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The map label for this gene is thsA

Identifier: 84488959

GI number: 84488959

Start: 148609

End: 150216

Strand: Direct

Name: thsA

Synonym: Msp_0130

Alternate gene names: 84488959

Gene position: 148609-150216 (Clockwise)

Preceding gene: 84488958

Following gene: 84488963

Centisome position: 8.41

GC content: 33.58

Gene sequence:

>1608_bases
ATGGTACAAAATAACCAACAACCATTAATAGTTCTAGCTGATGGTTCTACACGAACAAGTGGTAGTCAAGCAACTAAAAA
CAATATAATGGCTGCAAAACTATTATCCAACGTACTTAAAACAACATTAGGTCCAAGAGGAATGGACAAAATGTTAATTA
ACTCTATTGGTGATGTGAAAATAACCAACGATGGTTACACAGTACTTAAAGAAACAGAACCAGATCATCCTGCAGCAAAA
ATGATTGTAGACCTTGCAAAAATGCAAGAAGAAGAATATGGTGATGGAACAACAACAGCAGTAGTGTTAGTTGGAGAAAT
ATTAAAAGAAGCAGAAAAACTAATTGAACAAGGAATACCAACATCCACAATAGTAAAAGGATTTGAAGAATCAAAAAACA
AAACCCTTGAAGTATTAGATGAAATAGCAATTCCTGCTCAAGAAGAAGAACTAATAAACGTTGCAAGAACATCCATGTCT
GGAAAAGGATCTTTTACAAACCTTGATAAAATGGCAAAAGAATTAGTTGAAGCATTACTAAATGTTGAAGAAGATGGCCA
AATAGATCAAGACATGATCAAAATCAGAAAAATCCATGGAGAAGGTACAGAAGACACAGAAATCTCAGAATGTGTAACTG
TAGATAAAAATGTTTTAGAATCAGAAATGCCAAAAGATGTTAAAGATGCTAAAATAGCACTTCTACAATATCCAATGGAT
GCAAGAGAACTACAAAATGATGCTAAAATAAAACTCACCACACCAGGTGAATACCAAGCATACTTAGATAAAGAAGCACA
AATGCTTCAAGATGAAGTACAAAAACTTGTAGATGCAGGAGTAACAGTACTCTTCAACAACAAAAAAATCAGTGACCTAT
GTCAACACTACCTTACAAAAGCTGGAATACTAACAGCAAAAAGAGTAAAAGCAGGAGATCTTGAAAGATTATCCAAAGCA
ACAGGTGCAAACATAGTAAATGATATTAAAGAACTTACAAGTGATGATCTTGGAGAAGCAGGTCATGTATATGAAAGAGA
AGTATTTGAAGACAGAGAATACATATTCATAGAAGACTGTAAATATGCTGGAGTTTTAAACATCATAATCAGAGGAAGTA
CAAAACACATTACTGATCAACTAGAACAAGCAATCAACGATGCAATAGGAGCAGTAATAAAAACAAGACAAGATGATAAA
GCACTTCCTGGAGGAGGAGCAGCAGATATTGCAGCATCCAAAGCCTTAAGAAAATATGCAAATAAATTCACTGATAAAGA
ACAATTAGTAATTAAAGCATATGCTGATGCATTAGAACAATTACCAGTAGCTTTAGCTAAAAATGCTGGAATGGACACAA
TAGATGTCTTAACAAAACTTTTAGCAAAACAAAATGAATCCACAAATATGGGAGTAAATGTAATAAAAAGAGATGTATCT
GATATGAAAGCAGATAAAATCCTTGATTCACAAAATTCCAAAAAAGCAATAGTAGAATCAGCTACAGAAATAGCAGGTGA
AATACTACGTATTGATGATGTGGTATCAACAAAACCAATGACTCCTGTAGGTGGAGACATGCCTGGAACACCAAATCCAT
ACATGTAA

Upstream 100 bases:

>100_bases
AGCATATTATTCATTAAAAAAGAAATTCATTTAATCAGTCTATAATAAAAAAAAGAATTTAAAAAAATTAATAATATCTA
AAAATTGGAGGATAATTAAT

Downstream 100 bases:

>100_bases
ACAATAAGAAGATTAAGATAACTTCTTAATAATCTTCTTTTTTAAAAACTAGTTTTAATTCATATTTAAAAAAAGTAAAA
ATTAGTTAATAAACTATTTC

Product: ThsA

Products: NA

Alternate protein names: Chaperonin subunit alpha; Thermosome subunit 1 [H]

Number of amino acids: Translated: 535; Mature: 535

Protein sequence:

>535_residues
MVQNNQQPLIVLADGSTRTSGSQATKNNIMAAKLLSNVLKTTLGPRGMDKMLINSIGDVKITNDGYTVLKETEPDHPAAK
MIVDLAKMQEEEYGDGTTTAVVLVGEILKEAEKLIEQGIPTSTIVKGFEESKNKTLEVLDEIAIPAQEEELINVARTSMS
GKGSFTNLDKMAKELVEALLNVEEDGQIDQDMIKIRKIHGEGTEDTEISECVTVDKNVLESEMPKDVKDAKIALLQYPMD
ARELQNDAKIKLTTPGEYQAYLDKEAQMLQDEVQKLVDAGVTVLFNNKKISDLCQHYLTKAGILTAKRVKAGDLERLSKA
TGANIVNDIKELTSDDLGEAGHVYEREVFEDREYIFIEDCKYAGVLNIIIRGSTKHITDQLEQAINDAIGAVIKTRQDDK
ALPGGGAADIAASKALRKYANKFTDKEQLVIKAYADALEQLPVALAKNAGMDTIDVLTKLLAKQNESTNMGVNVIKRDVS
DMKADKILDSQNSKKAIVESATEIAGEILRIDDVVSTKPMTPVGGDMPGTPNPYM

Sequences:

>Translated_535_residues
MVQNNQQPLIVLADGSTRTSGSQATKNNIMAAKLLSNVLKTTLGPRGMDKMLINSIGDVKITNDGYTVLKETEPDHPAAK
MIVDLAKMQEEEYGDGTTTAVVLVGEILKEAEKLIEQGIPTSTIVKGFEESKNKTLEVLDEIAIPAQEEELINVARTSMS
GKGSFTNLDKMAKELVEALLNVEEDGQIDQDMIKIRKIHGEGTEDTEISECVTVDKNVLESEMPKDVKDAKIALLQYPMD
ARELQNDAKIKLTTPGEYQAYLDKEAQMLQDEVQKLVDAGVTVLFNNKKISDLCQHYLTKAGILTAKRVKAGDLERLSKA
TGANIVNDIKELTSDDLGEAGHVYEREVFEDREYIFIEDCKYAGVLNIIIRGSTKHITDQLEQAINDAIGAVIKTRQDDK
ALPGGGAADIAASKALRKYANKFTDKEQLVIKAYADALEQLPVALAKNAGMDTIDVLTKLLAKQNESTNMGVNVIKRDVS
DMKADKILDSQNSKKAIVESATEIAGEILRIDDVVSTKPMTPVGGDMPGTPNPYM
>Mature_535_residues
MVQNNQQPLIVLADGSTRTSGSQATKNNIMAAKLLSNVLKTTLGPRGMDKMLINSIGDVKITNDGYTVLKETEPDHPAAK
MIVDLAKMQEEEYGDGTTTAVVLVGEILKEAEKLIEQGIPTSTIVKGFEESKNKTLEVLDEIAIPAQEEELINVARTSMS
GKGSFTNLDKMAKELVEALLNVEEDGQIDQDMIKIRKIHGEGTEDTEISECVTVDKNVLESEMPKDVKDAKIALLQYPMD
ARELQNDAKIKLTTPGEYQAYLDKEAQMLQDEVQKLVDAGVTVLFNNKKISDLCQHYLTKAGILTAKRVKAGDLERLSKA
TGANIVNDIKELTSDDLGEAGHVYEREVFEDREYIFIEDCKYAGVLNIIIRGSTKHITDQLEQAINDAIGAVIKTRQDDK
ALPGGGAADIAASKALRKYANKFTDKEQLVIKAYADALEQLPVALAKNAGMDTIDVLTKLLAKQNESTNMGVNVIKRDVS
DMKADKILDSQNSKKAIVESATEIAGEILRIDDVVSTKPMTPVGGDMPGTPNPYM

Specific function: Molecular chaperone; binds unfolded polypeptides in vitro, and has a weak ATPase activity [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TCP-1 chaperonin family [H]

Homologues:

Organism=Homo sapiens, GI24307939, Length=520, Percent_Identity=33.8461538461538, Blast_Score=296, Evalue=3e-80,
Organism=Homo sapiens, GI63162572, Length=522, Percent_Identity=31.8007662835249, Blast_Score=282, Evalue=7e-76,
Organism=Homo sapiens, GI57863257, Length=536, Percent_Identity=32.089552238806, Blast_Score=279, Evalue=4e-75,
Organism=Homo sapiens, GI5453607, Length=519, Percent_Identity=31.7919075144509, Blast_Score=266, Evalue=3e-71,
Organism=Homo sapiens, GI58331173, Length=503, Percent_Identity=33.9960238568588, Blast_Score=263, Evalue=3e-70,
Organism=Homo sapiens, GI4502643, Length=502, Percent_Identity=32.4701195219124, Blast_Score=257, Evalue=2e-68,
Organism=Homo sapiens, GI38455427, Length=516, Percent_Identity=32.9457364341085, Blast_Score=246, Evalue=3e-65,
Organism=Homo sapiens, GI302058290, Length=503, Percent_Identity=32.4055666003976, Blast_Score=239, Evalue=6e-63,
Organism=Homo sapiens, GI261399877, Length=479, Percent_Identity=31.3152400835073, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI48762932, Length=528, Percent_Identity=31.25, Blast_Score=232, Evalue=6e-61,
Organism=Homo sapiens, GI5453603, Length=538, Percent_Identity=28.8104089219331, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI58761484, Length=522, Percent_Identity=28.9272030651341, Blast_Score=227, Evalue=2e-59,
Organism=Homo sapiens, GI302058292, Length=503, Percent_Identity=30.4174950298211, Blast_Score=205, Evalue=9e-53,
Organism=Homo sapiens, GI58331171, Length=502, Percent_Identity=28.8844621513944, Blast_Score=199, Evalue=8e-51,
Organism=Homo sapiens, GI261399875, Length=433, Percent_Identity=29.5612009237875, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI7657253, Length=497, Percent_Identity=22.7364185110664, Blast_Score=156, Evalue=5e-38,
Organism=Homo sapiens, GI57863259, Length=381, Percent_Identity=28.0839895013123, Blast_Score=155, Evalue=1e-37,
Organism=Homo sapiens, GI58331185, Length=293, Percent_Identity=30.7167235494881, Blast_Score=151, Evalue=2e-36,
Organism=Escherichia coli, GI1790586, Length=478, Percent_Identity=24.4769874476987, Blast_Score=65, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI25144674, Length=518, Percent_Identity=35.3281853281853, Blast_Score=307, Evalue=1e-83,
Organism=Caenorhabditis elegans, GI17564182, Length=533, Percent_Identity=31.5196998123827, Blast_Score=283, Evalue=1e-76,
Organism=Caenorhabditis elegans, GI17532601, Length=538, Percent_Identity=31.5985130111524, Blast_Score=277, Evalue=1e-74,
Organism=Caenorhabditis elegans, GI25148561, Length=538, Percent_Identity=30.8550185873606, Blast_Score=264, Evalue=8e-71,
Organism=Caenorhabditis elegans, GI25144678, Length=505, Percent_Identity=31.8811881188119, Blast_Score=254, Evalue=1e-67,
Organism=Caenorhabditis elegans, GI17532603, Length=503, Percent_Identity=33.7972166998012, Blast_Score=244, Evalue=9e-65,
Organism=Caenorhabditis elegans, GI25147750, Length=526, Percent_Identity=30.0380228136882, Blast_Score=242, Evalue=3e-64,
Organism=Caenorhabditis elegans, GI32566944, Length=440, Percent_Identity=31.1363636363636, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI71998178, Length=563, Percent_Identity=28.7744227353464, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI25144680, Length=384, Percent_Identity=32.5520833333333, Blast_Score=211, Evalue=9e-55,
Organism=Caenorhabditis elegans, GI71981457, Length=326, Percent_Identity=31.2883435582822, Blast_Score=170, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17555558, Length=563, Percent_Identity=24.6891651865009, Blast_Score=82, Evalue=9e-16,
Organism=Saccharomyces cerevisiae, GI6322446, Length=527, Percent_Identity=31.1195445920304, Blast_Score=273, Evalue=6e-74,
Organism=Saccharomyces cerevisiae, GI6322524, Length=530, Percent_Identity=32.2641509433962, Blast_Score=259, Evalue=6e-70,
Organism=Saccharomyces cerevisiae, GI6322350, Length=525, Percent_Identity=30.4761904761905, Blast_Score=259, Evalue=9e-70,
Organism=Saccharomyces cerevisiae, GI6320418, Length=537, Percent_Identity=30.3538175046555, Blast_Score=259, Evalue=9e-70,
Organism=Saccharomyces cerevisiae, GI6322049, Length=521, Percent_Identity=30.1343570057582, Blast_Score=232, Evalue=1e-61,
Organism=Saccharomyces cerevisiae, GI6320058, Length=512, Percent_Identity=30.078125, Blast_Score=219, Evalue=7e-58,
Organism=Saccharomyces cerevisiae, GI6320393, Length=530, Percent_Identity=29.4339622641509, Blast_Score=206, Evalue=9e-54,
Organism=Saccharomyces cerevisiae, GI6322452, Length=539, Percent_Identity=29.1280148423006, Blast_Score=196, Evalue=1e-50,
Organism=Drosophila melanogaster, GI17647245, Length=522, Percent_Identity=35.2490421455939, Blast_Score=301, Evalue=9e-82,
Organism=Drosophila melanogaster, GI24652903, Length=500, Percent_Identity=35.2, Blast_Score=290, Evalue=2e-78,
Organism=Drosophila melanogaster, GI24649027, Length=532, Percent_Identity=31.9548872180451, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24649029, Length=532, Percent_Identity=31.9548872180451, Blast_Score=283, Evalue=2e-76,
Organism=Drosophila melanogaster, GI24645179, Length=487, Percent_Identity=33.8809034907598, Blast_Score=266, Evalue=4e-71,
Organism=Drosophila melanogaster, GI24647512, Length=543, Percent_Identity=31.1233885819521, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI24647510, Length=543, Percent_Identity=31.1233885819521, Blast_Score=263, Evalue=2e-70,
Organism=Drosophila melanogaster, GI18859933, Length=520, Percent_Identity=31.7307692307692, Blast_Score=241, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24583944, Length=504, Percent_Identity=31.9444444444444, Blast_Score=237, Evalue=2e-62,
Organism=Drosophila melanogaster, GI28571140, Length=527, Percent_Identity=29.4117647058824, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI18858175, Length=527, Percent_Identity=29.4117647058824, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI19921848, Length=522, Percent_Identity=31.0344827586207, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24641193, Length=536, Percent_Identity=25, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24641191, Length=536, Percent_Identity=25, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI45550936, Length=536, Percent_Identity=24.2537313432836, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550132, Length=536, Percent_Identity=24.2537313432836, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45550935, Length=536, Percent_Identity=24.2537313432836, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017998
- InterPro:   IPR002194
- InterPro:   IPR002423
- InterPro:   IPR012714 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58456; Mature: 58456

Theoretical pI: Translated: 4.58; Mature: 4.58

Prosite motif: PS00750 TCP1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVQNNQQPLIVLADGSTRTSGSQATKNNIMAAKLLSNVLKTTLGPRGMDKMLINSIGDVK
CCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEE
ITNDGYTVLKETEPDHPAAKMIVDLAKMQEEEYGDGTTTAVVLVGEILKEAEKLIEQGIP
ECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
TSTIVKGFEESKNKTLEVLDEIAIPAQEEELINVARTSMSGKGSFTNLDKMAKELVEALL
HHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
NVEEDGQIDQDMIKIRKIHGEGTEDTEISECVTVDKNVLESEMPKDVKDAKIALLQYPMD
CCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
ARELQNDAKIKLTTPGEYQAYLDKEAQMLQDEVQKLVDAGVTVLFNNKKISDLCQHYLTK
HHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHH
AGILTAKRVKAGDLERLSKATGANIVNDIKELTSDDLGEAGHVYEREVFEDREYIFIEDC
HHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEECC
KYAGVLNIIIRGSTKHITDQLEQAINDAIGAVIKTRQDDKALPGGGAADIAASKALRKYA
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
NKFTDKEQLVIKAYADALEQLPVALAKNAGMDTIDVLTKLLAKQNESTNMGVNVIKRDVS
HHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
DMKADKILDSQNSKKAIVESATEIAGEILRIDDVVSTKPMTPVGGDMPGTPNPYM
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MVQNNQQPLIVLADGSTRTSGSQATKNNIMAAKLLSNVLKTTLGPRGMDKMLINSIGDVK
CCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCEE
ITNDGYTVLKETEPDHPAAKMIVDLAKMQEEEYGDGTTTAVVLVGEILKEAEKLIEQGIP
ECCCCCEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCC
TSTIVKGFEESKNKTLEVLDEIAIPAQEEELINVARTSMSGKGSFTNLDKMAKELVEALL
HHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHH
NVEEDGQIDQDMIKIRKIHGEGTEDTEISECVTVDKNVLESEMPKDVKDAKIALLQYPMD
CCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCC
ARELQNDAKIKLTTPGEYQAYLDKEAQMLQDEVQKLVDAGVTVLFNNKKISDLCQHYLTK
HHHCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCHHHHHHHHHHH
AGILTAKRVKAGDLERLSKATGANIVNDIKELTSDDLGEAGHVYEREVFEDREYIFIEDC
HHHHHHHHCCCCCHHHHHHHHCCHHHHHHHHHHHCCCCCCCCHHHHHHHCCCCEEEEECC
KYAGVLNIIIRGSTKHITDQLEQAINDAIGAVIKTRQDDKALPGGGAADIAASKALRKYA
CCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHH
NKFTDKEQLVIKAYADALEQLPVALAKNAGMDTIDVLTKLLAKQNESTNMGVNVIKRDVS
HHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHH
DMKADKILDSQNSKKAIVESATEIAGEILRIDDVVSTKPMTPVGGDMPGTPNPYM
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]