Click here to switch to the map view.

The map label for this gene is ung [H]

Identifier: 84625708

GI number: 84625708

Start: 4569268

End: 4569993

Strand: Reverse

Name: ung [H]

Synonym: XOO_4051

Alternate gene names: 84625708

Gene position: 4569993-4569268 (Counterclockwise)

Preceding gene: 84625709

Following gene: 84625707

Centisome position: 92.51

GC content: 65.15

Gene sequence:

>726_bases
ATGACCGAAGTGGAAGCGCGTATCCAGCTGGAACCGTCGTGGAAGGCAAAGGTTGGCGACTGGTTGCTGTGCTCTCAGAT
GCAGGAGCTGTCTGCCTTCCTGCGCCAACGCAAGGCGGTCGGCGCGCGCGTGTTTCCGCCTGGCCCGCAGATCTTCGCTG
CCTTCGACGCCACCCCGTTCGATCAGGTCAAGGTCGTGATCCTGGGTCAGGACCCGTATCACGGCGAAGGCCAGGCGCAC
GGGCTGTGTTTTTCGGTGCTGCCGGGCGTGCCGGTGCCGCCGTCGCTGCTCAACATCTACAAAGAGATACAGGACGATCT
GGGCATCGCGCGGCCGGATCACGGCTACCTGATGCCCTGGGCGCGCCAGGGCGTGCTGTTGCTCAATGCCGTGCTGACGG
TGGAGCAGGGCCGGGCAGGCGCTCATCAGAACAAGGGCTGGGAAGGCTTCACCGATCATGTGGTGGAAACCCTCAACCGC
GAGCGCGAGGGCTTGGTGTTCCTGCTCTGGGGCAGCTACGCGCAGTCCAAGGGCAGGGTCATCGACCAGGCGCGCCATCG
CGTGTTCAAGGCGCCGCATCCGTCGCCGTTGTCGGCGCATCGCGGCTTCCTGGGCTGCCAGCATTTCTCCAAGACCAACG
CGCATTTGCAACGGCGCGGGATCAGCCCGATCGACTGGTCGCTGCCGCCGCGCAATGAGTTGGACACCACCTCCGCTGGC
GCCTGA

Upstream 100 bases:

>100_bases
CCAACGATCTGGTGCAAAAACCGATCGAAGAGCGCCTGCTGGTGACCAAGGTGCTGTTCCAGCTGCGCCTGGCACGTCTG
GAGGATCAGGCGGTCACGCT

Downstream 100 bases:

>100_bases
ACGGTGAGGCCGGCAGCCCGTTTCGCAACCGATTTGTCACGGTTTGCATAGGAGCTGAGTGGTAGCGTATCCGTCGAGAT
CGGGGTGCTGAGCTGTAGAA

Product: uracil-DNA glycosylase

Products: NA

Alternate protein names: UDG [H]

Number of amino acids: Translated: 241; Mature: 240

Protein sequence:

>241_residues
MTEVEARIQLEPSWKAKVGDWLLCSQMQELSAFLRQRKAVGARVFPPGPQIFAAFDATPFDQVKVVILGQDPYHGEGQAH
GLCFSVLPGVPVPPSLLNIYKEIQDDLGIARPDHGYLMPWARQGVLLLNAVLTVEQGRAGAHQNKGWEGFTDHVVETLNR
EREGLVFLLWGSYAQSKGRVIDQARHRVFKAPHPSPLSAHRGFLGCQHFSKTNAHLQRRGISPIDWSLPPRNELDTTSAG
A

Sequences:

>Translated_241_residues
MTEVEARIQLEPSWKAKVGDWLLCSQMQELSAFLRQRKAVGARVFPPGPQIFAAFDATPFDQVKVVILGQDPYHGEGQAH
GLCFSVLPGVPVPPSLLNIYKEIQDDLGIARPDHGYLMPWARQGVLLLNAVLTVEQGRAGAHQNKGWEGFTDHVVETLNR
EREGLVFLLWGSYAQSKGRVIDQARHRVFKAPHPSPLSAHRGFLGCQHFSKTNAHLQRRGISPIDWSLPPRNELDTTSAG
A
>Mature_240_residues
TEVEARIQLEPSWKAKVGDWLLCSQMQELSAFLRQRKAVGARVFPPGPQIFAAFDATPFDQVKVVILGQDPYHGEGQAHG
LCFSVLPGVPVPPSLLNIYKEIQDDLGIARPDHGYLMPWARQGVLLLNAVLTVEQGRAGAHQNKGWEGFTDHVVETLNRE
REGLVFLLWGSYAQSKGRVIDQARHRVFKAPHPSPLSAHRGFLGCQHFSKTNAHLQRRGISPIDWSLPPRNELDTTSAGA

Specific function: Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine [H]

COG id: COG0692

COG function: function code L; Uracil DNA glycosylase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the uracil-DNA glycosylase family [H]

Homologues:

Organism=Homo sapiens, GI19718751, Length=215, Percent_Identity=54.4186046511628, Blast_Score=225, Evalue=3e-59,
Organism=Homo sapiens, GI6224979, Length=215, Percent_Identity=54.4186046511628, Blast_Score=224, Evalue=7e-59,
Organism=Escherichia coli, GI1788934, Length=210, Percent_Identity=58.0952380952381, Blast_Score=252, Evalue=2e-68,
Organism=Caenorhabditis elegans, GI17556304, Length=217, Percent_Identity=48.3870967741936, Blast_Score=216, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6323620, Length=242, Percent_Identity=43.801652892562, Blast_Score=172, Evalue=3e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002043
- InterPro:   IPR018085
- InterPro:   IPR005122 [H]

Pfam domain/function: PF03167 UDG [H]

EC number: =3.2.2.27 [H]

Molecular weight: Translated: 26753; Mature: 26622

Theoretical pI: Translated: 8.50; Mature: 8.50

Prosite motif: PS00130 U_DNA_GLYCOSYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEVEARIQLEPSWKAKVGDWLLCSQMQELSAFLRQRKAVGARVFPPGPQIFAAFDATPF
CCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCC
DQVKVVILGQDPYHGEGQAHGLCFSVLPGVPVPPSLLNIYKEIQDDLGIARPDHGYLMPW
CCEEEEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCH
ARQGVLLLNAVLTVEQGRAGAHQNKGWEGFTDHVVETLNREREGLVFLLWGSYAQSKGRV
HHCCCEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCHH
IDQARHRVFKAPHPSPLSAHRGFLGCQHFSKTNAHLQRRGISPIDWSLPPRNELDTTSAG
HHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
A
C
>Mature Secondary Structure 
TEVEARIQLEPSWKAKVGDWLLCSQMQELSAFLRQRKAVGARVFPPGPQIFAAFDATPF
CCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCC
DQVKVVILGQDPYHGEGQAHGLCFSVLPGVPVPPSLLNIYKEIQDDLGIARPDHGYLMPW
CCEEEEEEECCCCCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCH
ARQGVLLLNAVLTVEQGRAGAHQNKGWEGFTDHVVETLNREREGLVFLLWGSYAQSKGRV
HHCCCEEHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCEEEEEECCCCCCCCHH
IDQARHRVFKAPHPSPLSAHRGFLGCQHFSKTNAHLQRRGISPIDWSLPPRNELDTTSAG
HHHHHHHHCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]