaster, GI21357643, Length=417, Percent_Identity=26.1390887290168, Blast_Score=125, Evalue=7e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 47536; Mature: 47405

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDFGSDFDLGTTLRQVRRLLPQMQRLSSQTKRQALLALSRCLLERSDLLLEANTLDLES
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHH
CREQTVPEWILNGLKLTPERLQRSAQLLTLLAQQPDPIGKLEKGHRQENGLFIGRYRVPL
HHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCEEEEEEHHHH
GLIALVYEIYPEFALNGIGMCLKAGNGVILASSGPIQKTHQAMVNLLAETAYEHGIPEGA
HHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCH
IQTLPAQDRTADPQVDSPLLPLLQQTRYLDLVIPCGRPGWVEFLLQASKVPTLATHLGYG
HHCCCCCCCCCCCCCCCCHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCHHHHHCCCC
HIYLDRTAPWPLVKSVLLDPLAQYGSEGIPIYQPLTLWLLIHTDWAANHLTALVEDLLGH
EEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCC
GIAVQAAAPILEQFPQLQPLGQGFDSTERPHLRLQPIADLTEAIAWINKNGCRQSETILT
CEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCEEC
DSQSAAQRFLQEVDAALIHINTSPLSAGRGAGIPTLGAFRDLSLGISTQRLHVRGPIDVE
CCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEECCCCCHH
ALTTVKVVAQGDL
HHHEEEEEECCCC
>Mature Secondary Structure 
TDFGSDFDLGTTLRQVRRLLPQMQRLSSQTKRQALLALSRCLLERSDLLLEANTLDLES
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCHHH
CREQTVPEWILNGLKLTPERLQRSAQLLTLLAQQPDPIGKLEKGHRQENGLFIGRYRVPL
HHHCCCHHHHHCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHCCCCCCCEEEEEEHHHH
GLIALVYEIYPEFALNGIGMCLKAGNGVILASSGPIQKTHQAMVNLLAETAYEHGIPEGA
HHHHHHHHHHHHHHHHHHHHHEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCH
IQTLPAQDRTADPQVDSPLLPLLQQTRYLDLVIPCGRPGWVEFLLQASKVPTLATHLGYG
HHCCCCCCCCCCCCCCCCHHHHHHHCCEEEEEEECCCCHHHHHHHHHHCCCHHHHHCCCC
HIYLDRTAPWPLVKSVLLDPLAQYGSEGIPIYQPLTLWLLIHTDWAANHLTALVEDLLGH
EEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHCC
GIAVQAAAPILEQFPQLQPLGQGFDSTERPHLRLQPIADLTEAIAWINKNGCRQSETILT
CEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHCCCCCCCCCCEEC
DSQSAAQRFLQEVDAALIHINTSPLSAGRGAGIPTLGAFRDLSLGISTQRLHVRGPIDVE
CCHHHHHHHHHHHHHEEEEEECCCCCCCCCCCCCCCHHHHHHHCCCCCCEEEECCCCCHH
ALTTVKVVAQGDL
HHHEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 14621292 [H]