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The map label for this gene is dxr

Identifier: 85059917

GI number: 85059917

Start: 3343808

End: 3345004

Strand: Reverse

Name: dxr

Synonym: SG1939

Alternate gene names: 85059917

Gene position: 3345004-3343808 (Counterclockwise)

Preceding gene: 85059918

Following gene: 85059916

Centisome position: 80.19

GC content: 62.57

Gene sequence:

>1197_bases
ATGCGGCATTTGACGATTCTGGGAAGTACTGGCTCCATTGGCAATAGTACGCTGGCGGTGGTAAAGCACAATCCCGACCA
ATACACCGTGCGTGCGCTGGTGGCGGGCAACAACGTTGCCTTGATGACCGAGCAATGCCTGGCTTTCCGTCCCGCCTACG
CTTGTATGGCGGATGACACCGCGGCGCGGACGCTCAAGGCTAATCTGGCCGCGGCGGGCGTCGCCACCGCCGTACTGTCG
GGCGTGCAGGCGGCCTGTGAGCTGGCCACGCTGGATGAGGTGGATACGGTGATGGCCGCGATTGTCGGCGCCGCCGGGCT
CGCCGCGACGCTGGCGGCGCTGCGAGCCGGCAAGCGGGTTTTGATGGCCAATAAAGAGTCGCTCGTCACCTGCGGCCGGC
TGTTCATGAACGAAGCGCGTCGCCATCATGCCCGGTTACTGCCGGTGGACAGCGAACACAACGCGATTTTTCAGAGTTTA
CCTGAACCACTTCAGCGTGGGTTGGGTTACGCTTCCCTGGCGAAACATGGAGTGTCGCGTATCGTGTTGACGGGCTCCGG
CGGCCCCTTTCGCCAGACGCCGCTGGCGGCGCTGGCCACGATGACGCCGGAGCAGGCCTGCGCGCATCCTAATTGGTCGA
TGGGCCGCAAGATTTCGGTGGATTCCGCCACCATGATGAACAAAGGTCTGGAATATATCGAAGCGCGCTGGTTGTTCAAT
GCCGCGGCAGAGCAGATGGAAGTGCTGCTGCATCCCCAGTCCATCATTCACTCCATGGTGCGCTACACCGACGGCAGCGT
GCTGGCGCAATTAGGATCCCCCGACATGCGCACGCCCATCGCTCACGCGATGGCGTACCCCGAACGGGTGCCGTCCGGCG
TCGCGCCGCTGGATTTTTTACGCCTCGGCACGCTGAGTTTCGCGCAGCCGGACACCGCACGCTATCCCTGCCTGCAACTG
GCTGTCGACGCCAGCCAGCAGGGGCAGGCGGCGACGACAACGCTCAACGCCGCCAATGAAATCGCGGTGGCGGCGTTTTT
GCACGGCGATATTCGTTTTACCGATATCGCCGCCGTGAATCGGCGGGTGCTGGAACAAATCAGTCTGCCTGAACCGGACA
GCGTGGAAGAGGTGCTGGCCATCGACAGCCAGGCGCGGGAAAAGGCCCGCCAGAGCGTTATTCATTTTGGACAGTGA

Upstream 100 bases:

>100_bases
CTGCGGCGTTTTTTTGTGTAAGCCGCCATAGACAAAACGGAGCCATCGTCTCAGACTAGACGTTTCCCTCATATTCTAAC
GCGGTATAAAAAGTAACTTC

Downstream 100 bases:

>100_bases
GGCGCCGGGGCGCCGCGATGGCTGATTTGTTCGTTGACCGGCAAAATGATATAGTCTGCGCTACTCATCCCGTCGATGAA
GGCCAGCCGGGTAAAATTAG

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 398; Mature: 398

Protein sequence:

>398_residues
MRHLTILGSTGSIGNSTLAVVKHNPDQYTVRALVAGNNVALMTEQCLAFRPAYACMADDTAARTLKANLAAAGVATAVLS
GVQAACELATLDEVDTVMAAIVGAAGLAATLAALRAGKRVLMANKESLVTCGRLFMNEARRHHARLLPVDSEHNAIFQSL
PEPLQRGLGYASLAKHGVSRIVLTGSGGPFRQTPLAALATMTPEQACAHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
AAAEQMEVLLHPQSIIHSMVRYTDGSVLAQLGSPDMRTPIAHAMAYPERVPSGVAPLDFLRLGTLSFAQPDTARYPCLQL
AVDASQQGQAATTTLNAANEIAVAAFLHGDIRFTDIAAVNRRVLEQISLPEPDSVEEVLAIDSQAREKARQSVIHFGQ

Sequences:

>Translated_398_residues
MRHLTILGSTGSIGNSTLAVVKHNPDQYTVRALVAGNNVALMTEQCLAFRPAYACMADDTAARTLKANLAAAGVATAVLS
GVQAACELATLDEVDTVMAAIVGAAGLAATLAALRAGKRVLMANKESLVTCGRLFMNEARRHHARLLPVDSEHNAIFQSL
PEPLQRGLGYASLAKHGVSRIVLTGSGGPFRQTPLAALATMTPEQACAHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
AAAEQMEVLLHPQSIIHSMVRYTDGSVLAQLGSPDMRTPIAHAMAYPERVPSGVAPLDFLRLGTLSFAQPDTARYPCLQL
AVDASQQGQAATTTLNAANEIAVAAFLHGDIRFTDIAAVNRRVLEQISLPEPDSVEEVLAIDSQAREKARQSVIHFGQ
>Mature_398_residues
MRHLTILGSTGSIGNSTLAVVKHNPDQYTVRALVAGNNVALMTEQCLAFRPAYACMADDTAARTLKANLAAAGVATAVLS
GVQAACELATLDEVDTVMAAIVGAAGLAATLAALRAGKRVLMANKESLVTCGRLFMNEARRHHARLLPVDSEHNAIFQSL
PEPLQRGLGYASLAKHGVSRIVLTGSGGPFRQTPLAALATMTPEQACAHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
AAAEQMEVLLHPQSIIHSMVRYTDGSVLAQLGSPDMRTPIAHAMAYPERVPSGVAPLDFLRLGTLSFAQPDTARYPCLQL
AVDASQQGQAATTTLNAANEIAVAAFLHGDIRFTDIAAVNRRVLEQISLPEPDSVEEVLAIDSQAREKARQSVIHFGQ

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=396, Percent_Identity=69.6969696969697, Blast_Score=556, Evalue=1e-160,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_SODGM (Q2NRL1)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_455619.1
- ProteinModelPortal:   Q2NRL1
- SMR:   Q2NRL1
- STRING:   Q2NRL1
- GeneID:   3867851
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1939
- NMPDR:   fig|343509.6.peg.4193
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   Q2NRL1
- ProtClustDB:   PRK05447
- BioCyc:   SGLO343509:SG1939-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 42423; Mature: 42423

Theoretical pI: Translated: 7.13; Mature: 7.13

Prosite motif: NA

Important sites: BINDING 125-125 BINDING 152-152 BINDING 186-186 BINDING 209-209 BINDING 231-231

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHLTILGSTGSIGNSTLAVVKHNPDQYTVRALVAGNNVALMTEQCLAFRPAYACMADDT
CCEEEEEECCCCCCCCEEEEEEECCCCEEEEEEEECCCEEEEHHHHHHHCCHHHHHCCCH
AARTLKANLAAAGVATAVLSGVQAACELATLDEVDTVMAAIVGAAGLAATLAALRAGKRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LMANKESLVTCGRLFMNEARRHHARLLPVDSEHNAIFQSLPEPLQRGLGYASLAKHGVSR
EEECCHHHHHHHHHHHHHHHHHHCEECCCCCCCHHHHHHCHHHHHHCCCHHHHHHCCCEE
IVLTGSGGPFRQTPLAALATMTPEQACAHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
EEEECCCCCCCCCHHHHHHHCCHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHH
AAAEQMEVLLHPQSIIHSMVRYTDGSVLAQLGSPDMRTPIAHAMAYPERVPSGVAPLDFL
HHHHHHHHHCCCHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHCHHHCCCCCCCHHHH
RLGTLSFAQPDTARYPCLQLAVDASQQGQAATTTLNAANEIAVAAFLHGDIRFTDIAAVN
HHCCCCCCCCCCCCCCHHEEEECCCCCCCCHHEECCCCCHHEEEEEEECCCEEEHHHHHH
RRVLEQISLPEPDSVEEVLAIDSQAREKARQSVIHFGQ
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MRHLTILGSTGSIGNSTLAVVKHNPDQYTVRALVAGNNVALMTEQCLAFRPAYACMADDT
CCEEEEEECCCCCCCCEEEEEEECCCCEEEEEEEECCCEEEEHHHHHHHCCHHHHHCCCH
AARTLKANLAAAGVATAVLSGVQAACELATLDEVDTVMAAIVGAAGLAATLAALRAGKRV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
LMANKESLVTCGRLFMNEARRHHARLLPVDSEHNAIFQSLPEPLQRGLGYASLAKHGVSR
EEECCHHHHHHHHHHHHHHHHHHCEECCCCCCCHHHHHHCHHHHHHCCCHHHHHHCCCEE
IVLTGSGGPFRQTPLAALATMTPEQACAHPNWSMGRKISVDSATMMNKGLEYIEARWLFN
EEEECCCCCCCCCHHHHHHHCCHHHHHCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHH
AAAEQMEVLLHPQSIIHSMVRYTDGSVLAQLGSPDMRTPIAHAMAYPERVPSGVAPLDFL
HHHHHHHHHCCCHHHHHHHHHHCCCHHHHHCCCCCCCCHHHHHHHCHHHCCCCCCCHHHH
RLGTLSFAQPDTARYPCLQLAVDASQQGQAATTTLNAANEIAVAAFLHGDIRFTDIAAVN
HHCCCCCCCCCCCCCCHHEEEECCCCCCCCHHEECCCCCHHEEEEEEECCCEEEHHHHHH
RRVLEQISLPEPDSVEEVLAIDSQAREKARQSVIHFGQ
HHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA