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The map label for this gene is mdtH

Identifier: 85059223

GI number: 85059223

Start: 2103825

End: 2105042

Strand: Reverse

Name: mdtH

Synonym: SG1245

Alternate gene names: 85059223

Gene position: 2105042-2103825 (Counterclockwise)

Preceding gene: 85059226

Following gene: 85059222

Centisome position: 50.47

GC content: 58.87

Gene sequence:

>1218_bases
ATGTCGTCGGTCTCGCAAGCTCGGAGCTTGGGTAAATATTTTCTGTTAATGGATAATATGCTGGTGGTAATGGGCTTTTA
TGTCGTCTTCCCGCTCATTTCCATCCGTTTTGTTGATCAACTTGGCTGGGCCGCGCTGCTGGTGGGCATTGCGCTGGGCC
TGCGACAATTTATCCAGCAGGGGCTGGGGATTTTTGGCGGCGCCTTCGCCGACAGACTGGGGGCGAAGCCGATGATTATC
GCCGGTATGCTGATGCGCGCCCTGGGGTTTGTCTTGATGGGCATCGCCGATGAACCCTGGCTGCTGTGGCTTTCCTGCGC
GCTTTCCGCGCTCGGCGGCACCTTGTTCGATCCGCCCCGGACGGCGCTGGTGATTAAATTGACGCGTCCGTGGGAGCGTG
GCCGCTTCTATTCGCTATTGATGATGCAGGATAGCGCCTGCTCCGTCATCGGCGCGCTGCTCGGCAGTTGGCTGCTGCGC
TATGATTTCAAACTGGTCTGCCTGGCCGGCGCGGTGCTGTTTGTCTTTGCCGCCATCTTCAACGCCTGGCTGCTGCCGGG
TTATCGCATTTCCACCGTGCGGGCGCCCATGCTGGAAGGGATGCGCCGGGTGCTGCGTGACCAGCGTTTTGTCACCTACG
TACTGACCTTGACCGGTTATTACATGCTGTCGGTGCAGGTGATGTTAATGCTGCCGATTCGCATCAATGAGGTTGCCGGA
CAGCCGGCGGCGGTGAAATGGATGTATGCTATCGAAGCAGCGCTGTCGCTGTCGTTGCTCTACCCCATTGCACGCTGGAG
CGAAAAGCGCTTCAGGCTGGAAACCCGGTTGATGGCGGGACTGACCGTTATGCTGTTGAGCCTGTTTCCCATCGGTCTGA
TTGAGGATCTGCGCGCCCTGTTTATGTTGATTGGCCTGTTTTATATTGGTTCAATTATTGCCGAACCCGCGCGTGAAACT
CTGGGCGCCTCGCTGGCGGATAACCGCGCCCGCGGCAGCTACATGGGCTTCAGCAGGCTGGGCCTGGCATTGGGCGGCGC
TATCGGCTATAGCGGCGGCGGCTGGCTGTATGATGTCGGCAACCGGCTGGAGATCCCTCAGCTTCCCTGGTTCATGCTGG
GGCTGATAGGCTTTATCACGCTGCTGGGCTTATATCGTCAATTCCAGCAGCGTCCCATCGAGCCCGCGATGCTTAACGGC
CGCGGCGAAGGCTCCTGA

Upstream 100 bases:

>100_bases
TTCCGCGCTATTAAAAAATATCTAAGCACACTATCGCTAAACAAATATTCCGGTCAGAATAGGCTGTCCTCATAGCCTTT
ATTGCATCTTAGGGTGGAGC

Downstream 100 bases:

>100_bases
CAGCGCGTCTCGTCTTGAGAGGCCTGCGCCGTCTGGACCCGCGCTGCGGTTGATCCCTCGCGTAATGTTACCCATACTTT
AATTTCAAAGTACCCTGTCG

Product: multidrug resistance protein MdtH

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 405; Mature: 404

Protein sequence:

>405_residues
MSSVSQARSLGKYFLLMDNMLVVMGFYVVFPLISIRFVDQLGWAALLVGIALGLRQFIQQGLGIFGGAFADRLGAKPMII
AGMLMRALGFVLMGIADEPWLLWLSCALSALGGTLFDPPRTALVIKLTRPWERGRFYSLLMMQDSACSVIGALLGSWLLR
YDFKLVCLAGAVLFVFAAIFNAWLLPGYRISTVRAPMLEGMRRVLRDQRFVTYVLTLTGYYMLSVQVMLMLPIRINEVAG
QPAAVKWMYAIEAALSLSLLYPIARWSEKRFRLETRLMAGLTVMLLSLFPIGLIEDLRALFMLIGLFYIGSIIAEPARET
LGASLADNRARGSYMGFSRLGLALGGAIGYSGGGWLYDVGNRLEIPQLPWFMLGLIGFITLLGLYRQFQQRPIEPAMLNG
RGEGS

Sequences:

>Translated_405_residues
MSSVSQARSLGKYFLLMDNMLVVMGFYVVFPLISIRFVDQLGWAALLVGIALGLRQFIQQGLGIFGGAFADRLGAKPMII
AGMLMRALGFVLMGIADEPWLLWLSCALSALGGTLFDPPRTALVIKLTRPWERGRFYSLLMMQDSACSVIGALLGSWLLR
YDFKLVCLAGAVLFVFAAIFNAWLLPGYRISTVRAPMLEGMRRVLRDQRFVTYVLTLTGYYMLSVQVMLMLPIRINEVAG
QPAAVKWMYAIEAALSLSLLYPIARWSEKRFRLETRLMAGLTVMLLSLFPIGLIEDLRALFMLIGLFYIGSIIAEPARET
LGASLADNRARGSYMGFSRLGLALGGAIGYSGGGWLYDVGNRLEIPQLPWFMLGLIGFITLLGLYRQFQQRPIEPAMLNG
RGEGS
>Mature_404_residues
SSVSQARSLGKYFLLMDNMLVVMGFYVVFPLISIRFVDQLGWAALLVGIALGLRQFIQQGLGIFGGAFADRLGAKPMIIA
GMLMRALGFVLMGIADEPWLLWLSCALSALGGTLFDPPRTALVIKLTRPWERGRFYSLLMMQDSACSVIGALLGSWLLRY
DFKLVCLAGAVLFVFAAIFNAWLLPGYRISTVRAPMLEGMRRVLRDQRFVTYVLTLTGYYMLSVQVMLMLPIRINEVAGQ
PAAVKWMYAIEAALSLSLLYPIARWSEKRFRLETRLMAGLTVMLLSLFPIGLIEDLRALFMLIGLFYIGSIIAEPARETL
GASLADNRARGSYMGFSRLGLALGGAIGYSGGGWLYDVGNRLEIPQLPWFMLGLIGFITLLGLYRQFQQRPIEPAMLNGR
GEGS

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. DHA1 family. MdtH (TC 2.A.1.2.21) subfamily

Homologues:

Organism=Escherichia coli, GI87081828, Length=391, Percent_Identity=76.7263427109974, Blast_Score=581, Evalue=1e-167,
Organism=Escherichia coli, GI87081738, Length=342, Percent_Identity=23.6842105263158, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MDTH_SODGM (Q2NTK5)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_454925.1
- ProteinModelPortal:   Q2NTK5
- STRING:   Q2NTK5
- GeneID:   3866768
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1245
- NMPDR:   fig|343509.6.peg.2585
- eggNOG:   COG0477
- HOGENOM:   HBG403347
- OMA:   LSMIPIG
- PhylomeDB:   Q2NTK5
- ProtClustDB:   PRK11646
- BioCyc:   SGLO343509:SG1245-MONOMER
- HAMAP:   MF_01529
- InterPro:   IPR020846
- InterPro:   IPR022855
- InterPro:   IPR011701
- InterPro:   IPR016196

Pfam domain/function: PF07690 MFS_1; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 44893; Mature: 44761

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xe762e54)-; HASH(0xc246460)-; HASH(0xae86030)-; HASH(0xf208c70)-; HASH(0xf1fa3d8)-; HASH(0xb02594c)-; HASH(0xed9cbfc)-; HASH(0xd3b442c)-; HASH(0xf226b5c)-; HASH(0xf226db4)-; HASH(0xf2375f8)-; HASH(0xe6d401c)-;

Cys/Met content:

0.7 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCH
>Mature Secondary Structure 
SSVSQARSLGKYFLLMDNMLVVMGFYVVFPLISIRFVDQLGWAALLVGIALGLRQFIQQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GLGIFGGAFADRLGAKPMIIAGMLMRALGFVLMGIADEPWLLWLSCALSALGGTLFDPPR
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCC
TALVIKLTRPWERGRFYSLLMMQDSACSVIGALLGSWLLRYDFKLVCLAGAVLFVFAAIF
CEEEEEEECCCCCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NAWLLPGYRISTVRAPMLEGMRRVLRDQRFVTYVLTLTGYYMLSVQVMLMLPIRINEVAG
HHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCC
QPAAVKWMYAIEAALSLSLLYPIARWSEKRFRLETRLMAGLTVMLLSLFPIGLIEDLRAL
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FMLIGLFYIGSIIAEPARETLGASLADNRARGSYMGFSRLGLALGGAIGYSGGGWLYDVG
HHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEECC
NRLEIPQLPWFMLGLIGFITLLGLYRQFQQRPIEPAMLNGRGEGS
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA