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The map label for this gene is hisD [H]

Identifier: 86607575

GI number: 86607575

Start: 84796

End: 86109

Strand: Direct

Name: hisD [H]

Synonym: CYB_0073

Alternate gene names: 86607575

Gene position: 84796-86109 (Clockwise)

Preceding gene: 86607574

Following gene: 86607576

Centisome position: 2.78

GC content: 62.63

Gene sequence:

>1314_bases
ATGCTGAGAATCGTCACCCAGCTAGCCGAGGCTGAAGCCGAGCTCAGACGGATCTCGGAGCGCACTCAGGCTGACCAGAA
CCTGCACCGCGAAGCAACTGTGCGGGAGATCCTGCAAGCGGTACGCCGTCAGGGGGATCGGGCCCTGCTGACCTATACGG
CTGAGTTCGACCAGGTGGAGCTGAGCGTTGCCGAGCTGAAGGTGTCTGGGGCCGAGCTAGAGGCAGCTTACCAGGCGGTA
TCTCCGCAATTGCTTTCAGCCCTACGGCTGGCCAAGCAGCGCATTGAAGCTTTTCACCGGCAGCGGGTGCCCAGCAGTTG
GGTAAGCTTTCCCGGCCCTGAGATCGTCTTGGGCAAGCAATACCGCCCTGTGGATCGCGCCGGCCTCTACATTCCGGGAG
GGCGAGCCGCCTATCCCAGCACGGTGTTGATGAACGCCATCCCGGCCCAGGTGGCAGGGGTGCCCGAGATTGTGATGGTG
ACGCCACCGGGATCTGACGGGTTGGGGGGCAAGGGGATTAGCCCGGCCATTTTGGTGGCCGCCCAAGAAGTAGGCATCCA
CACCATCTATCGCGTTGGGGGGGCTCAGGCAATAGGGGCTTTGGCCTACGGCACCGAGACCATCCCCAAGGTGGACGTGA
TCACCGGCCCCGGCAACATCTACGTAACTTTGGCCAAAAAGCTGGTGTACGGCACGGTGGGGATCGACTCGCTGGCCGGG
CCATCGGAGGTGTTGATCATCGCCGACGAGAGCGCCAACCCCCTTTATGTGGCTGCCGATTTGCTGGCCCAAGCCGAGCA
CGATCCCTTGGCGGCGGCCATCCTTCTGACCACCGATCTCCAGCTGGCCCAGCAGGTGCAGCAGGCGGTGGCCACCCAGA
TGGAGGCCCATCCCAACCGTCTGATGGTGGAAAAGTCGGTGGTGAATTACGGGCTGATTGCGGTGGTGCCGGATCTGACG
GCGGCGGTGGCTTTGTCCAACCTGTTTGCGCCAGAGCATTTGGAACTGCAGGTGGCAGATCCCTGGGCTTTGCTGGATCC
CATTCGCCATGCGGGGGCCATTTTCTTGGGCCACCATACTCCGGAGGCGGTAGGAGATTACCTGGCCGGCCCCAACCATA
CCTTGCCCACCGCCGGTGCGGCCCGCTATGCCTCGGCTTTGGGGGTGGAAACTTTCCTAAAGCATTCCAGTCTGATTCAA
TACAGCTCAGCGGCTTTGCGGGAGGTGGCCAGCGCCATTCAGGCTCTCACACAAGCGGAAGGGTTGCCCGCCCACGGCCA
GTCGGTACAGGTGCGGTTGGCGGAGGAGCGCTAA

Upstream 100 bases:

>100_bases
TCGCCGCAAGCCGACCCAGCGAAAGATCCGCTTTGCTACCGCGATGCCGCCGGATCCCTCGTTACTATGGGGTTGCGGCA
CTCTACGCGAAGGAGTCGCT

Downstream 100 bases:

>100_bases
TCAAGCCCTGGTCGCAGTTAGCTAGACCGCCGGGAAGCCCCACCCTCTGTTAGTGACTAGTGGCTAGTCACTATCCACTC
ACCACTATCCAGGGTGAGGG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH 2 [H]

Number of amino acids: Translated: 437; Mature: 437

Protein sequence:

>437_residues
MLRIVTQLAEAEAELRRISERTQADQNLHREATVREILQAVRRQGDRALLTYTAEFDQVELSVAELKVSGAELEAAYQAV
SPQLLSALRLAKQRIEAFHRQRVPSSWVSFPGPEIVLGKQYRPVDRAGLYIPGGRAAYPSTVLMNAIPAQVAGVPEIVMV
TPPGSDGLGGKGISPAILVAAQEVGIHTIYRVGGAQAIGALAYGTETIPKVDVITGPGNIYVTLAKKLVYGTVGIDSLAG
PSEVLIIADESANPLYVAADLLAQAEHDPLAAAILLTTDLQLAQQVQQAVATQMEAHPNRLMVEKSVVNYGLIAVVPDLT
AAVALSNLFAPEHLELQVADPWALLDPIRHAGAIFLGHHTPEAVGDYLAGPNHTLPTAGAARYASALGVETFLKHSSLIQ
YSSAALREVASAIQALTQAEGLPAHGQSVQVRLAEER

Sequences:

>Translated_437_residues
MLRIVTQLAEAEAELRRISERTQADQNLHREATVREILQAVRRQGDRALLTYTAEFDQVELSVAELKVSGAELEAAYQAV
SPQLLSALRLAKQRIEAFHRQRVPSSWVSFPGPEIVLGKQYRPVDRAGLYIPGGRAAYPSTVLMNAIPAQVAGVPEIVMV
TPPGSDGLGGKGISPAILVAAQEVGIHTIYRVGGAQAIGALAYGTETIPKVDVITGPGNIYVTLAKKLVYGTVGIDSLAG
PSEVLIIADESANPLYVAADLLAQAEHDPLAAAILLTTDLQLAQQVQQAVATQMEAHPNRLMVEKSVVNYGLIAVVPDLT
AAVALSNLFAPEHLELQVADPWALLDPIRHAGAIFLGHHTPEAVGDYLAGPNHTLPTAGAARYASALGVETFLKHSSLIQ
YSSAALREVASAIQALTQAEGLPAHGQSVQVRLAEER
>Mature_437_residues
MLRIVTQLAEAEAELRRISERTQADQNLHREATVREILQAVRRQGDRALLTYTAEFDQVELSVAELKVSGAELEAAYQAV
SPQLLSALRLAKQRIEAFHRQRVPSSWVSFPGPEIVLGKQYRPVDRAGLYIPGGRAAYPSTVLMNAIPAQVAGVPEIVMV
TPPGSDGLGGKGISPAILVAAQEVGIHTIYRVGGAQAIGALAYGTETIPKVDVITGPGNIYVTLAKKLVYGTVGIDSLAG
PSEVLIIADESANPLYVAADLLAQAEHDPLAAAILLTTDLQLAQQVQQAVATQMEAHPNRLMVEKSVVNYGLIAVVPDLT
AAVALSNLFAPEHLELQVADPWALLDPIRHAGAIFLGHHTPEAVGDYLAGPNHTLPTAGAARYASALGVETFLKHSSLIQ
YSSAALREVASAIQALTQAEGLPAHGQSVQVRLAEER

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=405, Percent_Identity=43.2098765432099, Blast_Score=295, Evalue=5e-81,
Organism=Saccharomyces cerevisiae, GI6319819, Length=429, Percent_Identity=39.1608391608392, Blast_Score=278, Evalue=8e-76,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46426; Mature: 46426

Theoretical pI: Translated: 5.57; Mature: 5.57

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRIVTQLAEAEAELRRISERTQADQNLHREATVREILQAVRRQGDRALLTYTAEFDQVE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHE
LSVAELKVSGAELEAAYQAVSPQLLSALRLAKQRIEAFHRQRVPSSWVSFPGPEIVLGKQ
EEHHHEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEECCC
YRPVDRAGLYIPGGRAAYPSTVLMNAIPAQVAGVPEIVMVTPPGSDGLGGKGISPAILVA
CCCCCCCCEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHEEE
AQEVGIHTIYRVGGAQAIGALAYGTETIPKVDVITGPGNIYVTLAKKLVYGTVGIDSLAG
HHHCCHHHEEECCCHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEHHHHHHCCCCCCCCC
PSEVLIIADESANPLYVAADLLAQAEHDPLAAAILLTTDLQLAQQVQQAVATQMEAHPNR
CCEEEEEECCCCCCEEEHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCC
LMVEKSVVNYGLIAVVPDLTAAVALSNLFAPEHLELQVADPWALLDPIRHAGAIFLGHHT
EEEEHHHHCCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCEEEEECCC
PEAVGDYLAGPNHTLPTAGAARYASALGVETFLKHSSLIQYSSAALREVASAIQALTQAE
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLPAHGQSVQVRLAEER
CCCCCCCEEEEEEECCC
>Mature Secondary Structure
MLRIVTQLAEAEAELRRISERTQADQNLHREATVREILQAVRRQGDRALLTYTAEFDQVE
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCHHE
LSVAELKVSGAELEAAYQAVSPQLLSALRLAKQRIEAFHRQRVPSSWVSFPGPEIVLGKQ
EEHHHEEECCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCCCCEEECCC
YRPVDRAGLYIPGGRAAYPSTVLMNAIPAQVAGVPEIVMVTPPGSDGLGGKGISPAILVA
CCCCCCCCEECCCCCCCCCHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHEEE
AQEVGIHTIYRVGGAQAIGALAYGTETIPKVDVITGPGNIYVTLAKKLVYGTVGIDSLAG
HHHCCHHHEEECCCHHHHHHHHCCCCCCCCEEEEECCCCEEEEEEHHHHHHCCCCCCCCC
PSEVLIIADESANPLYVAADLLAQAEHDPLAAAILLTTDLQLAQQVQQAVATQMEAHPNR
CCEEEEEECCCCCCEEEHHHHHHHCCCCCCEEEEEEHHHHHHHHHHHHHHHHHHHCCCCC
LMVEKSVVNYGLIAVVPDLTAAVALSNLFAPEHLELQVADPWALLDPIRHAGAIFLGHHT
EEEEHHHHCCCCEEEHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHHHHCCEEEEECCC
PEAVGDYLAGPNHTLPTAGAARYASALGVETFLKHSSLIQYSSAALREVASAIQALTQAE
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GLPAHGQSVQVRLAEER
CCCCCCCEEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA