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The map label for this gene is pyrH

Identifier: 85859432

GI number: 85859432

Start: 1637580

End: 1638311

Strand: Direct

Name: pyrH

Synonym: SYN_00920

Alternate gene names: 85859432

Gene position: 1637580-1638311 (Clockwise)

Preceding gene: 85859431

Following gene: 85859433

Centisome position: 51.51

GC content: 50.27

Gene sequence:

>732_bases
GTGGTCAATTTCTTGGAAAAGCCGGTTTATAAAAGGGTCCTGCTGAAGCTCAGCGGGGAAGCCCTGATGGGCGGTCACCG
AAGCAGCAGTATTGATCCGGAAATGGTCAATGCAATTGCTGCTGAAATAAAGGAGGTCGTCAATCTGGGCGTTTCTCTGG
GGGTTGTGGTCGGTGGCGGAAATATTTTTCGTGGTGTCGAAGCCAATGCGAAAGGTATGGACAGAACTTCTGCGGATTAC
ATGGGCATGCTTGCCACGGTGATCAACAGTCTGGCCCTGCAGAGCGCTTTTGAAAGAATTGGAATCGACACGCGGGTGCA
GTCCGCCATCGCTATGCGGGAAATTGCCGAGCCCTTTATCCAGCGGAAAGCGATGAGCCACCTGGAAAAGAGACGGGTGA
TGATTTTTGCGGCTGGAACTGGAAATCCCTACTTTACCACCGATACGGCCGCTGTTTTACGGGCGATGGAAATCAAGGCG
GATGTGATCATGAAAGCGACCAAGGTGGACGGGGTTTATGACAAGGACCCGGTTGCTTATTCCGATGCCGTAATGTACAA
AAATATCACCTATAGTGATGTGTTGGCTCAGAACCTGAAAGTAATGGACGCAACCGCGATATCTCTCTGCCGGGATAACC
ATCTGCCCATCCTGGTGTTCAATCTTCAGAAACCCGGCAATATTGTCAGATGTATTTCCGGAATACCCATAGGAACCCTT
GTTGGAGATTAA

Upstream 100 bases:

>100_bases
TCATTATTCGACGTTTCGCCCGTTATCAGCTCGGAGAGGAACTCAAAAAATAATTTTTTGCAGGAAATTCCTGATATTTA
AAGGAATACGTTAAAGGCAA

Downstream 100 bases:

>100_bases
CAAATGAAGGACATGGTCTTTGACGAACTGAAGCAGAATATGGAAAAAGGATTGCAGGCTCTGGAAAAATCCTTTAACAA
AGTGCGTACGGGAAGAGCTT

Product: uridylate kinase

Products: NA

Alternate protein names: UK; Uridine monophosphate kinase; UMP kinase; UMPK

Number of amino acids: Translated: 243; Mature: 243

Protein sequence:

>243_residues
MVNFLEKPVYKRVLLKLSGEALMGGHRSSSIDPEMVNAIAAEIKEVVNLGVSLGVVVGGGNIFRGVEANAKGMDRTSADY
MGMLATVINSLALQSAFERIGIDTRVQSAIAMREIAEPFIQRKAMSHLEKRRVMIFAAGTGNPYFTTDTAAVLRAMEIKA
DVIMKATKVDGVYDKDPVAYSDAVMYKNITYSDVLAQNLKVMDATAISLCRDNHLPILVFNLQKPGNIVRCISGIPIGTL
VGD

Sequences:

>Translated_243_residues
MVNFLEKPVYKRVLLKLSGEALMGGHRSSSIDPEMVNAIAAEIKEVVNLGVSLGVVVGGGNIFRGVEANAKGMDRTSADY
MGMLATVINSLALQSAFERIGIDTRVQSAIAMREIAEPFIQRKAMSHLEKRRVMIFAAGTGNPYFTTDTAAVLRAMEIKA
DVIMKATKVDGVYDKDPVAYSDAVMYKNITYSDVLAQNLKVMDATAISLCRDNHLPILVFNLQKPGNIVRCISGIPIGTL
VGD
>Mature_243_residues
MVNFLEKPVYKRVLLKLSGEALMGGHRSSSIDPEMVNAIAAEIKEVVNLGVSLGVVVGGGNIFRGVEANAKGMDRTSADY
MGMLATVINSLALQSAFERIGIDTRVQSAIAMREIAEPFIQRKAMSHLEKRRVMIFAAGTGNPYFTTDTAAVLRAMEIKA
DVIMKATKVDGVYDKDPVAYSDAVMYKNITYSDVLAQNLKVMDATAISLCRDNHLPILVFNLQKPGNIVRCISGIPIGTL
VGD

Specific function: Catalyzes the reversible phosphorylation of UMP to UDP

COG id: COG0528

COG function: function code F; Uridylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UMP kinase family

Homologues:

Organism=Escherichia coli, GI1786367, Length=235, Percent_Identity=51.9148936170213, Blast_Score=246, Evalue=1e-66,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PYRH_SYNAS (Q2LTQ5)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_461634.1
- ProteinModelPortal:   Q2LTQ5
- SMR:   Q2LTQ5
- STRING:   Q2LTQ5
- GeneID:   3883140
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_00920
- NMPDR:   fig|56780.10.peg.1576
- eggNOG:   COG0528
- HOGENOM:   HBG497552
- OMA:   RHMEKGR
- PhylomeDB:   Q2LTQ5
- BioCyc:   SACI56780:SYN_00920-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01220_B
- InterPro:   IPR001048
- InterPro:   IPR011817
- InterPro:   IPR015963
- Gene3D:   G3DSA:3.40.1160.10
- PIRSF:   PIRSF005650
- TIGRFAMs:   TIGR02075

Pfam domain/function: PF00696 AA_kinase; SSF53633 Aa_kinase

EC number: =2.7.4.22

Molecular weight: Translated: 26312; Mature: 26312

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: NA

Important sites: BINDING 59-59 BINDING 60-60 BINDING 64-64 BINDING 79-79 BINDING 167-167 BINDING 173-173 BINDING 176-176

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
5.3 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
5.3 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVNFLEKPVYKRVLLKLSGEALMGGHRSSSIDPEMVNAIAAEIKEVVNLGVSLGVVVGGG
CCCHHHHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECC
NIFRGVEANAKGMDRTSADYMGMLATVINSLALQSAFERIGIDTRVQSAIAMREIAEPFI
CEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QRKAMSHLEKRRVMIFAAGTGNPYFTTDTAAVLRAMEIKADVIMKATKVDGVYDKDPVAY
HHHHHHHHHHCEEEEEEECCCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SDAVMYKNITYSDVLAQNLKVMDATAISLCRDNHLPILVFNLQKPGNIVRCISGIPIGTL
CCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEHHCCCCCHHC
VGD
CCC
>Mature Secondary Structure
MVNFLEKPVYKRVLLKLSGEALMGGHRSSSIDPEMVNAIAAEIKEVVNLGVSLGVVVGGG
CCCHHHHHHHHHHHHHHCCCHHCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEEEEEEECC
NIFRGVEANAKGMDRTSADYMGMLATVINSLALQSAFERIGIDTRVQSAIAMREIAEPFI
CEEECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHH
QRKAMSHLEKRRVMIFAAGTGNPYFTTDTAAVLRAMEIKADVIMKATKVDGVYDKDPVAY
HHHHHHHHHHCEEEEEEECCCCCCEECHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
SDAVMYKNITYSDVLAQNLKVMDATAISLCRDNHLPILVFNLQKPGNIVRCISGIPIGTL
CCHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCEEEHHCCCCCHHC
VGD
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA