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The map label for this gene is hisD [H]

Identifier: 84623776

GI number: 84623776

Start: 2345383

End: 2346678

Strand: Direct

Name: hisD [H]

Synonym: XOO_2119

Alternate gene names: 84623776

Gene position: 2345383-2346678 (Clockwise)

Preceding gene: 84623775

Following gene: 84623777

Centisome position: 47.48

GC content: 66.36

Gene sequence:

>1296_bases
ATGAAGATTCTCGATTGGTCACAACTCGATGTCGCCGCACGGACCGATGCGTTGACTCGCCCGGTGCAGACCGTGGCCGC
ACAGACGCGCAATGCGGTCGCCGCGTTGATTGCCGACGTGCGCACGCGCGGCGATGCGGCATTGCGCGAGATCACCGCGC
GCTTCGATGGCGTGTCGCTGGAGCGCTTCGCAGTGAGCGAAGCCGAATTCGCCGCCGCCGAAGCGGCCGTTGCGCCGGAA
CTGCGCCAGGCCATGCAGGATGCCGTGGCACGCATCGACACCTTCCACCGCGCTGGCATGAGCGAAGGTTATGCGGTGGA
AACCGCGCCGGGTGTGGTGTGCGAAAAGATCGTGCGGCCGATCGGCCGTGTGGGCCTGTACGTGCCGGCCGGCAGCGCGC
CGTTGCCGTCGACGGCCTTGATGTTGGGCGTTCCGGCGCGTCTGGCCGGTTGCCGCGCGGTGGTGTTGTGTACGCCGCCG
CGCAAGGACGGTAGCGTGGATCCGGCAGTGCTGGTCGCGGCGTGGCTCACCGGCGTGCGCCGTGTGTTCAAGCTCGGCGG
TGCGCAGGCGATTGCGGCGATGGCGTATGGCACCGAGTCGGTGCCCAGCTGCGACAAGTTGTTCGGCCCGGGCAACAGCT
ATGTCACCGAAGCCAAGCAGCAGGTGGCGCAGTCCGGTGCGGCGGCGATCGACATGCCGGCCGGCCCGTCCGAAGTCTTG
GTGATCGCCGATGCCGGCGCGCAAGCGGCGTTCGTGGCTGCCGACCTGCTATCGCAGGCCGAACACGGCGCGGATTCGCA
GGTGTTGTTGCTGTCCGACAGCGACGTGTTGATCGATGCGGTGCAGGCGCAGCTGGAGATACAGCTGGCGCATCTCTCAC
GTGCCGACATCGCGCGTCAGGCGCTGGCGCAATCGCGCTTGATCAAGGTGCAGACGCTGGATGAGGCGTTTGCGATCAGC
AACCGCTATGCGCCGGAGCATCTGATTCTTGCGCTGCGCGAACCGCGCGCGTGGCTGGCGCAAGTCGAGGCAGCCGGCTC
GGTATTTCTCGGCGATTACACACCCGAAGCACTCGGCGATTATTGCAGTGGCACCAACCACGTGTTGCCGACCAGCGGTG
CGGCGCGCGCGTATAGCGGCGTCAGCGTGGCCAGTTTCCAGAACATGTTCAGCGTGCAGGCGGCCAGCAAGGCCGGCATC
GCTGGCATTGGTGAATGCGCGTTGATACTCGCGCGCGCAGAAGGCTTGGACGCGCATGCCAATGCAGTAGCACTGCGCAT
GGGAGTGGCAGCATGA

Upstream 100 bases:

>100_bases
AGACCATGTGCCACGGTGCGGTGACCTGGCAACGCCTGGAAGAACTCGAACGCGCAGGTGCGCAAGGCTTGATGGTATTG
ACGGTGGAGCGCTCGCTGGC

Downstream 100 bases:

>100_bases
GCACGTCATCTATTCTGCATCTCGTGCGCGAAGATCTGCGCGCGTTCGCAGGATATTCGTCGGCGCGCACCAGCGCATTG
CAGGGCGATGTGTGGCTCAA

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MKILDWSQLDVAARTDALTRPVQTVAAQTRNAVAALIADVRTRGDAALREITARFDGVSLERFAVSEAEFAAAEAAVAPE
LRQAMQDAVARIDTFHRAGMSEGYAVETAPGVVCEKIVRPIGRVGLYVPAGSAPLPSTALMLGVPARLAGCRAVVLCTPP
RKDGSVDPAVLVAAWLTGVRRVFKLGGAQAIAAMAYGTESVPSCDKLFGPGNSYVTEAKQQVAQSGAAAIDMPAGPSEVL
VIADAGAQAAFVAADLLSQAEHGADSQVLLLSDSDVLIDAVQAQLEIQLAHLSRADIARQALAQSRLIKVQTLDEAFAIS
NRYAPEHLILALREPRAWLAQVEAAGSVFLGDYTPEALGDYCSGTNHVLPTSGAARAYSGVSVASFQNMFSVQAASKAGI
AGIGECALILARAEGLDAHANAVALRMGVAA

Sequences:

>Translated_431_residues
MKILDWSQLDVAARTDALTRPVQTVAAQTRNAVAALIADVRTRGDAALREITARFDGVSLERFAVSEAEFAAAEAAVAPE
LRQAMQDAVARIDTFHRAGMSEGYAVETAPGVVCEKIVRPIGRVGLYVPAGSAPLPSTALMLGVPARLAGCRAVVLCTPP
RKDGSVDPAVLVAAWLTGVRRVFKLGGAQAIAAMAYGTESVPSCDKLFGPGNSYVTEAKQQVAQSGAAAIDMPAGPSEVL
VIADAGAQAAFVAADLLSQAEHGADSQVLLLSDSDVLIDAVQAQLEIQLAHLSRADIARQALAQSRLIKVQTLDEAFAIS
NRYAPEHLILALREPRAWLAQVEAAGSVFLGDYTPEALGDYCSGTNHVLPTSGAARAYSGVSVASFQNMFSVQAASKAGI
AGIGECALILARAEGLDAHANAVALRMGVAA
>Mature_431_residues
MKILDWSQLDVAARTDALTRPVQTVAAQTRNAVAALIADVRTRGDAALREITARFDGVSLERFAVSEAEFAAAEAAVAPE
LRQAMQDAVARIDTFHRAGMSEGYAVETAPGVVCEKIVRPIGRVGLYVPAGSAPLPSTALMLGVPARLAGCRAVVLCTPP
RKDGSVDPAVLVAAWLTGVRRVFKLGGAQAIAAMAYGTESVPSCDKLFGPGNSYVTEAKQQVAQSGAAAIDMPAGPSEVL
VIADAGAQAAFVAADLLSQAEHGADSQVLLLSDSDVLIDAVQAQLEIQLAHLSRADIARQALAQSRLIKVQTLDEAFAIS
NRYAPEHLILALREPRAWLAQVEAAGSVFLGDYTPEALGDYCSGTNHVLPTSGAARAYSGVSVASFQNMFSVQAASKAGI
AGIGECALILARAEGLDAHANAVALRMGVAA

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=427, Percent_Identity=51.288056206089, Blast_Score=413, Evalue=1e-116,
Organism=Saccharomyces cerevisiae, GI6319819, Length=433, Percent_Identity=46.8822170900693, Blast_Score=382, Evalue=1e-107,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 44705; Mature: 44705

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKILDWSQLDVAARTDALTRPVQTVAAQTRNAVAALIADVRTRGDAALREITARFDGVSL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCH
ERFAVSEAEFAAAEAAVAPELRQAMQDAVARIDTFHRAGMSEGYAVETAPGVVCEKIVRP
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHH
IGRVGLYVPAGSAPLPSTALMLGVPARLAGCRAVVLCTPPRKDGSVDPAVLVAAWLTGVR
HHHCEEEECCCCCCCCCHHHEECCCHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
RVFKLGGAQAIAAMAYGTESVPSCDKLFGPGNSYVTEAKQQVAQSGAAAIDMPAGPSEVL
HHHHHCCHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCEE
VIADAGAQAAFVAADLLSQAEHGADSQVLLLSDSDVLIDAVQAQLEIQLAHLSRADIARQ
EEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALAQSRLIKVQTLDEAFAISNRYAPEHLILALREPRAWLAQVEAAGSVFLGDYTPEALGD
HHHHHHEEEEEEHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHCCCEEECCCCHHHHHH
YCSGTNHVLPTSGAARAYSGVSVASFQNMFSVQAASKAGIAGIGECALILARAEGLDAHA
HHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCC
NAVALRMGVAA
CCEEEEECCCC
>Mature Secondary Structure
MKILDWSQLDVAARTDALTRPVQTVAAQTRNAVAALIADVRTRGDAALREITARFDGVSL
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCCCH
ERFAVSEAEFAAAEAAVAPELRQAMQDAVARIDTFHRAGMSEGYAVETAPGVVCEKIVRP
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHH
IGRVGLYVPAGSAPLPSTALMLGVPARLAGCRAVVLCTPPRKDGSVDPAVLVAAWLTGVR
HHHCEEEECCCCCCCCCHHHEECCCHHHCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHH
RVFKLGGAQAIAAMAYGTESVPSCDKLFGPGNSYVTEAKQQVAQSGAAAIDMPAGPSEVL
HHHHHCCHHHHHHHHCCCCCCCCHHHHCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCEE
VIADAGAQAAFVAADLLSQAEHGADSQVLLLSDSDVLIDAVQAQLEIQLAHLSRADIARQ
EEECCCCCHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHH
ALAQSRLIKVQTLDEAFAISNRYAPEHLILALREPRAWLAQVEAAGSVFLGDYTPEALGD
HHHHHHEEEEEEHHHHHHHCCCCCCCCEEEEECCCHHHHHHHHHCCCEEECCCCHHHHHH
YCSGTNHVLPTSGAARAYSGVSVASFQNMFSVQAASKAGIAGIGECALILARAEGLDAHA
HHCCCCCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCC
NAVALRMGVAA
CCEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12024217 [H]