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The map label for this gene is 85857919

Identifier: 85857919

GI number: 85857919

Start: 76434

End: 78059

Strand: Direct

Name: 85857919

Synonym: SYN_00166

Alternate gene names: NA

Gene position: 76434-78059 (Clockwise)

Preceding gene: 85857918

Following gene: 85857921

Centisome position: 2.4

GC content: 53.94

Gene sequence:

>1626_bases
TTGCAGAGGTTCATAATTATGAAAATCAAATTTTTAGGCGCGGCGAGAACGGTGACAGGGTCCTGTTATATTCTGGAAAC
GCAGGGGCATCGCTTTGCGATTGACTGCGGCATGCATCAGGGAAATGAGGAGATCGAGAAGCGGAACTGGAATGTGGAGC
TTTATGAGCCTGAAAAGATTGAGTTTTTTCTGATTACCCATGCCCATATCGATCATACCGGTCTTCTGCCCCGCCTTGTT
CAGAAAGGGTTTCGGGGGCCGATTTATGCGACGCAACCGACCGTGGATCTGCTGAGGATTCTCCTGCTGGATTCCGCCCA
TATCCAGGAAATGGAAGCCCAGTGGAAAAGCCGGAAGCGCCTGCGCTTCGGAGAGAAACGCGTGGGGCCGCTTTATACAC
AGCGGGATGCCGAAGCGGTTTTTCCGATGTTGAAAAGCGTTTCCTATGACAAACCCTTTGAACCCTTCCCGGGGCTTAAG
GTGAACTTCATGGATGCGGGGCATATCCTGGGCTCTTCATTTCTGGAACTCTGGCTGAAGGAAAACGGCGTTCCTGCAAA
ACTTGTTTTTTCCGGGGATATCGGTCGACCAGCCCAGTTGCTCATGGACGATCCCGGGATTATCGCCGAGGCGGACTATC
TCTTTCTCGAATCCACCTACGGCAACCGGAATCACAAGAATGAGCAGGACAGCCTGAACGAGCTGGCCGAGGCCATCGCC
TACAGCTATGAATGCAGGCAGAAGATGGTGATTCCCGCATTTGCCGTCGAACGGACGCAGGAGATGATGTACTGTCTCTA
TCTGCTGTCCAAAAAGGGACAGCTGCCTAAGGACATGCCCATTTACCTGGACAGCCCCCTGGCGATCCAGGCTACGGAAA
TCTTCCGCCGCCATGCCACCTTTCTGGATGATGAAACACAGGCACTGATCCTGAAGGGAGAAAACCCCCTGCGCCTCCCC
CAGCTCCGTTGTACGCAGACCACGGAGGAATCCATCGCCATCAACCAGACCGAGGGGCCGGCCATCATCATCTCCGCCAG
TGGAATGGCCAACGCCGGTCGGATTCGCCATCATCTCCGCCATAATCTGTGGCGTGAAGGCGCCAGCATCGTCTTTGTGG
GTTTTCAGGCCGAGGGAACCACAGGACGAAAGATTATCGACGGTGCGAAAAGAGTCCGCATCCTGAATGAAAATGTGGCC
GTCAAGGCCCGGATTTTCACAATCGGCGGTTTTTCGGCGCATGCCGGGCAGAGCCAGCTTCTCGAATGGCTCAGTCATTT
TAAAAATCATGGGCTGGAGGTTTTTCTGGTTCACGGTGAATATTCCGCTCAGCAGGTTCTGGCGGACCGCATCCGGGAAC
GGTTCGGCTACAAGGTGATTATTCCGGAATATCTGGAAGAAACGTTCCTGAAGATCGGCGAGGAAATCAAAAGAGTGGAA
TTCCCGGAAAAGGCGGCGCCGAAGATCGACTGGGCCTATCTGATCGGCGATCTGGAAGCCCGGATGGAGCAATTGCGCCA
GAGACAGCCGCAGCTGGAGTCCAAATCCTGGGTGCAGCAGACCGAATTTCGCGATCGGATTCTGGAGCTTAACCGGGATC
TGATGGAAACCATTTCGGAAATCTGA

Upstream 100 bases:

>100_bases
TGCGGGACGGCGACATCATCACCTTCCGATTCAACGTCTGATCTTTCTTTTTCCCTTACAGGCAAGACGAAGAGCAGACG
GCCTATCATCCAAATTCTTA

Downstream 100 bases:

>100_bases
TGGGGCGGTGCAGGGGAAATTACCGGACCAGACGGTATTCGAAAGTCGCAACGACATTCAGCCGGGAAAGCTGAAAAACG
TCGGGCAGAGGTGCATAGCG

Product: metallo-beta-lactamase protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 541

Protein sequence:

>541_residues
MQRFIIMKIKFLGAARTVTGSCYILETQGHRFAIDCGMHQGNEEIEKRNWNVELYEPEKIEFFLITHAHIDHTGLLPRLV
QKGFRGPIYATQPTVDLLRILLLDSAHIQEMEAQWKSRKRLRFGEKRVGPLYTQRDAEAVFPMLKSVSYDKPFEPFPGLK
VNFMDAGHILGSSFLELWLKENGVPAKLVFSGDIGRPAQLLMDDPGIIAEADYLFLESTYGNRNHKNEQDSLNELAEAIA
YSYECRQKMVIPAFAVERTQEMMYCLYLLSKKGQLPKDMPIYLDSPLAIQATEIFRRHATFLDDETQALILKGENPLRLP
QLRCTQTTEESIAINQTEGPAIIISASGMANAGRIRHHLRHNLWREGASIVFVGFQAEGTTGRKIIDGAKRVRILNENVA
VKARIFTIGGFSAHAGQSQLLEWLSHFKNHGLEVFLVHGEYSAQQVLADRIRERFGYKVIIPEYLEETFLKIGEEIKRVE
FPEKAAPKIDWAYLIGDLEARMEQLRQRQPQLESKSWVQQTEFRDRILELNRDLMETISEI

Sequences:

>Translated_541_residues
MQRFIIMKIKFLGAARTVTGSCYILETQGHRFAIDCGMHQGNEEIEKRNWNVELYEPEKIEFFLITHAHIDHTGLLPRLV
QKGFRGPIYATQPTVDLLRILLLDSAHIQEMEAQWKSRKRLRFGEKRVGPLYTQRDAEAVFPMLKSVSYDKPFEPFPGLK
VNFMDAGHILGSSFLELWLKENGVPAKLVFSGDIGRPAQLLMDDPGIIAEADYLFLESTYGNRNHKNEQDSLNELAEAIA
YSYECRQKMVIPAFAVERTQEMMYCLYLLSKKGQLPKDMPIYLDSPLAIQATEIFRRHATFLDDETQALILKGENPLRLP
QLRCTQTTEESIAINQTEGPAIIISASGMANAGRIRHHLRHNLWREGASIVFVGFQAEGTTGRKIIDGAKRVRILNENVA
VKARIFTIGGFSAHAGQSQLLEWLSHFKNHGLEVFLVHGEYSAQQVLADRIRERFGYKVIIPEYLEETFLKIGEEIKRVE
FPEKAAPKIDWAYLIGDLEARMEQLRQRQPQLESKSWVQQTEFRDRILELNRDLMETISEI
>Mature_541_residues
MQRFIIMKIKFLGAARTVTGSCYILETQGHRFAIDCGMHQGNEEIEKRNWNVELYEPEKIEFFLITHAHIDHTGLLPRLV
QKGFRGPIYATQPTVDLLRILLLDSAHIQEMEAQWKSRKRLRFGEKRVGPLYTQRDAEAVFPMLKSVSYDKPFEPFPGLK
VNFMDAGHILGSSFLELWLKENGVPAKLVFSGDIGRPAQLLMDDPGIIAEADYLFLESTYGNRNHKNEQDSLNELAEAIA
YSYECRQKMVIPAFAVERTQEMMYCLYLLSKKGQLPKDMPIYLDSPLAIQATEIFRRHATFLDDETQALILKGENPLRLP
QLRCTQTTEESIAINQTEGPAIIISASGMANAGRIRHHLRHNLWREGASIVFVGFQAEGTTGRKIIDGAKRVRILNENVA
VKARIFTIGGFSAHAGQSQLLEWLSHFKNHGLEVFLVHGEYSAQQVLADRIRERFGYKVIIPEYLEETFLKIGEEIKRVE
FPEKAAPKIDWAYLIGDLEARMEQLRQRQPQLESKSWVQQTEFRDRILELNRDLMETISEI

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=451, Percent_Identity=26.8292682926829, Blast_Score=148, Evalue=1e-35,
Organism=Homo sapiens, GI33300633, Length=484, Percent_Identity=24.3801652892562, Blast_Score=120, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI32566029, Length=452, Percent_Identity=25.2212389380531, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI32564696, Length=473, Percent_Identity=24.5243128964059, Blast_Score=123, Evalue=2e-28,
Organism=Saccharomyces cerevisiae, GI6323307, Length=467, Percent_Identity=23.5546038543897, Blast_Score=125, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24648013, Length=438, Percent_Identity=25.3424657534247, Blast_Score=139, Evalue=7e-33,
Organism=Drosophila melanogaster, GI21358523, Length=470, Percent_Identity=26.3829787234043, Blast_Score=135, Evalue=7e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 62075; Mature: 62075

Theoretical pI: Translated: 6.84; Mature: 6.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRFIIMKIKFLGAARTVTGSCYILETQGHRFAIDCGMHQGNEEIEKRNWNVELYEPEKI
CCCEEEEEEEECCCCEEECCEEEEEEECCCEEEEECCCCCCCHHHHHCCCCEEEECCCCE
EFFLITHAHIDHTGLLPRLVQKGFRGPIYATQPTVDLLRILLLDSAHIQEMEAQWKSRKR
EEEEEEECCCCCCCHHHHHHHHCCCCCCEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHH
LRFGEKRVGPLYTQRDAEAVFPMLKSVSYDKPFEPFPGLKVNFMDAGHILGSSFLELWLK
HHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHH
ENGVPAKLVFSGDIGRPAQLLMDDPGIIAEADYLFLESTYGNRNHKNEQDSLNELAEAIA
CCCCCEEEEEECCCCCCHHHEECCCCCEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHH
YSYECRQKMVIPAFAVERTQEMMYCLYLLSKKGQLPKDMPIYLDSPLAIQATEIFRRHAT
HHHHHHHCEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEEHHHHHHHHHHH
FLDDETQALILKGENPLRLPQLRCTQTTEESIAINQTEGPAIIISASGMANAGRIRHHLR
HCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECCCCCCHHHHHHHHH
HNLWREGASIVFVGFQAEGTTGRKIIDGAKRVRILNENVAVKARIFTIGGFSAHAGQSQL
HHHHHCCCCEEEEEEECCCCCCHHHHCCHHHEEEECCCEEEEEEEEEEECCCCCCCHHHH
LEWLSHFKNHGLEVFLVHGEYSAQQVLADRIRERFGYKVIIPEYLEETFLKIGEEIKRVE
HHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHCC
FPEKAAPKIDWAYLIGDLEARMEQLRQRQPQLESKSWVQQTEFRDRILELNRDLMETISE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
I
C
>Mature Secondary Structure
MQRFIIMKIKFLGAARTVTGSCYILETQGHRFAIDCGMHQGNEEIEKRNWNVELYEPEKI
CCCEEEEEEEECCCCEEECCEEEEEEECCCEEEEECCCCCCCHHHHHCCCCEEEECCCCE
EFFLITHAHIDHTGLLPRLVQKGFRGPIYATQPTVDLLRILLLDSAHIQEMEAQWKSRKR
EEEEEEECCCCCCCHHHHHHHHCCCCCCEECCCHHHHHHHHHHCCHHHHHHHHHHHHHHH
LRFGEKRVGPLYTQRDAEAVFPMLKSVSYDKPFEPFPGLKVNFMDAGHILGSSFLELWLK
HHCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHHHH
ENGVPAKLVFSGDIGRPAQLLMDDPGIIAEADYLFLESTYGNRNHKNEQDSLNELAEAIA
CCCCCEEEEEECCCCCCHHHEECCCCCEEECCEEEEEECCCCCCCCCHHHHHHHHHHHHH
YSYECRQKMVIPAFAVERTQEMMYCLYLLSKKGQLPKDMPIYLDSPLAIQATEIFRRHAT
HHHHHHHCEECHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCCCEEHHHHHHHHHHH
FLDDETQALILKGENPLRLPQLRCTQTTEESIAINQTEGPAIIISASGMANAGRIRHHLR
HCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEECCCCCEEEEECCCCCCHHHHHHHHH
HNLWREGASIVFVGFQAEGTTGRKIIDGAKRVRILNENVAVKARIFTIGGFSAHAGQSQL
HHHHHCCCCEEEEEEECCCCCCHHHHCCHHHEEEECCCEEEEEEEEEEECCCCCCCHHHH
LEWLSHFKNHGLEVFLVHGEYSAQQVLADRIRERFGYKVIIPEYLEETFLKIGEEIKRVE
HHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHCC
FPEKAAPKIDWAYLIGDLEARMEQLRQRQPQLESKSWVQQTEFRDRILELNRDLMETISE
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHC
I
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA