Click here to switch to the map view.

The map label for this gene is trpD

Identifier: 84489870

GI number: 84489870

Start: 1215850

End: 1216899

Strand: Direct

Name: trpD

Synonym: Msp_1076

Alternate gene names: 84489870

Gene position: 1215850-1216899 (Clockwise)

Preceding gene: 84489869

Following gene: 84489871

Centisome position: 68.79

GC content: 28.76

Gene sequence:

>1050_bases
ATGATTAGTGAAGTATTAGATGATATTATTGATAAAAATCGAAATTTAACAGTTGATGAAGCTTATGAATGTATGGATGA
TTTAGTTAGTGGAAATTATCCTAATGTAGTTGTATCATCATTTTTAACTGCTCTTAGAATGAAAGGTGAAACTATTGATG
AAATCACTGGTTTAACTAGAAGTATGAAAAATCATGCAGTGCAAATTGATTATAAACCAGAAGATTATCTTATAGAAACC
TGTGGTACTGGTGGAGATACATTTAAAACATTTAATGTAAGTACTGTTGCATCTATTATTGCTAGTGCTGGTGGAGCTAA
AATATCCAAACATGGAAATAGAAGTGTTAGTAGTAAATTTGGTGGAGCAGATGCTCTTGAAGCTTTAGGTGTTAATATTG
AATTAAGTCCTGAGAAAGTAATTAATTCTATTGATAAATGCAACTTTGCATTTATATTTGCACCCATATATCATGTTGCT
ACAAAGAATGTTATGATGATTAGAAAACAGTTGAAAACTAGAACTGTTTTTAATTTATTAGGTCCAATTTCATGTCCTAC
AAATGTTAATGCTAGATTAACTGGAATTTATGATCCAGAACTTCTTGAAACAATTGCAAAGGTTGCTATGAATCTTGGAG
TAGAATGTGGTATGATAGTACATGGATTTGATGAAAATGGAAATCCAGCTATGGATGAAATATCAAATATTGGAAAAACA
AAAGTAGCTTTTATTGATAATGGAGACATTACTGTTAAATATATTACTCCAGAAGATTTTGGTCTAAGTTTTTCAAAACC
TGAAGATATTGTTGCACCTGAAACTCCCCAAGAACACATACAGATTATATATAACATATTAAATAATGTTACTACAACAT
CACAAGATAGAGCACGACTTGATTTATGTTTAATGAATTCTGCAAGTATATTATATCTTACTAAAAAGGTAGATTCATTA
GAAGAAGGAGTTATTTATTCAAGAAAGTTAATTGAAGATGGTAGTGCTAAAAAACAATTAGAAAAAATAATTAAATATAG
TAATGAATAA

Upstream 100 bases:

>100_bases
TTAATATTATTGAAGATAACTTAGATAATGAAGATGTTATGTTTGGATGTATAGCTGAATATATACAAAGTATGAAAGAT
GCTACAAAAAGGTAATTAGA

Downstream 100 bases:

>100_bases
CTAAACTCTTTTTTACTTTTTTTTAAAAAAAATATTTTTTATAACAAATATCATGTAATAAAAAGAATATATTATACTAT
AGATATACTTTTTTATTTAA

Product: anthranilate phosphoribosyltransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 349; Mature: 349

Protein sequence:

>349_residues
MISEVLDDIIDKNRNLTVDEAYECMDDLVSGNYPNVVVSSFLTALRMKGETIDEITGLTRSMKNHAVQIDYKPEDYLIET
CGTGGDTFKTFNVSTVASIIASAGGAKISKHGNRSVSSKFGGADALEALGVNIELSPEKVINSIDKCNFAFIFAPIYHVA
TKNVMMIRKQLKTRTVFNLLGPISCPTNVNARLTGIYDPELLETIAKVAMNLGVECGMIVHGFDENGNPAMDEISNIGKT
KVAFIDNGDITVKYITPEDFGLSFSKPEDIVAPETPQEHIQIIYNILNNVTTTSQDRARLDLCLMNSASILYLTKKVDSL
EEGVIYSRKLIEDGSAKKQLEKIIKYSNE

Sequences:

>Translated_349_residues
MISEVLDDIIDKNRNLTVDEAYECMDDLVSGNYPNVVVSSFLTALRMKGETIDEITGLTRSMKNHAVQIDYKPEDYLIET
CGTGGDTFKTFNVSTVASIIASAGGAKISKHGNRSVSSKFGGADALEALGVNIELSPEKVINSIDKCNFAFIFAPIYHVA
TKNVMMIRKQLKTRTVFNLLGPISCPTNVNARLTGIYDPELLETIAKVAMNLGVECGMIVHGFDENGNPAMDEISNIGKT
KVAFIDNGDITVKYITPEDFGLSFSKPEDIVAPETPQEHIQIIYNILNNVTTTSQDRARLDLCLMNSASILYLTKKVDSL
EEGVIYSRKLIEDGSAKKQLEKIIKYSNE
>Mature_349_residues
MISEVLDDIIDKNRNLTVDEAYECMDDLVSGNYPNVVVSSFLTALRMKGETIDEITGLTRSMKNHAVQIDYKPEDYLIET
CGTGGDTFKTFNVSTVASIIASAGGAKISKHGNRSVSSKFGGADALEALGVNIELSPEKVINSIDKCNFAFIFAPIYHVA
TKNVMMIRKQLKTRTVFNLLGPISCPTNVNARLTGIYDPELLETIAKVAMNLGVECGMIVHGFDENGNPAMDEISNIGKT
KVAFIDNGDITVKYITPEDFGLSFSKPEDIVAPETPQEHIQIIYNILNNVTTTSQDRARLDLCLMNSASILYLTKKVDSL
EEGVIYSRKLIEDGSAKKQLEKIIKYSNE

Specific function: Tryptophan biosynthesis; first step. Tryptophan biosynthesis; second step. [C]

COG id: COG0547

COG function: function code E; Anthranilate phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anthranilate phosphoribosyltransferase family

Homologues:

Organism=Escherichia coli, GI1787517, Length=289, Percent_Identity=34.2560553633218, Blast_Score=165, Evalue=5e-42,
Organism=Saccharomyces cerevisiae, GI6320561, Length=335, Percent_Identity=34.0298507462687, Blast_Score=135, Evalue=1e-32,

Paralogues:

None

Copy number: 945 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 900 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): TRPD_METST (Q2NFE4)

Other databases:

- EMBL:   CP000102
- RefSeq:   YP_448102.1
- HSSP:   P50384
- ProteinModelPortal:   Q2NFE4
- SMR:   Q2NFE4
- STRING:   Q2NFE4
- GeneID:   3855009
- GenomeReviews:   CP000102_GR
- KEGG:   mst:Msp_1076
- NMPDR:   fig|339860.6.peg.1029
- eggNOG:   arNOG05391
- HOGENOM:   HBG559996
- OMA:   HGNKSAS
- PhylomeDB:   Q2NFE4
- ProtClustDB:   PRK00188
- BioCyc:   MSTA339860:MSP_1076-MONOMER
- HAMAP:   MF_00211
- InterPro:   IPR005940
- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- Gene3D:   G3DSA:1.20.970.10
- Gene3D:   G3DSA:3.40.1030.10
- TIGRFAMs:   TIGR01245

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; SSF47648 Glyco_trans_3; SSF52418 Glyco_trans_3

EC number: =2.4.2.18

Molecular weight: Translated: 38354; Mature: 38354

Theoretical pI: Translated: 4.77; Mature: 4.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MISEVLDDIIDKNRNLTVDEAYECMDDLVSGNYPNVVVSSFLTALRMKGETIDEITGLTR
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
SMKNHAVQIDYKPEDYLIETCGTGGDTFKTFNVSTVASIIASAGGAKISKHGNRSVSSKF
HHHCCEEEEEECCCCCEEEECCCCCCCEEEECHHHHHHHHHHCCCCEECCCCCCCHHHHC
GGADALEALGVNIELSPEKVINSIDKCNFAFIFAPIYHVATKNVMMIRKQLKTRTVFNLL
CCHHHHHHHCCCEEECHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GPISCPTNVNARLTGIYDPELLETIAKVAMNLGVECGMIVHGFDENGNPAMDEISNIGKT
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHCCCCE
KVAFIDNGDITVKYITPEDFGLSFSKPEDIVAPETPQEHIQIIYNILNNVTTTSQDRARL
EEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHE
DLCLMNSASILYLTKKVDSLEEGVIYSRKLIEDGSAKKQLEKIIKYSNE
EEEEECCCEEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MISEVLDDIIDKNRNLTVDEAYECMDDLVSGNYPNVVVSSFLTALRMKGETIDEITGLTR
CHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHH
SMKNHAVQIDYKPEDYLIETCGTGGDTFKTFNVSTVASIIASAGGAKISKHGNRSVSSKF
HHHCCEEEEEECCCCCEEEECCCCCCCEEEECHHHHHHHHHHCCCCEECCCCCCCHHHHC
GGADALEALGVNIELSPEKVINSIDKCNFAFIFAPIYHVATKNVMMIRKQLKTRTVFNLL
CCHHHHHHHCCCEEECHHHHHHHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHH
GPISCPTNVNARLTGIYDPELLETIAKVAMNLGVECGMIVHGFDENGNPAMDEISNIGKT
CCCCCCCCCCEEEEECCCHHHHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHCCCCE
KVAFIDNGDITVKYITPEDFGLSFSKPEDIVAPETPQEHIQIIYNILNNVTTTSQDRARL
EEEEEECCCEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHE
DLCLMNSASILYLTKKVDSLEEGVIYSRKLIEDGSAKKQLEKIIKYSNE
EEEEECCCEEEEEEHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA