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The map label for this gene is modD [H]

Identifier: 85860739

GI number: 85860739

Start: 2918644

End: 2919567

Strand: Direct

Name: modD [H]

Synonym: SYN_00382

Alternate gene names: 85860739

Gene position: 2918644-2919567 (Clockwise)

Preceding gene: 85860733

Following gene: 85860740

Centisome position: 91.8

GC content: 55.19

Gene sequence:

>924_bases
ATGATCATGTTTTACATTCCCGACCACTATATTGAAACCCTGATTAACGAAGATCTCCAACTGATGGACGTGACCACCCT
CAGTATGGGGATCGAAGACCTCCCGGGCCGGTTGACATGTTACCCCAAAAGGGAATGCGTCATCGCCGGAGTGGAGGAAG
CAGCCTGCATCTTCACAAAAATCGGCGCCGAAGCTGAAATCATGATCCCCAGCGGCCGGCGCGTGGAGGAAGGGAAGATC
TGTCTTGCTGTCGTCGGTACCGCCGGAATGCTCCATGCCGGCTGGAAGGTCGCCCAAAATGTGATGGAATACGCCTCCGG
CATCGCAACCCGGACCGCAGAGATGGTCCGTAATGCCCGAGCGGTCAAACCGGACATCAAGATAGCGGTCACACGGAAAC
ATTTTCCCGGCGCCAAGGCGCTTTCCCTCAAGGCGGCACTGGCGGGAGGCGCCAGCATCCACAGGCTCGGCCTCTCGGAC
TCCATCCTGGCCTTCGAGCAGCACCGGGTATTTGCCGGTACCGATGATGACTTTCTCTCTCTGATTCCTGCCATGGCCCG
TGAATTTCCAGAGAAAAAGATCGCCGTGGAAACGGATTCCCCGGAAGAGGGACTGTCTTTCGTCCGGGCGGGCGCCCATG
TGGTGCAGTGCGAAAGGTTCACATTCGAAGAGCTTGCAGAGTTCGTTTCTGCAGCAAAGCAGCTCAATCCGTCCCTGGAA
ATATCCGCCGCGGGGGGAATCAACGCATCCAACGCTGCAGAATACGCGGCCACAGGGGTCGATTTCCTGGTGACTTCATG
GATTTATTTTGGAAAACCGGAAGATGTAAAAGTGCGGATGACGTGCGAGAGATATGAAGGAGAGAGAGAAAAGGTTCTGA
AGTTCTCTTCGGGTCATTACAATACGGTTCAGTGCAATGGATGA

Upstream 100 bases:

>100_bases
ATCTTCATGTTGAAAGTTCAAATACAGAAAAAAAGGCCGTCTCGATATGCAGATTGATTTTCATATCGAAAAGCCATGAA
TCACAATCCTGTAAGGAGAG

Downstream 100 bases:

>100_bases
TCCGAGTAGATTTCGAATAAAAATCGTGATAGTCAGCATAAGCATGGGCACTGGCGAAAGTTTCTTTGATCTGCCGGAGA
ACATGGTCCCGAATTTTTGA

Product: pyrophosphorylase ModD

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 307; Mature: 307

Protein sequence:

>307_residues
MIMFYIPDHYIETLINEDLQLMDVTTLSMGIEDLPGRLTCYPKRECVIAGVEEAACIFTKIGAEAEIMIPSGRRVEEGKI
CLAVVGTAGMLHAGWKVAQNVMEYASGIATRTAEMVRNARAVKPDIKIAVTRKHFPGAKALSLKAALAGGASIHRLGLSD
SILAFEQHRVFAGTDDDFLSLIPAMAREFPEKKIAVETDSPEEGLSFVRAGAHVVQCERFTFEELAEFVSAAKQLNPSLE
ISAAGGINASNAAEYAATGVDFLVTSWIYFGKPEDVKVRMTCERYEGEREKVLKFSSGHYNTVQCNG

Sequences:

>Translated_307_residues
MIMFYIPDHYIETLINEDLQLMDVTTLSMGIEDLPGRLTCYPKRECVIAGVEEAACIFTKIGAEAEIMIPSGRRVEEGKI
CLAVVGTAGMLHAGWKVAQNVMEYASGIATRTAEMVRNARAVKPDIKIAVTRKHFPGAKALSLKAALAGGASIHRLGLSD
SILAFEQHRVFAGTDDDFLSLIPAMAREFPEKKIAVETDSPEEGLSFVRAGAHVVQCERFTFEELAEFVSAAKQLNPSLE
ISAAGGINASNAAEYAATGVDFLVTSWIYFGKPEDVKVRMTCERYEGEREKVLKFSSGHYNTVQCNG
>Mature_307_residues
MIMFYIPDHYIETLINEDLQLMDVTTLSMGIEDLPGRLTCYPKRECVIAGVEEAACIFTKIGAEAEIMIPSGRRVEEGKI
CLAVVGTAGMLHAGWKVAQNVMEYASGIATRTAEMVRNARAVKPDIKIAVTRKHFPGAKALSLKAALAGGASIHRLGLSD
SILAFEQHRVFAGTDDDFLSLIPAMAREFPEKKIAVETDSPEEGLSFVRAGAHVVQCERFTFEELAEFVSAAKQLNPSLE
ISAAGGINASNAAEYAATGVDFLVTSWIYFGKPEDVKVRMTCERYEGEREKVLKFSSGHYNTVQCNG

Specific function: NAD biosynthesis; aspartate to NaMN; third (last) step. [C]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=255, Percent_Identity=27.843137254902, Blast_Score=75, Evalue=9e-14,
Organism=Escherichia coli, GI1786299, Length=228, Percent_Identity=24.5614035087719, Blast_Score=69, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6321162, Length=272, Percent_Identity=26.8382352941176, Blast_Score=80, Evalue=4e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006242
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: 2.4.2.-

Molecular weight: Translated: 33490; Mature: 33490

Theoretical pI: Translated: 5.26; Mature: 5.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIMFYIPDHYIETLINEDLQLMDVTTLSMGIEDLPGRLTCYPKRECVIAGVEEAACIFTK
CEEEEECHHHHHHHHCCCCEEEEEHHHHCCHHHCCCCEEECCCCCEEEECCCHHHHEEEE
IGAEAEIMIPSGRRVEEGKICLAVVGTAGMLHAGWKVAQNVMEYASGIATRTAEMVRNAR
CCCCEEEECCCCCEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVKPDIKIAVTRKHFPGAKALSLKAALAGGASIHRLGLSDSILAFEQHRVFAGTDDDFLS
CCCCCEEEEEEECCCCCCCCEEEHHHHCCCCEEEEECCCCCCEEEECCEEEECCCHHHHH
LIPAMAREFPEKKIAVETDSPEEGLSFVRAGAHVVQCERFTFEELAEFVSAAKQLNPSLE
HHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCEE
ISAAGGINASNAAEYAATGVDFLVTSWIYFGKPEDVKVRMTCERYEGEREKVLKFSSGHY
EEECCCCCCCCCHHHHHCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHEEECCCCC
NTVQCNG
EEEEECC
>Mature Secondary Structure
MIMFYIPDHYIETLINEDLQLMDVTTLSMGIEDLPGRLTCYPKRECVIAGVEEAACIFTK
CEEEEECHHHHHHHHCCCCEEEEEHHHHCCHHHCCCCEEECCCCCEEEECCCHHHHEEEE
IGAEAEIMIPSGRRVEEGKICLAVVGTAGMLHAGWKVAQNVMEYASGIATRTAEMVRNAR
CCCCEEEECCCCCEECCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AVKPDIKIAVTRKHFPGAKALSLKAALAGGASIHRLGLSDSILAFEQHRVFAGTDDDFLS
CCCCCEEEEEEECCCCCCCCEEEHHHHCCCCEEEEECCCCCCEEEECCEEEECCCHHHHH
LIPAMAREFPEKKIAVETDSPEEGLSFVRAGAHVVQCERFTFEELAEFVSAAKQLNPSLE
HHHHHHHHCCCCEEEEECCCCHHHHHHHHCCCCEEEECCCCHHHHHHHHHHHHHCCCCEE
ISAAGGINASNAAEYAATGVDFLVTSWIYFGKPEDVKVRMTCERYEGEREKVLKFSSGHY
EEECCCCCCCCCHHHHHCCHHHHHHHHHHCCCCCCEEEEEEEECCCCCHHHHEEECCCCC
NTVQCNG
EEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11248100 [H]