Click here to switch to the map view.

The map label for this gene is murC

Identifier: 86606524

GI number: 86606524

Start: 1879001

End: 1880533

Strand: Reverse

Name: murC

Synonym: CYA_1876

Alternate gene names: 86606524

Gene position: 1880533-1879001 (Counterclockwise)

Preceding gene: 86606528

Following gene: 86606523

Centisome position: 64.12

GC content: 61.12

Gene sequence:

>1533_bases
ATGGTGGAAACAGTTGGGGGGAAAGATGCCGTTGCGCCGGCGCCAGCTCGTTCTCCATCTCCGCCTGCGAAAAATTTGGA
TCCGTTGAACCCGCTACTTCCGGCTTATCATTTTGTCGGGATCGGCGGGGTGGGGATGTCGGCTCTGGCTTACATTTTGG
CCAAGCAGGGGTTTCGGGTTTCAGGGTCGGATATTGCCGCCAATGGCCGCACCCGTCGCCTGGAAGCCTTGGGGGTGCGC
TTTATTCAGGGGCACACTCTGGAGGGTTTGGCCGGGGATCCCCAGGTGGTCTACTCCAGCGCCATTCGCCCCACCAACCC
GGAATTAGCGGCGGCGCTGGACAAGGGACTAAAGGTTTGGCATCGAGCCGATTTGCTGGCTGCCCTGTTTAACCATCGTC
CCAGCATTGGGGTGGCGGGCACCCACGGCAAGACCACTACTAGCAGCATGATTGGCTACATGTTACTGGCGGCGGGCTGG
GATCCCACCTTGATCATCGGCGGGGAGATGGACGCCTGGGATGGCAATGCCCGTCTAGGCCAGGGGGAATACCTGGTAGC
CGAGGTGGACGAGTCGGATGGATCCCTGGTGCGGCTCTATCCCCAAATTGGCGTGATCACCAACATTGAGCTAGACCACC
CGGATCACTACGCCAATCTGGAGCAGGTGATCCGGGCCTTTCAGCAGTATGGGCAGCAGAGCCAAACCCTGGTGGCCTGT
CTGGACTGCCCCAACGTGGCCACCCACCTCAAGGTGGACATCGGCTACAGCCTGGCCGGCCATCCCCAAGCCCAGTACCA
GGCCCGTCAGATCCTCTACACTGCCGATTGCACCTCTGCCGAGATCTGGGAAAGGGGATCCCTCCTCGGCCAGCTCCGCC
TGCAGGTGCTGGGATCCCATAACCTCAGCAATGCCCTGGCGGCGGTTGCCGTGGGGCGACAGTTGGGCTTGGAGTTTGCG
GTGATTGCCTCGGCTCTGGCCGAGTTTCGAGGGGTGCAGCGGCGATTTGAAGTCAAAGGCGAGGTGGGTGGGGTCACCTT
TATCGACGACTATGCCCATCATCCCAGCGAGATTCGGGCTACGCTGCGGGCGGCACGGCTGCAGCAGCGGCGGGTGGTGG
CGGTGTTCCAGCCCCATCGCCACAGCCGCTTGGCCAAGTTGTTCCAGGACTTTGCTTGCTGCTTTGCGGATGCGCAGGTG
GTGGTGATCGTGCCCACTTATGGGGCGGGAGAAGCAGCGCCTGAGGGCTCCGACAGCTTGCGGCTGGCCGTGTCGGTGGC
GGAGCACCATCCCCATGTACGTTATGTGTCTTCTTTGCCGCAATTGCCGCAGGTGTTGCCGTCTATCTTGCAACCTGGAG
ATCTGGCAATTTTTTTGGGCGCAGGCGATCTCAATCAACAGATAGCCGCTACGATGCGGGCCTATGCGGCTCGGCTGGGG
GAGCAGCCTCTGGCAAACTTTGAAGGGAAATTGCCGGGGCAAGCGGAGGATGGGATCAGGGAGATGGGGGCTTCTGAGGT
ATTGGCATCATGA

Upstream 100 bases:

>100_bases
CTACCTAACCCAAGGGATTCCTGATATGATCTGCCGTGTCCGGGGCCTTTCTGCAGGTGCCGATTTCTAGGTGTGGTGCG
AGGAGTGAGGTGGAGTTGCG

Downstream 100 bases:

>100_bases
CTACAGCTCCCTGCGTGCCCAATGCCTCAAGCGTTGCCCGACTCTCTGGACGGATTCAAGCGGGGATCCCCTTGGCCCCT
CTGACCACCTTTCGCGTGGG

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase

Number of amino acids: Translated: 510; Mature: 510

Protein sequence:

>510_residues
MVETVGGKDAVAPAPARSPSPPAKNLDPLNPLLPAYHFVGIGGVGMSALAYILAKQGFRVSGSDIAANGRTRRLEALGVR
FIQGHTLEGLAGDPQVVYSSAIRPTNPELAAALDKGLKVWHRADLLAALFNHRPSIGVAGTHGKTTTSSMIGYMLLAAGW
DPTLIIGGEMDAWDGNARLGQGEYLVAEVDESDGSLVRLYPQIGVITNIELDHPDHYANLEQVIRAFQQYGQQSQTLVAC
LDCPNVATHLKVDIGYSLAGHPQAQYQARQILYTADCTSAEIWERGSLLGQLRLQVLGSHNLSNALAAVAVGRQLGLEFA
VIASALAEFRGVQRRFEVKGEVGGVTFIDDYAHHPSEIRATLRAARLQQRRVVAVFQPHRHSRLAKLFQDFACCFADAQV
VVIVPTYGAGEAAPEGSDSLRLAVSVAEHHPHVRYVSSLPQLPQVLPSILQPGDLAIFLGAGDLNQQIAATMRAYAARLG
EQPLANFEGKLPGQAEDGIREMGASEVLAS

Sequences:

>Translated_510_residues
MVETVGGKDAVAPAPARSPSPPAKNLDPLNPLLPAYHFVGIGGVGMSALAYILAKQGFRVSGSDIAANGRTRRLEALGVR
FIQGHTLEGLAGDPQVVYSSAIRPTNPELAAALDKGLKVWHRADLLAALFNHRPSIGVAGTHGKTTTSSMIGYMLLAAGW
DPTLIIGGEMDAWDGNARLGQGEYLVAEVDESDGSLVRLYPQIGVITNIELDHPDHYANLEQVIRAFQQYGQQSQTLVAC
LDCPNVATHLKVDIGYSLAGHPQAQYQARQILYTADCTSAEIWERGSLLGQLRLQVLGSHNLSNALAAVAVGRQLGLEFA
VIASALAEFRGVQRRFEVKGEVGGVTFIDDYAHHPSEIRATLRAARLQQRRVVAVFQPHRHSRLAKLFQDFACCFADAQV
VVIVPTYGAGEAAPEGSDSLRLAVSVAEHHPHVRYVSSLPQLPQVLPSILQPGDLAIFLGAGDLNQQIAATMRAYAARLG
EQPLANFEGKLPGQAEDGIREMGASEVLAS
>Mature_510_residues
MVETVGGKDAVAPAPARSPSPPAKNLDPLNPLLPAYHFVGIGGVGMSALAYILAKQGFRVSGSDIAANGRTRRLEALGVR
FIQGHTLEGLAGDPQVVYSSAIRPTNPELAAALDKGLKVWHRADLLAALFNHRPSIGVAGTHGKTTTSSMIGYMLLAAGW
DPTLIIGGEMDAWDGNARLGQGEYLVAEVDESDGSLVRLYPQIGVITNIELDHPDHYANLEQVIRAFQQYGQQSQTLVAC
LDCPNVATHLKVDIGYSLAGHPQAQYQARQILYTADCTSAEIWERGSLLGQLRLQVLGSHNLSNALAAVAVGRQLGLEFA
VIASALAEFRGVQRRFEVKGEVGGVTFIDDYAHHPSEIRATLRAARLQQRRVVAVFQPHRHSRLAKLFQDFACCFADAQV
VVIVPTYGAGEAAPEGSDSLRLAVSVAEHHPHVRYVSSLPQLPQVLPSILQPGDLAIFLGAGDLNQQIAATMRAYAARLG
EQPLANFEGKLPGQAEDGIREMGASEVLAS

Specific function: Cell wall formation

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family

Homologues:

Organism=Escherichia coli, GI1786279, Length=461, Percent_Identity=36.2255965292842, Blast_Score=207, Evalue=1e-54,
Organism=Escherichia coli, GI1790680, Length=379, Percent_Identity=31.1345646437995, Blast_Score=164, Evalue=1e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURC_SYNJA (Q2JTH3)

Other databases:

- EMBL:   CP000239
- RefSeq:   YP_475287.1
- ProteinModelPortal:   Q2JTH3
- SMR:   Q2JTH3
- STRING:   Q2JTH3
- GeneID:   3899854
- GenomeReviews:   CP000239_GR
- KEGG:   cya:CYA_1876
- TIGR:   CYA_1876
- eggNOG:   COG0773
- HOGENOM:   HBG476594
- OMA:   YQPHRYS
- ProtClustDB:   PRK00421
- BioCyc:   SSP321327:CYA_1876-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00046
- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758
- Gene3D:   G3DSA:3.90.190.20
- Gene3D:   G3DSA:3.40.1190.10
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR01082

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M; SSF53244 Mur_ligase_C; SSF53623 Mur_ligase_cen

EC number: =6.3.2.8

Molecular weight: Translated: 54578; Mature: 54578

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVETVGGKDAVAPAPARSPSPPAKNLDPLNPLLPAYHFVGIGGVGMSALAYILAKQGFRV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCEE
SGSDIAANGRTRRLEALGVRFIQGHTLEGLAGDPQVVYSSAIRPTNPELAAALDKGLKVW
CCCCEECCCCHHHHHHHCCHHCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHH
HRADLLAALFNHRPSIGVAGTHGKTTTSSMIGYMLLAAGWDPTLIIGGEMDAWDGNARLG
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCC
QGEYLVAEVDESDGSLVRLYPQIGVITNIELDHPDHYANLEQVIRAFQQYGQQSQTLVAC
CCCEEEEEECCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEE
LDCPNVATHLKVDIGYSLAGHPQAQYQARQILYTADCTSAEIWERGSLLGQLRLQVLGSH
ECCCCCCEEEEEEECCCCCCCCHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHCCC
NLSNALAAVAVGRQLGLEFAVIASALAEFRGVQRRFEVKGEVGGVTFIDDYAHHPSEIRA
CHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHCCCHHHHHH
TLRAARLQQRRVVAVFQPHRHSRLAKLFQDFACCFADAQVVVIVPTYGAGEAAPEGSDSL
HHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCE
RLAVSVAEHHPHVRYVSSLPQLPQVLPSILQPGDLAIFLGAGDLNQQIAATMRAYAARLG
EEEEEEHHCCCCHHHHHHCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHC
EQPLANFEGKLPGQAEDGIREMGASEVLAS
CCCCCCCCCCCCCCHHHHHHHCCHHHHHCC
>Mature Secondary Structure
MVETVGGKDAVAPAPARSPSPPAKNLDPLNPLLPAYHFVGIGGVGMSALAYILAKQGFRV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHCCCEE
SGSDIAANGRTRRLEALGVRFIQGHTLEGLAGDPQVVYSSAIRPTNPELAAALDKGLKVW
CCCCEECCCCHHHHHHHCCHHCCCCCCCCCCCCCHHHHHCCCCCCCHHHHHHHHHHHHHH
HRADLLAALFNHRPSIGVAGTHGKTTTSSMIGYMLLAAGWDPTLIIGGEMDAWDGNARLG
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCC
QGEYLVAEVDESDGSLVRLYPQIGVITNIELDHPDHYANLEQVIRAFQQYGQQSQTLVAC
CCCEEEEEECCCCCCEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCEEEEE
LDCPNVATHLKVDIGYSLAGHPQAQYQARQILYTADCTSAEIWERGSLLGQLRLQVLGSH
ECCCCCCEEEEEEECCCCCCCCHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHCCC
NLSNALAAVAVGRQLGLEFAVIASALAEFRGVQRRFEVKGEVGGVTFIDDYAHHPSEIRA
CHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEHHHCCCHHHHHH
TLRAARLQQRRVVAVFQPHRHSRLAKLFQDFACCFADAQVVVIVPTYGAGEAAPEGSDSL
HHHHHHHHHCCEEEEECCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCE
RLAVSVAEHHPHVRYVSSLPQLPQVLPSILQPGDLAIFLGAGDLNQQIAATMRAYAARLG
EEEEEEHHCCCCHHHHHHCCHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHC
EQPLANFEGKLPGQAEDGIREMGASEVLAS
CCCCCCCCCCCCCCHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA