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The map label for this gene is dxs

Identifier: 86606357

GI number: 86606357

Start: 1705551

End: 1707500

Strand: Reverse

Name: dxs

Synonym: CYA_1701

Alternate gene names: 86606357

Gene position: 1707500-1705551 (Counterclockwise)

Preceding gene: 86606359

Following gene: 86606353

Centisome position: 58.22

GC content: 61.59

Gene sequence:

>1950_bases
ATGCACCTGAGTGAGATCACTCACCCCAACCAGCTCCGCAACCTCAGCCTCAGCCAGTTGCGCAGCCTAGCCCGCCAGAT
TCGCGAAAAGCACTTGCAAACGGCTGCCAACTCTCCAGTCGGCTGTCACCTGGGGCCGGGGCTGGGCGTGGTGGAGCTGA
CCTTGGCGCTCTACAAAACCCTCGACCTGGATCGCGACAAGGTGATTTGGGATGTGGGCCACCAAGCCTATGCCCACAAA
ATGCTTACTGGCCGCTACCACAACTTCCATACCATTCGCCAGAAAGGAGGGATTTCCGGCTACCTCAAGCGGAGTGAGAG
CCGCTTCGACCACTTTGGGGCCGGGCACGCCTCCACCAGCATCTCGGCAGCCCTGGGCATGGCCATCGCTCGGGATCGGC
GGGGAGAAAACTTCAAGGTGGTGGCCATCATCGGGGATGGCGCCCTGACTGGGGGCATGGCCTATGAAGCCATCAACCAC
GCCGGGCACCTGCCCAAGACCAACTTGATGGTGATTCTCAACGACAACGGCATGTCGATTTCCCCCAATGTGGGGGCCAT
CCCGCGCTATTTAAACCGCCTGCGCCTCAGCCCACCGGTGCAGTTTTTGGCCGACAGCCTGGAGGAGCAGCTAAAGAACC
TACCTCTAGTTGGCTCCAGCCTCAGCCCGGAAATCGACCGTCTCAAGGAGACGGTGAAGCTGGTTACTGCCGTGCAGAAC
AACAAGGCCGGCATCATCTTTGAGGAGCTGGGCTTTACCTACGTAGGGCCGGTGGACGGGCACAACCTGGCGGAATTGTT
GGATGCTTTTGAGCTGGCCCACGGCATCTCTGGGCCGGTGCTGGTGCACGTGGCTACGGTCAAGGGCAAGGGCTACCCAC
CGGCAGAGGCTGAGCAGGTAAGCTATCACGCCCAATCCCGCTTCGACCTAGCCACCGGCAAACCCTATCCTCCTACCAAA
CCCACTCCCCCTAGCTATAGCAAGGTCTTCGGCCACACTCTTTGTAAACTGGCGGAGCGGGATCCCCGCATCATTGGCAT
CACGGCGGCTATGGACACCGGCACCGGCCTAGACAAGCTCAAAGAAAAACTGCCGGATCAGTTCGTGGATGTGGGGATTG
CCGAGCAGCACGCTGTTACTTTGGCTGCTGGCATGGCCTGCGAGGGGATGCGACCGGTGGTGGCCATCTATTCCACCTTC
CTGCAGCGGGCCTACGACCAGATCATCCACGATGTCTGCATTCAAAAGCTGCCGGTCTTTTTCTGCTTGGATCGGGCAGG
GGTGGTGGGAGCGGACGGCCCCACCCACCAGGGCATGTACGACATTGCCTATCTGCGCTGCATTCCCGAGATGGTGCTGA
TGGCCCCCAAAGACGAGGCGGAGCTGCAGCGCATGGTGGTGACCGGGATCCAGTACACAAAGGGCCCCATCGCCATGCGT
TACCCGCGCGGAGCTGGCGTGGGGGTGCCTCTGGCCGAAGAGGGGTGGGAGCCCATTCCCATCGGCAAAGCAGAGGTGCT
GCGCAGCGGCGGCGAGGTCCTGATCCTAGCCTATGGGTCGATGGTGCATCCCAGTTTGCAGGCAGCGGAGATCCTCAAGG
AACACGGCATCTCCACGACGGTAGTCAATGCCCGCTTTGCCAAGCCTCTGGATACCGAGCTGATCCTGCCCCTGGCCCAA
CAGAGCCGCCTGGTGGTGACGGTGGAAGAAGGCTGCCTCATGGGCGGGTTTGGCTCGGCAGTGGGGGAAGCTCTCCTGGA
TGCCGATATCCGAGTGCCGCTGTTGCGCCTGGGGGTGCCGGATGTGTGGGTGGAGCACGCCACTCCTGAAGAATCGCTGG
CGGAACTGGGCCTGAACAGCGTCGGCATTGCCGAGCGCATCCGGGCCAAGGTCGAGGCCCTTCAGGGACAGAGGGCCTCG
CAGGCTCAAGCTATTCTGGGCAGCTCCTGA

Upstream 100 bases:

>100_bases
TGCAGAAGCTCCCCGACGAAGCGAGAAGCCCGCACTCTATACGTCAGCATGAGTGCGGGAGTATGTCACAGTGAGATTAC
ACCGGAAGGACAAGTCCCCT

Downstream 100 bases:

>100_bases
GCCTACTCTTTCCCAAGGCCCATCTGCTGGTTGAACTGCTCGATGGCGGCTTGCTGCAGAGCCTCTGCAACAGGACGGGT
GCGCAGGAGGATTTGCACAT

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 649; Mature: 649

Protein sequence:

>649_residues
MHLSEITHPNQLRNLSLSQLRSLARQIREKHLQTAANSPVGCHLGPGLGVVELTLALYKTLDLDRDKVIWDVGHQAYAHK
MLTGRYHNFHTIRQKGGISGYLKRSESRFDHFGAGHASTSISAALGMAIARDRRGENFKVVAIIGDGALTGGMAYEAINH
AGHLPKTNLMVILNDNGMSISPNVGAIPRYLNRLRLSPPVQFLADSLEEQLKNLPLVGSSLSPEIDRLKETVKLVTAVQN
NKAGIIFEELGFTYVGPVDGHNLAELLDAFELAHGISGPVLVHVATVKGKGYPPAEAEQVSYHAQSRFDLATGKPYPPTK
PTPPSYSKVFGHTLCKLAERDPRIIGITAAMDTGTGLDKLKEKLPDQFVDVGIAEQHAVTLAAGMACEGMRPVVAIYSTF
LQRAYDQIIHDVCIQKLPVFFCLDRAGVVGADGPTHQGMYDIAYLRCIPEMVLMAPKDEAELQRMVVTGIQYTKGPIAMR
YPRGAGVGVPLAEEGWEPIPIGKAEVLRSGGEVLILAYGSMVHPSLQAAEILKEHGISTTVVNARFAKPLDTELILPLAQ
QSRLVVTVEEGCLMGGFGSAVGEALLDADIRVPLLRLGVPDVWVEHATPEESLAELGLNSVGIAERIRAKVEALQGQRAS
QAQAILGSS

Sequences:

>Translated_649_residues
MHLSEITHPNQLRNLSLSQLRSLARQIREKHLQTAANSPVGCHLGPGLGVVELTLALYKTLDLDRDKVIWDVGHQAYAHK
MLTGRYHNFHTIRQKGGISGYLKRSESRFDHFGAGHASTSISAALGMAIARDRRGENFKVVAIIGDGALTGGMAYEAINH
AGHLPKTNLMVILNDNGMSISPNVGAIPRYLNRLRLSPPVQFLADSLEEQLKNLPLVGSSLSPEIDRLKETVKLVTAVQN
NKAGIIFEELGFTYVGPVDGHNLAELLDAFELAHGISGPVLVHVATVKGKGYPPAEAEQVSYHAQSRFDLATGKPYPPTK
PTPPSYSKVFGHTLCKLAERDPRIIGITAAMDTGTGLDKLKEKLPDQFVDVGIAEQHAVTLAAGMACEGMRPVVAIYSTF
LQRAYDQIIHDVCIQKLPVFFCLDRAGVVGADGPTHQGMYDIAYLRCIPEMVLMAPKDEAELQRMVVTGIQYTKGPIAMR
YPRGAGVGVPLAEEGWEPIPIGKAEVLRSGGEVLILAYGSMVHPSLQAAEILKEHGISTTVVNARFAKPLDTELILPLAQ
QSRLVVTVEEGCLMGGFGSAVGEALLDADIRVPLLRLGVPDVWVEHATPEESLAELGLNSVGIAERIRAKVEALQGQRAS
QAQAILGSS
>Mature_649_residues
MHLSEITHPNQLRNLSLSQLRSLARQIREKHLQTAANSPVGCHLGPGLGVVELTLALYKTLDLDRDKVIWDVGHQAYAHK
MLTGRYHNFHTIRQKGGISGYLKRSESRFDHFGAGHASTSISAALGMAIARDRRGENFKVVAIIGDGALTGGMAYEAINH
AGHLPKTNLMVILNDNGMSISPNVGAIPRYLNRLRLSPPVQFLADSLEEQLKNLPLVGSSLSPEIDRLKETVKLVTAVQN
NKAGIIFEELGFTYVGPVDGHNLAELLDAFELAHGISGPVLVHVATVKGKGYPPAEAEQVSYHAQSRFDLATGKPYPPTK
PTPPSYSKVFGHTLCKLAERDPRIIGITAAMDTGTGLDKLKEKLPDQFVDVGIAEQHAVTLAAGMACEGMRPVVAIYSTF
LQRAYDQIIHDVCIQKLPVFFCLDRAGVVGADGPTHQGMYDIAYLRCIPEMVLMAPKDEAELQRMVVTGIQYTKGPIAMR
YPRGAGVGVPLAEEGWEPIPIGKAEVLRSGGEVLILAYGSMVHPSLQAAEILKEHGISTTVVNARFAKPLDTELILPLAQ
QSRLVVTVEEGCLMGGFGSAVGEALLDADIRVPLLRLGVPDVWVEHATPEESLAELGLNSVGIAERIRAKVEALQGQRAS
QAQAILGSS

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=574, Percent_Identity=25.7839721254355, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI4507521, Length=574, Percent_Identity=25.7839721254355, Blast_Score=136, Evalue=6e-32,
Organism=Homo sapiens, GI225637461, Length=419, Percent_Identity=28.4009546539379, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI133778974, Length=639, Percent_Identity=24.4131455399061, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI225637463, Length=419, Percent_Identity=28.4009546539379, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI225637459, Length=419, Percent_Identity=28.4009546539379, Blast_Score=105, Evalue=2e-22,
Organism=Homo sapiens, GI156564403, Length=266, Percent_Identity=22.9323308270677, Blast_Score=72, Evalue=1e-12,
Organism=Homo sapiens, GI291084858, Length=258, Percent_Identity=22.093023255814, Blast_Score=68, Evalue=3e-11,
Organism=Escherichia coli, GI1786622, Length=627, Percent_Identity=46.88995215311, Blast_Score=550, Evalue=1e-158,
Organism=Caenorhabditis elegans, GI17539652, Length=408, Percent_Identity=31.8627450980392, Blast_Score=149, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17538422, Length=285, Percent_Identity=25.6140350877193, Blast_Score=80, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6319698, Length=298, Percent_Identity=26.1744966442953, Blast_Score=80, Evalue=9e-16,
Organism=Drosophila melanogaster, GI45551847, Length=630, Percent_Identity=26.984126984127, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI45550715, Length=630, Percent_Identity=26.984126984127, Blast_Score=150, Evalue=2e-36,
Organism=Drosophila melanogaster, GI24645119, Length=586, Percent_Identity=27.6450511945392, Blast_Score=149, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24666278, Length=527, Percent_Identity=26.3757115749526, Blast_Score=130, Evalue=2e-30,
Organism=Drosophila melanogaster, GI21358145, Length=296, Percent_Identity=24.6621621621622, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24650940, Length=296, Percent_Identity=24.6621621621622, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_SYNJA (Q2JTX2)

Other databases:

- EMBL:   CP000239
- RefSeq:   YP_475120.1
- STRING:   Q2JTX2
- GeneID:   3897468
- GenomeReviews:   CP000239_GR
- KEGG:   cya:CYA_1701
- TIGR:   CYA_1701
- eggNOG:   COG1154
- HOGENOM:   HBG571647
- OMA:   QRFPDRY
- ProtClustDB:   PRK05444
- BioCyc:   SSP321327:CYA_1701-MONOMER
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 70061; Mature: 70061

Theoretical pI: Translated: 6.94; Mature: 6.94

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLSEITHPNQLRNLSLSQLRSLARQIREKHLQTAANSPVGCHLGPGLGVVELTLALYKT
CCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHH
LDLDRDKVIWDVGHQAYAHKMLTGRYHNFHTIRQKGGISGYLKRSESRFDHFGAGHASTS
HCCCCCCEEECCCHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHH
ISAALGMAIARDRRGENFKVVAIIGDGALTGGMAYEAINHAGHLPKTNLMVILNDNGMSI
HHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCEE
SPNVGAIPRYLNRLRLSPPVQFLADSLEEQLKNLPLVGSSLSPEIDRLKETVKLVTAVQN
CCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCC
NKAGIIFEELGFTYVGPVDGHNLAELLDAFELAHGISGPVLVHVATVKGKGYPPAEAEQV
CCCCEEEHHCCCEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHH
SYHAQSRFDLATGKPYPPTKPTPPSYSKVFGHTLCKLAERDPRIIGITAAMDTGTGLDKL
HHHHHCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHH
KEKLPDQFVDVGIAEQHAVTLAAGMACEGMRPVVAIYSTFLQRAYDQIIHDVCIQKLPVF
HHHCCHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
FCLDRAGVVGADGPTHQGMYDIAYLRCIPEMVLMAPKDEAELQRMVVTGIQYTKGPIAMR
EEECCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEE
YPRGAGVGVPLAEEGWEPIPIGKAEVLRSGGEVLILAYGSMVHPSLQAAEILKEHGISTT
CCCCCCCCCCCHHCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEE
VVNARFAKPLDTELILPLAQQSRLVVTVEEGCLMGGFGSAVGEALLDADIRVPLLRLGVP
EEECCCCCCCCCHHCCCCCCCCEEEEEEECCCEECCHHHHHHHHHHCCCCCCCHHHCCCC
DVWVEHATPEESLAELGLNSVGIAERIRAKVEALQGQRASQAQAILGSS
HHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCC
>Mature Secondary Structure
MHLSEITHPNQLRNLSLSQLRSLARQIREKHLQTAANSPVGCHLGPGLGVVELTLALYKT
CCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCHHHHHHHHHHHH
LDLDRDKVIWDVGHQAYAHKMLTGRYHNFHTIRQKGGISGYLKRSESRFDHFGAGHASTS
HCCCCCCEEECCCHHHHHHHHHHCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCCHHH
ISAALGMAIARDRRGENFKVVAIIGDGALTGGMAYEAINHAGHLPKTNLMVILNDNGMSI
HHHHHHHHHHHCCCCCCEEEEEEEECCCCCCCHHHHHHHHCCCCCCCCEEEEECCCCCEE
SPNVGAIPRYLNRLRLSPPVQFLADSLEEQLKNLPLVGSSLSPEIDRLKETVKLVTAVQN
CCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHCC
NKAGIIFEELGFTYVGPVDGHNLAELLDAFELAHGISGPVLVHVATVKGKGYPPAEAEQV
CCCCEEEHHCCCEEECCCCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCHHHH
SYHAQSRFDLATGKPYPPTKPTPPSYSKVFGHTLCKLAERDPRIIGITAAMDTGTGLDKL
HHHHHCCEECCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHH
KEKLPDQFVDVGIAEQHAVTLAAGMACEGMRPVVAIYSTFLQRAYDQIIHDVCIQKLPVF
HHHCCHHHHHCCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHH
FCLDRAGVVGADGPTHQGMYDIAYLRCIPEMVLMAPKDEAELQRMVVTGIQYTKGPIAMR
EEECCCCEECCCCCCCCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCEEEE
YPRGAGVGVPLAEEGWEPIPIGKAEVLRSGGEVLILAYGSMVHPSLQAAEILKEHGISTT
CCCCCCCCCCCHHCCCCCCCCCHHHHHHCCCCEEEEEECCCCCCCHHHHHHHHHCCCCEE
VVNARFAKPLDTELILPLAQQSRLVVTVEEGCLMGGFGSAVGEALLDADIRVPLLRLGVP
EEECCCCCCCCCHHCCCCCCCCEEEEEEECCCEECCHHHHHHHHHHCCCCCCCHHHCCCC
DVWVEHATPEESLAELGLNSVGIAERIRAKVEALQGQRASQAQAILGSS
HHHHCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA