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The map label for this gene is arcA [H]

Identifier: 85058381

GI number: 85058381

Start: 713907

End: 714623

Strand: Reverse

Name: arcA [H]

Synonym: SG0403

Alternate gene names: 85058381

Gene position: 714623-713907 (Counterclockwise)

Preceding gene: 85058385

Following gene: 85058380

Centisome position: 17.13

GC content: 53.14

Gene sequence:

>717_bases
ATGCAGACCCCGCACATTCTTATCGTTGAAGACGAGTCAGTCACCCGTAATACCCTCAAAAGCATTTTTGAAGCTGAGGG
CTATATGGTTCATGAAGCTACCGACGGCGCAGAGATGCACCGCGCGCTGTCGGAACATGATATTAATCTGGTTATCATGG
ATATCAACCTGCCGGGTAAAAATGGCTTGTTGCTGGCGCGAGAACTTCGGGAACATGCCAGCGTTGCCCTGATGTTTCTT
ACCGGCCGCGATAACGAGGTGGATAAAATCCTCGGATTGGAAATTGGCGCCGACGATTATATTACCAAGCCTTTCAACCC
GCGCGAACTCACTATCCGTGCGCGCAACCTGCTGTCCCGCACCATGAATCTAGGCGGCGCCCTGGAAGAGCGCAAGGTGG
TGGAAAGCTACAAATTTAACGGTTGGGAGCTCGATATTAATAGCCGTTCTTTGCTAAGTCCTCACGGCGAGAGCTATAAA
CTGCCCCGCAGCGAGTTTCGCGCCATGCTGCACTTTTGCGAAAATCCCGGCAAGATCCAATCGCGCGCCGAGCTGCTGAA
GAAAATGACCGGCCGCGAGCTGAAGGCCCACGACCGTACCGTTGACGTCACCATCCGTCGCATACGCAAGCATTTTGAAT
CCACGCCAGATACGCCGGAAATCATCGCCACCATACACGGCGAAGGGTATCGTTTCTGCGGCGATTTGGAAGAGTAA

Upstream 100 bases:

>100_bases
AAGCCTTGGAGGATGCATTTTGTTCCTCCGCTACCGTTAAGGACGACAGCGGCTTGAGTACCTCCTCTTTCAATTATGTT
GTTAATTTTAGGTAGCAAAC

Downstream 100 bases:

>100_bases
GTTTCACCAATGGCGCCCTCCCCACCAGGGGCGGGCGTTCGATTATCCCCACCGGTAAACGTTTCCGCGTCGCCCCGAAC
GGTGCCGCCCGTTACACCCG

Product: two-component response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MQTPHILIVEDESVTRNTLKSIFEAEGYMVHEATDGAEMHRALSEHDINLVIMDINLPGKNGLLLARELREHASVALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGGALEERKVVESYKFNGWELDINSRSLLSPHGESYK
LPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKAHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLEE

Sequences:

>Translated_238_residues
MQTPHILIVEDESVTRNTLKSIFEAEGYMVHEATDGAEMHRALSEHDINLVIMDINLPGKNGLLLARELREHASVALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGGALEERKVVESYKFNGWELDINSRSLLSPHGESYK
LPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKAHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLEE
>Mature_238_residues
MQTPHILIVEDESVTRNTLKSIFEAEGYMVHEATDGAEMHRALSEHDINLVIMDINLPGKNGLLLARELREHASVALMFL
TGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSRTMNLGGALEERKVVESYKFNGWELDINSRSLLSPHGESYK
LPRSEFRAMLHFCENPGKIQSRAELLKKMTGRELKAHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLEE

Specific function: Member of the two-component regulatory system ArcB/ArcA. Represses a wide variety of aerobic enzymes under anaerobic conditions. It also may be involved in the osmoregulation of envelope proteins. When activated by ArcB, it negatively regulates the expres

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1790863, Length=238, Percent_Identity=92.0168067226891, Blast_Score=449, Evalue=1e-127,
Organism=Escherichia coli, GI1787229, Length=233, Percent_Identity=42.0600858369099, Blast_Score=187, Evalue=4e-49,
Organism=Escherichia coli, GI1789809, Length=232, Percent_Identity=36.2068965517241, Blast_Score=149, Evalue=2e-37,
Organism=Escherichia coli, GI1788394, Length=233, Percent_Identity=32.618025751073, Blast_Score=128, Evalue=3e-31,
Organism=Escherichia coli, GI1786599, Length=231, Percent_Identity=33.7662337662338, Blast_Score=127, Evalue=5e-31,
Organism=Escherichia coli, GI1790860, Length=235, Percent_Identity=31.4893617021277, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1787375, Length=228, Percent_Identity=32.0175438596491, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI87082012, Length=230, Percent_Identity=32.6086956521739, Blast_Score=110, Evalue=9e-26,
Organism=Escherichia coli, GI1786911, Length=232, Percent_Identity=31.8965517241379, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI2367329, Length=225, Percent_Identity=32, Blast_Score=103, Evalue=7e-24,
Organism=Escherichia coli, GI1786784, Length=227, Percent_Identity=29.9559471365639, Blast_Score=95, Evalue=4e-21,
Organism=Escherichia coli, GI145693140, Length=232, Percent_Identity=29.3103448275862, Blast_Score=91, Evalue=9e-20,
Organism=Escherichia coli, GI1789402, Length=226, Percent_Identity=28.3185840707965, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1790552, Length=233, Percent_Identity=29.6137339055794, Blast_Score=83, Evalue=1e-17,
Organism=Escherichia coli, GI1788550, Length=212, Percent_Identity=27.3584905660377, Blast_Score=65, Evalue=5e-12,

Paralogues:

None

Copy number: 200 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR016032
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 27151; Mature: 27151

Theoretical pI: Translated: 6.19; Mature: 6.19

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQTPHILIVEDESVTRNTLKSIFEAEGYMVHEATDGAEMHRALSEHDINLVIMDINLPGK
CCCCCEEEEECCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCEEEEEEEECCCC
NGLLLARELREHASVALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSR
CCEEHHHHHHHCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHH
TMNLGGALEERKVVESYKFNGWELDINSRSLLSPHGESYKLPRSEFRAMLHFCENPGKIQ
HHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHH
SRAELLKKMTGRELKAHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLEE
HHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCCCC
>Mature Secondary Structure
MQTPHILIVEDESVTRNTLKSIFEAEGYMVHEATDGAEMHRALSEHDINLVIMDINLPGK
CCCCCEEEEECCCHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHCCCEEEEEEEECCCC
NGLLLARELREHASVALMFLTGRDNEVDKILGLEIGADDYITKPFNPRELTIRARNLLSR
CCEEHHHHHHHCCCEEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCEEEHHHHHHHHH
TMNLGGALEERKVVESYKFNGWELDINSRSLLSPHGESYKLPRSEFRAMLHFCENPGKIQ
HHHCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCHH
SRAELLKKMTGRELKAHDRTVDVTIRRIRKHFESTPDTPEIIATIHGEGYRFCGDLEE
HHHHHHHHHCCCCHHHCCCCHHHHHHHHHHHHCCCCCCCEEEEEEECCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]