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The map label for this gene is hisD

Identifier: 84488963

GI number: 84488963

Start: 153476

End: 154699

Strand: Direct

Name: hisD

Synonym: Msp_0134

Alternate gene names: 84488963

Gene position: 153476-154699 (Clockwise)

Preceding gene: 84488959

Following gene: 84488964

Centisome position: 8.68

GC content: 33.58

Gene sequence:

>1224_bases
ATGAATTCTAGTGATGTTATACAACCTGTACAGGAAATTATTGCAAATGTATGTGAAAATAAGGATAAAGCATTACATGA
TTATACTTTGAAATTTGATAAGGCAGATATCTCTGATTTTAAGGTACCTGTTGAGACTATTAAACAAAGTGTGGAAAATA
TTAGTCCTAAACTAAGAAAAGCATTGGAAGATGCAGCAGAAAATATTAGTAAGTTTCATAAAGCACAAATACCATCTGAT
TGGACAATGACAGTAAAAGATGGTGTTAAGGCTGGTCAAATTATAAGACCATTATCTCGTGTTGGTTGTTATATTCCTGG
TGGAAGGGCAGCATATCCTTCATCCATATTAATGACTGTTATTCCAGCAAAGATTGCTGGTGTAGAAGAGATTATTTGTT
GTACTCCTCCAGATAAAGATGGATGTGTTAGTGATGAAATTCTTGCAGCAGCATATATTGCTGGTGTAACTGATATTTAC
ATGGTGGGTGGTGCTCAAGCTATAGCAGCAATGGCATATTCTACTCAAACAATACCTTCTGTTGATAAGATTGTAGGACC
TGGTAATATTTTTGTAGCAACAGCTAAAAAATTAGTATATGGTGATGTGGATATTGAATTTCCAGCAGGTCCATCTGAAA
TGTTAGCATTGGTAGATGAAACAGCAAATCCTGAATATATTGCAACAGAATTATTAGCTCAAGCAGAACATGATCCTAAT
GCTGCAACAATACTTGTATCTACATCAAAAGAAGTGGCCCAAAAAACTGTAGAACATGTTATGGAATATCTTAAAACACA
AAAAAGAAGTGATATAATAGAAGAATCATTATCTAAATATGGTCATGTTCTAGTGGCAAGTAGTATGGAAGATGCTATAG
ATTTTACTAATGCATATGCTCCAGAACACTTGGTTATTGTGACAAAAGATCATTATAAAACATTAGAATCAATAAATAAT
GCTGGTTCTATCTTTTTAGGTAATCTTACACCAGTTGCTGGTGGAGATTATGGTTCTGGAACAAACCATGTTCTTCCAAC
AAGTGGTGGGGCAAGAATGTATTCTGGTTTATCTGCAGAATCTTTCCTTAAAAAACCAACAATACAAGAATTATCACCTG
AAGGTGTTAAAAATATTAAAGACATGGTTATAAACCTAGCAGAAGCAGAAGGATTATATGCTCATGCTTTATCTATTAAA
AAAAGAGCAGAAGATATGGAATAA

Upstream 100 bases:

>100_bases
ATTTAATTAAGAATATTTAATATAGTTGGAAGGATTTAAATTGCTAGAAATTATAGAGTTAAAACAAGAAGACTTTTCAA
AGTATACTCAGAGAATTCAA

Downstream 100 bases:

>100_bases
AATATTTTTTCTATTAAATAAATTTATCAATTAAGAAAAATATAAATATATATTAATATTTTATTAATTTTAACTAAAAT
CATAAAATGAATACATAGGT

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH [H]

Number of amino acids: Translated: 407; Mature: 407

Protein sequence:

>407_residues
MNSSDVIQPVQEIIANVCENKDKALHDYTLKFDKADISDFKVPVETIKQSVENISPKLRKALEDAAENISKFHKAQIPSD
WTMTVKDGVKAGQIIRPLSRVGCYIPGGRAAYPSSILMTVIPAKIAGVEEIICCTPPDKDGCVSDEILAAAYIAGVTDIY
MVGGAQAIAAMAYSTQTIPSVDKIVGPGNIFVATAKKLVYGDVDIEFPAGPSEMLALVDETANPEYIATELLAQAEHDPN
AATILVSTSKEVAQKTVEHVMEYLKTQKRSDIIEESLSKYGHVLVASSMEDAIDFTNAYAPEHLVIVTKDHYKTLESINN
AGSIFLGNLTPVAGGDYGSGTNHVLPTSGGARMYSGLSAESFLKKPTIQELSPEGVKNIKDMVINLAEAEGLYAHALSIK
KRAEDME

Sequences:

>Translated_407_residues
MNSSDVIQPVQEIIANVCENKDKALHDYTLKFDKADISDFKVPVETIKQSVENISPKLRKALEDAAENISKFHKAQIPSD
WTMTVKDGVKAGQIIRPLSRVGCYIPGGRAAYPSSILMTVIPAKIAGVEEIICCTPPDKDGCVSDEILAAAYIAGVTDIY
MVGGAQAIAAMAYSTQTIPSVDKIVGPGNIFVATAKKLVYGDVDIEFPAGPSEMLALVDETANPEYIATELLAQAEHDPN
AATILVSTSKEVAQKTVEHVMEYLKTQKRSDIIEESLSKYGHVLVASSMEDAIDFTNAYAPEHLVIVTKDHYKTLESINN
AGSIFLGNLTPVAGGDYGSGTNHVLPTSGGARMYSGLSAESFLKKPTIQELSPEGVKNIKDMVINLAEAEGLYAHALSIK
KRAEDME
>Mature_407_residues
MNSSDVIQPVQEIIANVCENKDKALHDYTLKFDKADISDFKVPVETIKQSVENISPKLRKALEDAAENISKFHKAQIPSD
WTMTVKDGVKAGQIIRPLSRVGCYIPGGRAAYPSSILMTVIPAKIAGVEEIICCTPPDKDGCVSDEILAAAYIAGVTDIY
MVGGAQAIAAMAYSTQTIPSVDKIVGPGNIFVATAKKLVYGDVDIEFPAGPSEMLALVDETANPEYIATELLAQAEHDPN
AATILVSTSKEVAQKTVEHVMEYLKTQKRSDIIEESLSKYGHVLVASSMEDAIDFTNAYAPEHLVIVTKDHYKTLESINN
AGSIFLGNLTPVAGGDYGSGTNHVLPTSGGARMYSGLSAESFLKKPTIQELSPEGVKNIKDMVINLAEAEGLYAHALSIK
KRAEDME

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine [H]

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1788331, Length=403, Percent_Identity=40.6947890818859, Blast_Score=321, Evalue=5e-89,
Organism=Saccharomyces cerevisiae, GI6319819, Length=410, Percent_Identity=39.5121951219512, Blast_Score=300, Evalue=4e-82,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131 [H]

Pfam domain/function: PF00815 Histidinol_dh [H]

EC number: =1.1.1.23 [H]

Molecular weight: Translated: 43793; Mature: 43793

Theoretical pI: Translated: 4.72; Mature: 4.72

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNSSDVIQPVQEIIANVCENKDKALHDYTLKFDKADISDFKVPVETIKQSVENISPKLRK
CCCHHHHHHHHHHHHHHHCCCCCHHHHEEEEECCCCCCCCCCCHHHHHHHHHHCCHHHHH
ALEDAAENISKFHKAQIPSDWTMTVKDGVKAGQIIRPLSRVGCYIPGGRAAYPSSILMTV
HHHHHHHHHHHHHHHCCCCCCEEEHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
IPAKIAGVEEIICCTPPDKDGCVSDEILAAAYIAGVTDIYMVGGAQAIAAMAYSTQTIPS
HHHHHCCCHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHEEECCHHHHHHHHHCCCCCCC
VDKIVGPGNIFVATAKKLVYGDVDIEFPAGPSEMLALVDETANPEYIATELLAQAEHDPN
HHHHCCCCCEEEEEHHHHEEECCEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
AATILVSTSKEVAQKTVEHVMEYLKTQKRSDIIEESLSKYGHVLVASSMEDAIDFTNAYA
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHCCCC
PEHLVIVTKDHYKTLESINNAGSIFLGNLTPVAGGDYGSGTNHVLPTSGGARMYSGLSAE
CCEEEEEECHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCEEECCCCHHHHCCCCHH
SFLKKPTIQELSPEGVKNIKDMVINLAEAEGLYAHALSIKKRAEDME
HHHCCCCHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNSSDVIQPVQEIIANVCENKDKALHDYTLKFDKADISDFKVPVETIKQSVENISPKLRK
CCCHHHHHHHHHHHHHHHCCCCCHHHHEEEEECCCCCCCCCCCHHHHHHHHHHCCHHHHH
ALEDAAENISKFHKAQIPSDWTMTVKDGVKAGQIIRPLSRVGCYIPGGRAAYPSSILMTV
HHHHHHHHHHHHHHHCCCCCCEEEHHCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHH
IPAKIAGVEEIICCTPPDKDGCVSDEILAAAYIAGVTDIYMVGGAQAIAAMAYSTQTIPS
HHHHHCCCHHEEEECCCCCCCCCHHHHHHHHHHHHHHHHEEECCHHHHHHHHHCCCCCCC
VDKIVGPGNIFVATAKKLVYGDVDIEFPAGPSEMLALVDETANPEYIATELLAQAEHDPN
HHHHCCCCCEEEEEHHHHEEECCEEECCCCHHHHHHHHHCCCCCHHHHHHHHHHCCCCCC
AATILVSTSKEVAQKTVEHVMEYLKTQKRSDIIEESLSKYGHVLVASSMEDAIDFTNAYA
CEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCHHHHHHHHCCCC
PEHLVIVTKDHYKTLESINNAGSIFLGNLTPVAGGDYGSGTNHVLPTSGGARMYSGLSAE
CCEEEEEECHHHHHHHHCCCCCCEEECCCCCCCCCCCCCCCCCEEECCCCHHHHCCCCHH
SFLKKPTIQELSPEGVKNIKDMVINLAEAEGLYAHALSIKKRAEDME
HHHCCCCHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]