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The map label for this gene is hisC [H]

Identifier: 84623777

GI number: 84623777

Start: 2346675

End: 2347766

Strand: Direct

Name: hisC [H]

Synonym: XOO_2120

Alternate gene names: 84623777

Gene position: 2346675-2347766 (Clockwise)

Preceding gene: 84623776

Following gene: 84623778

Centisome position: 47.5

GC content: 66.03

Gene sequence:

>1092_bases
ATGAGCACGTCATCTATTCTGCATCTCGTGCGCGAAGATCTGCGCGCGTTCGCAGGATATTCGTCGGCGCGCACCAGCGC
ATTGCAGGGCGATGTGTGGCTCAACGCCAACGAGTCGGCCTGGGGTAATCCGGCCGACCCAAGCGCCAGCACGCGGCGCT
ATCCCGACCCGCAACCGCAAGGCCTGCGCAGCGCGCTTGCGGCGCTGTACGGCTGCGCGCCGGAACAGCTGTTGATTGGC
CGCGGCAGCGACGAGGCGATCGATCTGCTGGTGCGTGGCCTGTGCGTGCCAGAGCGCGATGCGGTGCTGGTGACGCCACC
GGTCTTCGGCATGTACGCCGTATGCGCGCGATTGCAGAACGCGCCGTTGGTGGACGTGCCGCTGGTCGATGTGCCCGATG
GTTTCCATGCGGATATCCCGGCAATTGTGGCAGCGGCCTTGGCGTCGAACGCCAAGCTGGTGTTTCTATGCTCGCCTTCT
AATCCTGCCGGTTCGGCGATCGCACTGGACCAGATCGAACCTGCGTTGCAGGCATTGCAGGGCAAGGCGCTGGTGGTGGT
GGACGAGGCCTACGGCGAATTCTCCGAGGTGCCGTCGGCAGTCGGTCTGCTGGCACGCTACGACAATCTCGCGGTGCTGC
GCACGCTCTCCAAGGCGCATGCCTTGGCGGCTGCGCGGATCGGCACGTTGATTGCCAATGCCGAGCTGATCGCCGTGTTG
CGCCGCTGCCAGGCGCCATATCCGGTGCCGACGCCGTGCGCGGCGATGGCCGAGCAGGCCCTGTCTGCGCCGGCGCTGGA
GGTTACCCGCCGCCGTATCGCCGAGGTGCGGAGTGAACGCGCGCGCGTGCACAAAGCGCTTGTGCAACTGCCTGGTGTAC
GGCAGGTGTATCCCTCGCAAGGCAACTTCCTGCTGGTGCGTTTTGATGATGCCGAGGCGGCATTCCAGGCCCTGCTGGAG
GCTGGCGTGGTGGTGCGCGATCAACGTGCAGTCCCGCGCCTGTCCGACGCCTTGCGCATCACCTTGGGCACGCATGAACA
GAACGAGCGCGTACTGAGCGCGCTGCAACGCACGCAGGAGGCCGCCGCATGA

Upstream 100 bases:

>100_bases
CCGGCATCGCTGGCATTGGTGAATGCGCGTTGATACTCGCGCGCGCAGAAGGCTTGGACGCGCATGCCAATGCAGTAGCA
CTGCGCATGGGAGTGGCAGC

Downstream 100 bases:

>100_bases
CCCCGATTCTCTTCGTCGACCGTGATGGCACGCTGATCACCGAGCCGGCCGACTACCAGATCGATGCGTACGAGAAACTA
CGCTTCGTCGATCACGTGAT

Product: histidinol-phosphate aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 363; Mature: 362

Protein sequence:

>363_residues
MSTSSILHLVREDLRAFAGYSSARTSALQGDVWLNANESAWGNPADPSASTRRYPDPQPQGLRSALAALYGCAPEQLLIG
RGSDEAIDLLVRGLCVPERDAVLVTPPVFGMYAVCARLQNAPLVDVPLVDVPDGFHADIPAIVAAALASNAKLVFLCSPS
NPAGSAIALDQIEPALQALQGKALVVVDEAYGEFSEVPSAVGLLARYDNLAVLRTLSKAHALAAARIGTLIANAELIAVL
RRCQAPYPVPTPCAAMAEQALSAPALEVTRRRIAEVRSERARVHKALVQLPGVRQVYPSQGNFLLVRFDDAEAAFQALLE
AGVVVRDQRAVPRLSDALRITLGTHEQNERVLSALQRTQEAAA

Sequences:

>Translated_363_residues
MSTSSILHLVREDLRAFAGYSSARTSALQGDVWLNANESAWGNPADPSASTRRYPDPQPQGLRSALAALYGCAPEQLLIG
RGSDEAIDLLVRGLCVPERDAVLVTPPVFGMYAVCARLQNAPLVDVPLVDVPDGFHADIPAIVAAALASNAKLVFLCSPS
NPAGSAIALDQIEPALQALQGKALVVVDEAYGEFSEVPSAVGLLARYDNLAVLRTLSKAHALAAARIGTLIANAELIAVL
RRCQAPYPVPTPCAAMAEQALSAPALEVTRRRIAEVRSERARVHKALVQLPGVRQVYPSQGNFLLVRFDDAEAAFQALLE
AGVVVRDQRAVPRLSDALRITLGTHEQNERVLSALQRTQEAAA
>Mature_362_residues
STSSILHLVREDLRAFAGYSSARTSALQGDVWLNANESAWGNPADPSASTRRYPDPQPQGLRSALAALYGCAPEQLLIGR
GSDEAIDLLVRGLCVPERDAVLVTPPVFGMYAVCARLQNAPLVDVPLVDVPDGFHADIPAIVAAALASNAKLVFLCSPSN
PAGSAIALDQIEPALQALQGKALVVVDEAYGEFSEVPSAVGLLARYDNLAVLRTLSKAHALAAARIGTLIANAELIAVLR
RCQAPYPVPTPCAAMAEQALSAPALEVTRRRIAEVRSERARVHKALVQLPGVRQVYPSQGNFLLVRFDDAEAAFQALLEA
GVVVRDQRAVPRLSDALRITLGTHEQNERVLSALQRTQEAAA

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=360, Percent_Identity=42.5, Blast_Score=278, Evalue=3e-76,
Organism=Saccharomyces cerevisiae, GI6322075, Length=376, Percent_Identity=34.5744680851064, Blast_Score=187, Evalue=2e-48,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 38625; Mature: 38493

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTSSILHLVREDLRAFAGYSSARTSALQGDVWLNANESAWGNPADPSASTRRYPDPQPQ
CCHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCH
GLRSALAALYGCAPEQLLIGRGSDEAIDLLVRGLCVPERDAVLVTPPVFGMYAVCARLQN
HHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHCC
APLVDVPLVDVPDGFHADIPAIVAAALASNAKLVFLCSPSNPAGSAIALDQIEPALQALQ
CCEEECCEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHC
GKALVVVDEAYGEFSEVPSAVGLLARYDNLAVLRTLSKAHALAAARIGTLIANAELIAVL
CCEEEEEEHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRCQAPYPVPTPCAAMAEQALSAPALEVTRRRIAEVRSERARVHKALVQLPGVRQVYPSQ
HHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCC
GNFLLVRFDDAEAAFQALLEAGVVVRDQRAVPRLSDALRITLGTHEQNERVLSALQRTQE
CCEEEEEECCHHHHHHHHHHCCCEEECCCCCCCHHHCEEEEECCCCHHHHHHHHHHHHHH
AAA
HCC
>Mature Secondary Structure 
STSSILHLVREDLRAFAGYSSARTSALQGDVWLNANESAWGNPADPSASTRRYPDPQPQ
CHHHHHHHHHHHHHHHHCCCHHHHHHHCCCEEECCCCCCCCCCCCCCCCCCCCCCCCCH
GLRSALAALYGCAPEQLLIGRGSDEAIDLLVRGLCVPERDAVLVTPPVFGMYAVCARLQN
HHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHHCCCCCCCCEEECCCHHHHHHHHHHHCC
APLVDVPLVDVPDGFHADIPAIVAAALASNAKLVFLCSPSNPAGSAIALDQIEPALQALQ
CCEEECCEEECCCCCCCCHHHHHHHHHHCCCEEEEEECCCCCCCCEEEHHHHHHHHHHHC
GKALVVVDEAYGEFSEVPSAVGLLARYDNLAVLRTLSKAHALAAARIGTLIANAELIAVL
CCEEEEEEHHHCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRCQAPYPVPTPCAAMAEQALSAPALEVTRRRIAEVRSERARVHKALVQLPGVRQVYPSQ
HHHCCCCCCCCCHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEECCCC
GNFLLVRFDDAEAAFQALLEAGVVVRDQRAVPRLSDALRITLGTHEQNERVLSALQRTQE
CCEEEEEECCHHHHHHHHHHCCCEEECCCCCCCHHHCEEEEECCCCHHHHHHHHHHHHHH
AAA
HCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]