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The map label for this gene is fcl [C]

Identifier: 86606528

GI number: 86606528

Start: 1884050

End: 1885003

Strand: Reverse

Name: fcl [C]

Synonym: CYA_1879

Alternate gene names: 86606528

Gene position: 1885003-1884050 (Counterclockwise)

Preceding gene: 86606529

Following gene: 86606524

Centisome position: 64.27

GC content: 62.68

Gene sequence:

>954_bases
TTGTCCAGTGCCATCGATCTCAGCCAAAAGCGCATCTTGCTTACCGGAGGGAGCGGCTTTTTGGGCAAACACGTCCTGCA
GCAGTTGCAACTCCTGGGGGTCAAGCCGGAGCAGGTGCGGATCCCACGCTCCCGCACCCACGACCTGCGCCGCTGGGAGG
TCTGCCAAGAGGTGGTGCAGGGACAAGATGTCGTCATCCATTTGGCGGCCCATGTGGGCGGCATCGGCCTCAACCAGGCC
AAGCCGGCGGAGCTCTTCTACGACAACCTGATCATGGGATCCCAGCTCATCCACGCCGCCTACCTGGCGGGGGTGGAGAA
GTTTGTCTGCGTGGGCACCATCTGCGCCTATCCCAAGTTCACCCCCGTCCCCTTCAAGGAAGAAGATCTCTGGAACGGCT
ACCCGGAGGAGACCAACGCCCCCTACGGCATCGCCAAGAAAGCCCTGCTGGTGCAACTGCAGGCCTACCGGCAGCAGTAC
GGCTTCAACGGCATCTACCTCCTGCCGGTAAACCTCTACGGCCCCATGGACAACTTCGATCCGGAAAGCTCCCACGTGAT
CCCGGCCTTGATCCGCAAGGTGCATGAAGCCCAGCAGCGGGGCCAGAACTACGTCGAGGTGTGGGGAGATGGCAGCCCCA
CCCGCGAGTTTTTCTACGCCGAAGATGCGGCTCGGGGAATTCTCCTGGCCACCCAGCTCTACAACAGCCCTGAGCCACTC
AATTTGGGCACCGGCGAGGAGATCTCCATTCGGGATCTCATCGCCCTCATCTGCGAGCTGATGGAGTTTCGGGGCGAGAT
CCGCTGGCAAACCGACAGGCCCAACGGCCAGCCGCGCCGCTGCTTGGACGTCTCCAAAGCCCGCGAGAGGATAGGTTTTG
TGGCCAAGGTGAGCCTGCGGGAGGGGCTGCAGCGCACCATCGAGTGGTACCGCCGCCACGCCCCGGCAAACTAG

Upstream 100 bases:

>100_bases
TACAGGCAGAGCTGTCTTCAGGCTTGGGCAGTTAGAAGCTGCCGCCTTACCCCATAATGAAAGCCGGGGATTTTCCGCGC
CAGCCATGACGCCCAACAGC

Downstream 100 bases:

>100_bases
GCAACAACCTGGCTCTCCAGGCGGCCATCCTCCATGTGCAACACCCGGTCGGCAATGTCGAGGATGCGGTTGTCGTGGGT
CACCATGAGGATGGTGCAGC

Product: NAD-dependent epimerase/dehydratase family protein

Products: GDP-4-dehydro-6-deoxy-D-mannose; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MSSAIDLSQKRILLTGGSGFLGKHVLQQLQLLGVKPEQVRIPRSRTHDLRRWEVCQEVVQGQDVVIHLAAHVGGIGLNQA
KPAELFYDNLIMGSQLIHAAYLAGVEKFVCVGTICAYPKFTPVPFKEEDLWNGYPEETNAPYGIAKKALLVQLQAYRQQY
GFNGIYLLPVNLYGPMDNFDPESSHVIPALIRKVHEAQQRGQNYVEVWGDGSPTREFFYAEDAARGILLATQLYNSPEPL
NLGTGEEISIRDLIALICELMEFRGEIRWQTDRPNGQPRRCLDVSKARERIGFVAKVSLREGLQRTIEWYRRHAPAN

Sequences:

>Translated_317_residues
MSSAIDLSQKRILLTGGSGFLGKHVLQQLQLLGVKPEQVRIPRSRTHDLRRWEVCQEVVQGQDVVIHLAAHVGGIGLNQA
KPAELFYDNLIMGSQLIHAAYLAGVEKFVCVGTICAYPKFTPVPFKEEDLWNGYPEETNAPYGIAKKALLVQLQAYRQQY
GFNGIYLLPVNLYGPMDNFDPESSHVIPALIRKVHEAQQRGQNYVEVWGDGSPTREFFYAEDAARGILLATQLYNSPEPL
NLGTGEEISIRDLIALICELMEFRGEIRWQTDRPNGQPRRCLDVSKARERIGFVAKVSLREGLQRTIEWYRRHAPAN
>Mature_316_residues
SSAIDLSQKRILLTGGSGFLGKHVLQQLQLLGVKPEQVRIPRSRTHDLRRWEVCQEVVQGQDVVIHLAAHVGGIGLNQAK
PAELFYDNLIMGSQLIHAAYLAGVEKFVCVGTICAYPKFTPVPFKEEDLWNGYPEETNAPYGIAKKALLVQLQAYRQQYG
FNGIYLLPVNLYGPMDNFDPESSHVIPALIRKVHEAQQRGQNYVEVWGDGSPTREFFYAEDAARGILLATQLYNSPEPLN
LGTGEEISIRDLIALICELMEFRGEIRWQTDRPNGQPRRCLDVSKARERIGFVAKVSLREGLQRTIEWYRRHAPAN

Specific function: Putative nucleotide sugar epimerase/dehydrogenase [H]

COG id: COG0451

COG function: function code MG; Nucleoside-diphosphate-sugar epimerases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the fucose synthase family [H]

Homologues:

Organism=Homo sapiens, GI4507709, Length=307, Percent_Identity=34.2019543973941, Blast_Score=178, Evalue=7e-45,
Organism=Homo sapiens, GI7657641, Length=333, Percent_Identity=27.6276276276276, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI42516563, Length=326, Percent_Identity=25.7668711656442, Blast_Score=83, Evalue=3e-16,
Organism=Escherichia coli, GI1788365, Length=320, Percent_Identity=34.375, Blast_Score=202, Evalue=2e-53,
Organism=Escherichia coli, GI1788353, Length=343, Percent_Identity=23.9067055393586, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI48994969, Length=343, Percent_Identity=23.6151603498542, Blast_Score=80, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17554428, Length=306, Percent_Identity=29.0849673202614, Blast_Score=153, Evalue=1e-37,
Organism=Drosophila melanogaster, GI19922778, Length=311, Percent_Identity=29.5819935691318, Blast_Score=157, Evalue=1e-38,
Organism=Drosophila melanogaster, GI21356223, Length=328, Percent_Identity=25, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001509
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01370 Epimerase [H]

EC number: 1.1.1.271

Molecular weight: Translated: 35798; Mature: 35666

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSAIDLSQKRILLTGGSGFLGKHVLQQLQLLGVKPEQVRIPRSRTHDLRRWEVCQEVVQ
CCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCHHHEECCCHHHHHHHHHHHHHHHHC
GQDVVIHLAAHVGGIGLNQAKPAELFYDNLIMGSQLIHAAYLAGVEKFVCVGTICAYPKF
CCCEEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TPVPFKEEDLWNGYPEETNAPYGIAKKALLVQLQAYRQQYGFNGIYLLPVNLYGPMDNFD
CCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCC
PESSHVIPALIRKVHEAQQRGQNYVEVWGDGSPTREFFYAEDAARGILLATQLYNSPEPL
CCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHEEEHHHHCCCEEEEHHHCCCCCCC
NLGTGEEISIRDLIALICELMEFRGEIRWQTDRPNGQPRRCLDVSKARERIGFVAKVSLR
CCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EGLQRTIEWYRRHAPAN
HHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SSAIDLSQKRILLTGGSGFLGKHVLQQLQLLGVKPEQVRIPRSRTHDLRRWEVCQEVVQ
CCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCHHHEECCCHHHHHHHHHHHHHHHHC
GQDVVIHLAAHVGGIGLNQAKPAELFYDNLIMGSQLIHAAYLAGVEKFVCVGTICAYPKF
CCCEEEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TPVPFKEEDLWNGYPEETNAPYGIAKKALLVQLQAYRQQYGFNGIYLLPVNLYGPMDNFD
CCCCCCCCHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCCCC
PESSHVIPALIRKVHEAQQRGQNYVEVWGDGSPTREFFYAEDAARGILLATQLYNSPEPL
CCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCHHEEEHHHHCCCEEEEHHHCCCCCCC
NLGTGEEISIRDLIALICELMEFRGEIRWQTDRPNGQPRRCLDVSKARERIGFVAKVSLR
CCCCCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
EGLQRTIEWYRRHAPAN
HHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: GDP-L-fucose; NADP+

Specific reaction: GDP-L-fucose + NADP+ = GDP-4-dehydro-6-deoxy-D-mannose + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9163424 [H]