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The map label for this gene is uppS [H]

Identifier: 85059916

GI number: 85059916

Start: 3342851

End: 3343612

Strand: Reverse

Name: uppS [H]

Synonym: SG1938

Alternate gene names: 85059916

Gene position: 3343612-3342851 (Counterclockwise)

Preceding gene: 85059917

Following gene: 85059915

Centisome position: 80.16

GC content: 55.91

Gene sequence:

>762_bases
ATGTCGTCCGAAAATCAGCAAGAGCCAAAAGCGTTGCCTTCCTCCTCACCACGCCATGTGGCTATTATTATGGATGGCAA
CGGCCGCTGGGCTAAAAACCGGGGGAAATTACGTATCTTCGGTCACCAGGCCGGCGTCAAGTCGGTCCGCCGCGCGGTAA
GCTTTGCCGTCAGCCACCATTTCGACGCGTTGACGCTGTATGCGTTCAGCAGCGAAAACTGGAACCGACCTAGCCAGGAA
GTGTCCGCGCTAATGGAGCTGTTTGTCCGGGCGCTGGATAGCGAGGTGAAAAGCCTGCACAAGCATAACGTCCGGCTGCG
GATCATCGGCGACACCTCGCGCTTCGGCATGAGTTTGCAGGAGCGGATTCGCCGCTCCGAGGCGCTGACCTGCAATAATG
ACGGGTTGACCCTGAATATTGCCGCGAATTATGGTGGACGTTGGGATATCATTCAGGGGGTACGGCAACTTGCCGCCCGG
GTGCAAGAGGGTATCCTGCGACCTGACCAGATAGATGAGGACGCTTTGTGCCAGGTAGTCTGCATGAACGAGCTGGCCCC
TGTGGATCTCGTTATCCGCACCGGAGGGGAACATCGCATCAGTAATTTTTTGCTGTGGCAGATTGCCTACGCAGAGCTGT
TTTTTACCGACGTGTTATGGCCGGATTTTGACGACGCTGTTTTTGAAGGTGCGCTGGATGCTTTTGCTCAACGCGAGCGG
CGCTTCGGTGGAACAACACCTAATGATGCCAACGCATCCTAA

Upstream 100 bases:

>100_bases
ATTAGTTACAGGCCGTGTATGTACACGGCTTTTTTGTGCGTTCGGGGCCCTTCGTTCCGGTAAGACGGTGGTATTCTCAG
TGAGGAAATACGTAAGCGTG

Downstream 100 bases:

>100_bases
GGGGGATTTTTGCTGAAGTATCGCCTGATTACTGCCTTGGTCCTGATACCCATAGTTATCGCCGCACTGTTTTTGTTGCC
GTCGGTTGGCTTTGCCCTGG

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS [H]

Number of amino acids: Translated: 253; Mature: 252

Protein sequence:

>253_residues
MSSENQQEPKALPSSSPRHVAIIMDGNGRWAKNRGKLRIFGHQAGVKSVRRAVSFAVSHHFDALTLYAFSSENWNRPSQE
VSALMELFVRALDSEVKSLHKHNVRLRIIGDTSRFGMSLQERIRRSEALTCNNDGLTLNIAANYGGRWDIIQGVRQLAAR
VQEGILRPDQIDEDALCQVVCMNELAPVDLVIRTGGEHRISNFLLWQIAYAELFFTDVLWPDFDDAVFEGALDAFAQRER
RFGGTTPNDANAS

Sequences:

>Translated_253_residues
MSSENQQEPKALPSSSPRHVAIIMDGNGRWAKNRGKLRIFGHQAGVKSVRRAVSFAVSHHFDALTLYAFSSENWNRPSQE
VSALMELFVRALDSEVKSLHKHNVRLRIIGDTSRFGMSLQERIRRSEALTCNNDGLTLNIAANYGGRWDIIQGVRQLAAR
VQEGILRPDQIDEDALCQVVCMNELAPVDLVIRTGGEHRISNFLLWQIAYAELFFTDVLWPDFDDAVFEGALDAFAQRER
RFGGTTPNDANAS
>Mature_252_residues
SSENQQEPKALPSSSPRHVAIIMDGNGRWAKNRGKLRIFGHQAGVKSVRRAVSFAVSHHFDALTLYAFSSENWNRPSQEV
SALMELFVRALDSEVKSLHKHNVRLRIIGDTSRFGMSLQERIRRSEALTCNNDGLTLNIAANYGGRWDIIQGVRQLAARV
QEGILRPDQIDEDALCQVVCMNELAPVDLVIRTGGEHRISNFLLWQIAYAELFFTDVLWPDFDDAVFEGALDAFAQRERR
FGGTTPNDANAS

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide [H]

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family [H]

Homologues:

Organism=Homo sapiens, GI45580738, Length=243, Percent_Identity=34.5679012345679, Blast_Score=142, Evalue=3e-34,
Organism=Homo sapiens, GI45580742, Length=211, Percent_Identity=37.4407582938389, Blast_Score=140, Evalue=8e-34,
Organism=Escherichia coli, GI1786371, Length=252, Percent_Identity=78.1746031746032, Blast_Score=405, Evalue=1e-114,
Organism=Caenorhabditis elegans, GI71993029, Length=215, Percent_Identity=36.2790697674419, Blast_Score=124, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6319474, Length=212, Percent_Identity=36.7924528301887, Blast_Score=121, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6323748, Length=214, Percent_Identity=32.7102803738318, Blast_Score=110, Evalue=2e-25,
Organism=Drosophila melanogaster, GI18857969, Length=228, Percent_Identity=33.7719298245614, Blast_Score=123, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001441
- InterPro:   IPR018520 [H]

Pfam domain/function: PF01255 Prenyltransf [H]

EC number: =2.5.1.31 [H]

Molecular weight: Translated: 28411; Mature: 28280

Theoretical pI: Translated: 6.88; Mature: 6.88

Prosite motif: PS01066 UPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSENQQEPKALPSSSPRHVAIIMDGNGRWAKNRGKLRIFGHQAGVKSVRRAVSFAVSHH
CCCCCCCCCCCCCCCCCCEEEEEECCCCCEECCCCCEEEEECHHHHHHHHHHHHHHHHHC
FDALTLYAFSSENWNRPSQEVSALMELFVRALDSEVKSLHKHNVRLRIIGDTSRFGMSLQ
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHCHHHH
ERIRRSEALTCNNDGLTLNIAANYGGRWDIIQGVRQLAARVQEGILRPDQIDEDALCQVV
HHHHHHHCEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
CMNELAPVDLVIRTGGEHRISNFLLWQIAYAELFFTDVLWPDFDDAVFEGALDAFAQRER
HHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
RFGGTTPNDANAS
HCCCCCCCCCCCC
>Mature Secondary Structure 
SSENQQEPKALPSSSPRHVAIIMDGNGRWAKNRGKLRIFGHQAGVKSVRRAVSFAVSHH
CCCCCCCCCCCCCCCCCEEEEEECCCCCEECCCCCEEEEECHHHHHHHHHHHHHHHHHC
FDALTLYAFSSENWNRPSQEVSALMELFVRALDSEVKSLHKHNVRLRIIGDTSRFGMSLQ
CCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHCHHHH
ERIRRSEALTCNNDGLTLNIAANYGGRWDIIQGVRQLAARVQEGILRPDQIDEDALCQVV
HHHHHHHCEEECCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHH
CMNELAPVDLVIRTGGEHRISNFLLWQIAYAELFFTDVLWPDFDDAVFEGALDAFAQRER
HHCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
RFGGTTPNDANAS
HCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA