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The map label for this gene is moaA [H]

Identifier: 85860740

GI number: 85860740

Start: 2919664

End: 2920701

Strand: Direct

Name: moaA [H]

Synonym: SYN_00381

Alternate gene names: 85860740

Gene position: 2919664-2920701 (Clockwise)

Preceding gene: 85860739

Following gene: 85860741

Centisome position: 91.83

GC content: 49.42

Gene sequence:

>1038_bases
TTGAAAGGGTTATATGCTGAAAGCCATTTTTTCCCCATTTCGGGGCAAAGGATTACTATGAAAGACAGTTTTGGACGTCA
GATTAATTATCTGCGGATTTCGGTCACGGATCGCTGCAACTTGAGGTGCCGCTACTGCATGCCGGAGGAAGGCATTGAAA
GCAAACTGGGACATGAAGGAGTATTGAGCCTGGAAGCGTTCGCGCGCGTCGTTCGGCTTGCAGCCCAGGTCGGAATCCGC
AAGGTGCGACTGACGGGGGGAGAGCCGCTGGTCCGCAGAAACATCCCGCAATTGATTCGCTACATCGCCGATGTTCCACA
GATCGACGATATTGCATTGACAACCAACGGGATTCTGTTTGCCCCTATGGCGGAAGAATTAAAAGCTGCAGGACTCAACC
GCGTCAACATCAGCCTGGACAGTTTCAAGGAGGACCGGTTCCGTTTTATCACCCGGGTTGGAAATCTGGATCAGGCGAAA
AAGGCGATTTTCAAGGCGTTGGAGCTGAAGATGAATCCGGTGAAAATAAATACGGTAGTCATCAGGGGATTTAACGATGA
TGAGATTCTGGATTTTGCCCGCCTCGCTTATGATTATCCTCTGCACGTCCGTTTCATCGAGTTTATGCCGGTTGGAGACC
TTCTTTACTGGAAAAAGGACCGTTTGATGAAAACAGATGAGATCCTGGAGATGGTGAAAAAGCAGTTTCTCCTGACCCGC
TTCAAAGATATCCGAGGCAGTGGCCCGGCAAGATATTATAAAGCGGAAGGCGGCAAGGGTTCGATCGGTTTCATCAGCCC
CATGAGCAACCACTTCTGCGCTCAATGCAATCGGATTCGAATGACAGCCGACGGGATGATTCGAGGTTGTCTGTACGACA
AAAGGGAAGTTAATTTAAGACCTTCGCTGGAAAACGGCAGTGATGAAGAAATCCTGAATCTCCTTATTGAAACCATTACG
CAAAAACCGGCCCGGCACATGATGGACAGCGGCTGGGGAGCGAAAAATGAACGCAAGATGTTTCAAATAGGCGGTTAG

Upstream 100 bases:

>100_bases
ATGATCCGAGTAGATTTCGAATAAAAATCGTGATAGTCAGCATAAGCATGGGCACTGGCGAAAGTTTCTTTGATCTGCCG
GAGAACATGGTCCCGAATTT

Downstream 100 bases:

>100_bases
CATCCTGTCGGACCTGACCGGGAAATGACTTCATTATGTCGATTGCTCAATCCTTTTCCGTCATCCCCCATCAATAAGAT
CCTCTGAAGACATCTGAAAA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 345; Mature: 345

Protein sequence:

>345_residues
MKGLYAESHFFPISGQRITMKDSFGRQINYLRISVTDRCNLRCRYCMPEEGIESKLGHEGVLSLEAFARVVRLAAQVGIR
KVRLTGGEPLVRRNIPQLIRYIADVPQIDDIALTTNGILFAPMAEELKAAGLNRVNISLDSFKEDRFRFITRVGNLDQAK
KAIFKALELKMNPVKINTVVIRGFNDDEILDFARLAYDYPLHVRFIEFMPVGDLLYWKKDRLMKTDEILEMVKKQFLLTR
FKDIRGSGPARYYKAEGGKGSIGFISPMSNHFCAQCNRIRMTADGMIRGCLYDKREVNLRPSLENGSDEEILNLLIETIT
QKPARHMMDSGWGAKNERKMFQIGG

Sequences:

