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The map label for this gene is hisD

Identifier: 85059107

GI number: 85059107

Start: 1871356

End: 1872669

Strand: Reverse

Name: hisD

Synonym: SG1129

Alternate gene names: 85059107

Gene position: 1872669-1871356 (Counterclockwise)

Preceding gene: 85059108

Following gene: 85059106

Centisome position: 44.9

GC content: 64.99

Gene sequence:

>1314_bases
ATGACCGCCACAGTTTTTTCCCAACCGGTGCGCTGGCGCGATTGCGATGCGGCCCAACAGGCGCGACTCCTGACCCGTCC
GGCGGTGGATGCCCAGGCGGACATCAGCGCCACCGTCAGCGCCATAGTGCAGCAGGTCCGTCAGGAGGGCGACGCTGCGC
TGCGGGCCTTGAATGCCTGTTTTGACCGCACCGAGACGCCGCAACTGCGCATTACGGATGCGGAGGTGGCGCAAGCCGCC
CAGCGTTTGTCGCCGGCGATTAAGCAGGCGATGGCGGCGGCTGTGGCGAATATCGATACCTTTCACCGCGCCCAGCAGTT
GCCGGAGGTCGATGTGGAAACCCAGCCCGGCGTGCGCTGTCACCAGTTGACCCGGCCGGTGGCCGCGGTGGGGCTCTACA
TACCGGGCGGATCGGCGCCGCTGCTCTCCACGGTGCTGATGCTGGCGACGCCGGCGCGCATCGCCGGCTGCCGGCGGGTG
ATCCTCTGCTCACCGCCGCCCATCGCCGATGAAATTCTGTATGCCGCATCGCTGTGCGGAGTGCAGGACATTTATCAGGT
CGGCGGCGCGCAGGCAATTGCCGCCATGGCGTTCGGCACCGAGACCATCGCCAAGGTCGACAAGATTTTTGGCCCGGGCA
ATGCCTGGGTGACCGAGGCGAAACGCCAGGTCAGCCAGTGCCTGGACGGGGCCGCTATCGATATGCCCGCCGGGCCGTCT
GAAGTGCTTATCATCGCCGATGCTCAGGCCAATCCGGCGTTTGTCGCTGCCGACCTGCTGTCGCAGGCGGAACACGGCCC
CGACTCGCAGGTGATCCTGCTTACCCCCGACGCAAATCTGGCGCAGCGGGTGGCTCGGGAAACCGAACGTCAGTTGCAAT
CACTCTCCCGCGCCGCTATCGCCCACCAGGCGCTGGCCGGCAGCCGTCTTATCATTGCCGCCGATCTGGCCGAATGCGTC
GCCATTAGTAACCGCTATGGACCGGAGCATCTGATTATTCAAACCCGCGATGCGGGGCGCTGGGTAGAGGACATTACCAG
CGCCGGCTCCATTTTCCTCGGCGACTGGTCGCCTGAGTCCGCGGGCGATTACGCCTCCGGCACCAATCAAGTCCTGCCGA
CCTATGGTTATACCACCACCTGTTCCAGCCTGGGGCTGGCGGATTTCCAAAAACGGATGACGGTGCAAGAACTTACCCCC
GCCGGTCTGCTGGCACTGGCGCCGACGGTTGAAACCCTGGCGCAGGCCGAGCGCCTGACCGCACACAAAAACGCCATCAC
ACTGCGCGTTGCCGCGCTCAAGGAGCCGCAATGA

Upstream 100 bases:

>100_bases
GCAGCGAAACCCTGTTCTGGGAGACCATGGAAAATCTGAAGGCCCTCGGCGCCAGCTCGATTCTGGTGTTGCCCATTGAA
AAGATGATGGAGTGAGAACC

Downstream 100 bases:

>100_bases
GCATTCATCACTTAGCCCGCGCCAACGTGCTGGCGCTGGAGCCTTATCTCTCCGCGCGCCGGCTGGGCGGCCAAGGCAAT
ATTTGGCTGAACGCCAATGA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 437; Mature: 436

Protein sequence:

>437_residues
MTATVFSQPVRWRDCDAAQQARLLTRPAVDAQADISATVSAIVQQVRQEGDAALRALNACFDRTETPQLRITDAEVAQAA
QRLSPAIKQAMAAAVANIDTFHRAQQLPEVDVETQPGVRCHQLTRPVAAVGLYIPGGSAPLLSTVLMLATPARIAGCRRV
ILCSPPPIADEILYAASLCGVQDIYQVGGAQAIAAMAFGTETIAKVDKIFGPGNAWVTEAKRQVSQCLDGAAIDMPAGPS
EVLIIADAQANPAFVAADLLSQAEHGPDSQVILLTPDANLAQRVARETERQLQSLSRAAIAHQALAGSRLIIAADLAECV
AISNRYGPEHLIIQTRDAGRWVEDITSAGSIFLGDWSPESAGDYASGTNQVLPTYGYTTTCSSLGLADFQKRMTVQELTP
AGLLALAPTVETLAQAERLTAHKNAITLRVAALKEPQ

Sequences:

