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The map label for this gene is gmk

Identifier: 85858121

GI number: 85858121

Start: 289660

End: 290283

Strand: Direct

Name: gmk

Synonym: SYN_01279

Alternate gene names: 85858121

Gene position: 289660-290283 (Clockwise)

Preceding gene: 85858120

Following gene: 85858122

Centisome position: 9.11

GC content: 51.92

Gene sequence:

>624_bases
TTGAATAAAGCGGGTCAGGAAGCAAGAGGGTTTTTCATCGTTCTTTCCGCGGCATCGGGCACGGGAAAGACGTCGATACG
CCGGATTTTTCTTGAACGGTGTCCCGAGGTGCAATTTTCCGTTTCCTACACGACCAGAACGGCCCGGCCGGGAGAGGTGG
ACGGTCAGGATTACTTTTTCGTTACGGAGACGGATTTTCGGGAGCGGATTGATCAGGGTGAATTCGCCGAATGGGAAGAG
AACTACGGTCGTTACTACGGGACGTCGGGAAAAGTGATGACCCGGGTTCTGGAGCAGGGACGCGACATGATCCTGGATAT
CGAACCGAGAGGGGCAAAGACATTGAAAAAGAACTACCAGGGTGGTATCTATGTCTTTGTTTTGCCTCCCTCTTTGGCAG
AGCTGAAGGCGCGGCTGCGGAAAAGGGGGGAATCGGAAGCCGAAATCAGGAAACGCCTCGATAAGGTCCGGGAGGAGATT
GCGGAAGCCCGTGGTTACGATTATGTCATTTTCAATGATTCGCTGGAAAAGGCGGTCGAACGTCTCCAGGTGATTTATCA
GGCCGAAAAAAGTCGAGCTTCGAGAATGAGTAAACAGATTCAGGGTGTTCTGGATTCTGAGTAA

Upstream 100 bases:

>100_bases
ATCAATACAATCGGATCCAAGAGCAGTGATGCCCTGATTTCCCGGCAGGTTATCGAAATCAAGAGTGAACTGGCGAAACT
GAGAGAGCAGGTGCAGAATA

Downstream 100 bases:

>100_bases
ATATAAACATAAGCAGGAAATATTTTTCAGGGAGGCCTGTTCAACATGGCAAGAATTACTGTTGAAGATGCTTTAAAGGT
TGCAGGGAATCGTTTCGCAC

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 207; Mature: 207

Protein sequence:

>207_residues
MNKAGQEARGFFIVLSAASGTGKTSIRRIFLERCPEVQFSVSYTTRTARPGEVDGQDYFFVTETDFRERIDQGEFAEWEE
NYGRYYGTSGKVMTRVLEQGRDMILDIEPRGAKTLKKNYQGGIYVFVLPPSLAELKARLRKRGESEAEIRKRLDKVREEI
AEARGYDYVIFNDSLEKAVERLQVIYQAEKSRASRMSKQIQGVLDSE

Sequences:

>Translated_207_residues
MNKAGQEARGFFIVLSAASGTGKTSIRRIFLERCPEVQFSVSYTTRTARPGEVDGQDYFFVTETDFRERIDQGEFAEWEE
NYGRYYGTSGKVMTRVLEQGRDMILDIEPRGAKTLKKNYQGGIYVFVLPPSLAELKARLRKRGESEAEIRKRLDKVREEI
AEARGYDYVIFNDSLEKAVERLQVIYQAEKSRASRMSKQIQGVLDSE
>Mature_207_residues
MNKAGQEARGFFIVLSAASGTGKTSIRRIFLERCPEVQFSVSYTTRTARPGEVDGQDYFFVTETDFRERIDQGEFAEWEE
NYGRYYGTSGKVMTRVLEQGRDMILDIEPRGAKTLKKNYQGGIYVFVLPPSLAELKARLRKRGESEAEIRKRLDKVREEI
AEARGYDYVIFNDSLEKAVERLQVIYQAEKSRASRMSKQIQGVLDSE

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874831, Length=188, Percent_Identity=37.7659574468085, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI226874833, Length=188, Percent_Identity=37.7659574468085, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI4504221, Length=188, Percent_Identity=37.7659574468085, Blast_Score=116, Evalue=2e-26,
Organism=Homo sapiens, GI21361598, Length=182, Percent_Identity=31.3186813186813, Blast_Score=85, Evalue=4e-17,
Organism=Homo sapiens, GI262118259, Length=172, Percent_Identity=27.3255813953488, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI262118255, Length=172, Percent_Identity=27.3255813953488, Blast_Score=78, Evalue=5e-15,
Organism=Homo sapiens, GI4505237, Length=172, Percent_Identity=27.3255813953488, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI262118263, Length=172, Percent_Identity=27.3255813953488, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI38570142, Length=174, Percent_Identity=31.6091954022989, Blast_Score=77, Evalue=8e-15,
Organism=Homo sapiens, GI186700629, Length=174, Percent_Identity=25.8620689655172, Blast_Score=74, Evalue=9e-14,
Organism=Homo sapiens, GI186700627, Length=174, Percent_Identity=25.8620689655172, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI186972120, Length=174, Percent_Identity=25.8620689655172, Blast_Score=74, Evalue=1e-13,
Organism=Homo sapiens, GI14780902, Length=185, Percent_Identity=26.4864864864865, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI111154074, Length=178, Percent_Identity=26.4044943820225, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1790080, Length=191, Percent_Identity=42.4083769633508, Blast_Score=149, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI193203132, Length=172, Percent_Identity=37.7906976744186, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17508835, Length=172, Percent_Identity=37.7906976744186, Blast_Score=108, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71988048, Length=174, Percent_Identity=26.4367816091954, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71988041, Length=174, Percent_Identity=26.4367816091954, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17557440, Length=187, Percent_Identity=27.2727272727273, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI71982296, Length=105, Percent_Identity=36.1904761904762, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=183, Percent_Identity=42.0765027322404, Blast_Score=133, Evalue=2e-32,
Organism=Drosophila melanogaster, GI21356141, Length=174, Percent_Identity=36.7816091954023, Blast_Score=103, Evalue=6e-23,
Organism=Drosophila melanogaster, GI161077626, Length=175, Percent_Identity=30.8571428571429, Blast_Score=79, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24640542, Length=175, Percent_Identity=30.8571428571429, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI45554489, Length=175, Percent_Identity=30.8571428571429, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI221330166, Length=175, Percent_Identity=33.1428571428571, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221330162, Length=175, Percent_Identity=33.1428571428571, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI221330164, Length=175, Percent_Identity=33.1428571428571, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI116007136, Length=175, Percent_Identity=30.8571428571429, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI85724806, Length=175, Percent_Identity=30.8571428571429, Blast_Score=78, Evalue=4e-15,
Organism=Drosophila melanogaster, GI45554481, Length=175, Percent_Identity=30.8571428571429, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI161078485, Length=185, Percent_Identity=27.027027027027, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24648810, Length=185, Percent_Identity=27.027027027027, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI161078487, Length=185, Percent_Identity=27.027027027027, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281362232, Length=185, Percent_Identity=27.027027027027, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI281362230, Length=185, Percent_Identity=27.027027027027, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24648808, Length=185, Percent_Identity=27.027027027027, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_SYNAS (Q2LQ62)

Other databases:

- EMBL:   CP000252
- RefSeq:   YP_460323.1
- ProteinModelPortal:   Q2LQ62
- SMR:   Q2LQ62
- STRING:   Q2LQ62
- GeneID:   3884668
- GenomeReviews:   CP000252_GR
- KEGG:   sat:SYN_01279
- NMPDR:   fig|56780.10.peg.277
- eggNOG:   COG0194
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- BioCyc:   SACI56780:SYN_01279-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23778; Mature: 23778

Theoretical pI: Translated: 8.84; Mature: 8.84

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKAGQEARGFFIVLSAASGTGKTSIRRIFLERCPEVQFSVSYTTRTARPGEVDGQDYFF
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEEE
VTETDFRERIDQGEFAEWEENYGRYYGTSGKVMTRVLEQGRDMILDIEPRGAKTLKKNYQ
EECCHHHHHCCCCCCHHHHHHCCCEECCCHHHHHHHHHCCCCEEEEECCCCHHHHHHCCC
GGIYVFVLPPSLAELKARLRKRGESEAEIRKRLDKVREEIAEARGYDYVIFNDSLEKAVE
CCEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHH
RLQVIYQAEKSRASRMSKQIQGVLDSE
HHHHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNKAGQEARGFFIVLSAASGTGKTSIRRIFLERCPEVQFSVSYTTRTARPGEVDGQDYFF
CCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCCCEEEE
VTETDFRERIDQGEFAEWEENYGRYYGTSGKVMTRVLEQGRDMILDIEPRGAKTLKKNYQ
EECCHHHHHCCCCCCHHHHHHCCCEECCCHHHHHHHHHCCCCEEEEECCCCHHHHHHCCC
GGIYVFVLPPSLAELKARLRKRGESEAEIRKRLDKVREEIAEARGYDYVIFNDSLEKAVE
CCEEEEEECCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHH
RLQVIYQAEKSRASRMSKQIQGVLDSE
HHHHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA