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The map label for this gene is msrAB [H]

Identifier: 84489546

GI number: 84489546

Start: 848084

End: 849055

Strand: Direct

Name: msrAB [H]

Synonym: Msp_0737

Alternate gene names: 84489546

Gene position: 848084-849055 (Clockwise)

Preceding gene: 84489542

Following gene: 84489549

Centisome position: 47.98

GC content: 27.16

Gene sequence:

>972_bases
ATGATTGATAACTTAAATAAAAAAATATCTTACAAAAAAGAAAATTTAAGAACAATATATCTTGCAGGGGGATGTTTTTG
GGGTGTTGAAGCATATATTTCGAGGTTACTTGGAGTAGCTAAAACAACAGTAGGTTATGCAAATGGAAACACAGAAAATC
CCACTTATGATGAGGTATGTTTAGAAAATACAAATCATGTTGAATGTGTAAAAGTGGATTATGATAATAACATATTACCA
TTAAAGAAGTTATTGGAAGAATTTTTTAAAATAATAAATCCACTTACAATTAATAAACAAGGAAATGATGTAGGAGTACA
ATATAGAACTGGTATATATTATAGAAATGAAACAGACAAAAGAATAATAATAAATTTTATTAATAGAAAACAAGGAGAAT
ATTCACAAAAAATAGTAACAGAAGTATTACCCTTGAATAATTTTTATCCTGCTGAAAAATATCATCAGAAATATTTGGAA
AAAAATCCTACAGGTTACTGTCATATTGATTTAACACAACTTCCAAATCAGAAAAAACAATTAGAAGAATTATTAATTAA
AGAAGATATTATGAATTTAACACCTATTGAATTTGATGTTACACAAAAAAATGCTACAGAAAAGCCTTTCAGTGGAAAAT
ATAATGATTTTAATAAGAAGGGATTGTATGTGGATGTTGTAGGTGGAGAGCCATTATTTATATCAGATGATAAATTTGAT
TCAAAATGTGGATGGCCTTCTTTTACAAAACCTGTTAATGATAGTCATATTCAAAAGTTAAATGATACATCTCATGGTAT
GAAAAGAATAGAAGTTAGAAGTAAAAAGGCTAATTCACACCTAGGTCATGTTTTTGATGATGGACCTAGAGGTGAAAAGA
GGTATTGTATAAATTCTGCTTCAATGAAATTTATACCATATGATAAGTTAGAGGAGATGGGTTATGGAAGGTATGTTAAA
TATTTTAAGTAA

Upstream 100 bases:

>100_bases
AAAATAGAAAAAACAACGTTAGATATACATAAGCTTGTTAAAAAAATAGGTAATATATAAAAGAGAATATGTTAAATAAA
ATCTCTTTTGAGGTTTTAAT

Downstream 100 bases:

>100_bases
AATAATTGATTTTTAGAAATTCTTTTTTTTTAGTATTTTTTTCTACCTTAGTTTAAAGAAGTTAAATTCATTTAAAATAA
AAAAAAATAAGTATTGAAGA

Product: putative peptide methionine sulfoxide reductase MsrA/MsrB

Products: NA

Alternate protein names: Thioredoxin; Peptide methionine sulfoxide reductase msrA; Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase; Peptide methionine sulfoxide reductase msrB; Peptide-methionine (R)-S-oxide reductase [H]

Number of amino acids: Translated: 323; Mature: 323

Protein sequence:

>323_residues
MIDNLNKKISYKKENLRTIYLAGGCFWGVEAYISRLLGVAKTTVGYANGNTENPTYDEVCLENTNHVECVKVDYDNNILP
LKKLLEEFFKIINPLTINKQGNDVGVQYRTGIYYRNETDKRIIINFINRKQGEYSQKIVTEVLPLNNFYPAEKYHQKYLE
KNPTGYCHIDLTQLPNQKKQLEELLIKEDIMNLTPIEFDVTQKNATEKPFSGKYNDFNKKGLYVDVVGGEPLFISDDKFD
SKCGWPSFTKPVNDSHIQKLNDTSHGMKRIEVRSKKANSHLGHVFDDGPRGEKRYCINSASMKFIPYDKLEEMGYGRYVK
YFK

Sequences:

>Translated_323_residues
MIDNLNKKISYKKENLRTIYLAGGCFWGVEAYISRLLGVAKTTVGYANGNTENPTYDEVCLENTNHVECVKVDYDNNILP
LKKLLEEFFKIINPLTINKQGNDVGVQYRTGIYYRNETDKRIIINFINRKQGEYSQKIVTEVLPLNNFYPAEKYHQKYLE
KNPTGYCHIDLTQLPNQKKQLEELLIKEDIMNLTPIEFDVTQKNATEKPFSGKYNDFNKKGLYVDVVGGEPLFISDDKFD
SKCGWPSFTKPVNDSHIQKLNDTSHGMKRIEVRSKKANSHLGHVFDDGPRGEKRYCINSASMKFIPYDKLEEMGYGRYVK
YFK
>Mature_323_residues
MIDNLNKKISYKKENLRTIYLAGGCFWGVEAYISRLLGVAKTTVGYANGNTENPTYDEVCLENTNHVECVKVDYDNNILP
LKKLLEEFFKIINPLTINKQGNDVGVQYRTGIYYRNETDKRIIINFINRKQGEYSQKIVTEVLPLNNFYPAEKYHQKYLE
KNPTGYCHIDLTQLPNQKKQLEELLIKEDIMNLTPIEFDVTQKNATEKPFSGKYNDFNKKGLYVDVVGGEPLFISDDKFD
SKCGWPSFTKPVNDSHIQKLNDTSHGMKRIEVRSKKANSHLGHVFDDGPRGEKRYCINSASMKFIPYDKLEEMGYGRYVK
YFK

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI301336164, Length=149, Percent_Identity=42.2818791946309, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI301336162, Length=149, Percent_Identity=42.2818791946309, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI73089054, Length=149, Percent_Identity=42.2818791946309, Blast_Score=124, Evalue=1e-28,
Organism=Homo sapiens, GI37620216, Length=133, Percent_Identity=45.1127819548872, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI208609995, Length=173, Percent_Identity=38.150289017341, Blast_Score=118, Evalue=7e-27,
Organism=Homo sapiens, GI6912516, Length=173, Percent_Identity=38.150289017341, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI117606353, Length=122, Percent_Identity=45.9016393442623, Blast_Score=97, Evalue=1e-20,
Organism=Homo sapiens, GI208609993, Length=135, Percent_Identity=33.3333333333333, Blast_Score=72, Evalue=7e-13,
Organism=Escherichia coli, GI1788077, Length=124, Percent_Identity=47.5806451612903, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1790665, Length=155, Percent_Identity=38.0645161290323, Blast_Score=111, Evalue=5e-26,
Organism=Caenorhabditis elegans, GI115532676, Length=111, Percent_Identity=49.5495495495495, Blast_Score=110, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17553450, Length=111, Percent_Identity=49.5495495495495, Blast_Score=110, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=34.9315068493151, Blast_Score=80, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6320881, Length=174, Percent_Identity=36.7816091954023, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6319816, Length=147, Percent_Identity=34.0136054421769, Blast_Score=84, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45553335, Length=118, Percent_Identity=45.7627118644068, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21356369, Length=118, Percent_Identity=45.7627118644068, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI221378664, Length=115, Percent_Identity=46.0869565217391, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI24645799, Length=118, Percent_Identity=45.7627118644068, Blast_Score=113, Evalue=2e-25,
Organism=Drosophila melanogaster, GI221378662, Length=122, Percent_Identity=43.4426229508197, Blast_Score=110, Evalue=9e-25,
Organism=Drosophila melanogaster, GI24645804, Length=129, Percent_Identity=42.6356589147287, Blast_Score=109, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24645801, Length=129, Percent_Identity=42.6356589147287, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI24664627, Length=141, Percent_Identity=34.0425531914894, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI45553131, Length=141, Percent_Identity=34.0425531914894, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24664631, Length=141, Percent_Identity=34.0425531914894, Blast_Score=84, Evalue=1e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002579
- InterPro:   IPR011057
- InterPro:   IPR002569
- InterPro:   IPR013740
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01625 PMSR; PF08534 Redoxin; PF01641 SelR [H]

EC number: =1.8.4.11; =1.8.4.12 [H]

Molecular weight: Translated: 37427; Mature: 37427

Theoretical pI: Translated: 8.66; Mature: 8.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDNLNKKISYKKENLRTIYLAGGCFWGVEAYISRLLGVAKTTVGYANGNTENPTYDEVC
CCCCCCCHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHH
LENTNHVECVKVDYDNNILPLKKLLEEFFKIINPLTINKQGNDVGVQYRTGIYYRNETDK
HCCCCCEEEEEEECCCCEEHHHHHHHHHHHHHCCEEECCCCCEECEEEEEEEEEECCCCC
RIIINFINRKQGEYSQKIVTEVLPLNNFYPAEKYHQKYLEKNPTGYCHIDLTQLPNQKKQ
EEEEEEHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEHHHCCCHHHH
LEELLIKEDIMNLTPIEFDVTQKNATEKPFSGKYNDFNKKGLYVDVVGGEPLFISDDKFD
HHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCC
SKCGWPSFTKPVNDSHIQKLNDTSHGMKRIEVRSKKANSHLGHVFDDGPRGEKRYCINSA
CCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCC
SMKFIPYDKLEEMGYGRYVKYFK
CEEECCHHHHHHCCCCCEEEECC
>Mature Secondary Structure
MIDNLNKKISYKKENLRTIYLAGGCFWGVEAYISRLLGVAKTTVGYANGNTENPTYDEVC
CCCCCCCHHCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHEEECCCCCCCCCHHHHH
LENTNHVECVKVDYDNNILPLKKLLEEFFKIINPLTINKQGNDVGVQYRTGIYYRNETDK
HCCCCCEEEEEEECCCCEEHHHHHHHHHHHHHCCEEECCCCCEECEEEEEEEEEECCCCC
RIIINFINRKQGEYSQKIVTEVLPLNNFYPAEKYHQKYLEKNPTGYCHIDLTQLPNQKKQ
EEEEEEHHCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCEEEEEEHHHCCCHHHH
LEELLIKEDIMNLTPIEFDVTQKNATEKPFSGKYNDFNKKGLYVDVVGGEPLFISDDKFD
HHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEECCCCC
SKCGWPSFTKPVNDSHIQKLNDTSHGMKRIEVRSKKANSHLGHVFDDGPRGEKRYCINSA
CCCCCCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEECCC
SMKFIPYDKLEEMGYGRYVKYFK
CEEECCHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2854063; 8755589 [H]