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The map label for this gene is virB11 [H]

Identifier: 85373476

GI number: 85373476

Start: 684727

End: 685740

Strand: Direct

Name: virB11 [H]

Synonym: ELI_03245

Alternate gene names: 85373476

Gene position: 684727-685740 (Clockwise)

Preceding gene: 85373475

Following gene: 85373477

Centisome position: 22.43

GC content: 65.88

Gene sequence:

>1014_bases
ATGAGCGCGGACGTCCATCCCTTTGCGAAACAGGCCGAAGCGGCGGAAACCCCGCTGCCGGGCGATCGCAGCGTCTATCT
CGAGGCCTATCTCAAGCCGTTCCGCGAATGGCTCGACCGCGACACGGTGACGGAAATACTCGTCAACCGCCCTGGCGAAG
TCTGGATCGAGGATGCAGCCTCGCCAGGCATGCAACGCGTCGATACGCCGCATATCGATGACCGGCTGGTCCAGCGCCTC
GCCGAACAGGTCGCGCGGGTCAGCCATCAGGGCATCAACCGCGAGCATCCCCTGCTGGGCGCGACATTGCCCGACGGGGC
GCGGGTGCAGTTCTGCGGACCGCCTGCCAGCCGCAAGCATTGGTGCATGGCGATCCGTCGCCACCGGCGCCTGGACCTGC
CGCTCGACGCTTACGACTCCGGGCCGCTCTCACCGCCGCAGGAACAGGCCATGCCCGATGCGCAGGCCGAGCCGATCGCG
TTTCTGCGCGAAGCCATCCGGCAGCGGCGCACGATCCTGATTTCGGGCGGTACGAGCACCGGCAAGACGACGTTCCTCAA
CGCCATGCTGGGCGAAATTCCCAAAGAGCAGCGGGTCGTTCTGGTCGAGGATACGCCCGAACTGCGTTTGCCGGGCGAGA
ACGGCGTCGGTCTCGTCGCAGTCAAGGGCGAGCTTGGCGAGGCGAAGGTCACGGCCAATGAACTGCTGCAGGCGGCGCTG
CGCTTGCGCCCCGACCGCATCGTGCTGGGCGAATTGCGCGGCGCCGAAAGCGTCAGCTTCCTGCGCGCTATCAATACCGG
CCACCCGGGCAGTTTCTCGACCATCCACGCCAACTCGATCACCGGCGCGCTCGAGCAATTGTCGCTGATGGTCATGCAGA
CCGGCATCGGTCTTAGCCGCAGCGACACGATCGCTTATGCCTCCAACGTGATCGACGTCATCGTCCAGCTCGGCCGCAGC
GGGGAGGGCAAGCGCGGGATAAGCGAAATCGCGCTCGCCAAGGACCTCGTCTAG

Upstream 100 bases:

>100_bases
GGTCGGCCCGGTCATCCGGGTCCGCCAAGGTGAACCGATCCGCGTGTTCACTGCCCGCGATCTCGATTTCTCGACGGTGA
TGTAGGCGAAGGCCAGGCCG

Downstream 100 bases:

>100_bases
GAAGTTCACGCTACGGCTAGCAATTCTAAGGGCGCGACCGCTATAGGAAGAGCCATGGGCAGCCACCCGATTACGCAGGA
CAATGATCTCGACCCGCCTA

Product: type IV secretion system protein B11, putative

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 337; Mature: 336

Protein sequence:

>337_residues
MSADVHPFAKQAEAAETPLPGDRSVYLEAYLKPFREWLDRDTVTEILVNRPGEVWIEDAASPGMQRVDTPHIDDRLVQRL
AEQVARVSHQGINREHPLLGATLPDGARVQFCGPPASRKHWCMAIRRHRRLDLPLDAYDSGPLSPPQEQAMPDAQAEPIA
FLREAIRQRRTILISGGTSTGKTTFLNAMLGEIPKEQRVVLVEDTPELRLPGENGVGLVAVKGELGEAKVTANELLQAAL
RLRPDRIVLGELRGAESVSFLRAINTGHPGSFSTIHANSITGALEQLSLMVMQTGIGLSRSDTIAYASNVIDVIVQLGRS
GEGKRGISEIALAKDLV

Sequences:

>Translated_337_residues
MSADVHPFAKQAEAAETPLPGDRSVYLEAYLKPFREWLDRDTVTEILVNRPGEVWIEDAASPGMQRVDTPHIDDRLVQRL
AEQVARVSHQGINREHPLLGATLPDGARVQFCGPPASRKHWCMAIRRHRRLDLPLDAYDSGPLSPPQEQAMPDAQAEPIA
FLREAIRQRRTILISGGTSTGKTTFLNAMLGEIPKEQRVVLVEDTPELRLPGENGVGLVAVKGELGEAKVTANELLQAAL
RLRPDRIVLGELRGAESVSFLRAINTGHPGSFSTIHANSITGALEQLSLMVMQTGIGLSRSDTIAYASNVIDVIVQLGRS
GEGKRGISEIALAKDLV
>Mature_336_residues
SADVHPFAKQAEAAETPLPGDRSVYLEAYLKPFREWLDRDTVTEILVNRPGEVWIEDAASPGMQRVDTPHIDDRLVQRLA
EQVARVSHQGINREHPLLGATLPDGARVQFCGPPASRKHWCMAIRRHRRLDLPLDAYDSGPLSPPQEQAMPDAQAEPIAF
LREAIRQRRTILISGGTSTGKTTFLNAMLGEIPKEQRVVLVEDTPELRLPGENGVGLVAVKGELGEAKVTANELLQAALR
LRPDRIVLGELRGAESVSFLRAINTGHPGSFSTIHANSITGALEQLSLMVMQTGIGLSRSDTIAYASNVIDVIVQLGRSG
EGKRGISEIALAKDLV

Specific function: The type IV secretion system VirB/VirD4 is a major virulence determinant for subversion of human endothelial cell (HEC) function. VirB-dependent changes of HEC include massive cytoskeletal rearrangements, a proinflammatory activation by nuclear factor NF-

COG id: COG0630

COG function: function code NU; Type IV secretory pathway, VirB11 components, and related ATPases involved in archaeal flagella biosynthesis

Gene ontology:

Cell location: Cell inner membrane (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GSP E family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR014155
- InterPro:   IPR001482 [H]

Pfam domain/function: PF00437 GSPII_E [H]

EC number: NA

Molecular weight: Translated: 36739; Mature: 36608

Theoretical pI: Translated: 6.32; Mature: 6.32

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSADVHPFAKQAEAAETPLPGDRSVYLEAYLKPFREWLDRDTVTEILVNRPGEVWIEDAA
CCCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCEEEECCC
SPGMQRVDTPHIDDRLVQRLAEQVARVSHQGINREHPLLGATLPDGARVQFCGPPASRKH
CCCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCEEEEECCCCCCHH
WCMAIRRHRRLDLPLDAYDSGPLSPPQEQAMPDAQAEPIAFLREAIRQRRTILISGGTST
HHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCEEEEECCCCC
GKTTFLNAMLGEIPKEQRVVLVEDTPELRLPGENGVGLVAVKGELGEAKVTANELLQAAL
CHHHHHHHHHHHCCCCCEEEEEECCCCEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
RLRPDRIVLGELRGAESVSFLRAINTGHPGSFSTIHANSITGALEQLSLMVMQTGIGLSR
HCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCC
SDTIAYASNVIDVIVQLGRSGEGKRGISEIALAKDLV
CCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
SADVHPFAKQAEAAETPLPGDRSVYLEAYLKPFREWLDRDTVTEILVNRPGEVWIEDAA
CCCCCHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCCEEEECCC
SPGMQRVDTPHIDDRLVQRLAEQVARVSHQGINREHPLLGATLPDGARVQFCGPPASRKH
CCCCHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCEEEEECCCCCCHH
WCMAIRRHRRLDLPLDAYDSGPLSPPQEQAMPDAQAEPIAFLREAIRQRRTILISGGTST
HHHHHHHHCCCCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHCCEEEEECCCCC
GKTTFLNAMLGEIPKEQRVVLVEDTPELRLPGENGVGLVAVKGELGEAKVTANELLQAAL
CHHHHHHHHHHHCCCCCEEEEEECCCCEECCCCCCCEEEEECCCCCCCCCCHHHHHHHHH
RLRPDRIVLGELRGAESVSFLRAINTGHPGSFSTIHANSITGALEQLSLMVMQTGIGLSR
HCCCCEEEEECCCCCHHHHHHHHHCCCCCCCCEEEECHHHHHHHHHHHHHHHHHCCCCCC
SDTIAYASNVIDVIVQLGRSGEGKRGISEIALAKDLV
CCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 10882236 [H]