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The map label for this gene is apt

Identifier: 83719836

GI number: 83719836

Start: 545741

End: 546307

Strand: Direct

Name: apt

Synonym: BTH_I0493

Alternate gene names: 83719836

Gene position: 545741-546307 (Clockwise)

Preceding gene: 83720313

Following gene: 83719075

Centisome position: 14.33

GC content: 66.49

Gene sequence:

>567_bases
ATGATGTCCACATCGTCGGACGCGCAGCTCGATCCCGTCGAGTTCATTCACAGCCGCATCCGCACGGTGCCGAACTGGCC
GCAGCCGGGCGTGATGTTCCGCGACATCACGCCGCTCCTGCAAAGCGCGAAGGCGATGCGCGTGCTCGTCGACCTGTTCG
TCGAGCGCTATGTCGACGCGAAGCTCGACTACATCGCGGGCCTCGACGCGCGCGGCTTCATCATCGCGCCCATCGTCGCG
TACGAGCTGTCCGTCGGCTTCGTGCCGATCCGCAAGGTCGGCAAGCTGCCGTACAAGACGCAGCGCGAATCGTACGCGCT
CGAATACGGCACCGCGACCGTCGAGATCCACGAAGACGCGTGCAAGCCGGGCGACCGTGTGGTGATCGTCGACGACCTGA
TCGCGACGGGCGGCACGATGATGGCGGGCAAGAACCTGCTCGATCGGCTGGGCGCCGTCGTCGTGGAAGGCGCGGCGATC
GTCGATTTGCCGGATCTCGGCGGCTCGGCGCTGCTGCGCGGGGCCGGCCTGTCGCTCTATACGGTCACCGAATTCGCCGG
ACACTGA

Upstream 100 bases:

>100_bases
GACCGCGGCGGCGTGACGCCGCGCGGCCGCCGATTTTTTGAGTCGTCGAGCGATCGACGAACGGTGCGGGCATCCGGCGC
CGTTTTTTTCGGAGAGTTTC

Downstream 100 bases:

>100_bases
GCGCGGCGCGCCGCCCCGCACGCCGGACATCCCCGGCGCCGGTTTCATCCCGCGCTTGCCCGAGCGCGGCCCGTTCGTTC
ACCGATGTCCACCGATTCAA

Product: adenine phosphoribosyltransferase

Products: NA

Alternate protein names: APRT

Number of amino acids: Translated: 188; Mature: 188

Protein sequence:

>188_residues
MMSTSSDAQLDPVEFIHSRIRTVPNWPQPGVMFRDITPLLQSAKAMRVLVDLFVERYVDAKLDYIAGLDARGFIIAPIVA
YELSVGFVPIRKVGKLPYKTQRESYALEYGTATVEIHEDACKPGDRVVIVDDLIATGGTMMAGKNLLDRLGAVVVEGAAI
VDLPDLGGSALLRGAGLSLYTVTEFAGH

Sequences:

>Translated_188_residues
MMSTSSDAQLDPVEFIHSRIRTVPNWPQPGVMFRDITPLLQSAKAMRVLVDLFVERYVDAKLDYIAGLDARGFIIAPIVA
YELSVGFVPIRKVGKLPYKTQRESYALEYGTATVEIHEDACKPGDRVVIVDDLIATGGTMMAGKNLLDRLGAVVVEGAAI
VDLPDLGGSALLRGAGLSLYTVTEFAGH
>Mature_188_residues
MMSTSSDAQLDPVEFIHSRIRTVPNWPQPGVMFRDITPLLQSAKAMRVLVDLFVERYVDAKLDYIAGLDARGFIIAPIVA
YELSVGFVPIRKVGKLPYKTQRESYALEYGTATVEIHEDACKPGDRVVIVDDLIATGGTMMAGKNLLDRLGAVVVEGAAI
VDLPDLGGSALLRGAGLSLYTVTEFAGH

Specific function: Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis

COG id: COG0503

COG function: function code F; Adenine/guanine phosphoribosyltransferases and related PRPP-binding proteins

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purine/pyrimidine phosphoribosyltransferase family

Homologues:

Organism=Homo sapiens, GI4502171, Length=160, Percent_Identity=50, Blast_Score=154, Evalue=5e-38,
Organism=Homo sapiens, GI71773201, Length=129, Percent_Identity=50.3875968992248, Blast_Score=130, Evalue=6e-31,
Organism=Escherichia coli, GI1786675, Length=176, Percent_Identity=48.2954545454545, Blast_Score=177, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI17509087, Length=165, Percent_Identity=42.4242424242424, Blast_Score=124, Evalue=2e-29,
Organism=Saccharomyces cerevisiae, GI6323619, Length=182, Percent_Identity=36.8131868131868, Blast_Score=112, Evalue=3e-26,
Organism=Saccharomyces cerevisiae, GI6320649, Length=168, Percent_Identity=33.3333333333333, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI17136334, Length=180, Percent_Identity=41.6666666666667, Blast_Score=132, Evalue=1e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): APT_BURTA (Q2T199)

Other databases:

- EMBL:   CP000086
- RefSeq:   YP_441050.1
- HSSP:   P07741
- ProteinModelPortal:   Q2T199
- SMR:   Q2T199
- STRING:   Q2T199
- GeneID:   3849765
- GenomeReviews:   CP000086_GR
- KEGG:   bte:BTH_I0493
- TIGR:   BTH_I0493
- eggNOG:   COG0503
- HOGENOM:   HBG703830
- OMA:   GILFYDI
- ProtClustDB:   PRK02304
- BioCyc:   BTHA271848:BTH_I0493-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00004
- InterPro:   IPR005764
- InterPro:   IPR000836
- TIGRFAMs:   TIGR01090

Pfam domain/function: PF00156 Pribosyltran

EC number: =2.4.2.7

Molecular weight: Translated: 20351; Mature: 20351

Theoretical pI: Translated: 5.00; Mature: 5.00

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSTSSDAQLDPVEFIHSRIRTVPNWPQPGVMFRDITPLLQSAKAMRVLVDLFVERYVDA
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLDYIAGLDARGFIIAPIVAYELSVGFVPIRKVGKLPYKTQRESYALEYGTATVEIHEDA
HHHHHHCCCCCCEEEHHHHHHHHHCCCEEHHHHCCCCCCCCCCCEEEEECCEEEEECCCC
CKPGDRVVIVDDLIATGGTMMAGKNLLDRLGAVVVEGAAIVDLPDLGGSALLRGAGLSLY
CCCCCEEEEEECHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCEEE
TVTEFAGH
EECCCCCC
>Mature Secondary Structure
MMSTSSDAQLDPVEFIHSRIRTVPNWPQPGVMFRDITPLLQSAKAMRVLVDLFVERYVDA
CCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLDYIAGLDARGFIIAPIVAYELSVGFVPIRKVGKLPYKTQRESYALEYGTATVEIHEDA
HHHHHHCCCCCCEEEHHHHHHHHHCCCEEHHHHCCCCCCCCCCCEEEEECCEEEEECCCC
CKPGDRVVIVDDLIATGGTMMAGKNLLDRLGAVVVEGAAIVDLPDLGGSALLRGAGLSLY
CCCCCEEEEEECHHHCCCCHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHCCCCEEE
TVTEFAGH
EECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA