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The map label for this gene is zwf [H]

Identifier: 84623848

GI number: 84623848

Start: 2429701

End: 2431131

Strand: Direct

Name: zwf [H]

Synonym: XOO_2191

Alternate gene names: 84623848

Gene position: 2429701-2431131 (Clockwise)

Preceding gene: 84623846

Following gene: 84623849

Centisome position: 49.18

GC content: 66.81

Gene sequence:

>1431_bases
ATGCACAACACCCTGATCCTGTTTGGCGCCACCGGCGATCTTGCCCAGCGCTACCTGTTCCCCTCCCTGCTGCGTCTGTA
CATCGATGGCCTGCTGCCGGAGGACTTCCGCATCCGTGCGCTGGCGCTGTCGCCGCACGACACCGAGGCATTCCGTGACG
TGCTGCGGCCGCGTCTGACCGAAGCGCTGCCGATCGCCACGCCCGAACAGATCCAGGCGCTGCTGCAGCGCGTTGACTAC
CGCTCGGTGGACCTGCGCAATGCCGAGTCGGTGGCCGATGCGGTCCGCGAGCTTGCGTCCCGCCAGATCGTGAGCTATCT
GGCGATCCCGCCAGGCCTGTACATCAGCACCTGCCAAGGCCTGGCGCTAGGTGGCGCGTTGGCGGCACCGCATCGTTTGA
TGCTGGAAAAGCCGATCGGCCACGACTCGGACAGCGCCCGCGACATCCTGCAGTCGATCGGCGCGCTGATCGACGAAGAC
CGTGTGTTCCGCCTCGACCATTACCTGGGCAAGGCGGCGGTGCAGAACCTGATCGCGCTGCGCTTCGGCAATACGTTGCT
GGAGGCTGTCTGGAACCGTACCTACATCGAGTCGGTGCAGATCCTGATTGCCGAAAGCGAAGGCGTGGACGGGCGCGATG
CCTACTACGCCCGCTCCGGCGCGCTGCGCGATATGGTGCAGAGCCACATCCTGCAGCTGTTGTGCCTGGTGGCGATGGAG
CCGCCGGCCTCGCTGGAAGCCGACCGCATCCGCGACGAGAAGGTCAAGGTACTGCGTGCACTGCGCCCGATGACCGCCGA
ACACGCCGCGCACGACAGCGTACGCGGCCGCTACACCGCCGGCAGCATCAACGGCCAACCGGCGCAGGCCTATCACCCGC
CGGAAGGCAGCGACGTGGAAACCTTCGTCGCGGTGACCGCGCATATCGACAACTGGCGTTGGGCCGGCGTGCCGTTTCAT
CTGTGCACCGGCAAGCGCCTGGCCGAGCGCTCCACGCGCATCGTGGTCACGCTCAAGCCGGTGACGCATTGGTTGTTCGA
GCGTCCGGACCGCCAGAACGCGGTGCCCAACCGCCTCACCTTCCAGCTGCAGCCGCAGGAAAACATCGAGCTGGGCCTGA
TGAGCAGCCTGGCCGGCCCGGAATGGGGCGCGATCGAGCTGCAGCCGCTGGAACTGGAGCTGTCGGTGCCCACCGGCCTG
CATCGCCGCATCGCCTATGAGCGCCTGTTCGTGGATGCCTTCAACGGCAACCCGGCGCTGTTCGTGCGCGATGACGAGGT
CAAGGCGGCGTGGTCGTGGATCGACAGCGTCAGCGACGCCTGGAAAGACGCCGCACTGCCGCTGCAGCCCTACCCGGCCG
GCAGCTGGGGTCCCGAATCGGCCACCCACTTCCTGCCCCCAGCCACCGACGCACAGGCAAACAACGCATGA

Upstream 100 bases:

>100_bases
CGCAAGTGTCGCTCAGGAACAGACGTACCGACCGCCGGCCATCCGGCGCCTTTCCGACAAGCTGCTGATAACGATGTCTC
CAGAATCTGAAACGCGGTCC

Downstream 100 bases:

>100_bases
CCGCTCCTTCCAAGCCGGTGCTGGTTGCCGATATCGGCGGAACCAATGCGCGTTTCGCGCTGGCCGATGTCGACGCCTCG
GTGCCGTTACTGGATGACAC

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MHNTLILFGATGDLAQRYLFPSLLRLYIDGLLPEDFRIRALALSPHDTEAFRDVLRPRLTEALPIATPEQIQALLQRVDY
RSVDLRNAESVADAVRELASRQIVSYLAIPPGLYISTCQGLALGGALAAPHRLMLEKPIGHDSDSARDILQSIGALIDED
RVFRLDHYLGKAAVQNLIALRFGNTLLEAVWNRTYIESVQILIAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAME
PPASLEADRIRDEKVKVLRALRPMTAEHAAHDSVRGRYTAGSINGQPAQAYHPPEGSDVETFVAVTAHIDNWRWAGVPFH
LCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPNRLTFQLQPQENIELGLMSSLAGPEWGAIELQPLELELSVPTGL
HRRIAYERLFVDAFNGNPALFVRDDEVKAAWSWIDSVSDAWKDAALPLQPYPAGSWGPESATHFLPPATDAQANNA

Sequences:

>Translated_476_residues
MHNTLILFGATGDLAQRYLFPSLLRLYIDGLLPEDFRIRALALSPHDTEAFRDVLRPRLTEALPIATPEQIQALLQRVDY
RSVDLRNAESVADAVRELASRQIVSYLAIPPGLYISTCQGLALGGALAAPHRLMLEKPIGHDSDSARDILQSIGALIDED
RVFRLDHYLGKAAVQNLIALRFGNTLLEAVWNRTYIESVQILIAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAME
PPASLEADRIRDEKVKVLRALRPMTAEHAAHDSVRGRYTAGSINGQPAQAYHPPEGSDVETFVAVTAHIDNWRWAGVPFH
LCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPNRLTFQLQPQENIELGLMSSLAGPEWGAIELQPLELELSVPTGL
HRRIAYERLFVDAFNGNPALFVRDDEVKAAWSWIDSVSDAWKDAALPLQPYPAGSWGPESATHFLPPATDAQANNA
>Mature_476_residues
MHNTLILFGATGDLAQRYLFPSLLRLYIDGLLPEDFRIRALALSPHDTEAFRDVLRPRLTEALPIATPEQIQALLQRVDY
RSVDLRNAESVADAVRELASRQIVSYLAIPPGLYISTCQGLALGGALAAPHRLMLEKPIGHDSDSARDILQSIGALIDED
RVFRLDHYLGKAAVQNLIALRFGNTLLEAVWNRTYIESVQILIAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAME
PPASLEADRIRDEKVKVLRALRPMTAEHAAHDSVRGRYTAGSINGQPAQAYHPPEGSDVETFVAVTAHIDNWRWAGVPFH
LCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPNRLTFQLQPQENIELGLMSSLAGPEWGAIELQPLELELSVPTGL
HRRIAYERLFVDAFNGNPALFVRDDEVKAAWSWIDSVSDAWKDAALPLQPYPAGSWGPESATHFLPPATDAQANNA

