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The map label for this gene is hemC

Identifier: 84490120

GI number: 84490120

Start: 1500246

End: 1501118

Strand: Direct

Name: hemC

Synonym: Msp_1332

Alternate gene names: 84490120

Gene position: 1500246-1501118 (Clockwise)

Preceding gene: 84490119

Following gene: 84490121

Centisome position: 84.88

GC content: 31.16

Gene sequence:

>873_bases
TTGATAGTTGGTACTAGAGGTAGTAAACTGGCCACCACACAAACTAAAACTGTTGTAAAAGCTCTTGAAGAAATTACTGG
AGAAGAAATTGAAACTAAAATAATTAAAACAACAGGAGATAAGATTAAAAATTCACAGTTATATAATATTGATGCTAAAG
GTATATTTACAAAAGAATTAGACACAGCCCTCATTGATGGAAGTATTGATTTTGCCGTACATAGTTTTAAGGATTTACCT
AGTGAATTAAATGACCAGCTTACAATAACTGCCATACCTCAAAGAGAAGCTATTAATGAAGTATTAATTTCTAATTATTC
ATGGGATGAACTACCAGAAAATGCTACATTAGGTACAAGTAGTGTTAGAAGAGAAGCATTCTGTAAATTACATGGTAAAA
AGATTCAAACAAAACCTATACGTGGAAATATAGATACTCGTATACGTAAAGTTGAAGAAGGAGAGTATGATGCTACAATA
ATGGCTTTAGCAGGTATTAACCGATTAGGCCTACAGGAACATATAAAAGAAGTATTTGATGAACAATACATAACTCCTCC
TGCAGGACAAGGAGCTTTAGCTGTGATGACACATAAAGATTCAGAATATAATGATGTTATTTCAAAATTAAATCATGAAG
ATTCTAGAATTGAAGCTATGACAGAAAAAGCTATTCTTGAAACTATAGGTGTTGGATGCCAATGGCCTATTGGTATAGTC
TCAAAGGTAGATGGTAATAACATAAATATACATTGTAAATTATTAAGTCCTGAAGGTAAACTTTTAGCAGATGTAAACAA
AACAACAGATAAAAACAATGCTATTAATACTGCAAAAGTTATTGGAACAAAATTAAGAGAGGATACTTTATGA

Upstream 100 bases:

>100_bases
AAATAATTTACTAATTTTTTTTAAGATAAAAAAAAATTAATTATCACTACTACAAAATACGTGACTAAAATTATCACGTC
AAGTCGAGGAGGCAGATTAA

Downstream 100 bases:

>100_bases
AACAGACAAATGTAGGTGTTATTGGAGTAGGATCTATGGGTTACAACCACGTACGTATATACTCTGAATTAGAAAATGCG
AATTTAGTAGCTATATCAGA

Product: porphobilinogen deaminase

Products: NA

Alternate protein names: PBG; Hydroxymethylbilane synthase; HMBS; Pre-uroporphyrinogen synthase [H]

Number of amino acids: Translated: 290; Mature: 290

Protein sequence:

>290_residues
MIVGTRGSKLATTQTKTVVKALEEITGEEIETKIIKTTGDKIKNSQLYNIDAKGIFTKELDTALIDGSIDFAVHSFKDLP
SELNDQLTITAIPQREAINEVLISNYSWDELPENATLGTSSVRREAFCKLHGKKIQTKPIRGNIDTRIRKVEEGEYDATI
MALAGINRLGLQEHIKEVFDEQYITPPAGQGALAVMTHKDSEYNDVISKLNHEDSRIEAMTEKAILETIGVGCQWPIGIV
SKVDGNNINIHCKLLSPEGKLLADVNKTTDKNNAINTAKVIGTKLREDTL

Sequences:

>Translated_290_residues
MIVGTRGSKLATTQTKTVVKALEEITGEEIETKIIKTTGDKIKNSQLYNIDAKGIFTKELDTALIDGSIDFAVHSFKDLP
SELNDQLTITAIPQREAINEVLISNYSWDELPENATLGTSSVRREAFCKLHGKKIQTKPIRGNIDTRIRKVEEGEYDATI
MALAGINRLGLQEHIKEVFDEQYITPPAGQGALAVMTHKDSEYNDVISKLNHEDSRIEAMTEKAILETIGVGCQWPIGIV
SKVDGNNINIHCKLLSPEGKLLADVNKTTDKNNAINTAKVIGTKLREDTL
>Mature_290_residues
MIVGTRGSKLATTQTKTVVKALEEITGEEIETKIIKTTGDKIKNSQLYNIDAKGIFTKELDTALIDGSIDFAVHSFKDLP
SELNDQLTITAIPQREAINEVLISNYSWDELPENATLGTSSVRREAFCKLHGKKIQTKPIRGNIDTRIRKVEEGEYDATI
MALAGINRLGLQEHIKEVFDEQYITPPAGQGALAVMTHKDSEYNDVISKLNHEDSRIEAMTEKAILETIGVGCQWPIGIV
SKVDGNNINIHCKLLSPEGKLLADVNKTTDKNNAINTAKVIGTKLREDTL

Specific function: Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps [H]

COG id: COG0181

COG function: function code H; Porphobilinogen deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMBS family [H]

Homologues:

Organism=Homo sapiens, GI20149500, Length=245, Percent_Identity=35.9183673469388, Blast_Score=149, Evalue=2e-36,
Organism=Homo sapiens, GI66933009, Length=245, Percent_Identity=35.9183673469388, Blast_Score=149, Evalue=2e-36,
Organism=Escherichia coli, GI48994974, Length=294, Percent_Identity=32.9931972789116, Blast_Score=157, Evalue=8e-40,
Organism=Saccharomyces cerevisiae, GI6319996, Length=255, Percent_Identity=32.9411764705882, Blast_Score=134, Evalue=2e-32,
Organism=Drosophila melanogaster, GI20130425, Length=256, Percent_Identity=32.8125, Blast_Score=142, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000860
- InterPro:   IPR022419
- InterPro:   IPR022417
- InterPro:   IPR022418 [H]

Pfam domain/function: PF01379 Porphobil_deam; PF03900 Porphobil_deamC [H]

EC number: =2.5.1.61 [H]

Molecular weight: Translated: 31999; Mature: 31999

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVGTRGSKLATTQTKTVVKALEEITGEEIETKIIKTTGDKIKNSQLYNIDAKGIFTKEL
CEECCCCCEEEHHHHHHHHHHHHHHCCCHHHHHEEECCCCCCCCCEEEEECCCCEEHHHH
DTALIDGSIDFAVHSFKDLPSELNDQLTITAIPQREAINEVLISNYSWDELPENATLGTS
HHHHCCCCHHHHHHHHHHCHHHHCCCEEEEECCCHHHHHHHHHCCCCHHHCCCCCCCCHH
SVRREAFCKLHGKKIQTKPIRGNIDTRIRKVEEGEYDATIMALAGINRLGLQEHIKEVFD
HHHHHHHHHHCCCEEECCCCCCCHHHHHEECCCCCCCEEEEEECCCCCCCHHHHHHHHHH
EQYITPPAGQGALAVMTHKDSEYNDVISKLNHEDSRIEAMTEKAILETIGVGCQWPIGIV
HCCCCCCCCCCEEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEE
SKVDGNNINIHCKLLSPEGKLLADVNKTTDKNNAINTAKVIGTKLREDTL
EEECCCCEEEEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure
MIVGTRGSKLATTQTKTVVKALEEITGEEIETKIIKTTGDKIKNSQLYNIDAKGIFTKEL
CEECCCCCEEEHHHHHHHHHHHHHHCCCHHHHHEEECCCCCCCCCEEEEECCCCEEHHHH
DTALIDGSIDFAVHSFKDLPSELNDQLTITAIPQREAINEVLISNYSWDELPENATLGTS
HHHHCCCCHHHHHHHHHHCHHHHCCCEEEEECCCHHHHHHHHHCCCCHHHCCCCCCCCHH
SVRREAFCKLHGKKIQTKPIRGNIDTRIRKVEEGEYDATIMALAGINRLGLQEHIKEVFD
HHHHHHHHHHCCCEEECCCCCCCHHHHHEECCCCCCCEEEEEECCCCCCCHHHHHHHHHH
EQYITPPAGQGALAVMTHKDSEYNDVISKLNHEDSRIEAMTEKAILETIGVGCQWPIGIV
HCCCCCCCCCCEEEEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCEE
SKVDGNNINIHCKLLSPEGKLLADVNKTTDKNNAINTAKVIGTKLREDTL
EEECCCCEEEEEEEECCCCCEEEECCCCCCCCCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]