>Translated_437_residues
MTATVFSQPVRWRDCDAAQQARLLTRPAVDAQADISATVSAIVQQVRQEGDAALRALNACFDRTETPQLRITDAEVAQAA
QRLSPAIKQAMAAAVANIDTFHRAQQLPEVDVETQPGVRCHQLTRPVAAVGLYIPGGSAPLLSTVLMLATPARIAGCRRV
ILCSPPPIADEILYAASLCGVQDIYQVGGAQAIAAMAFGTETIAKVDKIFGPGNAWVTEAKRQVSQCLDGAAIDMPAGPS
EVLIIADAQANPAFVAADLLSQAEHGPDSQVILLTPDANLAQRVARETERQLQSLSRAAIAHQALAGSRLIIAADLAECV
AISNRYGPEHLIIQTRDAGRWVEDITSAGSIFLGDWSPESAGDYASGTNQVLPTYGYTTTCSSLGLADFQKRMTVQELTP
AGLLALAPTVETLAQAERLTAHKNAITLRVAALKEPQ
>Mature_436_residues
TATVFSQPVRWRDCDAAQQARLLTRPAVDAQADISATVSAIVQQVRQEGDAALRALNACFDRTETPQLRITDAEVAQAAQ
RLSPAIKQAMAAAVANIDTFHRAQQLPEVDVETQPGVRCHQLTRPVAAVGLYIPGGSAPLLSTVLMLATPARIAGCRRVI
LCSPPPIADEILYAASLCGVQDIYQVGGAQAIAAMAFGTETIAKVDKIFGPGNAWVTEAKRQVSQCLDGAAIDMPAGPSE
VLIIADAQANPAFVAADLLSQAEHGPDSQVILLTPDANLAQRVARETERQLQSLSRAAIAHQALAGSRLIIAADLAECVA
ISNRYGPEHLIIQTRDAGRWVEDITSAGSIFLGDWSPESAGDYASGTNQVLPTYGYTTTCSSLGLADFQKRMTVQELTPA
GLLALAPTVETLAQAERLTAHKNAITLRVAALKEPQ

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=430, Percent_Identity=72.3255813953488, Blast_Score=640, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319819, Length=449, Percent_Identity=43.2071269487751, Blast_Score=338, Evalue=9e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 46253; Mature: 46122

Theoretical pI: Translated: 4.98; Mature: 4.98

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTATVFSQPVRWRDCDAAQQARLLTRPAVDAQADISATVSAIVQQVRQEGDAALRALNAC
CCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDRTETPQLRITDAEVAQAAQRLSPAIKQAMAAAVANIDTFHRAQQLPEVDVETQPGVRC
HCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
HQLTRPVAAVGLYIPGGSAPLLSTVLMLATPARIAGCRRVILCSPPPIADEILYAASLCG
HHHHCCHHHEEEEECCCCCHHHHHHHHHHCCHHHHCCCEEEEECCCCHHHHHHHHHHHHC
VQDIYQVGGAQAIAAMAFGTETIAKVDKIFGPGNAWVTEAKRQVSQCLDGAAIDMPAGPS
HHHHHHHCCHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEECCCCCCC
EVLIIADAQANPAFVAADLLSQAEHGPDSQVILLTPDANLAQRVARETERQLQSLSRAAI
CEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
AHQALAGSRLIIAADLAECVAISNRYGPEHLIIQTRDAGRWVEDITSAGSIFLGDWSPES
HHHHHCCCEEEEEHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHCCCCEEEECCCCCC
AGDYASGTNQVLPTYGYTTTCSSLGLADFQKRMTVQELTPAGLLALAPTVETLAQAERLT
CCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AHKNAITLRVAALKEPQ
HHCCEEEEEEECCCCCC
>Mature Secondary Structure 
TATVFSQPVRWRDCDAAQQARLLTRPAVDAQADISATVSAIVQQVRQEGDAALRALNAC
CCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
FDRTETPQLRITDAEVAQAAQRLSPAIKQAMAAAVANIDTFHRAQQLPEVDVETQPGVRC
HCCCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHH
HQLTRPVAAVGLYIPGGSAPLLSTVLMLATPARIAGCRRVILCSPPPIADEILYAASLCG
HHHHCCHHHEEEEECCCCCHHHHHHHHHHCCHHHHCCCEEEEECCCCHHHHHHHHHHHHC
VQDIYQVGGAQAIAAMAFGTETIAKVDKIFGPGNAWVTEAKRQVSQCLDGAAIDMPAGPS
HHHHHHHCCHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEECCCCCCC
EVLIIADAQANPAFVAADLLSQAEHGPDSQVILLTPDANLAQRVARETERQLQSLSRAAI
CEEEEEECCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHH
AHQALAGSRLIIAADLAECVAISNRYGPEHLIIQTRDAGRWVEDITSAGSIFLGDWSPES
HHHHHCCCEEEEEHHHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHCCCCEEEECCCCCC
AGDYASGTNQVLPTYGYTTTCSSLGLADFQKRMTVQELTPAGLLALAPTVETLAQAERLT
CCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHH
AHKNAITLRVAALKEPQ
HHCCEEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA