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The map label for this gene is sdaC [H]

Identifier: 85058900

GI number: 85058900

Start: 1509311

End: 1510594

Strand: Reverse

Name: sdaC [H]

Synonym: SG0922

Alternate gene names: 85058900

Gene position: 1510594-1509311 (Counterclockwise)

Preceding gene: 85058901

Following gene: 85058898

Centisome position: 36.22

GC content: 53.27

Gene sequence:

>1284_bases
ATGGACATAACAAAAGCTTCCCCCGCACGGGCGATCCCGTCCGATGCGTCCTGGCGTAAAACTGATACGGTCTGGATGTT
GGGGCTATATGGCACGGCGATTGGCGCCGGCGTGCTATTTTTACCCATCAATGCAGGTATCGGCGGGCTTCTGCCACTGC
TTATAATGGCGCTTATCGCCTTTCCCATGACCTTTTTCGCCCATCGGGGCATGACGCGTTTTGTGCTGTCGGGCAACGGC
AAATGCAATGACATTACCGATGTCGTCAAGGAACATTTCGGCAACCGCGTCGGTAACCTGATTACGCTGCTGTACTTTTT
CGCTATCTATCCCATCCTGCTGGTTTACAGCGTCGCCATCACCAATACCGTCGAGAGTTTTATCGTACATCAGCTAGGTT
ACAACGCGCCGCCGCGGGCGTTATTGGCGCTGCTGCTGATAGTCGGGCTGATGATGATCATCTGGCTTGGCAAGGACATT
ATTGTGAAGTCCATGAGCGTTCTGGTGTTCCCGTTTGTGGCGGTACTGGTGTTTTTGTCGTTTTATCTCATTCCGTACTG
GAGCGGCGCAATTTTCCATTCCCCGCTGGTGCAGCCCCAGGCCGACGGCGGCGGACTGCTCAGCACCCTGTGGCTGGCGG
TGCCGGTCATGGTGTTTTCGTTTAATCATTCCCCCATTATCTCCTCATTCGCGATGTCAAAACGCGAAGAATATGGCGAA
GGGGCCGAGGCAAAATGCGCCCGCGTTTTGGCCTGTAGCCACGTAATGATGGTGCTGACGGTAATGTTTTTCGTTTTTAG
CTGCGCCCTTAGCCTCTCGCCGGAAAACATGCAGGAAGCCAAAGATCAAAATATATCCATGCTGTCGTACCTTGCCAACC
ACTTTGATAATCCGTTCATCGCCTCACTGGGGCCGATTATCGCTTTGGTGGCTATTGCCAAATCATTTCTCGGCCACTAT
CTCGGCGCTAGTGAAGGTTTTAGTGGGCTGGTAACCTCGGCATTACAGGCCCGCGGCAAGGAAATTTCCGCCAGCACGAT
GAGCAAGGTCACCGCCGTATTCATGCTGCTGACCGCCTGGCTGGTGGCCACCATTAACCCCAGCATTTTGGGGATGATTG
AAACCCTGGGCGGCCCCATCATTGCCATGCTGCTGTTTTTAATGCCGATGTACGCTATTCATAAAGTGCCCGCCATGACG
CGCTACCGCGGTTTGGCAAGTAATTACTTCGTTTGGGCGATTGGGCTTATCGCACTGACCGGGACAATTTACAAGCTGAT
GTAA

Upstream 100 bases:

>100_bases
ACATATAATTGAACAACATAAATATAATCATATTAAACAGAGTAACGGCGACGGCTATTATCAATCACCGGTCAGCCTTT
GCATTATATTCGGAGAATTT

Downstream 100 bases:

>100_bases
TAATAAACGCGTCCGGCGTCCGGCGACAGTCCTGCCACCCCGGTGGCGTAGCGCCGGTGGCTTCGGGTGTGATGCAGTAA
CGGCGCCCACAGCAAAAGCG

Product: serine transport protein

Products: Proton [Cytoplasm]; D-serine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MDITKASPARAIPSDASWRKTDTVWMLGLYGTAIGAGVLFLPINAGIGGLLPLLIMALIAFPMTFFAHRGMTRFVLSGNG
KCNDITDVVKEHFGNRVGNLITLLYFFAIYPILLVYSVAITNTVESFIVHQLGYNAPPRALLALLLIVGLMMIIWLGKDI
IVKSMSVLVFPFVAVLVFLSFYLIPYWSGAIFHSPLVQPQADGGGLLSTLWLAVPVMVFSFNHSPIISSFAMSKREEYGE
GAEAKCARVLACSHVMMVLTVMFFVFSCALSLSPENMQEAKDQNISMLSYLANHFDNPFIASLGPIIALVAIAKSFLGHY
LGASEGFSGLVTSALQARGKEISASTMSKVTAVFMLLTAWLVATINPSILGMIETLGGPIIAMLLFLMPMYAIHKVPAMT
RYRGLASNYFVWAIGLIALTGTIYKLM

Sequences:

>Translated_427_residues
MDITKASPARAIPSDASWRKTDTVWMLGLYGTAIGAGVLFLPINAGIGGLLPLLIMALIAFPMTFFAHRGMTRFVLSGNG
KCNDITDVVKEHFGNRVGNLITLLYFFAIYPILLVYSVAITNTVESFIVHQLGYNAPPRALLALLLIVGLMMIIWLGKDI
IVKSMSVLVFPFVAVLVFLSFYLIPYWSGAIFHSPLVQPQADGGGLLSTLWLAVPVMVFSFNHSPIISSFAMSKREEYGE
GAEAKCARVLACSHVMMVLTVMFFVFSCALSLSPENMQEAKDQNISMLSYLANHFDNPFIASLGPIIALVAIAKSFLGHY
LGASEGFSGLVTSALQARGKEISASTMSKVTAVFMLLTAWLVATINPSILGMIETLGGPIIAMLLFLMPMYAIHKVPAMT
RYRGLASNYFVWAIGLIALTGTIYKLM
>Mature_427_residues
MDITKASPARAIPSDASWRKTDTVWMLGLYGTAIGAGVLFLPINAGIGGLLPLLIMALIAFPMTFFAHRGMTRFVLSGNG
KCNDITDVVKEHFGNRVGNLITLLYFFAIYPILLVYSVAITNTVESFIVHQLGYNAPPRALLALLLIVGLMMIIWLGKDI
IVKSMSVLVFPFVAVLVFLSFYLIPYWSGAIFHSPLVQPQADGGGLLSTLWLAVPVMVFSFNHSPIISSFAMSKREEYGE
GAEAKCARVLACSHVMMVLTVMFFVFSCALSLSPENMQEAKDQNISMLSYLANHFDNPFIASLGPIIALVAIAKSFLGHY
LGASEGFSGLVTSALQARGKEISASTMSKVTAVFMLLTAWLVATINPSILGMIETLGGPIIAMLLFLMPMYAIHKVPAMT
RYRGLASNYFVWAIGLIALTGTIYKLM

Specific function: Involved in the import of serine into the cell. May be required for phage C1 adsorption by interacting with DrcB. May also be involved in ampicillin sensitivity [H]

COG id: COG0814

COG function: function code E; Amino acid permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid/polyamine transporter 2 family. SdaC/TdcC subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789160, Length=427, Percent_Identity=66.9789227166276, Blast_Score=572, Evalue=1e-164,
Organism=Escherichia coli, GI1789504, Length=440, Percent_Identity=47.9545454545455, Blast_Score=395, Evalue=1e-111,
Organism=Escherichia coli, GI1789211, Length=393, Percent_Identity=37.6590330788804, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI145693183, Length=432, Percent_Identity=27.5462962962963, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1789961, Length=394, Percent_Identity=25.6345177664975, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004694
- InterPro:   IPR018227 [H]

Pfam domain/function: PF03222 Trp_Tyr_perm [H]

EC number: NA

Molecular weight: Translated: 46421; Mature: 46421

Theoretical pI: Translated: 9.00; Mature: 9.00

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
5.4 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDITKASPARAIPSDASWRKTDTVWMLGLYGTAIGAGVLFLPINAGIGGLLPLLIMALIA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHH
FPMTFFAHRGMTRFVLSGNGKCNDITDVVKEHFGNRVGNLITLLYFFAIYPILLVYSVAI
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNTVESFIVHQLGYNAPPRALLALLLIVGLMMIIWLGKDIIVKSMSVLVFPFVAVLVFLS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
FYLIPYWSGAIFHSPLVQPQADGGGLLSTLWLAVPVMVFSFNHSPIISSFAMSKREEYGE
HHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
GAEAKCARVLACSHVMMVLTVMFFVFSCALSLSPENMQEAKDQNISMLSYLANHFDNPFI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCCHH
ASLGPIIALVAIAKSFLGHYLGASEGFSGLVTSALQARGKEISASTMSKVTAVFMLLTAW
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LVATINPSILGMIETLGGPIIAMLLFLMPMYAIHKVPAMTRYRGLASNYFVWAIGLIALT
HHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
GTIYKLM
HHHHHCC
>Mature Secondary Structure
MDITKASPARAIPSDASWRKTDTVWMLGLYGTAIGAGVLFLPINAGIGGLLPLLIMALIA
CCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHHHHH
FPMTFFAHRGMTRFVLSGNGKCNDITDVVKEHFGNRVGNLITLLYFFAIYPILLVYSVAI
HHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TNTVESFIVHQLGYNAPPRALLALLLIVGLMMIIWLGKDIIVKSMSVLVFPFVAVLVFLS
HHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
FYLIPYWSGAIFHSPLVQPQADGGGLLSTLWLAVPVMVFSFNHSPIISSFAMSKREEYGE
HHHHHHHCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
GAEAKCARVLACSHVMMVLTVMFFVFSCALSLSPENMQEAKDQNISMLSYLANHFDNPFI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHHHHHCCCCHH
ASLGPIIALVAIAKSFLGHYLGASEGFSGLVTSALQARGKEISASTMSKVTAVFMLLTAW
HHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
LVATINPSILGMIETLGGPIIAMLLFLMPMYAIHKVPAMTRYRGLASNYFVWAIGLIALT
HHHHCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHHH
GTIYKLM
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; D-serine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + D-serine [Periplasm] = Proton [Cytoplasm] + D-serine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]