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The map label for this gene is lysS

Identifier: 85059967

GI number: 85059967

Start: 3444266

End: 3445786

Strand: Reverse

Name: lysS

Synonym: SG1989

Alternate gene names: 85059967

Gene position: 3445786-3444266 (Counterclockwise)

Preceding gene: 85059968

Following gene: 85059966

Centisome position: 82.61

GC content: 56.67

Gene sequence:

>1521_bases
ATGTCTGAATCACACTCACAGGACGGTGCCCCTCAGGCGCTGGATATGAATAACGAGCTGCGTTCGCGGCGGGAAAAACT
CGGCCAGTTGCGTCAGCAGGGTATTGCTTTTCCCAACGATTTCCGCCGGGATGCCGTGTCCGACCAGCTGCACGCCCGCT
ACGGCGAGAAGAGCAATGAAGAACTAGAAGCGTTAAACATTGAGGTCAGCATTGCCGGCCGCATGATGACCCGCCGTATT
ATGGGCAAAGCCTCCTTCGCTACCCTGCAGGACGTGGGCGGGAAAATCCAGCTGTACGTCGCCCGCGACGATTTGCCGGA
AGGGCAATACAACGAGCAGTTCAAAAAATGGGACCTCGGCGACATTCTGGGCACGCGCGGCAAATTATTTAAAACCCGCA
CCGGCGAGTTGTCGGTCCACTGTAGCGAAATTCGCCTGCTGACCAAAGCGATGCGTCCGCTGCCGGATAAGTTTCACGGC
CTGGCCGATCAGGAAACCCGCTATCGCCAACGCTATCTTGATTTGATCGCCAACGACGAATCACGCCAAACCTTCAAAGT
GCGTTCGCGCATTATGGCGGAAATTCGCCGTTTTATGATGGATAACGATTTCATGGAAGTGGAAACACCGATGATGCAAA
CCATCCCCGGCGGCGCCGCGGCGCGTCCGTTCATCACCCATCATAACGCGCTGGGTATCGATATGTATCTGCGTATCGCG
CCGGAGCTGTATTTGAAACGGCTGGTGGTGGGCGGCTTTGAGCGGGTATTTGAAATCAACCGCAATTTCCGCAATGAAGG
CTTGTCGCCGCGCCACAATCCCGAGTTCACTATGATGGAACTCTATATGGCCTATGCGGACTACCGCGACCTGATTGTGC
TGGTTGAAACGTTGTTCCGCACCCTGACGCAGCGGGTACTCGGCAGCAGCGTGGTGCACAATGGCGATCAAACCTTCGAT
TTCGGCAAGCCGTTTACCCAGATGACCATGAAAGAGGCCATCTGCCATTATCGCCCGGAGACCCGGCCGGAAGCACTGGA
CGATATGGCTTCCGCCACCGCCATCGCCGAGTCACTGGGCATTAAGGTTGACAAAAGCTGGGGTTTGGGGCGGGTGCAGA
CCGAGGTTTTTGAAGAAACGGCGGAAAGCCATCTCATTCAGCCGACCTTCATCACCGCCTACCCGGCGGAAGTTTCGCCG
CTGGCGCGCCGCAATGATGACAATCCGTTCTTTACCGATCGTTTTGAATTCTTCATCGGCGGGCGCGAAATCGGAAACGG
TTTCTCGGAGCTCAACGATGCCGAAGATCAGGCGGCGCGCTTTGCCGAGCAGGCCCAGGCCAAAGACGCCGGCGACGATG
AAGCGATGTTCTATGACGAGGACTATGTCACCGCGCTTGAGCACGGCCTGCCGCCGACCGCCGGGTTGGGCATCGGTATC
GATCGCCTGATGATGCTGTTAACCAATAGCCATACCATTCGCGACGTGATCCTGTTCCCGGCGTTGCGTCCGCAAAAATA
G

Upstream 100 bases:

