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The map label for this gene is ilvD

Identifier: 86606353

GI number: 86606353

Start: 1699913

End: 1701610

Strand: Reverse

Name: ilvD

Synonym: CYA_1697

Alternate gene names: 86606353

Gene position: 1701610-1699913 (Counterclockwise)

Preceding gene: 86606357

Following gene: 86606350

Centisome position: 58.02

GC content: 64.43

Gene sequence:

>1698_bases
ATGGCCAACCCTCCTTTTCCGCTGCGCAGCCAAGTGGTCACCCAGGGGGTGCAGCGCTCTCCCAACCGCGCCATGCTCAG
GGCCGTGGGCTTCCGTGATGAGGACTTCGGCAAGCCCATCGTCGGCATTGCCAACGCCCACAGCACCATCACTCCCTGCA
ACATCGGCATCCAAACCCTGGCCGAGCGCGCCGAAGCTGCCCTCAGGGCCGCCGGCTGCATGCCTCAGGTCTTCGGCACC
ATCACCATCAGCGACGGCATTTCCATGGGTACGGAGGGGATGAAATACTCCTTGGTGTCGCGGGAGGTGATCGCCGATTC
TATCGAGACGGTGGTCAACGGCCAGAGCATGGATGGTCTCTTGGCCATCGGCGGCTGCGACAAAAACATGCCGGGGGCGA
TGATCGCCATGGCCCGTCTCAACGTGCCCGCCATCTTCGTCTACGGCGGCACCATCAAGCCGGGGCATTACAACGGCCGC
GACCTCACCATCGTCAGCGCCTTTGAAGCCGTAGGGGAGTACAGCGCTGGCCGCATCTCCGAGGACGAGCTGCTGGCAGT
CGAGCGCCATGCTTGTCCCGGTGCTGGATCCTGCGGCGGCATGTACACGGCCAACACCATGTCCAGCGCCTTTGAGGCCA
TGGGCATGAGCCTGCCCTACTCTTCCACGATGGCGGCAGAGGACGAAGAGAAAGCCGAAAGCGCTGCCCAATCGGCCAAG
GTCTTGGCTGAGGCCATCCAAGCCAATATCCGACCCCGGGACATCATCACCCGCCAGAGCATTGAGAACGCCATCTCGGT
CATCATGGCGGTAGGGGGATCCACCAACGCCGTGCTCCACTTTTTGGCCATTGCCCACGCAGCAGAAGTGCCCCTGACGC
TGGATGACTTCGAGACCATCCGCGCCCGCGTGCCCGTCCTCTGCGACCTCAAGCCTTCAGGCCGGTTTGTTGCCACCGAT
CTGCACCGGGCCGGCGGGATCCCCCAAGTAATGAAGATCTTGCTCAACCACGGCCTGCTGCACGGCGACTGCCTCACCAT
CTCCGGCCAGACGATTGCCGAGGTTTTGCGGGACGTGCCCGACGAGCCCAGCCCCGACCAAGAGGTCATCCGCCCCTGGC
ACAGCCCCCTTTACCCCCAAGGGCACATCGCTATCCTCAAAGGCAACCTCGCGCCCGAAGGGGCGGTGGCCAAGATCAGC
GGCGTCAAGACTCCCAAGATCGCGGGGCCGGCGCGAGTCTTCAACTCAGAAGAATCCTGCCTGCAGGCCATCCTCGCCGG
CCAAATTCGACCGGGGGACGTAGTGGTGATCCGCTACGAGGGCCCCAAGGGCGGCCCCGGCATGCGGGAGATGCTCTCCC
CCACTTCGGCCATCATCGGCGCCGGCCTGGGGGACAGCGTGGGCCTGATTACCGATGGCCGCTTCTCCGGCGGCACCTAC
GGCATGGTGGTGGGCCATGTGGCCCCTGAGGCCTACGTAGGCGGCCCCATTGCCCTGGTGGAGGAAGGGGATCTCATTAC
CATCGATGCCCCCGCTCGCCTGTTGCACCTGCATGTTAGTGAGGAAGAGCTGGCCCGCCGCCGCGCCCGCTGGGCTCCGC
CCGAGCCCCGCTACAAACGGGGTGTTCTGGCCAAGTACGCCAAGCTGGTCTCCAGCAGCAGCCTGGGGGCAGTGACGGAT
TTAAACCTGTGGGATTAA

Upstream 100 bases:

>100_bases
TCGTTCGGCTTGCCTGGCGAAAAACCGAGTAGGATAGGTTCTACTTGTTTTTTTTGAATTGGATCCCAGCGCGGGCTTAT
TGTCCCGCTCTTTACCTATG

Downstream 100 bases:

>100_bases
TTCCTCGTAGCCCTGGCGTCTCAACCTAACCTGAAGCGACTATGAGTGCAAGAAAGCGGCAGAGATGAAGGATCCCTGCC
GCCTGATTGCGTGATGCGGT

Product: dihydroxy-acid dehydratase

Products: NA

Alternate protein names: DAD

Number of amino acids: Translated: 565; Mature: 564

Protein sequence:

>565_residues
MANPPFPLRSQVVTQGVQRSPNRAMLRAVGFRDEDFGKPIVGIANAHSTITPCNIGIQTLAERAEAALRAAGCMPQVFGT
ITISDGISMGTEGMKYSLVSREVIADSIETVVNGQSMDGLLAIGGCDKNMPGAMIAMARLNVPAIFVYGGTIKPGHYNGR
DLTIVSAFEAVGEYSAGRISEDELLAVERHACPGAGSCGGMYTANTMSSAFEAMGMSLPYSSTMAAEDEEKAESAAQSAK
VLAEAIQANIRPRDIITRQSIENAISVIMAVGGSTNAVLHFLAIAHAAEVPLTLDDFETIRARVPVLCDLKPSGRFVATD
LHRAGGIPQVMKILLNHGLLHGDCLTISGQTIAEVLRDVPDEPSPDQEVIRPWHSPLYPQGHIAILKGNLAPEGAVAKIS
GVKTPKIAGPARVFNSEESCLQAILAGQIRPGDVVVIRYEGPKGGPGMREMLSPTSAIIGAGLGDSVGLITDGRFSGGTY
GMVVGHVAPEAYVGGPIALVEEGDLITIDAPARLLHLHVSEEELARRRARWAPPEPRYKRGVLAKYAKLVSSSSLGAVTD
LNLWD

Sequences:

>Translated_565_residues
MANPPFPLRSQVVTQGVQRSPNRAMLRAVGFRDEDFGKPIVGIANAHSTITPCNIGIQTLAERAEAALRAAGCMPQVFGT
ITISDGISMGTEGMKYSLVSREVIADSIETVVNGQSMDGLLAIGGCDKNMPGAMIAMARLNVPAIFVYGGTIKPGHYNGR
DLTIVSAFEAVGEYSAGRISEDELLAVERHACPGAGSCGGMYTANTMSSAFEAMGMSLPYSSTMAAEDEEKAESAAQSAK
VLAEAIQANIRPRDIITRQSIENAISVIMAVGGSTNAVLHFLAIAHAAEVPLTLDDFETIRARVPVLCDLKPSGRFVATD
LHRAGGIPQVMKILLNHGLLHGDCLTISGQTIAEVLRDVPDEPSPDQEVIRPWHSPLYPQGHIAILKGNLAPEGAVAKIS
GVKTPKIAGPARVFNSEESCLQAILAGQIRPGDVVVIRYEGPKGGPGMREMLSPTSAIIGAGLGDSVGLITDGRFSGGTY
GMVVGHVAPEAYVGGPIALVEEGDLITIDAPARLLHLHVSEEELARRRARWAPPEPRYKRGVLAKYAKLVSSSSLGAVTD
LNLWD
>Mature_564_residues
ANPPFPLRSQVVTQGVQRSPNRAMLRAVGFRDEDFGKPIVGIANAHSTITPCNIGIQTLAERAEAALRAAGCMPQVFGTI
TISDGISMGTEGMKYSLVSREVIADSIETVVNGQSMDGLLAIGGCDKNMPGAMIAMARLNVPAIFVYGGTIKPGHYNGRD
LTIVSAFEAVGEYSAGRISEDELLAVERHACPGAGSCGGMYTANTMSSAFEAMGMSLPYSSTMAAEDEEKAESAAQSAKV
LAEAIQANIRPRDIITRQSIENAISVIMAVGGSTNAVLHFLAIAHAAEVPLTLDDFETIRARVPVLCDLKPSGRFVATDL
HRAGGIPQVMKILLNHGLLHGDCLTISGQTIAEVLRDVPDEPSPDQEVIRPWHSPLYPQGHIAILKGNLAPEGAVAKISG
VKTPKIAGPARVFNSEESCLQAILAGQIRPGDVVVIRYEGPKGGPGMREMLSPTSAIIGAGLGDSVGLITDGRFSGGTYG
MVVGHVAPEAYVGGPIALVEEGDLITIDAPARLLHLHVSEEELARRRARWAPPEPRYKRGVLAKYAKLVSSSSLGAVTDL
NLWD

Specific function: Valine and isoleucine biosynthesis; fourth step. [C]

COG id: COG0129

COG function: function code EG; Dihydroxyacid dehydratase/phosphogluconate dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ilvD/edd family

Homologues:

Organism=Escherichia coli, GI48994964, Length=606, Percent_Identity=38.7788778877888, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI2367371, Length=532, Percent_Identity=34.2105263157895, Blast_Score=208, Evalue=9e-55,
Organism=Escherichia coli, GI1788157, Length=483, Percent_Identity=33.9544513457557, Blast_Score=206, Evalue=4e-54,
Organism=Escherichia coli, GI1786464, Length=516, Percent_Identity=34.1085271317829, Blast_Score=197, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6322476, Length=559, Percent_Identity=48.479427549195, Blast_Score=541, Evalue=1e-154,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ILVD_SYNJA (Q2JTX6)

Other databases:

- EMBL:   CP000239
- RefSeq:   YP_475116.1
- ProteinModelPortal:   Q2JTX6
- SMR:   Q2JTX6
- STRING:   Q2JTX6
- GeneID:   3897464
- GenomeReviews:   CP000239_GR
- KEGG:   cya:CYA_1697
- TIGR:   CYA_1697
- eggNOG:   COG0129
- HOGENOM:   HBG671001
- OMA:   NMPGAMI
- ProtClustDB:   PRK00911
- BioCyc:   SSP321327:CYA_1697-MONOMER
- HAMAP:   MF_00012
- InterPro:   IPR015928
- InterPro:   IPR004404
- InterPro:   IPR000581
- InterPro:   IPR020558
- PANTHER:   PTHR21000
- TIGRFAMs:   TIGR00110

Pfam domain/function: PF00920 ILVD_EDD; SSF52016 Aconitase/3IPM_dehydase_swvl

EC number: =4.2.1.9

Molecular weight: Translated: 59621; Mature: 59490

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: PS00886 ILVD_EDD_1; PS00887 ILVD_EDD_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANPPFPLRSQVVTQGVQRSPNRAMLRAVGFRDEDFGKPIVGIANAHSTITPCNIGIQTL
CCCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCHHHCCCEEEEECCCCCCCCCCCCHHHH
AERAEAALRAAGCMPQVFGTITISDGISMGTEGMKYSLVSREVIADSIETVVNGQSMDGL
HHHHHHHHHHHCCCCHHHEEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCE
LAIGGCDKNMPGAMIAMARLNVPAIFVYGGTIKPGHYNGRDLTIVSAFEAVGEYSAGRIS
EEEECCCCCCCCHHEEEECCCCCEEEEECCEECCCCCCCCCEEEEHHHHHHCCCCCCCCC
EDELLAVERHACPGAGSCGGMYTANTMSSAFEAMGMSLPYSSTMAAEDEEKAESAAQSAK
CHHEEEEHHHCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
VLAEAIQANIRPRDIITRQSIENAISVIMAVGGSTNAVLHFLAIAHAAEVPLTLDDFETI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEHHHHHHH
RARVPVLCDLKPSGRFVATDLHRAGGIPQVMKILLNHGLLHGDCLTISGQTIAEVLRDVP
HHCCCEEEECCCCCCEEEECHHHHCCCHHHHHHHHHCCCEECCEEEECCHHHHHHHHHCC
DEPSPDQEVIRPWHSPLYPQGHIAILKGNLAPEGAVAKISGVKTPKIAGPARVFNSEESC
CCCCCCHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHCCCHHHH
LQAILAGQIRPGDVVVIRYEGPKGGPGMREMLSPTSAIIGAGLGDSVGLITDGRFSGGTY
HHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCCCCEEECCCCCCCEE
GMVVGHVAPEAYVGGPIALVEEGDLITIDAPARLLHLHVSEEELARRRARWAPPEPRYKR
EEEEECCCCCHHCCCCEEEEECCCEEEECCCCEEEEEECCHHHHHHHHHCCCCCCCHHHH
GVLAKYAKLVSSSSLGAVTDLNLWD
HHHHHHHHHHCCCCCCCEECCCCCC
>Mature Secondary Structure 
ANPPFPLRSQVVTQGVQRSPNRAMLRAVGFRDEDFGKPIVGIANAHSTITPCNIGIQTL
CCCCCCHHHHHHHHHHHCCCCHHHHHHCCCCCHHHCCCEEEEECCCCCCCCCCCCHHHH
AERAEAALRAAGCMPQVFGTITISDGISMGTEGMKYSLVSREVIADSIETVVNGQSMDGL
HHHHHHHHHHHCCCCHHHEEEEEECCCCCCCCCCEEHHHHHHHHHHHHHHHHCCCCCCCE
LAIGGCDKNMPGAMIAMARLNVPAIFVYGGTIKPGHYNGRDLTIVSAFEAVGEYSAGRIS
EEEECCCCCCCCHHEEEECCCCCEEEEECCEECCCCCCCCCEEEEHHHHHHCCCCCCCCC
EDELLAVERHACPGAGSCGGMYTANTMSSAFEAMGMSLPYSSTMAAEDEEKAESAAQSAK
CHHEEEEHHHCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHH
VLAEAIQANIRPRDIITRQSIENAISVIMAVGGSTNAVLHFLAIAHAAEVPLTLDDFETI
HHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCEEHHHHHHH
RARVPVLCDLKPSGRFVATDLHRAGGIPQVMKILLNHGLLHGDCLTISGQTIAEVLRDVP
HHCCCEEEECCCCCCEEEECHHHHCCCHHHHHHHHHCCCEECCEEEECCHHHHHHHHHCC
DEPSPDQEVIRPWHSPLYPQGHIAILKGNLAPEGAVAKISGVKTPKIAGPARVFNSEESC
CCCCCCHHHHHHHCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCCCCCHHHHCCCHHHH
LQAILAGQIRPGDVVVIRYEGPKGGPGMREMLSPTSAIIGAGLGDSVGLITDGRFSGGTY
HHHHHHCCCCCCCEEEEEECCCCCCCCHHHHHCCHHHHHCCCCCCCCCEEECCCCCCCEE
GMVVGHVAPEAYVGGPIALVEEGDLITIDAPARLLHLHVSEEELARRRARWAPPEPRYKR
EEEEECCCCCHHCCCCEEEEECCCEEEECCCCEEEEEECCHHHHHHHHHCCCCCCCHHHH
GVLAKYAKLVSSSSLGAVTDLNLWD
HHHHHHHHHHCCCCCCCEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA