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The map label for this gene is mmsB [H]

Identifier: 84623399

GI number: 84623399

Start: 1924414

End: 1925301

Strand: Direct

Name: mmsB [H]

Synonym: XOO_1742

Alternate gene names: 84623399

Gene position: 1924414-1925301 (Clockwise)

Preceding gene: 84623398

Following gene: 84623400

Centisome position: 38.95

GC content: 66.89

Gene sequence:

>888_bases
ATGAGCAATATCGCGTTTATCGGCCTGGGCAATATGGGCGGGCCAATGGCTGCCAATCTGATCAAGGCCGGGCATCAGCT
GCGGGCATTCGATCTGGCACCGGCTGCCCTGGACGCTGCAACAGCGGCCGGTGCGCATGCCGCCAGCTCCGCGCAGGACA
CGCTGGCCGATGCCGAAATCGTGATCTCGATGCTGCCTGCGAGCCGCCACGTCGAAGGCTTGTACCTGGGCGACTCCGGC
ATCCTGGCGCAGATTCCGCACGGTGCGCTGGTCATCGACTGCAGCACCATCGCACCCCTGTCTGCGCGCAAGGTGGCCGA
TGCGGCCACGGCGCGTGGCCTGACAATGTTGGACGCCCCGGTCTCCGGCGGCACCGCCGGTGCTGCAGCCGGCACCCTGA
CCTTCATCGTCGGCGGCGCTGCCGAGGTGCTGGAGCGCGCGCGTCCGGTGCTGCAGGCCATGGGCAAGAACATTTTCCAC
GTCGGCGACAACGGGGCAGGGCAGGTCGCCAAGCTCTGCAACAACATGGCCCTGGGCGTGATCATGGCCGCCACCGGCGA
AGCGCTGGCGCTCGGCGTCGCGCAAGGCTTGGACCCTGCAGTGCTGTCGCAGATGATGGCGGTCAGCACCGGGCGCAGTT
GGGCCACCGAAGTGTGCAATCCCTGGCCCGGCGTGCTGCCCAATGCCCCGGCATCGCGCGGCTACAGCGGTGGCTTCGGC
AACGACTTGATGCTCAAGGATCTGGGGTTGGTCGCCGAGTCGGCGGTACAGGCCGGTGTCTCGATTCCGCTCGGTGAGCT
GGCGCGCAACCTGTACGCAATGAACAGCCAGGCTGGCAACGGGGCGCTGGATTTTTCCAGCGTGGTCAAGCTGGTCGCCA
AGGTCTGA

Upstream 100 bases:

>100_bases
GAACACTGCAGTCGCACTGGAAGCTGCGCGTGGATCGCTCCGCCAGCGCGTGACAACCAAACAATCTGTTGAAGATCGTC
CTGATCTGGAAACCGACACC

Downstream 100 bases:

>100_bases
GTCGCGAACTGGGTCGCGTCGCGCATCCATCGTTGAGCGGTGCGGATGGTGGAGAAGCGCTGAAACCTTTGCGTGCGCTT
CATCAACTGCACCCACCGCG

Product: 3-hydroxyisobutirate dehydrogenase

Products: NA

Alternate protein names: HIBADH [H]

Number of amino acids: Translated: 295; Mature: 294

Protein sequence:

>295_residues
MSNIAFIGLGNMGGPMAANLIKAGHQLRAFDLAPAALDAATAAGAHAASSAQDTLADAEIVISMLPASRHVEGLYLGDSG
ILAQIPHGALVIDCSTIAPLSARKVADAATARGLTMLDAPVSGGTAGAAAGTLTFIVGGAAEVLERARPVLQAMGKNIFH
VGDNGAGQVAKLCNNMALGVIMAATGEALALGVAQGLDPAVLSQMMAVSTGRSWATEVCNPWPGVLPNAPASRGYSGGFG
NDLMLKDLGLVAESAVQAGVSIPLGELARNLYAMNSQAGNGALDFSSVVKLVAKV

Sequences:

>Translated_295_residues
MSNIAFIGLGNMGGPMAANLIKAGHQLRAFDLAPAALDAATAAGAHAASSAQDTLADAEIVISMLPASRHVEGLYLGDSG
ILAQIPHGALVIDCSTIAPLSARKVADAATARGLTMLDAPVSGGTAGAAAGTLTFIVGGAAEVLERARPVLQAMGKNIFH
VGDNGAGQVAKLCNNMALGVIMAATGEALALGVAQGLDPAVLSQMMAVSTGRSWATEVCNPWPGVLPNAPASRGYSGGFG
NDLMLKDLGLVAESAVQAGVSIPLGELARNLYAMNSQAGNGALDFSSVVKLVAKV
>Mature_294_residues
SNIAFIGLGNMGGPMAANLIKAGHQLRAFDLAPAALDAATAAGAHAASSAQDTLADAEIVISMLPASRHVEGLYLGDSGI
LAQIPHGALVIDCSTIAPLSARKVADAATARGLTMLDAPVSGGTAGAAAGTLTFIVGGAAEVLERARPVLQAMGKNIFHV
GDNGAGQVAKLCNNMALGVIMAATGEALALGVAQGLDPAVLSQMMAVSTGRSWATEVCNPWPGVLPNAPASRGYSGGFGN
DLMLKDLGLVAESAVQAGVSIPLGELARNLYAMNSQAGNGALDFSSVVKLVAKV

Specific function: D-galactarate metabolism; third step. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=291, Percent_Identity=42.6116838487972, Blast_Score=239, Evalue=2e-63,
Organism=Homo sapiens, GI40556376, Length=201, Percent_Identity=29.3532338308458, Blast_Score=88, Evalue=1e-17,
Organism=Escherichia coli, GI145693186, Length=262, Percent_Identity=38.1679389312977, Blast_Score=172, Evalue=2e-44,
Organism=Escherichia coli, GI1790315, Length=293, Percent_Identity=38.5665529010239, Blast_Score=171, Evalue=7e-44,
Organism=Escherichia coli, GI1786719, Length=288, Percent_Identity=33.6805555555556, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1789092, Length=295, Percent_Identity=31.1864406779661, Blast_Score=108, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17557316, Length=296, Percent_Identity=42.2297297297297, Blast_Score=223, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24655230, Length=292, Percent_Identity=44.5205479452055, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI19922568, Length=292, Percent_Identity=44.5205479452055, Blast_Score=239, Evalue=2e-63,
Organism=Drosophila melanogaster, GI28574115, Length=293, Percent_Identity=23.2081911262799, Blast_Score=75, Evalue=6e-14,
Organism=Drosophila melanogaster, GI24655240, Length=65, Percent_Identity=47.6923076923077, Blast_Score=66, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR011548
- InterPro:   IPR016040 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.31 [H]

Molecular weight: Translated: 29421; Mature: 29290

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNIAFIGLGNMGGPMAANLIKAGHQLRAFDLAPAALDAATAAGAHAASSAQDTLADAEI
CCCEEEEEECCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCHHCCCHHHHHHHHHH
VISMLPASRHVEGLYLGDSGILAQIPHGALVIDCSTIAPLSARKVADAATARGLTMLDAP
HHHHCCCCCCCCEEEECCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEECC
VSGGTAGAAAGTLTFIVGGAAEVLERARPVLQAMGKNIFHVGDNGAGQVAKLCNNMALGV
CCCCCCCHHHHHHHHEECCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCHHHEE
IMAATGEALALGVAQGLDPAVLSQMMAVSTGRSWATEVCNPWPGVLPNAPASRGYSGGFG
EEECCCCHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC
NDLMLKDLGLVAESAVQAGVSIPLGELARNLYAMNSQAGNGALDFSSVVKLVAKV
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCC
>Mature Secondary Structure 
SNIAFIGLGNMGGPMAANLIKAGHQLRAFDLAPAALDAATAAGAHAASSAQDTLADAEI
CCEEEEEECCCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHCCCHHCCCHHHHHHHHHH
VISMLPASRHVEGLYLGDSGILAQIPHGALVIDCSTIAPLSARKVADAATARGLTMLDAP
HHHHCCCCCCCCEEEECCCCCEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCEEEECC
VSGGTAGAAAGTLTFIVGGAAEVLERARPVLQAMGKNIFHVGDNGAGQVAKLCNNMALGV
CCCCCCCHHHHHHHHEECCHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHCCHHHEE
IMAATGEALALGVAQGLDPAVLSQMMAVSTGRSWATEVCNPWPGVLPNAPASRGYSGGFG
EEECCCCHHHHHHHHCCCHHHHHHHHHHHCCCHHHHHHCCCCCCCCCCCCCCCCCCCCCC
NDLMLKDLGLVAESAVQAGVSIPLGELARNLYAMNSQAGNGALDFSSVVKLVAKV
CCHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1339433; 10984043 [H]