>100_bases
GCGTACCGGCGTGGAAACGCGCAACGCCCAGTCAGTGCTGGATGGCGATCTGGACAAATTTATTGAAGCCAGTCTTAAAG
TAGGGCTATGAGGAACCCAT

Downstream 100 bases:

>100_bases
CCTTCCAGGGGCGGATGAAAAGCGTGTCCGCCCCGTCTGTCATCGATGCACCATGGCGGAACATCCCGCCGCATGATGGT
GCTCTTTGTCCGTGGGGTCA

Product: lysyl-tRNA synthetase

Products: NA

Alternate protein names: Lysine--tRNA ligase; LysRS

Number of amino acids: Translated: 506; Mature: 505

Protein sequence:

>506_residues
MSESHSQDGAPQALDMNNELRSRREKLGQLRQQGIAFPNDFRRDAVSDQLHARYGEKSNEELEALNIEVSIAGRMMTRRI
MGKASFATLQDVGGKIQLYVARDDLPEGQYNEQFKKWDLGDILGTRGKLFKTRTGELSVHCSEIRLLTKAMRPLPDKFHG
LADQETRYRQRYLDLIANDESRQTFKVRSRIMAEIRRFMMDNDFMEVETPMMQTIPGGAAARPFITHHNALGIDMYLRIA
PELYLKRLVVGGFERVFEINRNFRNEGLSPRHNPEFTMMELYMAYADYRDLIVLVETLFRTLTQRVLGSSVVHNGDQTFD
FGKPFTQMTMKEAICHYRPETRPEALDDMASATAIAESLGIKVDKSWGLGRVQTEVFEETAESHLIQPTFITAYPAEVSP
LARRNDDNPFFTDRFEFFIGGREIGNGFSELNDAEDQAARFAEQAQAKDAGDDEAMFYDEDYVTALEHGLPPTAGLGIGI
DRLMMLLTNSHTIRDVILFPALRPQK

Sequences:

>Translated_506_residues
MSESHSQDGAPQALDMNNELRSRREKLGQLRQQGIAFPNDFRRDAVSDQLHARYGEKSNEELEALNIEVSIAGRMMTRRI
MGKASFATLQDVGGKIQLYVARDDLPEGQYNEQFKKWDLGDILGTRGKLFKTRTGELSVHCSEIRLLTKAMRPLPDKFHG
LADQETRYRQRYLDLIANDESRQTFKVRSRIMAEIRRFMMDNDFMEVETPMMQTIPGGAAARPFITHHNALGIDMYLRIA
PELYLKRLVVGGFERVFEINRNFRNEGLSPRHNPEFTMMELYMAYADYRDLIVLVETLFRTLTQRVLGSSVVHNGDQTFD
FGKPFTQMTMKEAICHYRPETRPEALDDMASATAIAESLGIKVDKSWGLGRVQTEVFEETAESHLIQPTFITAYPAEVSP
LARRNDDNPFFTDRFEFFIGGREIGNGFSELNDAEDQAARFAEQAQAKDAGDDEAMFYDEDYVTALEHGLPPTAGLGIGI
DRLMMLLTNSHTIRDVILFPALRPQK
>Mature_505_residues
SESHSQDGAPQALDMNNELRSRREKLGQLRQQGIAFPNDFRRDAVSDQLHARYGEKSNEELEALNIEVSIAGRMMTRRIM
GKASFATLQDVGGKIQLYVARDDLPEGQYNEQFKKWDLGDILGTRGKLFKTRTGELSVHCSEIRLLTKAMRPLPDKFHGL
ADQETRYRQRYLDLIANDESRQTFKVRSRIMAEIRRFMMDNDFMEVETPMMQTIPGGAAARPFITHHNALGIDMYLRIAP
ELYLKRLVVGGFERVFEINRNFRNEGLSPRHNPEFTMMELYMAYADYRDLIVLVETLFRTLTQRVLGSSVVHNGDQTFDF
GKPFTQMTMKEAICHYRPETRPEALDDMASATAIAESLGIKVDKSWGLGRVQTEVFEETAESHLIQPTFITAYPAEVSPL
ARRNDDNPFFTDRFEFFIGGREIGNGFSELNDAEDQAARFAEQAQAKDAGDDEAMFYDEDYVTALEHGLPPTAGLGIGID
RLMMLLTNSHTIRDVILFPALRPQK

Specific function: Unknown

COG id: COG1190

COG function: function code J; Lysyl-tRNA synthetase (class II)

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family

Homologues:

Organism=Homo sapiens, GI5031815, Length=516, Percent_Identity=42.4418604651163, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI194272210, Length=516, Percent_Identity=42.4418604651163, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI45439306, Length=464, Percent_Identity=24.1379310344828, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI40789249, Length=294, Percent_Identity=25.1700680272109, Blast_Score=87, Evalue=4e-17,
Organism=Homo sapiens, GI226491502, Length=335, Percent_Identity=24.4776119402985, Blast_Score=72, Evalue=9e-13,
Organism=Escherichia coli, GI1789256, Length=506, Percent_Identity=80.2371541501976, Blast_Score=850, Evalue=0.0,
Organism=Escherichia coli, GI1790571, Length=506, Percent_Identity=78.4584980237154, Blast_Score=834, Evalue=0.0,
Organism=Escherichia coli, GI87082379, Length=318, Percent_Identity=31.1320754716981, Blast_Score=144, Evalue=9e-36,
Organism=Escherichia coli, GI1788173, Length=295, Percent_Identity=29.1525423728814, Blast_Score=92, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17535927, Length=452, Percent_Identity=42.0353982300885, Blast_Score=344, Evalue=5e-95,
Organism=Caenorhabditis elegans, GI17535925, Length=452, Percent_Identity=42.0353982300885, Blast_Score=344, Evalue=5e-95,
Organism=Caenorhabditis elegans, GI71994340, Length=452, Percent_Identity=42.0353982300885, Blast_Score=343, Evalue=9e-95,
Organism=Caenorhabditis elegans, GI17551876, Length=507, Percent_Identity=23.8658777120316, Blast_Score=91, Evalue=1e-18,
Organism=Caenorhabditis elegans, GI32566633, Length=297, Percent_Identity=25.9259259259259, Blast_Score=90, Evalue=2e-18,
Organism=Saccharomyces cerevisiae, GI6320242, Length=519, Percent_Identity=41.4258188824663, Blast_Score=363, Evalue=1e-101,
Organism=Saccharomyces cerevisiae, GI6324256, Length=477, Percent_Identity=30.6079664570231, Blast_Score=180, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6321807, Length=448, Percent_Identity=25.6696428571429, Blast_Score=96, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6323011, Length=482, Percent_Identity=24.2738589211618, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6325153, Length=229, Percent_Identity=28.3842794759825, Blast_Score=66, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24640849, Length=485, Percent_Identity=41.8556701030928, Blast_Score=371, Evalue=1e-103,
Organism=Drosophila melanogaster, GI24640851, Length=485, Percent_Identity=41.8556701030928, Blast_Score=370, Evalue=1e-103,
Organism=Drosophila melanogaster, GI17136276, Length=464, Percent_Identity=22.8448275862069, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI24584738, Length=297, Percent_Identity=25.5892255892256, Blast_Score=85, Evalue=9e-17,
Organism=Drosophila melanogaster, GI19922416, Length=462, Percent_Identity=22.9437229437229, Blast_Score=79, Evalue=7e-15,

Paralogues:

None

Copy number: 1200 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): SYK_SODGM (Q2NRG1)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455669.1
- ProteinModelPortal:   Q2NRG1
- SMR:   Q2NRG1
- STRING:   Q2NRG1
- GeneID:   3867070
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1989
- NMPDR:   fig|343509.6.peg.4316
- eggNOG:   COG1190
- HOGENOM:   HBG631383
- OMA:   RNEGMDH
- PhylomeDB:   Q2NRG1
- ProtClustDB:   PRK00484
- BioCyc:   SGLO343509:SG1989-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00252
- InterPro:   IPR004364
- InterPro:   IPR018150
- InterPro:   IPR006195
- InterPro:   IPR002313
- InterPro:   IPR018149
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR004365
- Gene3D:   G3DSA:2.40.50.140
- PANTHER:   PTHR22594
- PANTHER:   PTHR22594:SF4
- PRINTS:   PR00982
- TIGRFAMs:   TIGR00499

Pfam domain/function: PF00152 tRNA-synt_2; PF01336 tRNA_anti; SSF50249 Nucleic_acid_OB

EC number: =6.1.1.6

Molecular weight: Translated: 57722; Mature: 57591

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESHSQDGAPQALDMNNELRSRREKLGQLRQQGIAFPNDFRRDAVSDQLHARYGEKSNE
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCC
ELEALNIEVSIAGRMMTRRIMGKASFATLQDVGGKIQLYVARDDLPEGQYNEQFKKWDLG
CEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHCCCHH
DILGTRGKLFKTRTGELSVHCSEIRLLTKAMRPLPDKFHGLADQETRYRQRYLDLIANDE
HHHCCCCCEEEECCCCEEEEHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHCCCC
SRQTFKVRSRIMAEIRRFMMDNDFMEVETPMMQTIPGGAAARPFITHHNALGIDMYLRIA
CHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHCCCCCCCCCEEECCCCCCHHHHHHHH
PELYLKRLVVGGFERVFEINRNFRNEGLSPRHNPEFTMMELYMAYADYRDLIVLVETLFR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TLTQRVLGSSVVHNGDQTFDFGKPFTQMTMKEAICHYRPETRPEALDDMASATAIAESLG
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
IKVDKSWGLGRVQTEVFEETAESHLIQPTFITAYPAEVSPLARRNDDNPFFTDRFEFFIG
CEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCCCCCCCCCHHHEEC
GREIGNGFSELNDAEDQAARFAEQAQAKDAGDDEAMFYDEDYVTALEHGLPPTAGLGIGI
CHHHCCCHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEECHHHHHHHHHCCCCCCCCCCCH
DRLMMLLTNSHTIRDVILFPALRPQK
HHHHHHHHCCCHHHHHHHHCCCCCCC
>Mature Secondary Structure 
SESHSQDGAPQALDMNNELRSRREKLGQLRQQGIAFPNDFRRDAVSDQLHARYGEKSNE
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCC
ELEALNIEVSIAGRMMTRRIMGKASFATLQDVGGKIQLYVARDDLPEGQYNEQFKKWDLG
CEEEEEEEEEEHHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHCCCHH
DILGTRGKLFKTRTGELSVHCSEIRLLTKAMRPLPDKFHGLADQETRYRQRYLDLIANDE
HHHCCCCCEEEECCCCEEEEHHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHCCCC
SRQTFKVRSRIMAEIRRFMMDNDFMEVETPMMQTIPGGAAARPFITHHNALGIDMYLRIA
CHHHHHHHHHHHHHHHHHHHCCCCHHHCCHHHHHCCCCCCCCCEEECCCCCCHHHHHHHH
PELYLKRLVVGGFERVFEINRNFRNEGLSPRHNPEFTMMELYMAYADYRDLIVLVETLFR
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TLTQRVLGSSVVHNGDQTFDFGKPFTQMTMKEAICHYRPETRPEALDDMASATAIAESLG
HHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHC
IKVDKSWGLGRVQTEVFEETAESHLIQPTFITAYPAEVSPLARRNDDNPFFTDRFEFFIG
CEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEECCCCCCHHHHCCCCCCCCCCCHHHEEC
GREIGNGFSELNDAEDQAARFAEQAQAKDAGDDEAMFYDEDYVTALEHGLPPTAGLGIGI
CHHHCCCHHHCCCHHHHHHHHHHHHHHCCCCCCCCEEECHHHHHHHHHCCCCCCCCCCCH
DRLMMLLTNSHTIRDVILFPALRPQK
HHHHHHHHCCCHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA