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The map label for this gene is emrA [H]

Identifier: 84623547

GI number: 84623547

Start: 2087541

End: 2088734

Strand: Direct

Name: emrA [H]

Synonym: XOO_1890

Alternate gene names: 84623547

Gene position: 2087541-2088734 (Clockwise)

Preceding gene: 84623546

Following gene: 84623548

Centisome position: 42.26

GC content: 64.99

Gene sequence:

>1194_bases
ATGAGCCAGACGACTTCAACTTCTCCTCAACCCGCACCAGCCGCGCCCAGCAAGCGCCGCGCTGCGCTGCGTATCGTGGC
CATTGTGGCGATCCTGGCGATCATCGGCCTGGTGGTGTGGTACTTCCTGGTCGGCCGTTGGCACGAAGACACCGACGACG
CGTACGTACAGGGCAATCAGGTGCAGATCACCCCGATGGTGGGCGGCACTGTGGTGAGTATCGGCGCCGAAGACGGCATG
CGCGTGGAGCGCGGCCAGTTGCTGGTGCAACTGGACCCGGCCGACACCGAGGGCGCAGTGCAGCAGGCCGAAGCCAATCT
TGCCAAGACCGTGCGTCAGGTGCGCGGTCTGTATCGCAGTGTTGAAGGTGCACAGGCCGAATTGTCCGCACGCGAGGTCG
CGCTGCGCAGTGCGCGCTCAGACTTCGCACGGCGTAAGGATCTGGCTGCCACCGGCGCGATCTCCAACGAAGAACTCGCG
CATGCTCGCGACGAACTGGCCGCGGCCGAAGCGGCCGTGAGCGGCTCGCGCGAGAGCTTTGAGCGTAACCGTGCGTTGGT
GGACGACAGCGCAGTGGCCAACCAGCCGGACGTGCAGACCGCCGCCGCGCAGCTGCGTCAGGCGTATCTGAATCATGCGC
GCACCGGCGTGGTGGCGCCCGTGTCGGGTTATGTCGCACGGCGCGCGGCACAAGTTGGCCAGCGTGTGCAGCCGGGCAGC
GTGCTGATGGTGGTGGTGCCGCTGGAGCAGGTGTGGGTGGAAGCCAACTTCAAGGAGACACAGCTCAAGCACATGCGTCT
GGGCCAGGAAGTGGAACTGCATTCGGATCTGTACGGCGGCGGAGTGAGCTACACCGGCCGTATCCAGAGCCTGGGTCTGG
GCACCGGCAGCGCGTTCTCGCTGTTGCCTGCGCAGAACGCCAGCGGTAACTGGATCAAGATCGTACAGCGCGTGCCGGTA
CGCATTGCAGTGGATTCCAAGCAGCTGGCCAGCAATCCGCTGCGGATCGGGTTGTCGATGAAGGTCGAAGTCAAGCTGCA
CGATCAGCAGGGCAGCGTGTTGCCGACCAAGCTCGCCAACGCTGCGGTGTTCTCCACCGACGTGTATGCGCAGCAGCTCA
AGGCTGCCGACGCCGACGTCCAACGCATCATCCAGGACAACCTGCCGTCGCAGGCTGCCAGCAAGGCGGGCTAA

Upstream 100 bases:

>100_bases
TTGCAGCGTGCGCTGGGCGGCGGATTCACGCCGGAGCCCGCGCGCGATACCGCACACACCGCGCCCACTTCCGCACAACC
GAATTCCTGAGACATCGACG

Downstream 100 bases:

>100_bases
GCCATCATGTCTTCGCAAGCTCCCACCGCGCCCGGCGGCCCGGCGGCGCCGGCGCCCGCGGCGGGTTTTCGACCGGCCAG
CGTGGCGTTGTGCACCGTGG

Product: multidrug resistance efflux pump

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 397; Mature: 396

Protein sequence:

>397_residues
MSQTTSTSPQPAPAAPSKRRAALRIVAIVAILAIIGLVVWYFLVGRWHEDTDDAYVQGNQVQITPMVGGTVVSIGAEDGM
RVERGQLLVQLDPADTEGAVQQAEANLAKTVRQVRGLYRSVEGAQAELSAREVALRSARSDFARRKDLAATGAISNEELA
HARDELAAAEAAVSGSRESFERNRALVDDSAVANQPDVQTAAAQLRQAYLNHARTGVVAPVSGYVARRAAQVGQRVQPGS
VLMVVVPLEQVWVEANFKETQLKHMRLGQEVELHSDLYGGGVSYTGRIQSLGLGTGSAFSLLPAQNASGNWIKIVQRVPV
RIAVDSKQLASNPLRIGLSMKVEVKLHDQQGSVLPTKLANAAVFSTDVYAQQLKAADADVQRIIQDNLPSQAASKAG

Sequences:

>Translated_397_residues
MSQTTSTSPQPAPAAPSKRRAALRIVAIVAILAIIGLVVWYFLVGRWHEDTDDAYVQGNQVQITPMVGGTVVSIGAEDGM
RVERGQLLVQLDPADTEGAVQQAEANLAKTVRQVRGLYRSVEGAQAELSAREVALRSARSDFARRKDLAATGAISNEELA
HARDELAAAEAAVSGSRESFERNRALVDDSAVANQPDVQTAAAQLRQAYLNHARTGVVAPVSGYVARRAAQVGQRVQPGS
VLMVVVPLEQVWVEANFKETQLKHMRLGQEVELHSDLYGGGVSYTGRIQSLGLGTGSAFSLLPAQNASGNWIKIVQRVPV
RIAVDSKQLASNPLRIGLSMKVEVKLHDQQGSVLPTKLANAAVFSTDVYAQQLKAADADVQRIIQDNLPSQAASKAG
>Mature_396_residues
SQTTSTSPQPAPAAPSKRRAALRIVAIVAILAIIGLVVWYFLVGRWHEDTDDAYVQGNQVQITPMVGGTVVSIGAEDGMR
VERGQLLVQLDPADTEGAVQQAEANLAKTVRQVRGLYRSVEGAQAELSAREVALRSARSDFARRKDLAATGAISNEELAH
ARDELAAAEAAVSGSRESFERNRALVDDSAVANQPDVQTAAAQLRQAYLNHARTGVVAPVSGYVARRAAQVGQRVQPGSV
LMVVVPLEQVWVEANFKETQLKHMRLGQEVELHSDLYGGGVSYTGRIQSLGLGTGSAFSLLPAQNASGNWIKIVQRVPVR
IAVDSKQLASNPLRIGLSMKVEVKLHDQQGSVLPTKLANAAVFSTDVYAQQLKAADADVQRIIQDNLPSQAASKAG

Specific function: The emr locus confers resistance to substances of high hydrophobicity. EmrA probably participate in a transport system to extrude toxins and drugs from the cell [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI1789041, Length=359, Percent_Identity=44.0111420612813, Blast_Score=307, Evalue=9e-85,
Organism=Escherichia coli, GI1788711, Length=339, Percent_Identity=42.4778761061947, Blast_Score=284, Evalue=5e-78,
Organism=Escherichia coli, GI1790519, Length=313, Percent_Identity=30.3514376996805, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI87081951, Length=307, Percent_Identity=29.9674267100977, Blast_Score=105, Evalue=3e-24,
Organism=Escherichia coli, GI1789637, Length=311, Percent_Identity=25.08038585209, Blast_Score=72, Evalue=8e-14,
Organism=Escherichia coli, GI1790024, Length=235, Percent_Identity=23.8297872340426, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1790012, Length=297, Percent_Identity=23.5690235690236, Blast_Score=63, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005694
- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42435; Mature: 42303

Theoretical pI: Translated: 9.20; Mature: 9.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQTTSTSPQPAPAAPSKRRAALRIVAIVAILAIIGLVVWYFLVGRWHEDTDDAYVQGNQ
CCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCE
VQITPMVGGTVVSIGAEDGMRVERGQLLVQLDPADTEGAVQQAEANLAKTVRQVRGLYRS
EEEEEEECCEEEEECCCCCCEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VEGAQAELSAREVALRSARSDFARRKDLAATGAISNEELAHARDELAAAEAAVSGSRESF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHH
ERNRALVDDSAVANQPDVQTAAAQLRQAYLNHARTGVVAPVSGYVARRAAQVGQRVQPGS
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHCCCCCCCC
VLMVVVPLEQVWVEANFKETQLKHMRLGQEVELHSDLYGGGVSYTGRIQSLGLGTGSAFS
EEEEEEEHHHHHEECCCHHHHHHHHHCCCCEEHHHHHCCCCCCCCCEEEEECCCCCCCEE
LLPAQNASGNWIKIVQRVPVRIAVDSKQLASNPLRIGLSMKVEVKLHDQQGSVLPTKLAN
EEECCCCCCCCEEHEECCCEEEEECCHHHHCCCEEEEEEEEEEEEEECCCCCCCHHHHHC
AAVFSTDVYAQQLKAADADVQRIIQDNLPSQAASKAG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC
>Mature Secondary Structure 
SQTTSTSPQPAPAAPSKRRAALRIVAIVAILAIIGLVVWYFLVGRWHEDTDDAYVQGNQ
CCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEECCE
VQITPMVGGTVVSIGAEDGMRVERGQLLVQLDPADTEGAVQQAEANLAKTVRQVRGLYRS
EEEEEEECCEEEEECCCCCCEEECCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VEGAQAELSAREVALRSARSDFARRKDLAATGAISNEELAHARDELAAAEAAVSGSRESF
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHH
ERNRALVDDSAVANQPDVQTAAAQLRQAYLNHARTGVVAPVSGYVARRAAQVGQRVQPGS
HHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCEECCHHHHHHHHHHHHCCCCCCCC
VLMVVVPLEQVWVEANFKETQLKHMRLGQEVELHSDLYGGGVSYTGRIQSLGLGTGSAFS
EEEEEEEHHHHHEECCCHHHHHHHHHCCCCEEHHHHHCCCCCCCCCEEEEECCCCCCCEE
LLPAQNASGNWIKIVQRVPVRIAVDSKQLASNPLRIGLSMKVEVKLHDQQGSVLPTKLAN
EEECCCCCCCCEEHEECCCEEEEECCHHHHCCCEEEEEEEEEEEEEECCCCCCCHHHHHC
AAVFSTDVYAQQLKAADADVQRIIQDNLPSQAASKAG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1409590; 9205837; 9278503; 8203018 [H]