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The map label for this gene is yrbE [H]

Identifier: 84490121

GI number: 84490121

Start: 1501115

End: 1502068

Strand: Direct

Name: yrbE [H]

Synonym: Msp_1333

Alternate gene names: 84490121

Gene position: 1501115-1502068 (Clockwise)

Preceding gene: 84490120

Following gene: 84490122

Centisome position: 84.93

GC content: 31.45

Gene sequence:

>954_bases
ATGAAACAGACAAATGTAGGTGTTATTGGAGTAGGATCTATGGGTTACAACCACGTACGTATATACTCTGAATTAGAAAA
TGCGAATTTAGTAGCTATATCAGATATGGTACGAGGTACACTTGATAAGGTATCGAAAGAATTTAATACTGTAGGTTATG
TTGATTATGATAATATACTTCAAATTGATGATATTGAAGTAGTAAATATCTGTGTACCAACAGTATTCCATCATGATGTA
GTTATGCGGGCAATAGAAGCAGGAAAAAATGTACTTGTAGAAAAACCTATTGCTTCAAAATTAAATGAAGCAGAAGAAAT
GATCAAAGCAGCAGAAGACGCAGGTGTAACTTTGGCAACAGGACATGTTGAAAGATTTAATCCGGCTGTAAGAGTTGCAA
AAAAATTAATTGATGAAGGAGCAATAGGTGAAGTTGTAACTGCAAATTCAAAAAGATTAGGTCCTTTTCCTCCAAGAATA
CGTGATGTTGGAGTTGCTATCGATTTAGCAATACATGATATTGATATTTTCAATTACCTATTTAATAGTAGGGCAAATAC
TGTATTTGCAAATATGAGTAGTAAACTTAAAAATTGTGAGTTTGAAGACCATGCAGAAATTATGACTAAATATGATAGTG
GAGTTTTAAGTATACTTGAAACTAACTGGTTAACACCATATAAAAAACGTCAATTAAATATTACTGGAATTGACGGAATT
ATAAGTGTTGATTATGGAAATCAAACTGTTACATTATTTAAAGAAAATAATCAGGTTGAAGACATAAAAGTTGAAAATAA
AGAACCTCTCAAAGAAGAATTAAGATCATTTGTTGATTGTGTACAAAACAATACTCCTCCAGAAGTATCTGGTAAAGATG
GATATGAAGCATTGAGAATTGTTGATGCTGCAATGACCTCATCCAAAGATAAAAGACTAGTGTATTTAGATTAA

Upstream 100 bases:

>100_bases
CTGAAGGTAAACTTTTAGCAGATGTAAACAAAACAACAGATAAAAACAATGCTATTAATACTGCAAAAGTTATTGGAACA
AAATTAAGAGAGGATACTTT

Downstream 100 bases:

>100_bases
AGTGATGAAAATGAAAAATAAATTAATTGAAAAAGCTACTGAACTTAGAAATAAGGGATTAACCACTGGTGAAATTGCAG
ATGAATTAAATATATCTAAA

Product: dehydrogenase

Products: 2,4,6/3,5-pentahydroxycyclohexanone; NADH; H+

Alternate protein names: NA

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MKQTNVGVIGVGSMGYNHVRIYSELENANLVAISDMVRGTLDKVSKEFNTVGYVDYDNILQIDDIEVVNICVPTVFHHDV
VMRAIEAGKNVLVEKPIASKLNEAEEMIKAAEDAGVTLATGHVERFNPAVRVAKKLIDEGAIGEVVTANSKRLGPFPPRI
RDVGVAIDLAIHDIDIFNYLFNSRANTVFANMSSKLKNCEFEDHAEIMTKYDSGVLSILETNWLTPYKKRQLNITGIDGI
ISVDYGNQTVTLFKENNQVEDIKVENKEPLKEELRSFVDCVQNNTPPEVSGKDGYEALRIVDAAMTSSKDKRLVYLD

Sequences:

>Translated_317_residues
MKQTNVGVIGVGSMGYNHVRIYSELENANLVAISDMVRGTLDKVSKEFNTVGYVDYDNILQIDDIEVVNICVPTVFHHDV
VMRAIEAGKNVLVEKPIASKLNEAEEMIKAAEDAGVTLATGHVERFNPAVRVAKKLIDEGAIGEVVTANSKRLGPFPPRI
RDVGVAIDLAIHDIDIFNYLFNSRANTVFANMSSKLKNCEFEDHAEIMTKYDSGVLSILETNWLTPYKKRQLNITGIDGI
ISVDYGNQTVTLFKENNQVEDIKVENKEPLKEELRSFVDCVQNNTPPEVSGKDGYEALRIVDAAMTSSKDKRLVYLD
>Mature_317_residues
MKQTNVGVIGVGSMGYNHVRIYSELENANLVAISDMVRGTLDKVSKEFNTVGYVDYDNILQIDDIEVVNICVPTVFHHDV
VMRAIEAGKNVLVEKPIASKLNEAEEMIKAAEDAGVTLATGHVERFNPAVRVAKKLIDEGAIGEVVTANSKRLGPFPPRI
RDVGVAIDLAIHDIDIFNYLFNSRANTVFANMSSKLKNCEFEDHAEIMTKYDSGVLSILETNWLTPYKKRQLNITGIDGI
ISVDYGNQTVTLFKENNQVEDIKVENKEPLKEELRSFVDCVQNNTPPEVSGKDGYEALRIVDAAMTSSKDKRLVYLD

Specific function: Unknown

COG id: COG0673

COG function: function code R; Predicted dehydrogenases and related proteins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gfo/idh/mocA family [H]

Homologues:

Organism=Escherichia coli, GI87082405, Length=278, Percent_Identity=27.6978417266187, Blast_Score=104, Evalue=6e-24,
Organism=Escherichia coli, GI1789848, Length=208, Percent_Identity=29.3269230769231, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1787574, Length=188, Percent_Identity=27.6595744680851, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI87081947, Length=189, Percent_Identity=29.1005291005291, Blast_Score=63, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6323975, Length=161, Percent_Identity=30.4347826086957, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR000683
- InterPro:   IPR004104 [H]

Pfam domain/function: PF01408 GFO_IDH_MocA; PF02894 GFO_IDH_MocA_C [H]

EC number: 1.1.1.18

Molecular weight: Translated: 35240; Mature: 35240

Theoretical pI: Translated: 4.78; Mature: 4.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKQTNVGVIGVGSMGYNHVRIYSELENANLVAISDMVRGTLDKVSKEFNTVGYVDYDNIL
CCCCCCCEEEECCCCCCEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHCCEEEECCCCEE
QIDDIEVVNICVPTVFHHDVVMRAIEAGKNVLVEKPIASKLNEAEEMIKAAEDAGVTLAT
EECCEEEEEEHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHCCEEEEE
GHVERFNPAVRVAKKLIDEGAIGEVVTANSKRLGPFPPRIRDVGVAIDLAIHDIDIFNYL
CCHHHCCHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCHHHCCEEEEEEEEHHHHHHHH
FNSRANTVFANMSSKLKNCEFEDHAEIMTKYDSGVLSILETNWLTPYKKRQLNITGIDGI
HHCCCCEEEECHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHCCCCCHHHCEEEEECCCCE
ISVDYGNQTVTLFKENNQVEDIKVENKEPLKEELRSFVDCVQNNTPPEVSGKDGYEALRI
EEEECCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
VDAAMTSSKDKRLVYLD
HHHHHCCCCCCEEEEEC
>Mature Secondary Structure
MKQTNVGVIGVGSMGYNHVRIYSELENANLVAISDMVRGTLDKVSKEFNTVGYVDYDNIL
CCCCCCCEEEECCCCCCEEEEEEECCCCCEEEEHHHHHHHHHHHHHHHCCEEEECCCCEE
QIDDIEVVNICVPTVFHHDVVMRAIEAGKNVLVEKPIASKLNEAEEMIKAAEDAGVTLAT
EECCEEEEEEHHHHHHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHCCEEEEE
GHVERFNPAVRVAKKLIDEGAIGEVVTANSKRLGPFPPRIRDVGVAIDLAIHDIDIFNYL
CCHHHCCHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCHHHCCEEEEEEEEHHHHHHHH
FNSRANTVFANMSSKLKNCEFEDHAEIMTKYDSGVLSILETNWLTPYKKRQLNITGIDGI
HHCCCCEEEECHHHHHHCCCCHHHHHHHHHHCCCHHHHHHHCCCCCHHHCEEEEECCCCE
ISVDYGNQTVTLFKENNQVEDIKVENKEPLKEELRSFVDCVQNNTPPEVSGKDGYEALRI
EEEECCCEEEEEEECCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
VDAAMTSSKDKRLVYLD
HHHHHCCCCCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: myo-inositol; NAD+

Specific reaction: myo-inositol + NAD+ = 2,4,6/3,5-pentahydroxycyclohexanone + NADH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377; 9025289 [H]