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The map label for this gene is hisB [H]

Identifier: 84623778

GI number: 84623778

Start: 2347763

End: 2348890

Strand: Direct

Name: hisB [H]

Synonym: XOO_2121

Alternate gene names: 84623778

Gene position: 2347763-2348890 (Clockwise)

Preceding gene: 84623777

Following gene: 84623779

Centisome position: 47.52

GC content: 63.03

Gene sequence:

>1128_bases
ATGACCCCGATTCTCTTCGTCGACCGTGATGGCACGCTGATCACCGAGCCGGCCGACTACCAGATCGATGCGTACGAGAA
ACTACGCTTCGTCGATCACGTGATTCCGGCGATGCTCAAGCTGCGTGATGCCGGCTACCAGTTCGTCATCGTCAGCAACC
AGGATGGGCTGGGCAGCGAGAGCTTCCCGCGCGCCTCCTTCGACGGCCCGAACAACCTGATGCTGCAGATCTTCGCCAGC
CAGGGCATCGAATTCCGCGAAGTGCTGATCGATTGCAGCTGGCCATCCGACAACGCACCCACACGCAAGCCCGGCGTCGG
CTTGATGGTGCCCTATTTGCAGGACCGCACTATCGACTGGGCGCGCTCGGCGATGGTGGGCGACCGCATCACCGACATCC
AGTTCGCGCAGAACCTCAATATCCGCGGGTTTCAGCTGCGCACTGACGAATTCGGCGGCGAGTGGGACTGGCCCGGCATC
GCCCACGAATTGGCCGATGCGCCACGCCGTGCGGTGGTCCAGCGCAATACCAAGGAAACCAGGATCCGCGTCGAACTGGA
TCTGGATCGTGTCGCCGAGCCCAAGACCGCCACCGGCTTGCCGTTCTTCGACCACATGCTGGAACAGATCGGCAAACACG
GCGGCTTTGCGCTGGACATCCGTGCCGAAGGCGACCTGCATATCGATGAGCACCACACCATCGAAGACACCGGCCTTGCG
CTGGGTCAGGCCCTGCGCGAAGCGCTGGGCGACAAGCGCGGCATCGGCCGCTATGGGTTCGATCCGGAAAGCAGCCCGTG
GCAGGTTGCCGGCGACACCGCGCAACATGGTTTCACGTTGCCGATGGACGAAACCATCGCCAGTGCTGCGCTGGATTTCA
GCGGCCGGCCGTATTTCGTGTTCGACGGCCAGTTCAAGCGCGATCGCTTGGGCGACATGCCGACCGAGCTGGTGCCGCAT
TTCTTCCGCTCGATCTGCGATGCGTCCGGCGTGAACCTGCATCTGACGGTGCGCGGCGAAAACGATCACCACAAGGTCGA
GGCCTGCTTCAAGGCGTTGGCGCGTGCATTGCGTCAGGCGATTCGCCGTGAGGGCAGCGCATTGCCCACCACCAAGGGCG
CGCTATGA

Upstream 100 bases:

>100_bases
CAGTCCCGCGCCTGTCCGACGCCTTGCGCATCACCTTGGGCACGCATGAACAGAACGAGCGCGTACTGAGCGCGCTGCAA
CGCACGCAGGAGGCCGCCGC

Downstream 100 bases:

>100_bases
CCGATGTTGCGCTGATCGATGCCGGTGGCGCCAATCTGGGCTCGGTGCGCTATGCATTGGAGCGACTGGGCGTTGAGGCA
CGCGTGGTGCGCGATGCAGC

Product: imidazole glycerol-phosphate dehydratase/histidinol phosphatase

Products: NA

Alternate protein names: Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; IGPD [H]

Number of amino acids: Translated: 375; Mature: 374

Protein sequence:

>375_residues
MTPILFVDRDGTLITEPADYQIDAYEKLRFVDHVIPAMLKLRDAGYQFVIVSNQDGLGSESFPRASFDGPNNLMLQIFAS
QGIEFREVLIDCSWPSDNAPTRKPGVGLMVPYLQDRTIDWARSAMVGDRITDIQFAQNLNIRGFQLRTDEFGGEWDWPGI
AHELADAPRRAVVQRNTKETRIRVELDLDRVAEPKTATGLPFFDHMLEQIGKHGGFALDIRAEGDLHIDEHHTIEDTGLA
LGQALREALGDKRGIGRYGFDPESSPWQVAGDTAQHGFTLPMDETIASAALDFSGRPYFVFDGQFKRDRLGDMPTELVPH
FFRSICDASGVNLHLTVRGENDHHKVEACFKALARALRQAIRREGSALPTTKGAL

Sequences:

>Translated_375_residues
MTPILFVDRDGTLITEPADYQIDAYEKLRFVDHVIPAMLKLRDAGYQFVIVSNQDGLGSESFPRASFDGPNNLMLQIFAS
QGIEFREVLIDCSWPSDNAPTRKPGVGLMVPYLQDRTIDWARSAMVGDRITDIQFAQNLNIRGFQLRTDEFGGEWDWPGI
AHELADAPRRAVVQRNTKETRIRVELDLDRVAEPKTATGLPFFDHMLEQIGKHGGFALDIRAEGDLHIDEHHTIEDTGLA
LGQALREALGDKRGIGRYGFDPESSPWQVAGDTAQHGFTLPMDETIASAALDFSGRPYFVFDGQFKRDRLGDMPTELVPH
FFRSICDASGVNLHLTVRGENDHHKVEACFKALARALRQAIRREGSALPTTKGAL
>Mature_374_residues
TPILFVDRDGTLITEPADYQIDAYEKLRFVDHVIPAMLKLRDAGYQFVIVSNQDGLGSESFPRASFDGPNNLMLQIFASQ
GIEFREVLIDCSWPSDNAPTRKPGVGLMVPYLQDRTIDWARSAMVGDRITDIQFAQNLNIRGFQLRTDEFGGEWDWPGIA
HELADAPRRAVVQRNTKETRIRVELDLDRVAEPKTATGLPFFDHMLEQIGKHGGFALDIRAEGDLHIDEHHTIEDTGLAL
GQALREALGDKRGIGRYGFDPESSPWQVAGDTAQHGFTLPMDETIASAALDFSGRPYFVFDGQFKRDRLGDMPTELVPHF
FRSICDASGVNLHLTVRGENDHHKVEACFKALARALRQAIRREGSALPTTKGAL

Specific function: Histidine biosynthesis; sixth step. Histidine biosynthesis; eighth step. [C]

COG id: COG0131

COG function: function code E; Imidazoleglycerol-phosphate dehydratase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family [H]

Homologues:

Organism=Escherichia coli, GI87082027, Length=372, Percent_Identity=52.9569892473118, Blast_Score=389, Evalue=1e-109,
Organism=Escherichia coli, GI1786399, Length=192, Percent_Identity=30.7291666666667, Blast_Score=70, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324776, Length=233, Percent_Identity=39.4849785407725, Blast_Score=168, Evalue=2e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR023214
- InterPro:   IPR006549
- InterPro:   IPR020566
- InterPro:   IPR005954
- InterPro:   IPR006543
- InterPro:   IPR000807
- InterPro:   IPR020565
- InterPro:   IPR013954
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00475 IGPD; PF08645 PNK3P [H]

EC number: =3.1.3.15; =4.2.1.19 [H]

Molecular weight: Translated: 41888; Mature: 41757

Theoretical pI: Translated: 5.16; Mature: 5.16

Prosite motif: PS00954 IGP_DEHYDRATASE_1 ; PS00955 IGP_DEHYDRATASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTPILFVDRDGTLITEPADYQIDAYEKLRFVDHVIPAMLKLRDAGYQFVIVSNQDGLGSE
CCCEEEEECCCCEEECCCCCEECHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
SFPRASFDGPNNLMLQIFASQGIEFREVLIDCSWPSDNAPTRKPGVGLMVPYLQDRTIDW
CCCCCCCCCCCCEEEEEEHHCCCEEEHEEEECCCCCCCCCCCCCCCCEEECCCCCCCHHH
ARSAMVGDRITDIQFAQNLNIRGFQLRTDEFGGEWDWPGIAHELADAPRRAVVQRNTKET
HHHHHHCCCCCHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHCCHHHHHHHCCCCCE
RIRVELDLDRVAEPKTATGLPFFDHMLEQIGKHGGFALDIRAEGDLHIDEHHTIEDTGLA
EEEEEECHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCCHHHHHH
LGQALREALGDKRGIGRYGFDPESSPWQVAGDTAQHGFTLPMDETIASAALDFSGRPYFV
HHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEE
FDGQFKRDRLGDMPTELVPHFFRSICDASGVNLHLTVRGENDHHKVEACFKALARALRQA
ECCCCCHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
IRREGSALPTTKGAL
HHHCCCCCCCCCCCC
>Mature Secondary Structure 
TPILFVDRDGTLITEPADYQIDAYEKLRFVDHVIPAMLKLRDAGYQFVIVSNQDGLGSE
CCEEEEECCCCEEECCCCCEECHHHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCCC
SFPRASFDGPNNLMLQIFASQGIEFREVLIDCSWPSDNAPTRKPGVGLMVPYLQDRTIDW
CCCCCCCCCCCCEEEEEEHHCCCEEEHEEEECCCCCCCCCCCCCCCCEEECCCCCCCHHH
ARSAMVGDRITDIQFAQNLNIRGFQLRTDEFGGEWDWPGIAHELADAPRRAVVQRNTKET
HHHHHHCCCCCHHHHHCCCCCEEEEEECCCCCCCCCCCHHHHHHHCCHHHHHHHCCCCCE
RIRVELDLDRVAEPKTATGLPFFDHMLEQIGKHGGFALDIRAEGDLHIDEHHTIEDTGLA
EEEEEECHHHCCCCCCCCCCCHHHHHHHHHHCCCCEEEEEECCCCEEECCCCCCHHHHHH
LGQALREALGDKRGIGRYGFDPESSPWQVAGDTAQHGFTLPMDETIASAALDFSGRPYFV
HHHHHHHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCHHHHHHHHHHCCCCCEEEE
FDGQFKRDRLGDMPTELVPHFFRSICDASGVNLHLTVRGENDHHKVEACFKALARALRQA
ECCCCCHHHCCCCCHHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHHHHHHHHHHHHHHH
IRREGSALPTTKGAL
HHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]