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The map label for this gene is grxA

Identifier: 85058901

GI number: 85058901

Start: 1512553

End: 1512819

Strand: Reverse

Name: grxA

Synonym: SG0923

Alternate gene names: 85058901

Gene position: 1512819-1512553 (Counterclockwise)

Preceding gene: 85058907

Following gene: 85058900

Centisome position: 36.27

GC content: 48.31

Gene sequence:

>267_bases
ATGTTTGCAGTCATTTTCGGTCGTCCGGGTTGTCCTTATTGTGTACGTGCTAAATCGCTGGCTGAAAAACTGACCGCGGA
ACGGGATGACTTCACCTACCGTTATATTGATATCCACGCCGAAGGCATCTCGAAAACCGACCTGTCGAAAACCGTCGGTA
AGCTGGTGGAAACGGTACCGCAGATTTTTGTCGATCAGATCCATATCGGCGGCTGTACTGATTTTGAAGCTTACGCCAAA
GAAAACCTAAGCCTGTACTCATCCTGA

Upstream 100 bases:

>100_bases
CTTTTTTTACCCGCCGGGGCAGGCATAGTGATCCGCGGCAAAAAAAGCAGCGCGCCACGCGCTTGCCGTTACGATATTCG
CTAATGTATGAGGAGTGGTT

Downstream 100 bases:

>100_bases
CAACGGCTAGAGCGCCCGTCGCTGGCGGGCCGCATGGGCTGAACGAACGTTACCGCTTACCCCGTCAACCGCAGGCTCAA
TGCACCGGATGGTGCATCAG

Product: glutaredoxin 1

Products: deoxyribonucleotides [C]

Alternate protein names: Grx1 [H]

Number of amino acids: Translated: 88; Mature: 88

Protein sequence:

>88_residues
MFAVIFGRPGCPYCVRAKSLAEKLTAERDDFTYRYIDIHAEGISKTDLSKTVGKLVETVPQIFVDQIHIGGCTDFEAYAK
ENLSLYSS

Sequences:

>Translated_88_residues
MFAVIFGRPGCPYCVRAKSLAEKLTAERDDFTYRYIDIHAEGISKTDLSKTVGKLVETVPQIFVDQIHIGGCTDFEAYAK
ENLSLYSS
>Mature_88_residues
MFAVIFGRPGCPYCVRAKSLAEKLTAERDDFTYRYIDIHAEGISKTDLSKTVGKLVETVPQIFVDQIHIGGCTDFEAYAK
ENLSLYSS

Specific function: The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing some disulfides in a coupled system with glutathione re

COG id: COG0695

COG function: function code O; Glutaredoxin and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 glutaredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1787073, Length=84, Percent_Identity=72.6190476190476, Blast_Score=131, Evalue=9e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011767
- InterPro:   IPR002109
- InterPro:   IPR014025
- InterPro:   IPR011902
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00462 Glutaredoxin [H]

EC number: NA

Molecular weight: Translated: 9840; Mature: 9840

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS00195 GLUTAREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.4 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
3.4 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFAVIFGRPGCPYCVRAKSLAEKLTAERDDFTYRYIDIHAEGISKTDLSKTVGKLVETVP
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHH
QIFVDQIHIGGCTDFEAYAKENLSLYSS
HHHHHHHCCCCCCCHHHHHHCCCCCCCC
>Mature Secondary Structure
MFAVIFGRPGCPYCVRAKSLAEKLTAERDDFTYRYIDIHAEGISKTDLSKTVGKLVETVP
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEEEEEECCCCCHHHHHHHHHHHHHHH
QIFVDQIHIGGCTDFEAYAKENLSLYSS
HHHHHHHCCCCCCCHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ribonucleotides [C]

Specific reaction: ribonucleotides = deoxyribonucleotides [C]

General reaction: deoxyribonucleotide biosynthesis [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]