Click here to switch to the map view.

The map label for this gene is mrdB [H]

Identifier: 85058774

GI number: 85058774

Start: 1349232

End: 1350344

Strand: Reverse

Name: mrdB [H]

Synonym: SG0796

Alternate gene names: 85058774

Gene position: 1350344-1349232 (Counterclockwise)

Preceding gene: 85058775

Following gene: 85058773

Centisome position: 32.37

GC content: 55.71

Gene sequence:

>1113_bases
ATGACTGATAATCCGCAACAAACTTCCCTGTGGAACAAGCTGCACATTGATGTGATGCTGCTGTTTTTCGTTACGCTGCT
GCTGGTGTACAGTGCCCTGGTGGTGTGGAGCGCCAGCGGCCAGGATGTCGGTATGATGGAGCGTAAGATTGCCCAGATAG
TGATGGGTCTACTGGTGATGCTGGTGATGGCGCAGGTGCCGCCTCGCGTCTATGAGGCCTGGGCACCGTATCTGTATATC
TTCTGCGTGTTTCTGCTGGTGCTGGTGGACGCCTTTGGCCAGATCAGTAAAGGTGCGCAACGCTGGCTGGATCTGGGCAT
TATCCGCTTCCAGCCTTCGGAAATCGCCAAAATCGCCGTGCCGCTGATGGTCGCGCGTTTTATCAACCGCGACAGTTGCC
CGCCGTCGCTGAAAAATACCACTATCGCGCTGGTGCTGATTTTTGTGCCCACGCTGCTGGTGGCGGTTCAGCCCGATTTG
GGCACCGCTATCCTTATTGCCGCCTCTGGCCTGTTCGTGCTGTTCCTGTCGGGAATGAGCTGGAAACTGATCGCCATCGC
CGCGCTGCTGGTGGCGGCGTTTATCCCCGTGCTATGGTTCTTTTTGATGCATGATTATCAGCGGGATCGGGTGATGATGC
TGCTCGATCCTGAAACCGATCCCCTGGGCGCCGGCTATCATATCATCCAGTCGAAAATCGCCATCGGCTCCGGCGGCCTG
TCGGGAAAAGGCTGGCTGCACGGCACCCAGTCACAGCTGGAATTCTTACCGGAACGCCATACCGACTTTATTTTTGCCGT
GCTGGGTGAGGAGCTGGGGCTTATCGGCGTGTTGGTGCTGCTGGCGCTTTATCTTGGCTTAATCATCCGCGGTCTGGTGA
TCGCCGCGCGGGCGCAGAACACCTTCGGCCGGGTAATGGCCGGCGGTTTGATGCTGATTTTGTTCGTTTACGTGTTCGTG
AATATCGGTATGGTTAGTGGTATCTTACCAGTGGTTGGCGTGCCGCTGCCGTTGGTAAGCTACGGCGGTTCGGCGCTCAT
CGTGTTAATGGCGGGGTTTGGTATCGTCATGTCGATACATACTCATCGAAAAATGTTGTCCAAAAGTTTATAG

Upstream 100 bases:

>100_bases
TACCCGCCAGATTCTGGATCATATCCTTCTGGGCAATAACACCACAGACTTACCCGCGGAGCCGCCCGCCCCGCCCGGCA
GCGAGAGTGATTAACCCATC

Downstream 100 bases:

>100_bases
AGGTGAGCAATGCAGAAGCTTAGATGCGTTATCGGCATGATGGGGTTGCTACTCGGCGCCTGTTCTACCCAGCAAGAGAC
GCAGCCGTCGGCGCCGGCAG

Product: cell wall shape-determining protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MTDNPQQTSLWNKLHIDVMLLFFVTLLLVYSALVVWSASGQDVGMMERKIAQIVMGLLVMLVMAQVPPRVYEAWAPYLYI
FCVFLLVLVDAFGQISKGAQRWLDLGIIRFQPSEIAKIAVPLMVARFINRDSCPPSLKNTTIALVLIFVPTLLVAVQPDL
GTAILIAASGLFVLFLSGMSWKLIAIAALLVAAFIPVLWFFLMHDYQRDRVMMLLDPETDPLGAGYHIIQSKIAIGSGGL
SGKGWLHGTQSQLEFLPERHTDFIFAVLGEELGLIGVLVLLALYLGLIIRGLVIAARAQNTFGRVMAGGLMLILFVYVFV
NIGMVSGILPVVGVPLPLVSYGGSALIVLMAGFGIVMSIHTHRKMLSKSL

Sequences:

>Translated_370_residues
MTDNPQQTSLWNKLHIDVMLLFFVTLLLVYSALVVWSASGQDVGMMERKIAQIVMGLLVMLVMAQVPPRVYEAWAPYLYI
FCVFLLVLVDAFGQISKGAQRWLDLGIIRFQPSEIAKIAVPLMVARFINRDSCPPSLKNTTIALVLIFVPTLLVAVQPDL
GTAILIAASGLFVLFLSGMSWKLIAIAALLVAAFIPVLWFFLMHDYQRDRVMMLLDPETDPLGAGYHIIQSKIAIGSGGL
SGKGWLHGTQSQLEFLPERHTDFIFAVLGEELGLIGVLVLLALYLGLIIRGLVIAARAQNTFGRVMAGGLMLILFVYVFV
NIGMVSGILPVVGVPLPLVSYGGSALIVLMAGFGIVMSIHTHRKMLSKSL
>Mature_369_residues
TDNPQQTSLWNKLHIDVMLLFFVTLLLVYSALVVWSASGQDVGMMERKIAQIVMGLLVMLVMAQVPPRVYEAWAPYLYIF
CVFLLVLVDAFGQISKGAQRWLDLGIIRFQPSEIAKIAVPLMVARFINRDSCPPSLKNTTIALVLIFVPTLLVAVQPDLG
TAILIAASGLFVLFLSGMSWKLIAIAALLVAAFIPVLWFFLMHDYQRDRVMMLLDPETDPLGAGYHIIQSKIAIGSGGLS
GKGWLHGTQSQLEFLPERHTDFIFAVLGEELGLIGVLVLLALYLGLIIRGLVIAARAQNTFGRVMAGGLMLILFVYVFVN
IGMVSGILPVVGVPLPLVSYGGSALIVLMAGFGIVMSIHTHRKMLSKSL

Specific function: This is one of the proteins responsible for the rod shape of E.coli. Is required for the expression of the enzymatic activity of PBP2, which is thought to synthesize peptidoglycan in the step of initiation of cell elongation [H]

COG id: COG0772

COG function: function code D; Bacterial cell division membrane protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ftsW/rodA/spoVE family [H]

Homologues:

Organism=Escherichia coli, GI1786853, Length=370, Percent_Identity=84.3243243243243, Blast_Score=608, Evalue=1e-175,
Organism=Escherichia coli, GI1786277, Length=325, Percent_Identity=32, Blast_Score=174, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001182
- InterPro:   IPR018365
- InterPro:   IPR011923 [H]

Pfam domain/function: PF01098 FTSW_RODA_SPOVE [H]

EC number: NA

Molecular weight: Translated: 40466; Mature: 40334

Theoretical pI: Translated: 8.99; Mature: 8.99

Prosite motif: PS00428 FTSW_RODA_SPOVE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
5.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCC
>Mature Secondary Structure 
TDNPQQTSLWNKLHIDVMLLFFVTLLLVYSALVVWSASGQDVGMMERKIAQIVMGLLVM
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
LVMAQVPPRVYEAWAPYLYIFCVFLLVLVDAFGQISKGAQRWLDLGIIRFQPSEIAKIAV
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECHHHHHHHHH
PLMVARFINRDSCPPSLKNTTIALVLIFVPTLLVAVQPDLGTAILIAASGLFVLFLSGMS
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCCCC
WKLIAIAALLVAAFIPVLWFFLMHDYQRDRVMMLLDPETDPLGAGYHIIQSKIAIGSGGL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCHHHHHHHHHCCCCCC
SGKGWLHGTQSQLEFLPERHTDFIFAVLGEELGLIGVLVLLALYLGLIIRGLVIAARAQN
CCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TFGRVMAGGLMLILFVYVFVNIGMVSGILPVVGVPLPLVSYGGSALIVLMAGFGIVMSIH
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHH
THRKMLSKSL
HHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]