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The map label for this gene is hisC

Identifier: 85059106

GI number: 85059106

Start: 1870277

End: 1871359

Strand: Reverse

Name: hisC

Synonym: SG1128

Alternate gene names: 85059106

Gene position: 1871359-1870277 (Counterclockwise)

Preceding gene: 85059107

Following gene: 85059105

Centisome position: 44.86

GC content: 60.57

Gene sequence:

>1083_bases
ATGAGCATTCATCACTTAGCCCGCGCCAACGTGCTGGCGCTGGAGCCTTATCTCTCCGCGCGCCGGCTGGGCGGCCAAGG
CAATATTTGGCTGAACGCCAATGAGTATCCCCTTCCGCCGGGGTACGGGTTGCGCGGCGGCAATCTCAACCGCTATCCTG
CCTGTCAACCGGCCGGCGTTATCAACGGTTATGCAGCCTACGCGGGTGTACAGCCGGAGCAGGTGGTAGTTTGCCGCGGC
GCCGATGAGGGCATAGAGTTACTCATCCGCGCGTTTTGCGAGCCGGGCGCCGATGCCATTCTGTTTTGCCCGCCCACCTA
CGGCATGTATAGCGTCAGCGCCGAAACGTTCGGCATCGCGCGCCGCACGGTTGAGGCCCGTCAGGACTGGCAGCTGGATC
TGCAGGCGATTCGCGCGCGGCTCGACGGCGTGAAGCTGGTGTATATTTGCAGCCCCAACAACCCCACCGGCAACCTGATA
GACCTCGAGACGCTACGCGCGATGCTGGAAATGACCCACGGCCGCGCGCTGCTGGTGGTCGATGAAGCCTATATCGATTT
TTGCCCGCAGGCGAGCGTGGTGAACTGGCTCGCCGAATACCCGCATCTGGTCATTCTGCGTACCCTGTCCAAGGCCTTCG
CCCTGGCCGGTCTGCGCTGCGGTTTTGTCCTGGCGAATGTCGAGGTGATTCAACTGTTGTTAAAAGTCATAGCCCCCTAC
CCGCTGGCGCTGCCGGTGGCGGATATCGCCGAGCAGGCGCTTTCGGACGAGGGATTGCGGCAAATGCGGACGCGGGTGGC
AGAGATCAACACCAACCGCGAGACGCTGGCGCATGGGTTGGCGGATTGCCCTTGTATTTGCGCGGTGTATCCCAGCGTCA
GCAATTATTTGCTGGTCCGGTGCGATCCGGCCTATCGGGTGTTCAAAACCCTCTGGGATCAGGGTACGATTTTACGCGAT
CAAAGCAAACAACCGGGCTTGGCCGATTGTTTGCGTATTACCATCGGCACTTTGGCGGAGTGCCAGAGCGTGATTGCAGT
GTTAAGGGCGTTGAAACCCTCTTCCAGCAAGGAGTCCCTGTGA

Upstream 100 bases:

>100_bases
TGGCACTGGCGCCGACGGTTGAAACCCTGGCGCAGGCCGAGCGCCTGACCGCACACAAAAACGCCATCACACTGCGCGTT
GCCGCGCTCAAGGAGCCGCA

Downstream 100 bases:

>100_bases
ATCAGAAAGTCCTGTTTATCGATCGTGATGGCACGCTCATCAACGAACCCCCCGCGGATTTCCAGGTGGACCGCATGGAT
AAGTTGGCGCTGGAGCCAGG

Product: histidinol-phosphate aminotransferase HisC

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase

Number of amino acids: Translated: 360; Mature: 359

Protein sequence:

>360_residues
MSIHHLARANVLALEPYLSARRLGGQGNIWLNANEYPLPPGYGLRGGNLNRYPACQPAGVINGYAAYAGVQPEQVVVCRG
ADEGIELLIRAFCEPGADAILFCPPTYGMYSVSAETFGIARRTVEARQDWQLDLQAIRARLDGVKLVYICSPNNPTGNLI
DLETLRAMLEMTHGRALLVVDEAYIDFCPQASVVNWLAEYPHLVILRTLSKAFALAGLRCGFVLANVEVIQLLLKVIAPY
PLALPVADIAEQALSDEGLRQMRTRVAEINTNRETLAHGLADCPCICAVYPSVSNYLLVRCDPAYRVFKTLWDQGTILRD
QSKQPGLADCLRITIGTLAECQSVIAVLRALKPSSSKESL

Sequences:

>Translated_360_residues
MSIHHLARANVLALEPYLSARRLGGQGNIWLNANEYPLPPGYGLRGGNLNRYPACQPAGVINGYAAYAGVQPEQVVVCRG
ADEGIELLIRAFCEPGADAILFCPPTYGMYSVSAETFGIARRTVEARQDWQLDLQAIRARLDGVKLVYICSPNNPTGNLI
DLETLRAMLEMTHGRALLVVDEAYIDFCPQASVVNWLAEYPHLVILRTLSKAFALAGLRCGFVLANVEVIQLLLKVIAPY
PLALPVADIAEQALSDEGLRQMRTRVAEINTNRETLAHGLADCPCICAVYPSVSNYLLVRCDPAYRVFKTLWDQGTILRD
QSKQPGLADCLRITIGTLAECQSVIAVLRALKPSSSKESL
>Mature_359_residues
SIHHLARANVLALEPYLSARRLGGQGNIWLNANEYPLPPGYGLRGGNLNRYPACQPAGVINGYAAYAGVQPEQVVVCRGA
DEGIELLIRAFCEPGADAILFCPPTYGMYSVSAETFGIARRTVEARQDWQLDLQAIRARLDGVKLVYICSPNNPTGNLID
LETLRAMLEMTHGRALLVVDEAYIDFCPQASVVNWLAEYPHLVILRTLSKAFALAGLRCGFVLANVEVIQLLLKVIAPYP
LALPVADIAEQALSDEGLRQMRTRVAEINTNRETLAHGLADCPCICAVYPSVSNYLLVRCDPAYRVFKTLWDQGTILRDQ
SKQPGLADCLRITIGTLAECQSVIAVLRALKPSSSKESL

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily

Homologues:

Organism=Escherichia coli, GI1788332, Length=350, Percent_Identity=66, Blast_Score=476, Evalue=1e-136,
Organism=Saccharomyces cerevisiae, GI6322075, Length=379, Percent_Identity=32.4538258575198, Blast_Score=162, Evalue=7e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS8_SODGM (Q2NTX2)

Other databases:

- EMBL:   AP008232
- RefSeq:   YP_454808.1
- ProteinModelPortal:   Q2NTX2
- SMR:   Q2NTX2
- STRING:   Q2NTX2
- GeneID:   3867556
- GenomeReviews:   AP008232_GR
- KEGG:   sgl:SG1128
- NMPDR:   fig|343509.6.peg.2311
- eggNOG:   COG0079
- HOGENOM:   HBG646350
- OMA:   FKTLWDQ
- PhylomeDB:   Q2NTX2
- BioCyc:   SGLO343509:SG1128-MONOMER
- HAMAP:   MF_01023
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.9

Molecular weight: Translated: 39380; Mature: 39249

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.6 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
3.6 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIHHLARANVLALEPYLSARRLGGQGNIWLNANEYPLPPGYGLRGGNLNRYPACQPAGV
CCCCHHHHCCEEEECCHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
INGYAAYAGVQPEQVVVCRGADEGIELLIRAFCEPGADAILFCPPTYGMYSVSAETFGIA
CCCHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEEECHHHHHHH
RRTVEARQDWQLDLQAIRARLDGVKLVYICSPNNPTGNLIDLETLRAMLEMTHGRALLVV
HHHHHHHHCHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEEHHHHHHHHHHCCCCEEEEE
DEAYIDFCPQASVVNWLAEYPHLVILRTLSKAFALAGLRCGFVLANVEVIQLLLKVIAPY
EHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PLALPVADIAEQALSDEGLRQMRTRVAEINTNRETLAHGLADCPCICAVYPSVSNYLLVR
CCCCCHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEECCCCCCEEEEE
CDPAYRVFKTLWDQGTILRDQSKQPGLADCLRITIGTLAECQSVIAVLRALKPSSSKESL
ECHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure 
SIHHLARANVLALEPYLSARRLGGQGNIWLNANEYPLPPGYGLRGGNLNRYPACQPAGV
CCCHHHHCCEEEECCHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCC
INGYAAYAGVQPEQVVVCRGADEGIELLIRAFCEPGADAILFCPPTYGMYSVSAETFGIA
CCCHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCEEEECCCCCCEEEECHHHHHHH
RRTVEARQDWQLDLQAIRARLDGVKLVYICSPNNPTGNLIDLETLRAMLEMTHGRALLVV
HHHHHHHHCHHHHHHHHHHHHCCEEEEEEECCCCCCCCEEEHHHHHHHHHHCCCCEEEEE
DEAYIDFCPQASVVNWLAEYPHLVILRTLSKAFALAGLRCGFVLANVEVIQLLLKVIAPY
EHHHHCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
PLALPVADIAEQALSDEGLRQMRTRVAEINTNRETLAHGLADCPCICAVYPSVSNYLLVR
CCCCCHHHHHHHHHCHHHHHHHHHHHHHCCCCHHHHHHCCCCCCEEEEECCCCCCEEEEE
CDPAYRVFKTLWDQGTILRDQSKQPGLADCLRITIGTLAECQSVIAVLRALKPSSSKESL
ECHHHHHHHHHHCCCCEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA