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The map label for this gene is mlaA [H]

Identifier: 85858107

GI number: 85858107

Start: 278217

End: 279266

Strand: Direct

Name: mlaA [H]

Synonym: SYN_01266

Alternate gene names: 85858107

Gene position: 278217-279266 (Clockwise)

Preceding gene: 85858106

Following gene: 85858108

Centisome position: 8.75

GC content: 54.57

Gene sequence:

>1050_bases
ATGAAAAAGCTCCGCTTATCCGTTTTTTTTCTTCTTGTCCTTAGCATTGTTGCGGGTTCCGCCGATCGATCGGATGCTTC
GATTTTCCCGGCGGGAACTGTGGCGCCCTTACAGCAGGGGATTGCAGGAGAATCCATTCATGAAGCCCCTGTTGTTCGGG
GATTGCCGGAAATGTCTGCAACGCCCGGGCCGATGCATGTCCAAGGCATGCAGATTTGCGCTGCCGCAGCCGTAAGGACT
GAAGAGAAGGCAGAAGGAGACGAAGAAGCCGGGAACGTTTCCGACCCGATGGAATCCCTTAATGCGCCGGAGGCGGAAGG
TGCAGAGGAAACAGATGTTTCCGATGACCTGGAATCGGACTATCTGCCGGAAGAAGGTGAGGAGCAGCCGACAGTAACGA
TCTCCGATCCCCTGGAGCCCTTCAACCGGGCCATGTATCATTTCAACGACAAGCTTTATTTCTGGCTGCTCAAGCCCGTG
GGCCAGGCCTATGGCAAGGTTGTACCCGAGCCGGCGCGGATCAGTGTCCGGAATTTCTTTTCCAATCTGGCCTTTCCGTT
CCGATTTCTAAGCTGCCTGCTGCAGGCGGATTTCCGCGGCGTTGCCACGGAAACAGGCCGTTTCACCGTCAACACAATCT
GGGGTATCGGAGGTTTTCTGGATGCGTCATCGAGCAGGGAGTTGAATATCCCGAAACAGGATGTGGATCTGGGGCAGACC
CTCGGTGTTTACGGTGTGGGGCATGGGTTTTATTTCGTCTGGCCGGTATTCGGTCCTTCCAGTCTGCGGGATTCCGCAGA
CATCGTGGGTGGATTTTTCCTCGATCCCGTTAATTATCTGAATCCCTGGTACACGCCGGCGGCCGTTCATGGATATGAAG
CGGTAAACGAGACCTCCCTGACTATAGGGGATTATGAGGCGCTCAAGGGAGCGGCCATCGATCCTTATGTCTCCATCCGG
GATGCCTTTGTCCAGTACCGGAAGAAGAAGATTGACGCCCGGAAGGTCAAGATGGAACATTCTGGATCGGTGGAAACGCA
GAAAAAATGA

Upstream 100 bases:

>100_bases
TCCTGAACGGTCAGAAGCCCGAACAACTGCTTCAGACCCTCAGGAAAAAGGTGAAGGAACAGCAGTAAAATCCAGGCAAA
ACGAAAGAGGGGTTCTGTCC

Downstream 100 bases:

>100_bases
CCGGACGGTAAGGGTCGAGCAAGGGCATCCTTGCTGCAAAGCCTCAAGGAGACTGTGTCGCAGGCAGAACAAAAGGAAAT
CGGGGGGACGGAATGATTGA

Product: surface lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MKKLRLSVFFLLVLSIVAGSADRSDASIFPAGTVAPLQQGIAGESIHEAPVVRGLPEMSATPGPMHVQGMQICAAAAVRT
EEKAEGDEEAGNVSDPMESLNAPEAEGAEETDVSDDLESDYLPEEGEEQPTVTISDPLEPFNRAMYHFNDKLYFWLLKPV
GQAYGKVVPEPARISVRNFFSNLAFPFRFLSCLLQADFRGVATETGRFTVNTIWGIGGFLDASSSRELNIPKQDVDLGQT
LGVYGVGHGFYFVWPVFGPSSLRDSADIVGGFFLDPVNYLNPWYTPAAVHGYEAVNETSLTIGDYEALKGAAIDPYVSIR
DAFVQYRKKKIDARKVKMEHSGSVETQKK

Sequences:

>Translated_349_residues
MKKLRLSVFFLLVLSIVAGSADRSDASIFPAGTVAPLQQGIAGESIHEAPVVRGLPEMSATPGPMHVQGMQICAAAAVRT
EEKAEGDEEAGNVSDPMESLNAPEAEGAEETDVSDDLESDYLPEEGEEQPTVTISDPLEPFNRAMYHFNDKLYFWLLKPV
GQAYGKVVPEPARISVRNFFSNLAFPFRFLSCLLQADFRGVATETGRFTVNTIWGIGGFLDASSSRELNIPKQDVDLGQT
LGVYGVGHGFYFVWPVFGPSSLRDSADIVGGFFLDPVNYLNPWYTPAAVHGYEAVNETSLTIGDYEALKGAAIDPYVSIR
DAFVQYRKKKIDARKVKMEHSGSVETQKK
>Mature_349_residues
MKKLRLSVFFLLVLSIVAGSADRSDASIFPAGTVAPLQQGIAGESIHEAPVVRGLPEMSATPGPMHVQGMQICAAAAVRT
EEKAEGDEEAGNVSDPMESLNAPEAEGAEETDVSDDLESDYLPEEGEEQPTVTISDPLEPFNRAMYHFNDKLYFWLLKPV
GQAYGKVVPEPARISVRNFFSNLAFPFRFLSCLLQADFRGVATETGRFTVNTIWGIGGFLDASSSRELNIPKQDVDLGQT
LGVYGVGHGFYFVWPVFGPSSLRDSADIVGGFFLDPVNYLNPWYTPAAVHGYEAVNETSLTIGDYEALKGAAIDPYVSIR
DAFVQYRKKKIDARKVKMEHSGSVETQKK

Specific function: Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane [H]

COG id: COG2853

COG function: function code M; Surface lipoprotein

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mlaA family [H]

Homologues:

Organism=Escherichia coli, GI1788688, Length=195, Percent_Identity=37.4358974358974, Blast_Score=108, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007428 [H]

Pfam domain/function: PF04333 VacJ [H]

EC number: NA

Molecular weight: Translated: 38156; Mature: 38156

Theoretical pI: Translated: 4.50; Mature: 4.50

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKLRLSVFFLLVLSIVAGSADRSDASIFPAGTVAPLQQGIAGESIHEAPVVRGLPEMSA
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHCCCCCCCC
TPGPMHVQGMQICAAAAVRTEEKAEGDEEAGNVSDPMESLNAPEAEGAEETDVSDDLESD
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHC
YLPEEGEEQPTVTISDPLEPFNRAMYHFNDKLYFWLLKPVGQAYGKVVPEPARISVRNFF
CCCCCCCCCCEEEECCCCCHHHHHHHHCCCEEEEEEEHHHHHHHHCCCCCCHHHHHHHHH
SNLAFPFRFLSCLLQADFRGVATETGRFTVNTIWGIGGFLDASSSRELNIPKQDVDLGQT
HHHCHHHHHHHHHHHHHHCCCEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHCCCHH
LGVYGVGHGFYFVWPVFGPSSLRDSADIVGGFFLDPVNYLNPWYTPAAVHGYEAVNETSL
CCCEEECCCEEEEEECCCCHHCCCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHCCCEE
TIGDYEALKGAAIDPYVSIRDAFVQYRKKKIDARKVKMEHSGSVETQKK
EECCHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHEEECCCCCCCCCCC
>Mature Secondary Structure
MKKLRLSVFFLLVLSIVAGSADRSDASIFPAGTVAPLQQGIAGESIHEAPVVRGLPEMSA
CCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHCCCCCCHHHHHHHCCCCCCCC
TPGPMHVQGMQICAAAAVRTEEKAEGDEEAGNVSDPMESLNAPEAEGAEETDVSDDLESD
CCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCCHHHC
YLPEEGEEQPTVTISDPLEPFNRAMYHFNDKLYFWLLKPVGQAYGKVVPEPARISVRNFF
CCCCCCCCCCEEEECCCCCHHHHHHHHCCCEEEEEEEHHHHHHHHCCCCCCHHHHHHHHH
SNLAFPFRFLSCLLQADFRGVATETGRFTVNTIWGIGGFLDASSSRELNIPKQDVDLGQT
HHHCHHHHHHHHHHHHHHCCCEECCCCEEEEEECCCCCCCCCCCCCCCCCCHHHHCCCHH
LGVYGVGHGFYFVWPVFGPSSLRDSADIVGGFFLDPVNYLNPWYTPAAVHGYEAVNETSL
CCCEEECCCEEEEEECCCCHHCCCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHCCCEE
TIGDYEALKGAAIDPYVSIRDAFVQYRKKKIDARKVKMEHSGSVETQKK
EECCHHHHCCCCCCCHHHHHHHHHHHHHHHCCHHHEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]