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The map label for this gene is mrdA [H]

Identifier: 85058775

GI number: 85058775

Start: 1350351

End: 1352255

Strand: Reverse

Name: mrdA [H]

Synonym: SG0797

Alternate gene names: 85058775

Gene position: 1352255-1350351 (Counterclockwise)

Preceding gene: 85058776

Following gene: 85058774

Centisome position: 32.42

GC content: 57.43

Gene sequence:

>1905_bases
ATGAAAATAGAACGTAACCCCTTTCGCGACTATTCAGCCGAGTCGGCGCTATTTGTGCGTCGCGCACTAGTGGCGTTCGC
CGGCATATTGCTGCTGAGCGGCGTCCTCATCGTCAATCTGTACCATTTGCAAATTACCCGCTTCGAGGATTACCGCACGC
GCTCCAATGAAAACCGCATCAAGCTGGTGCCTATCACGCCGAGCCGCGGCATTATCTACGATCGCAACGGCACGCCCCTG
GCGCTGAACCGCACCATCTATCAGTTGGAACTGGTACCGGAAAAGGTAGACAATTTAGCGCAGACGATTGCCGACATGCG
ACCGATTGTCGATTTGACCGATGATGATATTGCCAATTTTGAAAAAGAGCGTAAACGCTCCCGCCGTTTTACATCGCTTC
CACTTAAAGTCGGTTTGACCGACGTGCAGCAGGCCCGTTTCGCCGTCAACCAGTACCGCTTTCCCGGCGTCGAAGTGAAG
GGCTACCAGCGTCGCTATTATCCCTACGGCTCTGCACTCACCCACGTCATAGGCTATGTGTCGAAAATCAACGACCGCGA
CGTGGAACGTCTGGATAAAGAAGGGATCCTGCCGAACTATGCCGCGACGCACGATATCGGGAAATTGGGTATCGAACGCT
ACTATGAAAGTGCGCTGCACGGTAAAACCGGTTACGAAGAAGTGGAAGTCAACAACCGCGGCCGGGTGATCCGTCAGCTG
CACGAGCAGCCGCCCCAGGCGGGGAAGGATATTACCCTGACGTTGGATCTGAGCCTGCAACAATATATCGAGAAGCTGCT
GGCCGGCAGCCGCGCCTCGGTGGTCGTGGTGGATCCCCGTGACGGCGGCATCCGCGCGCTGGTATCCAACCCGAGCTACG
ATCCCAACCTGTTTGTCGACGGTATCTCCAGCAAGGAATACCACGCGCTGCTGGAAGATGAAAACCGCCCGCTTATCAAT
CGCGCCACCCAAGGCGTCTATCCGCCCGCCTCCACTGTAAAACCCTATATTTCGGTGTCGGCGCTCACGCTTGGCGTCAT
TAATAAAAATTTCTCCTTGTTCGATCCGGGATGGTGGCAATTGCCCGGCTCGGAGAAACGTTACCGCGACTGGAAACGCT
GGGGGCACGGCCGGTTGAACGTCACCCGGGCGCTGGAGGAGTCGGCGGACACCTTTTTCTATCAGGTAGCGTATGACATG
GGCATTGACCGGCTTTCCGAATGGATGACCAAATTTGGCTACGGCCAGTATACCGGTATCGATCTGTCCGAAGAGCGCGC
CGGCGTGATGCCGACCCGCGAGTGGAAAGTCGCACGCTTTAAAAAACCCTGGTACCAGGGGGATACCATTCCGGTCGGGA
TCGGCCAGGGTTACTGGACCGCCACGCCGCTGCAGATGTCCAAGGCGCTGATGACGCTGATTAACGACGGAGCGGTGAGG
ACGCCGCATCTGCTCTCCGGCACGCGGGAAAACGGCCGCCAGGTTCCCTACCGTCAGCCGGAGCATGTGCAAATCGGAGA
CCCACATTCCGGCTTCTGGGAAATAGCCAAAGACGGCATGTATGGCGTCGCCAACCGGCCAAACGGCACGGCGCGCAAGA
GTTTTGCCGACGCGCCTTACAAGGCGGCCGCCAAATCCGGTACAGCTCAGGTGTATGGTCTGAAGGCCAACGAAACCTAT
AATGCCCACAAAATCGCCGAACGCCTGCGCGACCATAAACTGATGACCGCCTTCGCCCCCTATGATAAACCGACGGTGGG
CGTAGTGGTCATTCTGGAAAACGGCGGCGTTGGACCGGCAGTGGGAACGATTACCCGCCAGATTCTGGATCATATCCTTC
TGGGCAATAACACCACAGACTTACCCGCGGAGCCGCCCGCCCCGCCCGGCAGCGAGAGTGATTAA

Upstream 100 bases:

>100_bases
GTCGCGGAGAGCCTGTATCGTGCGTGGAGCATTACAACCAATCACCCTTATCACCGTGAGTAACGCGGCGACGATGATTA
ACGTGAACTAATTCCGCTGA

Downstream 100 bases:

>100_bases
CCCATCATGACTGATAATCCGCAACAAACTTCCCTGTGGAACAAGCTGCACATTGATGTGATGCTGCTGTTTTTCGTTAC
GCTGCTGCTGGTGTACAGTG

Product: penicillin-binding protein 2

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 634; Mature: 634

Protein sequence:

>634_residues
MKIERNPFRDYSAESALFVRRALVAFAGILLLSGVLIVNLYHLQITRFEDYRTRSNENRIKLVPITPSRGIIYDRNGTPL
ALNRTIYQLELVPEKVDNLAQTIADMRPIVDLTDDDIANFEKERKRSRRFTSLPLKVGLTDVQQARFAVNQYRFPGVEVK
GYQRRYYPYGSALTHVIGYVSKINDRDVERLDKEGILPNYAATHDIGKLGIERYYESALHGKTGYEEVEVNNRGRVIRQL
HEQPPQAGKDITLTLDLSLQQYIEKLLAGSRASVVVVDPRDGGIRALVSNPSYDPNLFVDGISSKEYHALLEDENRPLIN
RATQGVYPPASTVKPYISVSALTLGVINKNFSLFDPGWWQLPGSEKRYRDWKRWGHGRLNVTRALEESADTFFYQVAYDM
GIDRLSEWMTKFGYGQYTGIDLSEERAGVMPTREWKVARFKKPWYQGDTIPVGIGQGYWTATPLQMSKALMTLINDGAVR
TPHLLSGTRENGRQVPYRQPEHVQIGDPHSGFWEIAKDGMYGVANRPNGTARKSFADAPYKAAAKSGTAQVYGLKANETY
NAHKIAERLRDHKLMTAFAPYDKPTVGVVVILENGGVGPAVGTITRQILDHILLGNNTTDLPAEPPAPPGSESD

Sequences:

>Translated_634_residues
MKIERNPFRDYSAESALFVRRALVAFAGILLLSGVLIVNLYHLQITRFEDYRTRSNENRIKLVPITPSRGIIYDRNGTPL
ALNRTIYQLELVPEKVDNLAQTIADMRPIVDLTDDDIANFEKERKRSRRFTSLPLKVGLTDVQQARFAVNQYRFPGVEVK
GYQRRYYPYGSALTHVIGYVSKINDRDVERLDKEGILPNYAATHDIGKLGIERYYESALHGKTGYEEVEVNNRGRVIRQL
HEQPPQAGKDITLTLDLSLQQYIEKLLAGSRASVVVVDPRDGGIRALVSNPSYDPNLFVDGISSKEYHALLEDENRPLIN
RATQGVYPPASTVKPYISVSALTLGVINKNFSLFDPGWWQLPGSEKRYRDWKRWGHGRLNVTRALEESADTFFYQVAYDM
GIDRLSEWMTKFGYGQYTGIDLSEERAGVMPTREWKVARFKKPWYQGDTIPVGIGQGYWTATPLQMSKALMTLINDGAVR
TPHLLSGTRENGRQVPYRQPEHVQIGDPHSGFWEIAKDGMYGVANRPNGTARKSFADAPYKAAAKSGTAQVYGLKANETY
NAHKIAERLRDHKLMTAFAPYDKPTVGVVVILENGGVGPAVGTITRQILDHILLGNNTTDLPAEPPAPPGSESD
>Mature_634_residues
MKIERNPFRDYSAESALFVRRALVAFAGILLLSGVLIVNLYHLQITRFEDYRTRSNENRIKLVPITPSRGIIYDRNGTPL
ALNRTIYQLELVPEKVDNLAQTIADMRPIVDLTDDDIANFEKERKRSRRFTSLPLKVGLTDVQQARFAVNQYRFPGVEVK
GYQRRYYPYGSALTHVIGYVSKINDRDVERLDKEGILPNYAATHDIGKLGIERYYESALHGKTGYEEVEVNNRGRVIRQL
HEQPPQAGKDITLTLDLSLQQYIEKLLAGSRASVVVVDPRDGGIRALVSNPSYDPNLFVDGISSKEYHALLEDENRPLIN
RATQGVYPPASTVKPYISVSALTLGVINKNFSLFDPGWWQLPGSEKRYRDWKRWGHGRLNVTRALEESADTFFYQVAYDM
GIDRLSEWMTKFGYGQYTGIDLSEERAGVMPTREWKVARFKKPWYQGDTIPVGIGQGYWTATPLQMSKALMTLINDGAVR
TPHLLSGTRENGRQVPYRQPEHVQIGDPHSGFWEIAKDGMYGVANRPNGTARKSFADAPYKAAAKSGTAQVYGLKANETY
NAHKIAERLRDHKLMTAFAPYDKPTVGVVVILENGGVGPAVGTITRQILDHILLGNNTTDLPAEPPAPPGSESD

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=632, Percent_Identity=80.6962025316456, Blast_Score=1065, Evalue=0.0,
Organism=Escherichia coli, GI1786272, Length=480, Percent_Identity=25, Blast_Score=125, Evalue=1e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 71288; Mature: 71288

Theoretical pI: Translated: 9.36; Mature: 9.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIERNPFRDYSAESALFVRRALVAFAGILLLSGVLIVNLYHLQITRFEDYRTRSNENRI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEHHHHCCCCCCEE
KLVPITPSRGIIYDRNGTPLALNRTIYQLELVPEKVDNLAQTIADMRPIVDLTDDDIANF
EEEEECCCCCEEECCCCCCEEECCEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCHHHHH
EKERKRSRRFTSLPLKVGLTDVQQARFAVNQYRFPGVEVKGYQRRYYPYGSALTHVIGYV
HHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHCCCCCEEECCCEEECCCHHHHHHHHHHH
SKINDRDVERLDKEGILPNYAATHDIGKLGIERYYESALHGKTGYEEVEVNNRGRVIRQL
HHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHH
HEQPPQAGKDITLTLDLSLQQYIEKLLAGSRASVVVVDPRDGGIRALVSNPSYDPNLFVD
HHCCCCCCCEEEEEEECCHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCCCCEEEE
GISSKEYHALLEDENRPLINRATQGVYPPASTVKPYISVSALTLGVINKNFSLFDPGWWQ
CCCCCHHHHHCCCCCCCHHHHHHCCCCCCHHHCCCCEEEEEEEEEEECCCCCEECCCCEE
LPGSEKRYRDWKRWGHGRLNVTRALEESADTFFYQVAYDMGIDRLSEWMTKFGYGQYTGI
CCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEHHHHHCHHHHHHHHHHCCCCCEECC
DLSEERAGVMPTREWKVARFKKPWYQGDTIPVGIGQGYWTATPLQMSKALMTLINDGAVR
CCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEECCCCCEECCHHHHHHHHHHHHCCCCCC
TPHLLSGTRENGRQVPYRQPEHVQIGDPHSGFWEIAKDGMYGVANRPNGTARKSFADAPY
CCHHHCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHCCCCEECCCCCCCCHHHHHCCCCH
KAAAKSGTAQVYGLKANETYNAHKIAERLRDHKLMTAFAPYDKPTVGVVVILENGGVGPA
HHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEECCCCCHH
VGTITRQILDHILLGNNTTDLPAEPPAPPGSESD
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKIERNPFRDYSAESALFVRRALVAFAGILLLSGVLIVNLYHLQITRFEDYRTRSNENRI
CCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEEEEEEHHHHCCCCCCEE
KLVPITPSRGIIYDRNGTPLALNRTIYQLELVPEKVDNLAQTIADMRPIVDLTDDDIANF
EEEEECCCCCEEECCCCCCEEECCEEEEEEECHHHHHHHHHHHHHHCCCCCCCCCHHHHH
EKERKRSRRFTSLPLKVGLTDVQQARFAVNQYRFPGVEVKGYQRRYYPYGSALTHVIGYV
HHHHHHHCCCCCCCEEECCHHHHHHHHHHHHHCCCCCEEECCCEEECCCHHHHHHHHHHH
SKINDRDVERLDKEGILPNYAATHDIGKLGIERYYESALHGKTGYEEVEVNNRGRVIRQL
HHCCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCHHHHHHH
HEQPPQAGKDITLTLDLSLQQYIEKLLAGSRASVVVVDPRDGGIRALVSNPSYDPNLFVD
HHCCCCCCCEEEEEEECCHHHHHHHHHCCCCCEEEEEECCCCCEEEEECCCCCCCCEEEE
GISSKEYHALLEDENRPLINRATQGVYPPASTVKPYISVSALTLGVINKNFSLFDPGWWQ
CCCCCHHHHHCCCCCCCHHHHHHCCCCCCHHHCCCCEEEEEEEEEEECCCCCEECCCCEE
LPGSEKRYRDWKRWGHGRLNVTRALEESADTFFYQVAYDMGIDRLSEWMTKFGYGQYTGI
CCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEHHHHHCHHHHHHHHHHCCCCCEECC
DLSEERAGVMPTREWKVARFKKPWYQGDTIPVGIGQGYWTATPLQMSKALMTLINDGAVR
CCCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEECCCCCEECCHHHHHHHHHHHHCCCCCC
TPHLLSGTRENGRQVPYRQPEHVQIGDPHSGFWEIAKDGMYGVANRPNGTARKSFADAPY
CCHHHCCCCCCCCCCCCCCCCEEECCCCCCCHHHHHCCCCEECCCCCCCCHHHHHCCCCH
KAAAKSGTAQVYGLKANETYNAHKIAERLRDHKLMTAFAPYDKPTVGVVVILENGGVGPA
HHHHCCCCEEEEEEECCCCCCHHHHHHHHHHCCEEEEECCCCCCCEEEEEEEECCCCCHH
VGTITRQILDHILLGNNTTDLPAEPPAPPGSESD
HHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]