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The map label for this gene is tuaD [H]

Identifier: 86605203

GI number: 86605203

Start: 502667

End: 504085

Strand: Reverse

Name: tuaD [H]

Synonym: CYA_0485

Alternate gene names: 86605203

Gene position: 504085-502667 (Counterclockwise)

Preceding gene: 86605207

Following gene: 86605202

Centisome position: 17.19

GC content: 65.12

Gene sequence:

>1419_bases
ATGGACATGGCGGTCGTGGGAGCTGGCTATGTGGGGTTGGTAACCGGCGCCTGTCTGGCCCACCTGGGCCACAGCGTTAT
TTGTATAGACAACAACCCTGTCAAAATCGAAAACCTGCAGCGAGGTCGTCTGCCCATCTACGAGCCCGGCCTGGAAGAGC
TGGTGCGGGAAGGCGCCGAGGCTGGCCGGCTGCACTTTACCACCGACCTGGGCCTGGGGGTGAAGGCCAGCGAAGTGATC
TTCATTGCCGTGGGCACCCCGGCTTTGCCCAGCGGCGAGCCAGACCTGCGCTACGTAGAGGCCGTGGCGCGAGGGATCGG
CCAGCACCTGGACAACCGCTACCGCGTCATCGTCAACAAGTCCACCGTGCCCATCGGCTCCGGCGACTGGGTGCGCATGC
TCATCCTCGACGGCGCCGCCGAGGCTGTCCAGCAGCGCCTAAGCAGCCAACAGATGGCCCTGGCTGGGGGGGATCCCACC
CCCTCCTCCCTGGCCACCCTGGACAGGTCTTCCTGGGTGCCGCCCTTCGACGTGGTGAGCAACCCCGAGTTTCTGCGGGA
GGGCAGCGCCATCCAGGATACCTTTTACCCCGACCGCATCGTGATTGGCTCCAACAGCCCCCGGGCCATCGAGATCCTGC
GGCAGCTTTACGAGCCCATCCTCAGCCGCCAGCAGGGCTTGGGCGGGGATCCCGTGCCCTTGCTGGTCACCGACCTGGCC
TCGGCCGAGATGATCAAATATGCGGCCAACGCCTTCCTGGCCACCAAGATCAGCTTCATCAACGAGATCGCCAACATCTG
CGAGCGCACTGGCGCCGACATCACCCAGGTGGCCGAAGGGATCGGCCTCGATAAGCGCATTGGCCGCGCCTTCCTCAACG
CTGGTCTAGGCTGGGGAGGGAGCTGCTTTCCCAAGGATCTGGCCGCTTTGATCCAGACGGCAGCCGACTACGGCTATGAG
GCCAAGCTGTTGCGGGCCACCGTCGAGGTCAACCGCGAGCAGCGGCAGCGCCTGCTGGAAAAGCTGCAGCAGGCCCTCAA
GGTGCTCAAGGGCAAGACCATCGGCCTTCTGGGCCTCACCTTCAAGCCCCACACCGACGACCTGCGGGATGCGCCGTCCC
TGACCCTCATCGAGCAGCTCCACCGGCTGGGGGCCAAGGTAAAAGCCTATGATCCCATTGTGTCGGCTTCGGGGATGCGG
GAGGGCCTGGCCCACGTGGTGGTGGAAACGGACGTGTTCCGCCTGGCCCAGGATTGCGACGCCCTGGTGCTGGTGACCGA
GTGGCCGGAGTTTTTGTCGCTGGATTACCGGCGCCTTGCCGAGCTGATGCGGCGGCCCCTCATCCTCGACGGCCGCAACT
GCCTTGACCGGCAGGCCGTTCAGCAGGCGGGCATTACCCTGATTGGAGTGGGCTGGTGA

Upstream 100 bases:

>100_bases
CCACCGACTCCCCCTAGGGGCCGACCTTCTTCGAGGGGATAGGAAATGCGGGCCGGCGGGGTATTTTAGAACCAAGCACC
GACGCGAGGGGGAGGCGGCC

Downstream 100 bases:

>100_bases
AGATCCTGGTTACGGGTGGTTTGGGGTTTATCGGCTCCCATCTGGTCAGCCGTCTGCTGCAGGAGGGCCACACGGTGATC
TGCCTCGACAACGGCTACAC

Product: UDP-glucose dehydrogenase

Products: NA

Alternate protein names: UDP-Glc dehydrogenase; UDP-GlcDH; UDPGDH; Teichuronic acid biosynthesis protein tuaD [H]

Number of amino acids: Translated: 472; Mature: 472

Protein sequence:

>472_residues
MDMAVVGAGYVGLVTGACLAHLGHSVICIDNNPVKIENLQRGRLPIYEPGLEELVREGAEAGRLHFTTDLGLGVKASEVI
FIAVGTPALPSGEPDLRYVEAVARGIGQHLDNRYRVIVNKSTVPIGSGDWVRMLILDGAAEAVQQRLSSQQMALAGGDPT
PSSLATLDRSSWVPPFDVVSNPEFLREGSAIQDTFYPDRIVIGSNSPRAIEILRQLYEPILSRQQGLGGDPVPLLVTDLA
SAEMIKYAANAFLATKISFINEIANICERTGADITQVAEGIGLDKRIGRAFLNAGLGWGGSCFPKDLAALIQTAADYGYE
AKLLRATVEVNREQRQRLLEKLQQALKVLKGKTIGLLGLTFKPHTDDLRDAPSLTLIEQLHRLGAKVKAYDPIVSASGMR
EGLAHVVVETDVFRLAQDCDALVLVTEWPEFLSLDYRRLAELMRRPLILDGRNCLDRQAVQQAGITLIGVGW

Sequences:

>Translated_472_residues
MDMAVVGAGYVGLVTGACLAHLGHSVICIDNNPVKIENLQRGRLPIYEPGLEELVREGAEAGRLHFTTDLGLGVKASEVI
FIAVGTPALPSGEPDLRYVEAVARGIGQHLDNRYRVIVNKSTVPIGSGDWVRMLILDGAAEAVQQRLSSQQMALAGGDPT
PSSLATLDRSSWVPPFDVVSNPEFLREGSAIQDTFYPDRIVIGSNSPRAIEILRQLYEPILSRQQGLGGDPVPLLVTDLA
SAEMIKYAANAFLATKISFINEIANICERTGADITQVAEGIGLDKRIGRAFLNAGLGWGGSCFPKDLAALIQTAADYGYE
AKLLRATVEVNREQRQRLLEKLQQALKVLKGKTIGLLGLTFKPHTDDLRDAPSLTLIEQLHRLGAKVKAYDPIVSASGMR
EGLAHVVVETDVFRLAQDCDALVLVTEWPEFLSLDYRRLAELMRRPLILDGRNCLDRQAVQQAGITLIGVGW
>Mature_472_residues
MDMAVVGAGYVGLVTGACLAHLGHSVICIDNNPVKIENLQRGRLPIYEPGLEELVREGAEAGRLHFTTDLGLGVKASEVI
FIAVGTPALPSGEPDLRYVEAVARGIGQHLDNRYRVIVNKSTVPIGSGDWVRMLILDGAAEAVQQRLSSQQMALAGGDPT
PSSLATLDRSSWVPPFDVVSNPEFLREGSAIQDTFYPDRIVIGSNSPRAIEILRQLYEPILSRQQGLGGDPVPLLVTDLA
SAEMIKYAANAFLATKISFINEIANICERTGADITQVAEGIGLDKRIGRAFLNAGLGWGGSCFPKDLAALIQTAADYGYE
AKLLRATVEVNREQRQRLLEKLQQALKVLKGKTIGLLGLTFKPHTDDLRDAPSLTLIEQLHRLGAKVKAYDPIVSASGMR
EGLAHVVVETDVFRLAQDCDALVLVTEWPEFLSLDYRRLAELMRRPLILDGRNCLDRQAVQQAGITLIGVGW

Specific function: Catalyzes the conversion of UDP-glucose into UDP- glucuronate, one of the precursors of teichuronic acid [H]

COG id: COG1004

COG function: function code M; Predicted UDP-glucose 6-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UDP-glucose/GDP-mannose dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4507813, Length=498, Percent_Identity=34.136546184739, Blast_Score=254, Evalue=1e-67,
Organism=Homo sapiens, GI296040438, Length=399, Percent_Identity=34.0852130325814, Blast_Score=203, Evalue=3e-52,
Organism=Homo sapiens, GI296040443, Length=316, Percent_Identity=36.3924050632911, Blast_Score=187, Evalue=1e-47,
Organism=Escherichia coli, GI1788340, Length=429, Percent_Identity=26.3403263403263, Blast_Score=153, Evalue=3e-38,
Organism=Escherichia coli, GI48994968, Length=394, Percent_Identity=28.4263959390863, Blast_Score=120, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI17560350, Length=494, Percent_Identity=34.412955465587, Blast_Score=268, Evalue=4e-72,
Organism=Drosophila melanogaster, GI17136908, Length=499, Percent_Identity=34.0681362725451, Blast_Score=269, Evalue=4e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR021157
- InterPro:   IPR016040
- InterPro:   IPR017476
- InterPro:   IPR014027
- InterPro:   IPR014026
- InterPro:   IPR014028
- InterPro:   IPR001732 [H]

Pfam domain/function: PF00984 UDPG_MGDP_dh; PF03720 UDPG_MGDP_dh_C; PF03721 UDPG_MGDP_dh_N [H]

EC number: =1.1.1.22 [H]

Molecular weight: Translated: 51273; Mature: 51273

Theoretical pI: Translated: 5.52; Mature: 5.52

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDMAVVGAGYVGLVTGACLAHLGHSVICIDNNPVKIENLQRGRLPIYEPGLEELVREGAE
CCEEEECCCHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHCCHH
AGRLHFTTDLGLGVKASEVIFIAVGTPALPSGEPDLRYVEAVARGIGQHLDNRYRVIVNK
CCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEC
STVPIGSGDWVRMLILDGAAEAVQQRLSSQQMALAGGDPTPSSLATLDRSSWVPPFDVVS
CCCCCCCCCEEEEEEECCHHHHHHHHHHHHHEEEECCCCCCHHHHHCCCCCCCCCHHHCC
NPEFLREGSAIQDTFYPDRIVIGSNSPRAIEILRQLYEPILSRQQGLGGDPVPLLVTDLA
CHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
SAEMIKYAANAFLATKISFINEIANICERTGADITQVAEGIGLDKRIGRAFLNAGLGWGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCC
SCFPKDLAALIQTAADYGYEAKLLRATVEVNREQRQRLLEKLQQALKVLKGKTIGLLGLT
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
FKPHTDDLRDAPSLTLIEQLHRLGAKVKAYDPIVSASGMREGLAHVVVETDVFRLAQDCD
ECCCCCHHHCCCCHHHHHHHHHHCCCEECCCCHHHHCHHHHHHHHHHHHHHHHHHHHCCC
ALVLVTEWPEFLSLDYRRLAELMRRPLILDGRNCLDRQAVQQAGITLIGVGW
EEEEEECCHHHHCCCHHHHHHHHHCCEEECCCHHHHHHHHHHCCCEEEEECC
>Mature Secondary Structure
MDMAVVGAGYVGLVTGACLAHLGHSVICIDNNPVKIENLQRGRLPIYEPGLEELVREGAE
CCEEEECCCHHHHHHHHHHHHCCCEEEEECCCCEEEECCCCCCCCCCCCCHHHHHHCCHH
AGRLHFTTDLGLGVKASEVIFIAVGTPALPSGEPDLRYVEAVARGIGQHLDNRYRVIVNK
CCCEEEEECCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEC
STVPIGSGDWVRMLILDGAAEAVQQRLSSQQMALAGGDPTPSSLATLDRSSWVPPFDVVS
CCCCCCCCCEEEEEEECCHHHHHHHHHHHHHEEEECCCCCCHHHHHCCCCCCCCCHHHCC
NPEFLREGSAIQDTFYPDRIVIGSNSPRAIEILRQLYEPILSRQQGLGGDPVPLLVTDLA
CHHHHHCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
SAEMIKYAANAFLATKISFINEIANICERTGADITQVAEGIGLDKRIGRAFLNAGLGWGG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHCCCCCCC
SCFPKDLAALIQTAADYGYEAKLLRATVEVNREQRQRLLEKLQQALKVLKGKTIGLLGLT
CCCHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEE
FKPHTDDLRDAPSLTLIEQLHRLGAKVKAYDPIVSASGMREGLAHVVVETDVFRLAQDCD
ECCCCCHHHCCCCHHHHHHHHHHCCCEECCCCHHHHCHHHHHHHHHHHHHHHHHHHHCCC
ALVLVTEWPEFLSLDYRRLAELMRRPLILDGRNCLDRQAVQQAGITLIGVGW
EEEEEECCHHHHCCCHHHHHHHHHCCEEECCCHHHHHHHHHHCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10048024; 9384377; 10376820 [H]