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The map label for this gene is hisG

Identifier: 85059108

GI number: 85059108

Start: 1872675

End: 1873574

Strand: Reverse

Name: hisG

Synonym: SG1130

Alternate gene names: 85059108

Gene position: 1873574-1872675 (Counterclockwise)

Preceding gene: 85059110

Following gene: 85059107

Centisome position: 44.92

GC content: 56.56

Gene sequence:

>900_bases
ATGTTGGACAAATCACGGTTACGGATAGCAATGCAGAAATCAGGCCGGTTAAGCAAAGAATCGCAGCAGTTGCTGGAACA
ATGCGGCATAAAAATCAATCTGCAACAGCAGCGCCTGCTGGCCTTTGCGGAAAATATGCCAATTGATATCATGCGAGTGC
GCGACGACGATATCCCGGGTCTGGTGATGGACGACGTGGTGGACCTCGGCATCATCGGCGAGAACGTATTGGAAGAGGAA
TTGCTGACCCGCCGCGCCCAGGGAGAAGATCCCCGTTACTTTACCCTGCGCCAGCTGGACTTCGGCGGTTGTCGACTGTC
GATAGCACTGCTACTGGACACCCCCTGGACCGGTCCCGAATGCCTGCGTGGCAAACGCATCGCCACCTCCTATCCGCATT
TGTTAAAACAGTACCTGGATAAACTCGATATCACCTTCAAGTCCTGTCTGCTGAACGGTTCGGTAGAGGTCGCACCGCGC
GCCGGTCTTGCCGATGCCATCTGCGATTTGGTGTCCACCGGCGCCACCCTTGAGGCCAACGGATTGCGCGAGGCGGAGGT
AATTTATCGCTCCAAGGCCTGCCTTATCCAGCGCGACGGCGAACTGTCGGTGGCGAAACAATCGCTGGTGGATAAGCTCC
TTATCCGTATTCAAGGAGTTATCCAGGCCCGGGAATCGAAATACATCATGATGCACGCCCCCACCGAGCGGCTGGATGAC
ATCATCAGTCTGCTGACCGGCGCGGAGCAGCCGACCATCCTGCCGCTGGCGGGGGATCAACACCGTGTGGCGATGCACAT
GGTCAGCAGCGAAACCCTGTTCTGGGAGACCATGGAAAATCTGAAGGCCCTCGGCGCCAGCTCGATTCTGGTGTTGCCCA
TTGAAAAGATGATGGAGTGA

Upstream 100 bases:

>100_bases
ATCTTCCAGTGGCGCAAGAATGTTCAGAGAGAGCCCTCGGAAGATTTCTTCCGAGGGCTTTTTGGCTTGGATAAATAATT
CAGTTACGGCAGAGGACATC

Downstream 100 bases:

>100_bases
GAACCATGACCGCCACAGTTTTTTCCCAACCGGTGCGCTGGCGCGATTGCGATGCGGCCCAACAGGCGCGACTCCTGACC
CGTCCGGCGGTGGATGCCCA

Product: ATP phosphoribosyltransferase

Products: NA

Alternate protein names: ATP-PRT; ATP-PRTase

Number of amino acids: Translated: 299; Mature: 299

Protein sequence:

>299_residues
MLDKSRLRIAMQKSGRLSKESQQLLEQCGIKINLQQQRLLAFAENMPIDIMRVRDDDIPGLVMDDVVDLGIIGENVLEEE
LLTRRAQGEDPRYFTLRQLDFGGCRLSIALLLDTPWTGPECLRGKRIATSYPHLLKQYLDKLDITFKSCLLNGSVEVAPR
AGLADAICDLVSTGATLEANGLREAEVIYRSKACLIQRDGELSVAKQSLVDKLLIRIQGVIQARESKYIMMHAPTERLDD
IISLLTGAEQPTILPLAGDQHRVAMHMVSSETLFWETMENLKALGASSILVLPIEKMME

Sequences:

>Translated_299_residues
MLDKSRLRIAMQKSGRLSKESQQLLEQCGIKINLQQQRLLAFAENMPIDIMRVRDDDIPGLVMDDVVDLGIIGENVLEEE
LLTRRAQGEDPRYFTLRQLDFGGCRLSIALLLDTPWTGPECLRGKRIATSYPHLLKQYLDKLDITFKSCLLNGSVEVAPR
AGLADAICDLVSTGATLEANGLREAEVIYRSKACLIQRDGELSVAKQSLVDKLLIRIQGVIQARESKYIMMHAPTERLDD
IISLLTGAEQPTILPLAGDQHRVAMHMVSSETLFWETMENLKALGASSILVLPIEKMME
>Mature_299_residues
MLDKSRLRIAMQKSGRLSKESQQLLEQCGIKINLQQQRLLAFAENMPIDIMRVRDDDIPGLVMDDVVDLGIIGENVLEEE
LLTRRAQGEDPRYFTLRQLDFGGCRLSIALLLDTPWTGPECLRGKRIATSYPHLLKQYLDKLDITFKSCLLNGSVEVAPR
AGLADAICDLVSTGATLEANGLREAEVIYRSKACLIQRDGELSVAKQSLVDKLLIRIQGVIQARESKYIMMHAPTERLDD
IISLLTGAEQPTILPLAGDQHRVAMHMVSSETLFWETMENLKALGASSILVLPIEKMME

Specific function: Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic

COG id: COG0040

COG function: function code E; ATP phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP phosphoribosyltransferase family. Long subfamily

Homologues:

Organism=Escherichia coli, GI1788330, Length=299, Percent_Identity=84.2809364548495, Blast_Score=516, Evalue=1e-147,
Organism=Saccharomyces cerevisiae, GI6320896, Length=298, Percent_Identity=29.5302013422819, Blast_Score=114, Evalue=1e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS1_SODGM (Q2NTX0)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_454810.1
- HSSP:   Q02129
- ProteinModelPortal:   Q2NTX0
- SMR:   Q2NTX0
- STRING:   Q2NTX0
- GeneID:   3867558
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1130
- NMPDR:   fig|343509.6.peg.2313
- eggNOG:   COG0040
- HOGENOM:   HBG391868
- OMA:   YLRPRDI
- PhylomeDB:   Q2NTX0
- ProtClustDB:   PRK00489
- BioCyc:   SGLO343509:SG1130-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00079
- InterPro:   IPR001348
- InterPro:   IPR013820
- InterPro:   IPR018198
- InterPro:   IPR020621
- InterPro:   IPR013115
- InterPro:   IPR011322
- InterPro:   IPR015867
- Gene3D:   G3DSA:3.30.70.120
- PANTHER:   PTHR21403
- TIGRFAMs:   TIGR00070
- TIGRFAMs:   TIGR03455

Pfam domain/function: PF01634 HisG; PF08029 HisG_C; SSF54913 N-reg_PII-like_a/b

EC number: =2.4.2.17

Molecular weight: Translated: 33416; Mature: 33416

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS01316 ATP_P_PHORIBOSYLTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
4.0 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDKSRLRIAMQKSGRLSKESQQLLEQCGIKINLQQQRLLAFAENMPIDIMRVRDDDIPG
CCCHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHCCCCEEEEEECCCCCCC
LVMDDVVDLGIIGENVLEEELLTRRAQGEDPRYFTLRQLDFGGCRLSIALLLDTPWTGPE
HHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEEEECCCCCHH
CLRGKRIATSYPHLLKQYLDKLDITFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEAN
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHCCCEEECC
GLREAEVIYRSKACLIQRDGELSVAKQSLVDKLLIRIQGVIQARESKYIMMHAPTERLDD
CCCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
IISLLTGAEQPTILPLAGDQHRVAMHMVSSETLFWETMENLKALGASSILVLPIEKMME
HHHHHHCCCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEHHHHCC
>Mature Secondary Structure
MLDKSRLRIAMQKSGRLSKESQQLLEQCGIKINLQQQRLLAFAENMPIDIMRVRDDDIPG
CCCHHHHHHHHHHCCCCCHHHHHHHHHCCCEEEEHHHHHHHHHCCCCEEEEEECCCCCCC
LVMDDVVDLGIIGENVLEEELLTRRAQGEDPRYFTLRQLDFGGCRLSIALLLDTPWTGPE
HHHHHHHHHHHHCHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCEEEEEEEEECCCCCHH
CLRGKRIATSYPHLLKQYLDKLDITFKSCLLNGSVEVAPRAGLADAICDLVSTGATLEAN
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCHHHHHHHHHHCCCEEECC
GLREAEVIYRSKACLIQRDGELSVAKQSLVDKLLIRIQGVIQARESKYIMMHAPTERLDD
CCCHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHH
IISLLTGAEQPTILPLAGDQHRVAMHMVSSETLFWETMENLKALGASSILVLPIEKMME
HHHHHHCCCCCEEEEECCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCEEEEEHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA