Click here to switch to the map view.

The map label for this gene is dapA

Identifier: 86605342

GI number: 86605342

Start: 638904

End: 639824

Strand: Reverse

Name: dapA

Synonym: CYA_0627

Alternate gene names: 86605342

Gene position: 639824-638904 (Counterclockwise)

Preceding gene: 86605344

Following gene: 86605341

Centisome position: 21.82

GC content: 55.81

Gene sequence:

>921_bases
GTGAATTTCGGTCGCGTGCTGACGGCAATGGTGACTCCCTTTACACCTGAGGGGGAGCTTAACTACGAAGAAGCCGCTCG
TTTGGCCGATTACTTGGTAACCCATGGCAGCGATGGTCTCGTGGTCTGTGGCACCACCGGCGAGTCTCCCACCCTAACCT
GGCAAGAGGAGTACGAACTGTTCCGCGTGGTGCGAGATGCGGTGGCCGGTCGGGCTAAAGTTATCGCCGGGACGGGATCC
AACTCCACCCGCGAAGCCATTGAAGCCACCAAAAAAGCTGCCCAATTGGGCTTGGATGGCTCTTTACAGGTGGTGCCCTA
CTACAACAAACCCACCCAAGCTGGCCTCTATCAGCACTTTAAGGCGATCGCCCAAGCCAGCGACCTGCCCATCATGCTCT
ACAACATTCCTGGTCGGACGGGGGTGAGCCTGCAGCCGGAAACTGTGGCGAAATTGGCGGAGTTGGAAACGATTGTCGCC
ATCAAGGAAGCTAGTGGTATAATGGACGCAGTCTCGGAAATTCGGCGGCTCACTCCCTCACATTTCGGCATCTACTCAGG
AGATGACTCTCTGACATTGCCGATCCTATCTTTGGGAGGCAGCGGTGTGGTCAGTGTAGCTAGCCACTTAGTTGGGCCGC
AACTGCAGGAATTGATTCAAAGCTACAGCAGGGGACAACACGACCAAGCCTTGACTTATCATTTGCGTCTGTTTCCGCTG
TTTAAGGCTTTGTTTATTGAGACCAACCCTGTTCCGATCAAAGCAGCGCTAGAGATGCAGGGTTGGCTAGTGGGGCAGGT
GCGCCCTCCGCTGGTGCCTCTCCAGGGCGGTTCTTTACAGGTTTTACGGCAAGTGCTGCAAGAAATGGGCCTCCTGGCTG
AAGCGCAGGGATCCGAACGAAGGACGGCGAAGGCTTCATGA

Upstream 100 bases:

>100_bases
ATGATAAGGGGATAATCAAGGCTCTAGCCCGCAGCATTGGATTTTGCGGGGTCACAGACCGGCGATGGCGAGCGGTGTGG
TTGATGGGGAGAGGCAACCT

Downstream 100 bases:

>100_bases
TTCGATTATTTTCTTAGGTTTTACCTTTACCATGACGAGAGTTTTTTAAGGGTTAGGGGGTCTTCTGTGGCGTTTGAGCT
GTGATTAAGACAGTTTTCCT

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 306; Mature: 306

Protein sequence:

>306_residues
MNFGRVLTAMVTPFTPEGELNYEEAARLADYLVTHGSDGLVVCGTTGESPTLTWQEEYELFRVVRDAVAGRAKVIAGTGS
NSTREAIEATKKAAQLGLDGSLQVVPYYNKPTQAGLYQHFKAIAQASDLPIMLYNIPGRTGVSLQPETVAKLAELETIVA
IKEASGIMDAVSEIRRLTPSHFGIYSGDDSLTLPILSLGGSGVVSVASHLVGPQLQELIQSYSRGQHDQALTYHLRLFPL
FKALFIETNPVPIKAALEMQGWLVGQVRPPLVPLQGGSLQVLRQVLQEMGLLAEAQGSERRTAKAS

Sequences:

>Translated_306_residues
MNFGRVLTAMVTPFTPEGELNYEEAARLADYLVTHGSDGLVVCGTTGESPTLTWQEEYELFRVVRDAVAGRAKVIAGTGS
NSTREAIEATKKAAQLGLDGSLQVVPYYNKPTQAGLYQHFKAIAQASDLPIMLYNIPGRTGVSLQPETVAKLAELETIVA
IKEASGIMDAVSEIRRLTPSHFGIYSGDDSLTLPILSLGGSGVVSVASHLVGPQLQELIQSYSRGQHDQALTYHLRLFPL
FKALFIETNPVPIKAALEMQGWLVGQVRPPLVPLQGGSLQVLRQVLQEMGLLAEAQGSERRTAKAS
>Mature_306_residues
MNFGRVLTAMVTPFTPEGELNYEEAARLADYLVTHGSDGLVVCGTTGESPTLTWQEEYELFRVVRDAVAGRAKVIAGTGS
NSTREAIEATKKAAQLGLDGSLQVVPYYNKPTQAGLYQHFKAIAQASDLPIMLYNIPGRTGVSLQPETVAKLAELETIVA
IKEASGIMDAVSEIRRLTPSHFGIYSGDDSLTLPILSLGGSGVVSVASHLVGPQLQELIQSYSRGQHDQALTYHLRLFPL
FKALFIETNPVPIKAALEMQGWLVGQVRPPLVPLQGGSLQVLRQVLQEMGLLAEAQGSERRTAKAS

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=286, Percent_Identity=28.3216783216783, Blast_Score=113, Evalue=2e-25,
Organism=Homo sapiens, GI13540533, Length=240, Percent_Identity=28.3333333333333, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=40.5498281786942, Blast_Score=233, Evalue=1e-62,
Organism=Escherichia coli, GI1786463, Length=283, Percent_Identity=33.2155477031802, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI87082415, Length=268, Percent_Identity=30.5970149253731, Blast_Score=115, Evalue=5e-27,
Organism=Escherichia coli, GI1789620, Length=225, Percent_Identity=29.3333333333333, Blast_Score=106, Evalue=2e-24,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_SYNJA (Q2JWL7)

Other databases:

- EMBL:   CP000239
- RefSeq:   YP_474105.1
- HSSP:   Q9X1K9
- ProteinModelPortal:   Q2JWL7
- SMR:   Q2JWL7
- STRING:   Q2JWL7
- GeneID:   3897302
- GenomeReviews:   CP000239_GR
- KEGG:   cya:CYA_0627
- TIGR:   CYA_0627
- eggNOG:   COG0329
- HOGENOM:   HBG358848
- OMA:   GMYRHFK
- ProtClustDB:   PRK03170
- BioCyc:   SSP321327:CYA_0627-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 32998; Mature: 32998

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 162-162 BINDING 107-107

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFGRVLTAMVTPFTPEGELNYEEAARLADYLVTHGSDGLVVCGTTGESPTLTWQEEYEL
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEHHHHHHH
FRVVRDAVAGRAKVIAGTGSNSTREAIEATKKAAQLGLDGSLQVVPYYNKPTQAGLYQHF
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHH
KAIAQASDLPIMLYNIPGRTGVSLQPETVAKLAELETIVAIKEASGIMDAVSEIRRLTPS
HHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HFGIYSGDDSLTLPILSLGGSGVVSVASHLVGPQLQELIQSYSRGQHDQALTYHLRLFPL
CCCEECCCCCEEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
FKALFIETNPVPIKAALEMQGWLVGQVRPPLVPLQGGSLQVLRQVLQEMGLLAEAQGSER
HHHHHHCCCCCCEEEEEEECCEEEECCCCCEEECCCCCHHHHHHHHHHCCCHHHCCCCCC
RTAKAS
CCCCCC
>Mature Secondary Structure
MNFGRVLTAMVTPFTPEGELNYEEAARLADYLVTHGSDGLVVCGTTGESPTLTWQEEYEL
CCHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEECCCCCCCEEHHHHHHH
FRVVRDAVAGRAKVIAGTGSNSTREAIEATKKAAQLGLDGSLQVVPYYNKPTQAGLYQHF
HHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHH
KAIAQASDLPIMLYNIPGRTGVSLQPETVAKLAELETIVAIKEASGIMDAVSEIRRLTPS
HHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCC
HFGIYSGDDSLTLPILSLGGSGVVSVASHLVGPQLQELIQSYSRGQHDQALTYHLRLFPL
CCCEECCCCCEEEEEEECCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
FKALFIETNPVPIKAALEMQGWLVGQVRPPLVPLQGGSLQVLRQVLQEMGLLAEAQGSER
HHHHHHCCCCCCEEEEEEECCEEEECCCCCEEECCCCCHHHHHHHHHHCCCHHHCCCCCC
RTAKAS
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA