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The map label for this gene is murB

Identifier: 86606523

GI number: 86606523

Start: 1878066

End: 1879004

Strand: Reverse

Name: murB

Synonym: CYA_1875

Alternate gene names: 86606523

Gene position: 1879004-1878066 (Counterclockwise)

Preceding gene: 86606524

Following gene: 86606520

Centisome position: 64.07

GC content: 61.66

Gene sequence:

>939_bases
ATGACTACAGCTCCCTGCGTGCCCAATGCCTCAAGCGTTGCCCGACTCTCTGGACGGATTCAAGCGGGGATCCCCTTGGC
CCCTCTGACCACCTTTCGCGTGGGCGGCAAAGCGGAGTGGTATTGCGAGCCGCACAACAATCTGGAGCTGCAGCAATGTT
TGGCCTGGGCGCGGGCGCAAGGGATCCCGGTTACACTGTTGGGGGCGGGCAGCAACCTGCTCATCAGCGATGCCGGCCTG
CCGGGGCTGGTGATCCACACCCGGCGTTTGCGCGGGATGCAACTGTTGGAGGGGGGGAGGATCTGGGCCGCTGCCGGAGA
ACCTTTGGTTAACCTGGCGCGGGCAGCCGCCAAGCGGGGCTGGAGTGGCTTGGAGTGGGCCATCGGGATCCCGGGCACGC
TGGGGGGAGCGGTGGTGATGAATGCCGGCGCCCACGGGCGCGCCATGTCGGACGTGTTGGTGGAAGTGCAGATTTTGGAT
GAAGAGCAGGAGCCCTGCCGCTTAGAACCGGTCGATCTGCAATTTGGCTACCGCCGCTCGCGGCTACAGGACTCTCCTTG
GACGGTGACGGGGGCAACGCTGCAGTTACTCCCAGGCCGGGATCCGGCTCAGGTGCAGCGACAAACCCAGCGCCACCTCA
ACCAGCGCCTGAGCTCTCAGCCCTATCATCTGCCCAGTTGTGGCAGCGTCTTTCGCAACCCCGAAACCCATCCTGCCGGC
TGGCTAATTGAGCAGGTCGGTCTGAAGGGCTACCGGATTGGCGGGGCCCAGATCTCCGAGCGCCATGCAAACTTCATCCT
CAATTGTGGTCAGGCCAGCGCCAACGACATCTACCGTCTGATTTGCTTGGCCCAAGAAAAGGTTTATCAACGATGGTCGA
TATTCCTAGAGCCAGAAGTGCGCATTCTGGGATCTTTTGACGATCCTTTGATAAGTTAA

Upstream 100 bases:

>100_bases
CTCGGCTGGGGGAGCAGCCTCTGGCAAACTTTGAAGGGAAATTGCCGGGGCAAGCGGAGGATGGGATCAGGGAGATGGGG
GCTTCTGAGGTATTGGCATC

Downstream 100 bases:

>100_bases
TTTGGCCTACCCCATTTTTTGATGATTGGATGGTTCTGATCTTGAACTGTCCTCACCAGTCCTTGATGGATTCTCGTTGA
TTATTTTGCGTCAGTTTATG

Product: UDP-N-acetylenolpyruvoylglucosamine reductase

Products: NA

Alternate protein names: UDP-N-acetylmuramate dehydrogenase

Number of amino acids: Translated: 312; Mature: 311

Protein sequence:

>312_residues
MTTAPCVPNASSVARLSGRIQAGIPLAPLTTFRVGGKAEWYCEPHNNLELQQCLAWARAQGIPVTLLGAGSNLLISDAGL
PGLVIHTRRLRGMQLLEGGRIWAAAGEPLVNLARAAAKRGWSGLEWAIGIPGTLGGAVVMNAGAHGRAMSDVLVEVQILD
EEQEPCRLEPVDLQFGYRRSRLQDSPWTVTGATLQLLPGRDPAQVQRQTQRHLNQRLSSQPYHLPSCGSVFRNPETHPAG
WLIEQVGLKGYRIGGAQISERHANFILNCGQASANDIYRLICLAQEKVYQRWSIFLEPEVRILGSFDDPLIS

Sequences:

>Translated_312_residues
MTTAPCVPNASSVARLSGRIQAGIPLAPLTTFRVGGKAEWYCEPHNNLELQQCLAWARAQGIPVTLLGAGSNLLISDAGL
PGLVIHTRRLRGMQLLEGGRIWAAAGEPLVNLARAAAKRGWSGLEWAIGIPGTLGGAVVMNAGAHGRAMSDVLVEVQILD
EEQEPCRLEPVDLQFGYRRSRLQDSPWTVTGATLQLLPGRDPAQVQRQTQRHLNQRLSSQPYHLPSCGSVFRNPETHPAG
WLIEQVGLKGYRIGGAQISERHANFILNCGQASANDIYRLICLAQEKVYQRWSIFLEPEVRILGSFDDPLIS
>Mature_311_residues
TTAPCVPNASSVARLSGRIQAGIPLAPLTTFRVGGKAEWYCEPHNNLELQQCLAWARAQGIPVTLLGAGSNLLISDAGLP
GLVIHTRRLRGMQLLEGGRIWAAAGEPLVNLARAAAKRGWSGLEWAIGIPGTLGGAVVMNAGAHGRAMSDVLVEVQILDE
EQEPCRLEPVDLQFGYRRSRLQDSPWTVTGATLQLLPGRDPAQVQRQTQRHLNQRLSSQPYHLPSCGSVFRNPETHPAGW
LIEQVGLKGYRIGGAQISERHANFILNCGQASANDIYRLICLAQEKVYQRWSIFLEPEVRILGSFDDPLIS

Specific function: Cell wall formation

COG id: COG0812

COG function: function code M; UDP-N-acetylmuramate dehydrogenase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain

Homologues:

Organism=Escherichia coli, GI1790407, Length=331, Percent_Identity=27.4924471299094, Blast_Score=100, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURB_SYNJA (Q2JTH4)

Other databases:

- EMBL:   CP000239
- RefSeq:   YP_475286.1
- STRING:   Q2JTH4
- GeneID:   3899853
- GenomeReviews:   CP000239_GR
- KEGG:   cya:CYA_1875
- TIGR:   CYA_1875
- eggNOG:   COG0812
- HOGENOM:   HBG686573
- OMA:   ISERHAN
- ProtClustDB:   PRK13905
- BioCyc:   SSP321327:CYA_1875-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00037
- InterPro:   IPR016169
- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR003170
- InterPro:   IPR011601
- InterPro:   IPR006094
- Gene3D:   G3DSA:3.30.465.10
- Gene3D:   G3DSA:3.30.43.10
- Gene3D:   G3DSA:3.90.78.10
- PANTHER:   PTHR21071
- TIGRFAMs:   TIGR00179

Pfam domain/function: PF01565 FAD_binding_4; PF02873 MurB_C; SSF56176 FAD-binding_2; SSF56194 MurB_C

EC number: =1.1.1.158

Molecular weight: Translated: 34044; Mature: 33913

Theoretical pI: Translated: 8.29; Mature: 8.29

Prosite motif: PS51387 FAD_PCMH

Important sites: ACT_SITE 178-178 ACT_SITE 229-229 ACT_SITE 299-299

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAPCVPNASSVARLSGRIQAGIPLAPLTTFRVGGKAEWYCEPHNNLELQQCLAWARAQ
CCCCCCCCCHHHHHHHCCCEECCCCCCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHC
GIPVTLLGAGSNLLISDAGLPGLVIHTRRLRGMQLLEGGRIWAAAGEPLVNLARAAAKRG
CCCEEEEECCCCEEEECCCCCEEEEEHHHHCCCEEECCCEEEEECCCHHHHHHHHHHHCC
WSGLEWAIGIPGTLGGAVVMNAGAHGRAMSDVLVEVQILDEEQEPCRLEPVDLQFGYRRS
CCCCEEEEECCCCCCCEEEEECCCCCCHHHHHEEEEEEECCCCCCCCCCEECCCCCCHHH
RLQDSPWTVTGATLQLLPGRDPAQVQRQTQRHLNQRLSSQPYHLPSCGSVFRNPETHPAG
HCCCCCEEEECCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCHH
WLIEQVGLKGYRIGGAQISERHANFILNCGQASANDIYRLICLAQEKVYQRWSIFLEPEV
HHHHHHCCCEEEECCCHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEECCCE
RILGSFDDPLIS
EEEECCCCCCCC
>Mature Secondary Structure 
TTAPCVPNASSVARLSGRIQAGIPLAPLTTFRVGGKAEWYCEPHNNLELQQCLAWARAQ
CCCCCCCCHHHHHHHCCCEECCCCCCCCEEEEECCCEEEEECCCCCCCHHHHHHHHHHC
GIPVTLLGAGSNLLISDAGLPGLVIHTRRLRGMQLLEGGRIWAAAGEPLVNLARAAAKRG
CCCEEEEECCCCEEEECCCCCEEEEEHHHHCCCEEECCCEEEEECCCHHHHHHHHHHHCC
WSGLEWAIGIPGTLGGAVVMNAGAHGRAMSDVLVEVQILDEEQEPCRLEPVDLQFGYRRS
CCCCEEEEECCCCCCCEEEEECCCCCCHHHHHEEEEEEECCCCCCCCCCEECCCCCCHHH
RLQDSPWTVTGATLQLLPGRDPAQVQRQTQRHLNQRLSSQPYHLPSCGSVFRNPETHPAG
HCCCCCEEEECCEEEEECCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCCCCHH
WLIEQVGLKGYRIGGAQISERHANFILNCGQASANDIYRLICLAQEKVYQRWSIFLEPEV
HHHHHHCCCEEEECCCHHHCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHEEEECCCE
RILGSFDDPLIS
EEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA