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The map label for this gene is fhuB

Identifier: 86361195

GI number: 86361195

Start: 523942

End: 525906

Strand: Direct

Name: fhuB

Synonym: RHE_PF00465

Alternate gene names: 86361195

Gene position: 523942-525906 (Clockwise)

Preceding gene: 86361194

Following gene: 86361197

Centisome position: 81.55

GC content: 68.19

Gene sequence:

>1965_bases
ATGAAAGCGCAAATTTCCGGCTTTGGCGCGCCCGCCCTCGCGGCGCTGCTGCTGTTTTCCGGCCTCGGCCTGGCTCTCCT
CGACCTGCTGCCGGCGTTGCCGCATCTGGAGACATCAGGCGGATACGACGCCCAGCACCTTCTCCTTCTCTATTCGACGC
TTCCGCGCATGGCGACGGCCCTGATCACCGGCGCCGCCCTCGCGCTGTCGGGCACGATCCTGCAGCAGGTGCTGCGCAAT
CCGCTCGCTTCGCCGACGACGCTTGGCGTTTCGGCCGGGGCGAATCTGGCGCTGGTCTCCGTCATGCTCGCCTTCCCCTC
GCTGACGGGATGGGGCCGCGACGCGGTCGCGCTTGCCGGAAGTGCCGCTGCCGCCTTCGCCATCTTCTCGATCAGCGCCC
GGCACGGCTTCTCGCCCTTTTCCCTCATCCTCTCGGGCATGATCATCGGCCTGTGGTGCGGAGCGGCGGCGGCCATCCTG
ATATTGATGAACGATCAATATCTCTCCGGGATCTTCATCTGGGGCGCTGGATCGCTCTCGCAGCAAAGCTGGGCGATCCC
GATATCGCTGCTGCCTAAGGTAGCCCTCCTCGCCGGCCTTGCCTTTCTCGCCGCGAGGCCGCTGGCGCTGAGCCAGCTCG
GCGATGCCGGCGCGACGAGCCTCGGTCTGCCGATCAAATGGTCGCGCGGCGTCATCCTGGCAATCGCAATTGCGCTGAGC
GCGCTGGTCACCAGTGCCGTCGGCGTTATCGGCTTCATCGGACTGGTCGCCCCGCAGATCGTTCGGCTGGCCGGCGCACG
CCGCGTCGTCAGCCAATTGATCTGGTCGCCCATTGCCGGCGCCGGCCTTCTTCTTCTGACCGACGAGGCGATCAAGCTCC
TTGCCCCCGGCGACTTCGTGCCGACAGGGGCAGTAACCGCGCTGCTCGGCGGACCGATCCTGATCGCTCTGTTGCCGCGC
CTTGCCACCGCCAGCCGCACGCCGCCAGGCATGGCTTCGCCAAGAGTTGCCGTCGCCAACAGAACGGTATCGCTTGGCCT
GCTGCTTCTCGCTGTCGCCGCGCTGGCAGCGGCAGCGATCTTCTTCGGACGCGCGCCGGACGGCGCCTGGGCGTGGCTGC
CGGCCGCCGCGTGGGATGACATCCTTCCCCTTCGCCTGCCGCGCGTCGCCGCAGCTTTCGGCGCCGGAACCGTGCTCGGC
GTGACCGGGCTGATCCTGCAGCGGCTGACCGGAAACGAAATGGCAAGCCCCGAAGTGCTCGGGGTTTCGGCCGGAGCGAC
GCTCGGCGTCGCGGCCGCCATGTTCGCCTTTGCCGCGCCAGGACTGACGGTGCAGCTTGCCTTTGCCGGCGGCGGCGCGC
TTGCGGTTCTACTGCTGATCTTCCTCTTGAGCGCCCGTTCGGGCTTCGGCCCGAACCGCGTGCTGCTCGCCGGCATCGCC
TTCGGCGCGATCCTCGACGCCGGGATCGGCGTGCTGGCGGCCAGCGGCGATCCGCGCGGTCTGGCGCTGATCCGCTGGAT
GTCGGGCTCGACCTATTTCGTCGACAACAACGTTGCCGCAAGCGCCCTCATCATTGCGCTTGCCTGCCTCATCGCGGCCT
TTCTCGCCAGCCGATGGCTCGCCCTGCTGCAGCTCGGCTCGGAAACGGCGAGTGAACTCGGCCTCAGGATCGCTCCGGCA
CGCGGCGTCCTCTTTGGGCTTTCGGCGATCATGACGGCCGCCGCCACGCTCGTCGTCGGCCCCTTGAGCTTCGTCGGACT
GATGGCGCCCCACCTCGCCCATGGCCTCGGACTTCGCCGTCCCTCCATCCAGCTCCTCGCCGCCGCGCTGATCGGCGCGA
CCCTGCTCGTCATCGCCGACTGGGCCGGCCGCATGATCGCCTTTCCCTACCAGGTCCCTGCGGGTTTGATCTCGGCCCTG
GTTGGGGCGCCGATGCTGCTGTTCGTTCTGCGCGGGCGACCTTAA

Upstream 100 bases:

>100_bases
AGCGGATCTCGGTCGTTCCAGGCGTGCTGATGTTTGGAATGGTCCAGGAAGCCCTGCGCTTTTCGACTTTGATGGTCGGC
GTTCTGGAGACTGCTGCCTG

Downstream 100 bases:

>100_bases
GGGGCCGCCGCCTTCATACCGCCAATGCTTCGGCGTCGACGCCTGCAGGGATGCGCAACGGACACGAAGGATCGGTCGCA
GCGCGCCATACTGCCTCGAC

Product: iron-hydroxamate transporter permease subunit

Products: ADP; phosphate; iron (III) hydroxamate [Cytoplasm] [C]

Alternate protein names: Ferric hydroxamate uptake protein B; Ferrichrome transport system permease protein fhuB; Ferrichrome uptake protein fhuB; Iron(III)-hydroxamate import system permease protein fhuB [H]

Number of amino acids: Translated: 654; Mature: 654

Protein sequence:

>654_residues
MKAQISGFGAPALAALLLFSGLGLALLDLLPALPHLETSGGYDAQHLLLLYSTLPRMATALITGAALALSGTILQQVLRN
PLASPTTLGVSAGANLALVSVMLAFPSLTGWGRDAVALAGSAAAAFAIFSISARHGFSPFSLILSGMIIGLWCGAAAAIL
ILMNDQYLSGIFIWGAGSLSQQSWAIPISLLPKVALLAGLAFLAARPLALSQLGDAGATSLGLPIKWSRGVILAIAIALS
ALVTSAVGVIGFIGLVAPQIVRLAGARRVVSQLIWSPIAGAGLLLLTDEAIKLLAPGDFVPTGAVTALLGGPILIALLPR
LATASRTPPGMASPRVAVANRTVSLGLLLLAVAALAAAAIFFGRAPDGAWAWLPAAAWDDILPLRLPRVAAAFGAGTVLG
VTGLILQRLTGNEMASPEVLGVSAGATLGVAAAMFAFAAPGLTVQLAFAGGGALAVLLLIFLLSARSGFGPNRVLLAGIA
FGAILDAGIGVLAASGDPRGLALIRWMSGSTYFVDNNVAASALIIALACLIAAFLASRWLALLQLGSETASELGLRIAPA
RGVLFGLSAIMTAAATLVVGPLSFVGLMAPHLAHGLGLRRPSIQLLAAALIGATLLVIADWAGRMIAFPYQVPAGLISAL
VGAPMLLFVLRGRP

Sequences:

>Translated_654_residues
MKAQISGFGAPALAALLLFSGLGLALLDLLPALPHLETSGGYDAQHLLLLYSTLPRMATALITGAALALSGTILQQVLRN
PLASPTTLGVSAGANLALVSVMLAFPSLTGWGRDAVALAGSAAAAFAIFSISARHGFSPFSLILSGMIIGLWCGAAAAIL
ILMNDQYLSGIFIWGAGSLSQQSWAIPISLLPKVALLAGLAFLAARPLALSQLGDAGATSLGLPIKWSRGVILAIAIALS
ALVTSAVGVIGFIGLVAPQIVRLAGARRVVSQLIWSPIAGAGLLLLTDEAIKLLAPGDFVPTGAVTALLGGPILIALLPR
LATASRTPPGMASPRVAVANRTVSLGLLLLAVAALAAAAIFFGRAPDGAWAWLPAAAWDDILPLRLPRVAAAFGAGTVLG
VTGLILQRLTGNEMASPEVLGVSAGATLGVAAAMFAFAAPGLTVQLAFAGGGALAVLLLIFLLSARSGFGPNRVLLAGIA
FGAILDAGIGVLAASGDPRGLALIRWMSGSTYFVDNNVAASALIIALACLIAAFLASRWLALLQLGSETASELGLRIAPA
RGVLFGLSAIMTAAATLVVGPLSFVGLMAPHLAHGLGLRRPSIQLLAAALIGATLLVIADWAGRMIAFPYQVPAGLISAL
VGAPMLLFVLRGRP
>Mature_654_residues
MKAQISGFGAPALAALLLFSGLGLALLDLLPALPHLETSGGYDAQHLLLLYSTLPRMATALITGAALALSGTILQQVLRN
PLASPTTLGVSAGANLALVSVMLAFPSLTGWGRDAVALAGSAAAAFAIFSISARHGFSPFSLILSGMIIGLWCGAAAAIL
ILMNDQYLSGIFIWGAGSLSQQSWAIPISLLPKVALLAGLAFLAARPLALSQLGDAGATSLGLPIKWSRGVILAIAIALS
ALVTSAVGVIGFIGLVAPQIVRLAGARRVVSQLIWSPIAGAGLLLLTDEAIKLLAPGDFVPTGAVTALLGGPILIALLPR
LATASRTPPGMASPRVAVANRTVSLGLLLLAVAALAAAAIFFGRAPDGAWAWLPAAAWDDILPLRLPRVAAAFGAGTVLG
VTGLILQRLTGNEMASPEVLGVSAGATLGVAAAMFAFAAPGLTVQLAFAGGGALAVLLLIFLLSARSGFGPNRVLLAGIA
FGAILDAGIGVLAASGDPRGLALIRWMSGSTYFVDNNVAASALIIALACLIAAFLASRWLALLQLGSETASELGLRIAPA
RGVLFGLSAIMTAAATLVVGPLSFVGLMAPHLAHGLGLRRPSIQLLAAALIGATLLVIADWAGRMIAFPYQVPAGLISAL
VGAPMLLFVLRGRP

Specific function: Part of the ABC transporter complex fhuCDB involved in iron(3+)-hydroxamate import. Responsible for the translocation of the substrate across the membrane [H]

COG id: COG0609

COG function: function code P; ABC-type Fe3+-siderophore transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786347, Length=618, Percent_Identity=41.1003236245955, Blast_Score=355, Evalue=6e-99,
Organism=Escherichia coli, GI1790740, Length=285, Percent_Identity=33.6842105263158, Blast_Score=119, Evalue=4e-28,
Organism=Escherichia coli, GI1786805, Length=283, Percent_Identity=37.4558303886926, Blast_Score=105, Evalue=1e-23,
Organism=Escherichia coli, GI1790741, Length=271, Percent_Identity=34.3173431734317, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1788004, Length=279, Percent_Identity=34.0501792114695, Blast_Score=98, Evalue=1e-21,
Organism=Escherichia coli, GI1786804, Length=269, Percent_Identity=33.0855018587361, Blast_Score=87, Evalue=2e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000522
- InterPro:   IPR006311 [H]

Pfam domain/function: PF01032 FecCD [H]

EC number: NA

Molecular weight: Translated: 65952; Mature: 65952

Theoretical pI: Translated: 11.39; Mature: 11.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKAQISGFGAPALAALLLFSGLGLALLDLLPALPHLETSGGYDAQHLLLLYSTLPRMATA
CCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LITGAALALSGTILQQVLRNPLASPTTLGVSAGANLALVSVMLAFPSLTGWGRDAVALAG
HHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHCC
SAAAAFAIFSISARHGFSPFSLILSGMIIGLWCGAAAAILILMNDQYLSGIFIWGAGSLS
HHHHHHHHHEEHHHCCCCHHHHHHHHHHHHHHHHHHHHEHHEECCCCCCEEEEEECCCCC
QQSWAIPISLLPKVALLAGLAFLAARPLALSQLGDAGATSLGLPIKWSRGVILAIAIALS
CCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHH
ALVTSAVGVIGFIGLVAPQIVRLAGARRVVSQLIWSPIAGAGLLLLTDEAIKLLAPGDFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHEECCCCCC
PTGAVTALLGGPILIALLPRLATASRTPPGMASPRVAVANRTVSLGLLLLAVAALAAAAI
CHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHH
FFGRAPDGAWAWLPAAAWDDILPLRLPRVAAAFGAGTVLGVTGLILQRLTGNEMASPEVL
HHCCCCCCCEEEECCHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEE
GVSAGATLGVAAAMFAFAAPGLTVQLAFAGGGALAVLLLIFLLSARSGFGPNRVLLAGIA
EECCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
FGAILDAGIGVLAASGDPRGLALIRWMSGSTYFVDNNVAASALIIALACLIAAFLASRWL
HHHHHHCCCCEEEECCCCCCEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
ALLQLGSETASELGLRIAPARGVLFGLSAIMTAAATLVVGPLSFVGLMAPHLAHGLGLRR
HHHHHCCHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PSIQLLAAALIGATLLVIADWAGRMIAFPYQVPAGLISALVGAPMLLFVLRGRP
CHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKAQISGFGAPALAALLLFSGLGLALLDLLPALPHLETSGGYDAQHLLLLYSTLPRMATA
CCCCCCCCCHHHHHHHHHHHCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
LITGAALALSGTILQQVLRNPLASPTTLGVSAGANLALVSVMLAFPSLTGWGRDAVALAG
HHHHHHHHHHHHHHHHHHHCCCCCCCEECCCCCCHHHHHHHHHHHCCCCCCCCCHHHHCC
SAAAAFAIFSISARHGFSPFSLILSGMIIGLWCGAAAAILILMNDQYLSGIFIWGAGSLS
HHHHHHHHHEEHHHCCCCHHHHHHHHHHHHHHHHHHHHEHHEECCCCCCEEEEEECCCCC
QQSWAIPISLLPKVALLAGLAFLAARPLALSQLGDAGATSLGLPIKWSRGVILAIAIALS
CCCCCCCHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHH
ALVTSAVGVIGFIGLVAPQIVRLAGARRVVSQLIWSPIAGAGLLLLTDEAIKLLAPGDFV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHEECCCCCC
PTGAVTALLGGPILIALLPRLATASRTPPGMASPRVAVANRTVSLGLLLLAVAALAAAAI
CHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHH
FFGRAPDGAWAWLPAAAWDDILPLRLPRVAAAFGAGTVLGVTGLILQRLTGNEMASPEVL
HHCCCCCCCEEEECCHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCEE
GVSAGATLGVAAAMFAFAAPGLTVQLAFAGGGALAVLLLIFLLSARSGFGPNRVLLAGIA
EECCCCHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
FGAILDAGIGVLAASGDPRGLALIRWMSGSTYFVDNNVAASALIIALACLIAAFLASRWL
HHHHHHCCCCEEEECCCCCCEEEEEEECCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHH
ALLQLGSETASELGLRIAPARGVLFGLSAIMTAAATLVVGPLSFVGLMAPHLAHGLGLRR
HHHHHCCHHHHHCCEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
PSIQLLAAALIGATLLVIADWAGRMIAFPYQVPAGLISALVGAPMLLFVLRGRP
CHHHHHHHHHHHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; iron (III) hydroxamate [Periplasm]; H2O [C]

Specific reaction: ATP + iron (III) hydroxamate [Periplasm] + H2O = ADP + phosphate + iron (III) hydroxamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677609; 10103258 [H]