>Translated_345_residues
MKGLYAESHFFPISGQRITMKDSFGRQINYLRISVTDRCNLRCRYCMPEEGIESKLGHEGVLSLEAFARVVRLAAQVGIR
KVRLTGGEPLVRRNIPQLIRYIADVPQIDDIALTTNGILFAPMAEELKAAGLNRVNISLDSFKEDRFRFITRVGNLDQAK
KAIFKALELKMNPVKINTVVIRGFNDDEILDFARLAYDYPLHVRFIEFMPVGDLLYWKKDRLMKTDEILEMVKKQFLLTR
FKDIRGSGPARYYKAEGGKGSIGFISPMSNHFCAQCNRIRMTADGMIRGCLYDKREVNLRPSLENGSDEEILNLLIETIT
QKPARHMMDSGWGAKNERKMFQIGG
>Mature_345_residues
MKGLYAESHFFPISGQRITMKDSFGRQINYLRISVTDRCNLRCRYCMPEEGIESKLGHEGVLSLEAFARVVRLAAQVGIR
KVRLTGGEPLVRRNIPQLIRYIADVPQIDDIALTTNGILFAPMAEELKAAGLNRVNISLDSFKEDRFRFITRVGNLDQAK
KAIFKALELKMNPVKINTVVIRGFNDDEILDFARLAYDYPLHVRFIEFMPVGDLLYWKKDRLMKTDEILEMVKKQFLLTR
FKDIRGSGPARYYKAEGGKGSIGFISPMSNHFCAQCNRIRMTADGMIRGCLYDKREVNLRPSLENGSDEEILNLLIETIT
QKPARHMMDSGWGAKNERKMFQIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI22027536, Length=342, Percent_Identity=40.6432748538012, Blast_Score=256, Evalue=2e-68,
Organism=Homo sapiens, GI116734668, Length=342, Percent_Identity=40.6432748538012, Blast_Score=256, Evalue=2e-68,
Organism=Escherichia coli, GI1786999, Length=314, Percent_Identity=34.0764331210191, Blast_Score=181, Evalue=8e-47,
Organism=Caenorhabditis elegans, GI32566329, Length=331, Percent_Identity=39.5770392749245, Blast_Score=227, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI17561210, Length=331, Percent_Identity=40.1812688821752, Blast_Score=227, Evalue=7e-60,
Organism=Caenorhabditis elegans, GI32566331, Length=313, Percent_Identity=39.297124600639, Blast_Score=225, Evalue=3e-59,
Organism=Drosophila melanogaster, GI28574488, Length=333, Percent_Identity=39.039039039039, Blast_Score=243, Evalue=2e-64,
Organism=Drosophila melanogaster, GI28574490, Length=314, Percent_Identity=39.8089171974522, Blast_Score=241, Evalue=5e-64,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 39440; Mature: 39440

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKGLYAESHFFPISGQRITMKDSFGRQINYLRISVTDRCNLRCRYCMPEEGIESKLGHEG
CCCCCCCCEEEECCCCEEEECCCCCCEEEEEEEEEECCCCCEEEECCCCCCHHHHCCCCC
VLSLEAFARVVRLAAQVGIRKVRLTGGEPLVRRNIPQLIRYIADVPQIDDIALTTNGILF
CEEHHHHHHHHHHHHHHCCEEEEECCCCCHHHCCHHHHHHHHHCCCCCCCEEEEECCEEE
APMAEELKAAGLNRVNISLDSFKEDRFRFITRVGNLDQAKKAIFKALELKMNPVKINTVV
CCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEE
IRGFNDDEILDFARLAYDYPLHVRFIEFMPVGDLLYWKKDRLMKTDEILEMVKKQFLLTR
EECCCCHHHHHHHHHHHCCCEEEEEEEEEECCCHHEECHHHCCCHHHHHHHHHHHHHHHH
FKDIRGSGPARYYKAEGGKGSIGFISPMSNHFCAQCNRIRMTADGMIRGCLYDKREVNLR
HHHHCCCCCCEEEECCCCCCCEEECCCCCCHHHHCCCEEEEEHHHHHHHHCCCCCCCCCC
PSLENGSDEEILNLLIETITQKPARHMMDSGWGAKNERKMFQIGG
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCEEEECC
>Mature Secondary Structure
MKGLYAESHFFPISGQRITMKDSFGRQINYLRISVTDRCNLRCRYCMPEEGIESKLGHEG
CCCCCCCCEEEECCCCEEEECCCCCCEEEEEEEEEECCCCCEEEECCCCCCHHHHCCCCC
VLSLEAFARVVRLAAQVGIRKVRLTGGEPLVRRNIPQLIRYIADVPQIDDIALTTNGILF
CEEHHHHHHHHHHHHHHCCEEEEECCCCCHHHCCHHHHHHHHHCCCCCCCEEEEECCEEE
APMAEELKAAGLNRVNISLDSFKEDRFRFITRVGNLDQAKKAIFKALELKMNPVKINTVV
CCCHHHHHHCCCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEEE
IRGFNDDEILDFARLAYDYPLHVRFIEFMPVGDLLYWKKDRLMKTDEILEMVKKQFLLTR
EECCCCHHHHHHHHHHHCCCEEEEEEEEEECCCHHEECHHHCCCHHHHHHHHHHHHHHHH
FKDIRGSGPARYYKAEGGKGSIGFISPMSNHFCAQCNRIRMTADGMIRGCLYDKREVNLR
HHHHCCCCCCEEEECCCCCCCEEECCCCCCHHHHCCCEEEEEHHHHHHHHCCCCCCCCCC
PSLENGSDEEILNLLIETITQKPARHMMDSGWGAKNERKMFQIGG
CCCCCCCHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA