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The map label for this gene is rmlA2 [C]

Identifier: 84490289

GI number: 84490289

Start: 1692236

End: 1693261

Strand: Direct

Name: rmlA2 [C]

Synonym: Msp_1509

Alternate gene names: 84490289

Gene position: 1692236-1693261 (Clockwise)

Preceding gene: 84490288

Following gene: 84490290

Centisome position: 95.75

GC content: 29.73

Gene sequence:

>1026_bases
ATGAAAGACACAGTGGGAATGATACTATGTGGTGGTTTTGGAAAAAGATTAAGACCTGTAACTGAAACAGTACCTAAACC
ATTAGTAGAACTAAAAGAAGATTACACAATACTTGATAAACAAATATTTGACTTTAAAAGTGCAGGAGTTAATAAAGTAA
TATTATTGACTGGATTCCTTGGAGAAAAAATAGAAGAACGTTATGGTAATGAATATATGGGCGTTACAATTGAATATGTT
AAAGAAGAAAAACCTCTTGGAACACTAAATGCCATACGTTTAGGAATGGAACACATGGATGATAACACACAATGTGTAAT
AAGAAACGGAGATGTTGTTGCAGATTTAAGTATTAAAAAAATGATAGAAGATGGTGAAAAATCACCATTTGATTTCACAA
TATTTGTAACACAAATGACATCACCTTATGGTATAGTTGAATTAAGTGGAGATAAAATAGTATTATTCAAGGAAAAACCA
TTACTTGATTACTATATAAATGGTGGAATATACTTTTCAAAAGGTAAGTTAGACTTCGGATCATATAAAACAGGAGATAT
TGAAAAAACAATATTCCCTGAATTAGCAAAAGATAAGAAACTTGGATATTATAAGGAAAATGGTTTATTTTGGATGGCAG
TAGACACGTCAAAAGAATTACAGCAAGTACAAAATGAATATAAAAACAGAGAAGATAAGCCATGGGGATATGAGAAAGTA
CTTATATATACTGATAAATATCTTACAAAAGAATTATTTATTAAAGAAGGTTATCAGACAAGCTTCCACTATCATCCAAA
TAAAGATGAAACAATGTACATTGTAAGTGGAAAAGGTTACATAGAATTTGAAGACAAAAAAGAATATTTTGGAGCAAAGG
ATACTGTAAGAATAGAACCACAAACACCACATACTATTGTTGCTATAGAAAACACAGTATTACATGAAGTATCTACACCA
GACTTAGATGATACAATTAGAATAAAAGATTTCTATGATTCACAAACACCTAGTGGTAAAAGATAG

Upstream 100 bases:

>100_bases
TTATTATAAAAAAAAGAAGTTTAAATAGTAAAAAATATTTTTATATAAAGTATTTTATAATATAAAAAAAAATATTACTA
AAATAAACAGAGTGATCCAA

Downstream 100 bases:

>100_bases
ATTGAATCTATCTTAAAAATTCTTTTTTACTTTTTTTAAAATTATTTATGGAGACGTGGTTTTATTAGTAATATAACTAT
TATTGATTATGGCAGTGGAA

Product: sugar phosphate nucleotidyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 341; Mature: 341

Protein sequence:

>341_residues
MKDTVGMILCGGFGKRLRPVTETVPKPLVELKEDYTILDKQIFDFKSAGVNKVILLTGFLGEKIEERYGNEYMGVTIEYV
KEEKPLGTLNAIRLGMEHMDDNTQCVIRNGDVVADLSIKKMIEDGEKSPFDFTIFVTQMTSPYGIVELSGDKIVLFKEKP
LLDYYINGGIYFSKGKLDFGSYKTGDIEKTIFPELAKDKKLGYYKENGLFWMAVDTSKELQQVQNEYKNREDKPWGYEKV
LIYTDKYLTKELFIKEGYQTSFHYHPNKDETMYIVSGKGYIEFEDKKEYFGAKDTVRIEPQTPHTIVAIENTVLHEVSTP
DLDDTIRIKDFYDSQTPSGKR

Sequences:

>Translated_341_residues
MKDTVGMILCGGFGKRLRPVTETVPKPLVELKEDYTILDKQIFDFKSAGVNKVILLTGFLGEKIEERYGNEYMGVTIEYV
KEEKPLGTLNAIRLGMEHMDDNTQCVIRNGDVVADLSIKKMIEDGEKSPFDFTIFVTQMTSPYGIVELSGDKIVLFKEKP
LLDYYINGGIYFSKGKLDFGSYKTGDIEKTIFPELAKDKKLGYYKENGLFWMAVDTSKELQQVQNEYKNREDKPWGYEKV
LIYTDKYLTKELFIKEGYQTSFHYHPNKDETMYIVSGKGYIEFEDKKEYFGAKDTVRIEPQTPHTIVAIENTVLHEVSTP
DLDDTIRIKDFYDSQTPSGKR
>Mature_341_residues
MKDTVGMILCGGFGKRLRPVTETVPKPLVELKEDYTILDKQIFDFKSAGVNKVILLTGFLGEKIEERYGNEYMGVTIEYV
KEEKPLGTLNAIRLGMEHMDDNTQCVIRNGDVVADLSIKKMIEDGEKSPFDFTIFVTQMTSPYGIVELSGDKIVLFKEKP
LLDYYINGGIYFSKGKLDFGSYKTGDIEKTIFPELAKDKKLGYYKENGLFWMAVDTSKELQQVQNEYKNREDKPWGYEKV
LIYTDKYLTKELFIKEGYQTSFHYHPNKDETMYIVSGKGYIEFEDKKEYFGAKDTVRIEPQTPHTIVAIENTVLHEVSTP
DLDDTIRIKDFYDSQTPSGKR

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761621, Length=224, Percent_Identity=32.1428571428571, Blast_Score=102, Evalue=4e-22,
Organism=Homo sapiens, GI11761619, Length=224, Percent_Identity=32.1428571428571, Blast_Score=102, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI133931050, Length=234, Percent_Identity=35.042735042735, Blast_Score=112, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6320148, Length=240, Percent_Identity=33.75, Blast_Score=97, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21355443, Length=225, Percent_Identity=32.8888888888889, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI24644084, Length=225, Percent_Identity=32.8888888888889, Blast_Score=97, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 39251; Mature: 39251

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKDTVGMILCGGFGKRLRPVTETVPKPLVELKEDYTILDKQIFDFKSAGVNKVILLTGFL
CCCCEEEEEECCCCCCCCHHHHHCCHHHHHHHCCCEEHHHHHHHHHHCCCCEEEEEECHH
GEKIEERYGNEYMGVTIEYVKEEKPLGTLNAIRLGMEHMDDNTQCVIRNGDVVADLSIKK
HHHHHHHHCCCEEEEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCEEEEHHHHH
MIEDGEKSPFDFTIFVTQMTSPYGIVELSGDKIVLFKEKPLLDYYINGGIYFSKGKLDFG
HHHCCCCCCEEEEEEEEECCCCCEEEEECCCEEEEEECCCCEEEEECCCEEEECCCCCCC
SYKTGDIEKTIFPELAKDKKLGYYKENGLFWMAVDTSKELQQVQNEYKNREDKPWGYEKV
CCCCCCCCHHHHHHHHCCCCCCEEECCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCEEE
LIYTDKYLTKELFIKEGYQTSFHYHPNKDETMYIVSGKGYIEFEDKKEYFGAKDTVRIEP
EEEECCHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCEEEECCCHHHCCCCCEEEECC
QTPHTIVAIENTVLHEVSTPDLDDTIRIKDFYDSQTPSGKR
CCCEEEEEEECEEEEECCCCCCCCEEEEEEECCCCCCCCCC
>Mature Secondary Structure
MKDTVGMILCGGFGKRLRPVTETVPKPLVELKEDYTILDKQIFDFKSAGVNKVILLTGFL
CCCCEEEEEECCCCCCCCHHHHHCCHHHHHHHCCCEEHHHHHHHHHHCCCCEEEEEECHH
GEKIEERYGNEYMGVTIEYVKEEKPLGTLNAIRLGMEHMDDNTQCVIRNGDVVADLSIKK
HHHHHHHHCCCEEEEEEEEEECCCCCCCHHHHHHHHHHCCCCCEEEEECCCEEEEHHHHH
MIEDGEKSPFDFTIFVTQMTSPYGIVELSGDKIVLFKEKPLLDYYINGGIYFSKGKLDFG
HHHCCCCCCEEEEEEEEECCCCCEEEEECCCEEEEEECCCCEEEEECCCEEEECCCCCCC
SYKTGDIEKTIFPELAKDKKLGYYKENGLFWMAVDTSKELQQVQNEYKNREDKPWGYEKV
CCCCCCCCHHHHHHHHCCCCCCEEECCCEEEEEECCHHHHHHHHHHHCCCCCCCCCCEEE
LIYTDKYLTKELFIKEGYQTSFHYHPNKDETMYIVSGKGYIEFEDKKEYFGAKDTVRIEP
EEEECCHHHHHHHHHCCCCEEEEECCCCCCEEEEEECCCEEEECCCHHHCCCCCEEEECC
QTPHTIVAIENTVLHEVSTPDLDDTIRIKDFYDSQTPSGKR
CCCEEEEEEECEEEEECCCCCCCCEEEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA