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The map label for this gene is lysA [H]

Identifier: 85059966

GI number: 85059966

Start: 3433777

End: 3435036

Strand: Reverse

Name: lysA [H]

Synonym: SG1988

Alternate gene names: 85059966

Gene position: 3435036-3433777 (Counterclockwise)

Preceding gene: 85059967

Following gene: 85059964

Centisome position: 82.35

GC content: 60.0

Gene sequence:

>1260_bases
ATGCCGCACGATCTTTACACCACGGAGCGCGCCTTGAATGCCGCGAATTTATTGCCGCTCCATCAGCGCTACGGCGGCCC
GGTCTGGGTATATGAAGCGGAAACCATCAGCGCGCTGATTGCGCAACTACGTCGCTTCGATACTATCCGCTTCGCTCAGA
AAGCCTGTTCCAATATCCATCTACTGCGCTTGATGCGTAGCCAGGGCGTTAAAGTCGATTCCGTGTCGCTCGGCGAGATT
GAGCGTGCACTACTGGCCGGTTTCCTGCCGGGCACCGAGAACGATGAAATCGTTTTTACCGCTGATTTACTGGATGAACC
GACGCTGGCGCGGGTCGTTGAACTCGGTATCCCAGTCAACGCCGGCTCGACGGATATGCTGGCGCAGCTCGGCGCCCGCT
CGCCGGGACACGGCGTCTGGCTGCGCATCAATCCCGGTTTTGGCCACGGTCATAGCCAAAAAACCAATACCGGCGGTGAA
AACAGCAAGCACGGCATCTGGTATGAGGATTTGCCTCAGGCCGTCGCGCTGATTCAGCACGACGGCCTGAGGCTCATCGG
CATACATATGCATATCGGTTCGGGGGTGGATTACGACCACCTTTCCCAGGTCTGCGACGCCATGGTGCAACAGGTTATGG
CAAGCGGGCTGGATCTCGCGGCCATTTCCGCGGGCGGCGGGCTATCGATCCCATACCGCTCGGGGGAGGAGGCGATTGAT
ACCGAGCACTACTTTGGTCTGTGGGATGCCGCCCGCCGGCGGATTAGCAGCCATCTCGGTCATCCGGTGACGCTTGAGAT
TGAACCTGGCCGGTTCTTAGTGGCGGAATCAGGCGTTCTGATAACTCAGGTCAGGGCGGTCAAAGACATGGGCAGCCGCC
ACTTCGTGCTGGTAGATGCGGGGTTTAATGATTTAATGCGCCCAGCGATGTACGGCAGTTACCACGCTATTTCGCTGTTG
CCGGCGGACGGCCGCGATCGCGGCGCACAACCGTTGCGCGAAACCGTCGTGGGGGGGCCGCTGTGCGAATCAGGCGACGT
TTTTACCCAGACGGCCGGCGGAGGCATTGCGCCGCGTCGTTTGCCGCTGGCTCAGGTAGGCGACTATCTCGTCTTTCACG
ATACCGGCGCTTATGGCGCCTCGATGTCGTCGAACTACAACAGCCGGCCGTTGCTGCCGGAGGTGTTATTTGAACAGGGG
CAGGCACGGCAGATCCGCCGCCGTCAGCGGCTGGAAGAGCTGTTTGACCTGGAGCGGTAA

Upstream 100 bases:

>100_bases
TAAGGGCAAAAAAGATATTTTATTAATAGCTGCCGATGAATTACAAAGAAGAGCCCCAGCCGGCGCTGTCGGGACCGACT
TTTTTCACGCGAGGACCACC

Downstream 100 bases:

>100_bases
CCGGGCGCTAAGGAGTGCGCCTGATTCCTCCCACTGCCCCGCGTGTGGCGACTATGGGTGGCGTGACAATCTGAGTCAAC
GCCGCCCGGGGCGACGTGGT

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MPHDLYTTERALNAANLLPLHQRYGGPVWVYEAETISALIAQLRRFDTIRFAQKACSNIHLLRLMRSQGVKVDSVSLGEI
ERALLAGFLPGTENDEIVFTADLLDEPTLARVVELGIPVNAGSTDMLAQLGARSPGHGVWLRINPGFGHGHSQKTNTGGE
NSKHGIWYEDLPQAVALIQHDGLRLIGIHMHIGSGVDYDHLSQVCDAMVQQVMASGLDLAAISAGGGLSIPYRSGEEAID
TEHYFGLWDAARRRISSHLGHPVTLEIEPGRFLVAESGVLITQVRAVKDMGSRHFVLVDAGFNDLMRPAMYGSYHAISLL
PADGRDRGAQPLRETVVGGPLCESGDVFTQTAGGGIAPRRLPLAQVGDYLVFHDTGAYGASMSSNYNSRPLLPEVLFEQG
QARQIRRRQRLEELFDLER

Sequences:

>Translated_419_residues
MPHDLYTTERALNAANLLPLHQRYGGPVWVYEAETISALIAQLRRFDTIRFAQKACSNIHLLRLMRSQGVKVDSVSLGEI
ERALLAGFLPGTENDEIVFTADLLDEPTLARVVELGIPVNAGSTDMLAQLGARSPGHGVWLRINPGFGHGHSQKTNTGGE
NSKHGIWYEDLPQAVALIQHDGLRLIGIHMHIGSGVDYDHLSQVCDAMVQQVMASGLDLAAISAGGGLSIPYRSGEEAID
TEHYFGLWDAARRRISSHLGHPVTLEIEPGRFLVAESGVLITQVRAVKDMGSRHFVLVDAGFNDLMRPAMYGSYHAISLL
PADGRDRGAQPLRETVVGGPLCESGDVFTQTAGGGIAPRRLPLAQVGDYLVFHDTGAYGASMSSNYNSRPLLPEVLFEQG
QARQIRRRQRLEELFDLER
>Mature_418_residues
PHDLYTTERALNAANLLPLHQRYGGPVWVYEAETISALIAQLRRFDTIRFAQKACSNIHLLRLMRSQGVKVDSVSLGEIE
RALLAGFLPGTENDEIVFTADLLDEPTLARVVELGIPVNAGSTDMLAQLGARSPGHGVWLRINPGFGHGHSQKTNTGGEN
SKHGIWYEDLPQAVALIQHDGLRLIGIHMHIGSGVDYDHLSQVCDAMVQQVMASGLDLAAISAGGGLSIPYRSGEEAIDT
EHYFGLWDAARRRISSHLGHPVTLEIEPGRFLVAESGVLITQVRAVKDMGSRHFVLVDAGFNDLMRPAMYGSYHAISLLP
ADGRDRGAQPLRETVVGGPLCESGDVFTQTAGGGIAPRRLPLAQVGDYLVFHDTGAYGASMSSNYNSRPLLPEVLFEQGQ
ARQIRRRQRLEELFDLER

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=411, Percent_Identity=73.7226277372263, Blast_Score=624, Evalue=1e-180,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 45781; Mature: 45649

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: PS00878 ODR_DC_2_1 ; PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPHDLYTTERALNAANLLPLHQRYGGPVWVYEAETISALIAQLRRFDTIRFAQKACSNIH
CCCCCHHHHHHHCHHHCCCHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LLRLMRSQGVKVDSVSLGEIERALLAGFLPGTENDEIVFTADLLDEPTLARVVELGIPVN
HHHHHHHCCCEEECCCHHHHHHHHHHHCCCCCCCCCEEEEHHHCCCCHHHHHHHHCCCCC
AGSTDMLAQLGARSPGHGVWLRINPGFGHGHSQKTNTGGENSKHGIWYEDLPQAVALIQH
CCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
DGLRLIGIHMHIGSGVDYDHLSQVCDAMVQQVMASGLDLAAISAGGGLSIPYRSGEEAID
CCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHC
TEHYFGLWDAARRRISSHLGHPVTLEIEPGRFLVAESGVLITQVRAVKDMGSRHFVLVDA
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCCHHHHHHHHHHCCCCEEEEEEC
GFNDLMRPAMYGSYHAISLLPADGRDRGAQPLRETVVGGPLCESGDVFTQTAGGGIAPRR
CHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCCCCCC
LPLAQVGDYLVFHDTGAYGASMSSNYNSRPLLPEVLFEQGQARQIRRRQRLEELFDLER
CCHHHHCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
PHDLYTTERALNAANLLPLHQRYGGPVWVYEAETISALIAQLRRFDTIRFAQKACSNIH
CCCCHHHHHHHCHHHCCCHHHHCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCHH
LLRLMRSQGVKVDSVSLGEIERALLAGFLPGTENDEIVFTADLLDEPTLARVVELGIPVN
HHHHHHHCCCEEECCCHHHHHHHHHHHCCCCCCCCCEEEEHHHCCCCHHHHHHHHCCCCC
AGSTDMLAQLGARSPGHGVWLRINPGFGHGHSQKTNTGGENSKHGIWYEDLPQAVALIQH
CCCHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHC
DGLRLIGIHMHIGSGVDYDHLSQVCDAMVQQVMASGLDLAAISAGGGLSIPYRSGEEAID
CCEEEEEEEEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCHHHC
TEHYFGLWDAARRRISSHLGHPVTLEIEPGRFLVAESGVLITQVRAVKDMGSRHFVLVDA
CHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCCHHHHHHHHHHCCCCEEEEEEC
GFNDLMRPAMYGSYHAISLLPADGRDRGAQPLRETVVGGPLCESGDVFTQTAGGGIAPRR
CHHHHHHHHHCCCCEEEEEECCCCCCCCCHHHHHHHCCCCCCCCCCEEEECCCCCCCCCC
LPLAQVGDYLVFHDTGAYGASMSSNYNSRPLLPEVLFEQGQARQIRRRQRLEELFDLER
CCHHHHCCEEEEECCCCCCCCCCCCCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6350601; 9278503 [H]