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The map label for this gene is yfnC [H]

Identifier: 85860295

GI number: 85860295

Start: 2476006

End: 2477172

Strand: Direct

Name: yfnC [H]

Synonym: SYN_01218

Alternate gene names: 85860295

Gene position: 2476006-2477172 (Clockwise)

Preceding gene: 85860294

Following gene: 85860296

Centisome position: 77.88

GC content: 53.47

Gene sequence:

>1167_bases
ATGCGAAGATTTAACTTCAAGATTCTCCTTCTTCTTTCTCTGGGCCATCTGGTAACGGATATCTATCAAGGGGCGCTGCC
TGTTATACTGCCGTTCCTTAAAGAGAGCCTTTCCCTCTCCTACACCCTGACCGGCGTCATCCTGATGACGGCCAATTTCA
CCTCTTCCCTGATTCAGCCTCTGCTCGGCTTTCTATCGGACAAACAGGACAAACCTCTCCTCCTGCCCCTGGGATGTTTC
TGCTCCGGGCTCGGTTTATCCCTCCTGGCCATACCGTCAAGCTACATTGTCGTGCTCGGGCTGGTCGTTATCAGCGGACT
CGGGGTTGCCTCCTATCATCCGGAAGGATATAAGACCGCCTATTATTTTACAGGGGAAAAACGGGCTACAGGAATGGCCA
TATTTTCAGTGGGCGGAAATCTGGGATTCGCCCTGGGACCCCTGATCGCGATTTTCGTTGTTAAATATTTCGGTCTTTCC
TCACTGCCTTTAATCATGCTGCCTTCCCTGCTGTTCCCGGTAATCCTCTTTTTTTACTGGGATAAAATTACCTCAGGCAG
GGTCGACAAAAAGCCCGCTCAGGAAACTCCTCATAAAATAGCCGGAACAACGTACTTATCCCTATTGATCCTCGTCGGCA
TCGTGATGATGCGCTCGTGGATTCAAATGGGGCTGATGAGTTACATTCCCTTTTATTACATAGACTATCTCCAGGGGGAT
CCCCTTCATGCCGGGGCGCTCGTGTCCGTCTTTCTGATGGGCGGGGTTTTCGGCACACTGGGCGGCTCACCCCTGGCCGA
CCGCTGGGGACACCAGCGCTACCTGACCCTTTCCATGCTCCTGGCCTCCATCGTACTGCCCCTTATTTTCGTTGCCCGGG
GCATTTTCCTGTTCGCCGTTCTCGGCCTTCTCGGCATGATCCTCATCTCCACCTTCACGGTCACCGTCGTCATGGCCCAA
CGTCTGCTGCCCCGCAATCTCGGGATTGCCTCCGGGCTGATGGTCGGCTTCGCCATTGGAGCGGGCGGCTTCTGTGTCAC
GCTGCTCGGAGTGATCGCCGATTCCTTCGGGGTGCCCTTCGCTCTGAAATCCATAGCGATTCTTCCTTTCATCGGGTTTC
TTCTCAGCTTGTCTCTAAAATATCAAAGGACTCCCGACAGAATATGA

Upstream 100 bases:

>100_bases
TGCGCGGTTACCCTGAGCATCATCCTGTTTTCAGTCATTCATCGATTCTTCAAACCTTATTTAAGAGATCTGACCTGAAG
GCGAATGAGGTTAATATGCA

Downstream 100 bases:

>100_bases
AGATCAAATCATTTGAATTCAATCTTCGCGAACTGGGAGGAGCAATGGGGGATTTCGGAACCCTCTTCCCCCTGGCCATC
GGCTACATCTATGTCTGCGG

Product: fosmidomycin resistance protein

Products: fosmidomycin [Periplasm]; Proton [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MRRFNFKILLLLSLGHLVTDIYQGALPVILPFLKESLSLSYTLTGVILMTANFTSSLIQPLLGFLSDKQDKPLLLPLGCF
CSGLGLSLLAIPSSYIVVLGLVVISGLGVASYHPEGYKTAYYFTGEKRATGMAIFSVGGNLGFALGPLIAIFVVKYFGLS
SLPLIMLPSLLFPVILFFYWDKITSGRVDKKPAQETPHKIAGTTYLSLLILVGIVMMRSWIQMGLMSYIPFYYIDYLQGD
PLHAGALVSVFLMGGVFGTLGGSPLADRWGHQRYLTLSMLLASIVLPLIFVARGIFLFAVLGLLGMILISTFTVTVVMAQ
RLLPRNLGIASGLMVGFAIGAGGFCVTLLGVIADSFGVPFALKSIAILPFIGFLLSLSLKYQRTPDRI

Sequences:

>Translated_388_residues
MRRFNFKILLLLSLGHLVTDIYQGALPVILPFLKESLSLSYTLTGVILMTANFTSSLIQPLLGFLSDKQDKPLLLPLGCF
CSGLGLSLLAIPSSYIVVLGLVVISGLGVASYHPEGYKTAYYFTGEKRATGMAIFSVGGNLGFALGPLIAIFVVKYFGLS
SLPLIMLPSLLFPVILFFYWDKITSGRVDKKPAQETPHKIAGTTYLSLLILVGIVMMRSWIQMGLMSYIPFYYIDYLQGD
PLHAGALVSVFLMGGVFGTLGGSPLADRWGHQRYLTLSMLLASIVLPLIFVARGIFLFAVLGLLGMILISTFTVTVVMAQ
RLLPRNLGIASGLMVGFAIGAGGFCVTLLGVIADSFGVPFALKSIAILPFIGFLLSLSLKYQRTPDRI
>Mature_388_residues
MRRFNFKILLLLSLGHLVTDIYQGALPVILPFLKESLSLSYTLTGVILMTANFTSSLIQPLLGFLSDKQDKPLLLPLGCF
CSGLGLSLLAIPSSYIVVLGLVVISGLGVASYHPEGYKTAYYFTGEKRATGMAIFSVGGNLGFALGPLIAIFVVKYFGLS
SLPLIMLPSLLFPVILFFYWDKITSGRVDKKPAQETPHKIAGTTYLSLLILVGIVMMRSWIQMGLMSYIPFYYIDYLQGD
PLHAGALVSVFLMGGVFGTLGGSPLADRWGHQRYLTLSMLLASIVLPLIFVARGIFLFAVLGLLGMILISTFTVTVVMAQ
RLLPRNLGIASGLMVGFAIGAGGFCVTLLGVIADSFGVPFALKSIAILPFIGFLLSLSLKYQRTPDRI

Specific function: Confers The Resistance Against Fosmidomycin. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily [H]

Homologues:

Organism=Escherichia coli, GI1786686, Length=393, Percent_Identity=32.5699745547074, Blast_Score=140, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 41986; Mature: 41986

Theoretical pI: Translated: 9.86; Mature: 9.86

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRFNFKILLLLSLGHLVTDIYQGALPVILPFLKESLSLSYTLTGVILMTANFTSSLIQP
CCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
LLGFLSDKQDKPLLLPLGCFCSGLGLSLLAIPSSYIVVLGLVVISGLGVASYHPEGYKTA
HHHHHCCCCCCCEEEEHHHHHHHHCHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCEEE
YYFTGEKRATGMAIFSVGGNLGFALGPLIAIFVVKYFGLSSLPLIMLPSLLFPVILFFYW
EEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
DKITSGRVDKKPAQETPHKIAGTTYLSLLILVGIVMMRSWIQMGLMSYIPFYYIDYLQGD
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PLHAGALVSVFLMGGVFGTLGGSPLADRWGHQRYLTLSMLLASIVLPLIFVARGIFLFAV
CCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLLGMILISTFTVTVVMAQRLLPRNLGIASGLMVGFAIGAGGFCVTLLGVIADSFGVPF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCH
ALKSIAILPFIGFLLSLSLKYQRTPDRI
HHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRRFNFKILLLLSLGHLVTDIYQGALPVILPFLKESLSLSYTLTGVILMTANFTSSLIQP
CCCCCHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHH
LLGFLSDKQDKPLLLPLGCFCSGLGLSLLAIPSSYIVVLGLVVISGLGVASYHPEGYKTA
HHHHHCCCCCCCEEEEHHHHHHHHCHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCEEE
YYFTGEKRATGMAIFSVGGNLGFALGPLIAIFVVKYFGLSSLPLIMLPSLLFPVILFFYW
EEEECCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
DKITSGRVDKKPAQETPHKIAGTTYLSLLILVGIVMMRSWIQMGLMSYIPFYYIDYLQGD
HHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PLHAGALVSVFLMGGVFGTLGGSPLADRWGHQRYLTLSMLLASIVLPLIFVARGIFLFAV
CCCHHHHHHHHHHHHHHHHCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGLLGMILISTFTVTVVMAQRLLPRNLGIASGLMVGFAIGAGGFCVTLLGVIADSFGVPF
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCH
ALKSIAILPFIGFLLSLSLKYQRTPDRI
HHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: fosmidomycin [Cytoplasm]; Proton [Periplasm] [C]

Specific reaction: fosmidomycin [Cytoplasm] + Proton [Periplasm] = fosmidomycin [Periplasm] + Proton [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9141694; 9384377 [H]