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=481, Percent_Identity=33.4719334719335, Blast_Score=246, Evalue=5e-65,
Organism=Homo sapiens, GI109389365, Length=481, Percent_Identity=33.4719334719335, Blast_Score=245, Evalue=5e-65,
Organism=Homo sapiens, GI52145310, Length=496, Percent_Identity=28.4274193548387, Blast_Score=171, Evalue=2e-42,
Organism=Escherichia coli, GI1788158, Length=464, Percent_Identity=40.301724137931, Blast_Score=346, Evalue=1e-96,
Organism=Caenorhabditis elegans, GI17538218, Length=484, Percent_Identity=33.0578512396694, Blast_Score=250, Evalue=1e-66,
Organism=Saccharomyces cerevisiae, GI6324088, Length=486, Percent_Identity=32.0987654320988, Blast_Score=232, Evalue=1e-61,
Organism=Drosophila melanogaster, GI24643350, Length=478, Percent_Identity=32.6359832635983, Blast_Score=235, Evalue=5e-62,
Organism=Drosophila melanogaster, GI24643352, Length=478, Percent_Identity=32.6359832635983, Blast_Score=234, Evalue=7e-62,
Organism=Drosophila melanogaster, GI221513548, Length=477, Percent_Identity=27.8825995807128, Blast_Score=160, Evalue=2e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 52864; Mature: 52864

Theoretical pI: Translated: 5.74; Mature: 5.74

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHNTLILFGATGDLAQRYLFPSLLRLYIDGLLPEDFRIRALALSPHDTEAFRDVLRPRLT
CCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHH
EALPIATPEQIQALLQRVDYRSVDLRNAESVADAVRELASRQIVSYLAIPPGLYISTCQG
HHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC
LALGGALAAPHRLMLEKPIGHDSDSARDILQSIGALIDEDRVFRLDHYLGKAAVQNLIAL
HHHCCHHHCCCHHEEECCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHH
RFGNTLLEAVWNRTYIESVQILIAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAME
HHHHHHHHHHHCHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PPASLEADRIRDEKVKVLRALRPMTAEHAAHDSVRGRYTAGSINGQPAQAYHPPEGSDVE
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCE
TFVAVTAHIDNWRWAGVPFHLCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPNRLT
EEEEEEEEECCCEECCCCEEECCCCHHHCCCCEEEEEECHHHHHHHCCCCCCCCCCCCEE
FQLQPQENIELGLMSSLAGPEWGAIELQPLELELSVPTGLHRRIAYERLFVDAFNGNPAL
EEECCCCCCCHHHHHHCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHEEEEECCCEEE
FVRDDEVKAAWSWIDSVSDAWKDAALPLQPYPAGSWGPESATHFLPPATDAQANNA
EEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MHNTLILFGATGDLAQRYLFPSLLRLYIDGLLPEDFRIRALALSPHDTEAFRDVLRPRLT
CCCCEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCHHHHHHHHHHHHH
EALPIATPEQIQALLQRVDYRSVDLRNAESVADAVRELASRQIVSYLAIPPGLYISTCQG
HHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCC
LALGGALAAPHRLMLEKPIGHDSDSARDILQSIGALIDEDRVFRLDHYLGKAAVQNLIAL
HHHCCHHHCCCHHEEECCCCCCCHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHHHHHHH
RFGNTLLEAVWNRTYIESVQILIAESEGVDGRDAYYARSGALRDMVQSHILQLLCLVAME
HHHHHHHHHHHCHHHHHEEEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PPASLEADRIRDEKVKVLRALRPMTAEHAAHDSVRGRYTAGSINGQPAQAYHPPEGSDVE
CCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCCE
TFVAVTAHIDNWRWAGVPFHLCTGKRLAERSTRIVVTLKPVTHWLFERPDRQNAVPNRLT
EEEEEEEEECCCEECCCCEEECCCCHHHCCCCEEEEEECHHHHHHHCCCCCCCCCCCCEE
FQLQPQENIELGLMSSLAGPEWGAIELQPLELELSVPTGLHRRIAYERLFVDAFNGNPAL
EEECCCCCCCHHHHHHCCCCCCCEEEEEEEEEEEECCCCHHHHHHHHHHEEEEECCCEEE
FVRDDEVKAAWSWIDSVSDAWKDAALPLQPYPAGSWGPESATHFLPPATDAQANNA
EEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2254282 [H]