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The map label for this gene is appB [H]

Identifier: 85859105

GI number: 85859105

Start: 1282477

End: 1283451

Strand: Direct

Name: appB [H]

Synonym: SYN_01341

Alternate gene names: 85859105

Gene position: 1282477-1283451 (Clockwise)

Preceding gene: 85859104

Following gene: 85859106

Centisome position: 40.34

GC content: 59.49

Gene sequence:

>975_bases
ATGCTGCGCTACATCCTGAAACGCCTGCTCTTCATGATTCCCCTGCTCATCGGGATCTCGATCATCTGTTTTGCCGTGAT
GCATCTGGCCCCCGGCCTGCCCACCGATCTGGAAACCCAGATGAATCCCCGGGCCTCCGCCGAGGCGCGGGAGCGGCTGA
AAGCCCTTTATGACCTGGACAAGCCCCTCTATGAGCAATACCTGATCTGGGCAAAGAAGCTCCTTGTCTTTGACCTCGGT
ACGTCTTTCTCCGCCGATCACCGCCCCGTGGCGGACAAAATTCTGGAGCGCCTGCCGATCACGATCACTCTGAACGTCCT
GTCCCTGCTTCTGATTCTCGCTGTCGCCATCCCCCTCGGGGTGCTTTCCGCCGTTCATCAGGACTCCCTTTTCGACAGGA
TTGCCGGCGTCATGGTCTTCATCGGCTTTGCCACGCCCACCTTCTGGCTGGCCCTCCTGCTGATGATCTTCTTCGGCCTT
CATCTCGGCTGGCTTCCCATTTCGGGCATCCGTTCCCTGAACTATGAATACCTGCCGCCGGCCGCGGCCTTCGTCGATCT
GGTGAAGCACCTGATTCTTCCCGTATTTCTGTCCGCTTTCGGCGGCCTTGCCGGGCTTTCCCGTTACATGCGGGCCAACA
TGCTGGAGGTGATCCGCCAGGATTACATCATGACGGCGCGGGCGAAGGGATTGAGCGAGCGGACCGTCATTTACAAACAT
GCCCTGCGTAATGCCCTGCTGCCGGTCATTACGATCCTGGGGCTTTCCGTTCCCGGGCTGATCGGCGGCAGTGTGATCTT
CGAGACGATTTTTGCGATTCCGGGCATGGGCCAGCTTTTCTACATGTCAGTCATGGCTCGGGACTACCCCACGGTGATGG
GGATTCTCTTCATCGGGGCCGTGCTGACGCTGATCGGCAACCTGCTGGCCGACGTTTCCTACGCGCTGGCCGATCCCAGG
ATCCGGGTGTCCTGA

Upstream 100 bases:

>100_bases
CTGGAGGCCCATTCAGCGGATCATCTGAGCAGAACGCTGGAAACGCTCCGCAAAAACAGGCTTTTCGGGCTGATCTGAAT
TCCGGGAGAATAGGGAAACC

Downstream 100 bases:

>100_bases
AAGGACTGGAATAGTTATGGATAAGGATTTTCGGCGTCGATTTATAAAAAACCGCCTTGCTCTGGCGGGGAGCGTCCTGG
TGCTGATCCTCTTTGTCGTT

Product: peptide ABC transporter permease

Products: ADP; phosphate; dipeptides [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MLRYILKRLLFMIPLLIGISIICFAVMHLAPGLPTDLETQMNPRASAEARERLKALYDLDKPLYEQYLIWAKKLLVFDLG
TSFSADHRPVADKILERLPITITLNVLSLLLILAVAIPLGVLSAVHQDSLFDRIAGVMVFIGFATPTFWLALLLMIFFGL
HLGWLPISGIRSLNYEYLPPAAAFVDLVKHLILPVFLSAFGGLAGLSRYMRANMLEVIRQDYIMTARAKGLSERTVIYKH
ALRNALLPVITILGLSVPGLIGGSVIFETIFAIPGMGQLFYMSVMARDYPTVMGILFIGAVLTLIGNLLADVSYALADPR
IRVS

Sequences:

>Translated_324_residues
MLRYILKRLLFMIPLLIGISIICFAVMHLAPGLPTDLETQMNPRASAEARERLKALYDLDKPLYEQYLIWAKKLLVFDLG
TSFSADHRPVADKILERLPITITLNVLSLLLILAVAIPLGVLSAVHQDSLFDRIAGVMVFIGFATPTFWLALLLMIFFGL
HLGWLPISGIRSLNYEYLPPAAAFVDLVKHLILPVFLSAFGGLAGLSRYMRANMLEVIRQDYIMTARAKGLSERTVIYKH
ALRNALLPVITILGLSVPGLIGGSVIFETIFAIPGMGQLFYMSVMARDYPTVMGILFIGAVLTLIGNLLADVSYALADPR
IRVS
>Mature_324_residues
MLRYILKRLLFMIPLLIGISIICFAVMHLAPGLPTDLETQMNPRASAEARERLKALYDLDKPLYEQYLIWAKKLLVFDLG
TSFSADHRPVADKILERLPITITLNVLSLLLILAVAIPLGVLSAVHQDSLFDRIAGVMVFIGFATPTFWLALLLMIFFGL
HLGWLPISGIRSLNYEYLPPAAAFVDLVKHLILPVFLSAFGGLAGLSRYMRANMLEVIRQDYIMTARAKGLSERTVIYKH
ALRNALLPVITILGLSVPGLIGGSVIFETIFAIPGMGQLFYMSVMARDYPTVMGILFIGAVLTLIGNLLADVSYALADPR
IRVS

Specific function: This protein is a component of an oligopeptide permease, a binding protein-dependent transport system. This APP system can completely substitute for the OPP system in both sporulation and genetic competence, though, unlike OPP, is incapable of transportin

COG id: COG0601

COG function: function code EP; ABC-type dipeptide/oligopeptide/nickel transport systems, permease components

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-1 domain [H]

Homologues:

Organism=Escherichia coli, GI1789965, Length=341, Percent_Identity=37.2434017595308, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI1789888, Length=323, Percent_Identity=38.390092879257, Blast_Score=208, Evalue=3e-55,
Organism=Escherichia coli, GI1787053, Length=322, Percent_Identity=35.7142857142857, Blast_Score=197, Evalue=5e-52,
Organism=Escherichia coli, GI1788504, Length=364, Percent_Identity=32.967032967033, Blast_Score=193, Evalue=1e-50,
Organism=Escherichia coli, GI1787497, Length=322, Percent_Identity=34.472049689441, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1787761, Length=331, Percent_Identity=36.8580060422961, Blast_Score=168, Evalue=4e-43,
Organism=Escherichia coli, GI1787550, Length=273, Percent_Identity=32.2344322344322, Blast_Score=153, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000515 [H]

Pfam domain/function: PF00528 BPD_transp_1 [H]

EC number: NA

Molecular weight: Translated: 35871; Mature: 35871

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS50928 ABC_TM1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRYILKRLLFMIPLLIGISIICFAVMHLAPGLPTDLETQMNPRASAEARERLKALYDLD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCHHHHHHHHHHHHCC
KPLYEQYLIWAKKLLVFDLGTSFSADHRPVADKILERLPITITLNVLSLLLILAVAIPLG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHH
VLSAVHQDSLFDRIAGVMVFIGFATPTFWLALLLMIFFGLHLGWLPISGIRSLNYEYLPP
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCH
AAAFVDLVKHLILPVFLSAFGGLAGLSRYMRANMLEVIRQDYIMTARAKGLSERTVIYKH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ALRNALLPVITILGLSVPGLIGGSVIFETIFAIPGMGQLFYMSVMARDYPTVMGILFIGA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLTLIGNLLADVSYALADPRIRVS
HHHHHHHHHHHHHHHHCCCCEECC
>Mature Secondary Structure
MLRYILKRLLFMIPLLIGISIICFAVMHLAPGLPTDLETQMNPRASAEARERLKALYDLD
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHCCCCCCCHHHHHHHHHHHHCC
KPLYEQYLIWAKKLLVFDLGTSFSADHRPVADKILERLPITITLNVLSLLLILAVAIPLG
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHH
VLSAVHQDSLFDRIAGVMVFIGFATPTFWLALLLMIFFGLHLGWLPISGIRSLNYEYLPP
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCH
AAAFVDLVKHLILPVFLSAFGGLAGLSRYMRANMLEVIRQDYIMTARAKGLSERTVIYKH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHH
ALRNALLPVITILGLSVPGLIGGSVIFETIFAIPGMGQLFYMSVMARDYPTVMGILFIGA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VLTLIGNLLADVSYALADPRIRVS
HHHHHHHHHHHHHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; dipeptides [Periplasm]; H2O [C]

Specific reaction: ATP + dipeptides [Periplasm] + H2O = ADP + phosphate + dipeptides [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7997159; 9384377 [H]