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The map label for this gene is adk

Identifier: 83591255

GI number: 83591255

Start: 2555931

End: 2556584

Strand: Reverse

Name: adk

Synonym: Moth_2439

Alternate gene names: 83591255

Gene position: 2556584-2555931 (Counterclockwise)

Preceding gene: 83591256

Following gene: 83591254

Centisome position: 97.25

GC content: 60.7

Gene sequence:

>654_bases
ATGCGCTTGGTATTACTTGGACCACCCGGCGCCGGGAAAGGGACCCAGGCCAGGGAGATTAACCAGCGCCTGGCCATACC
CCATATTTCTACCGGCGATATGTTCCGCGAGGCGATCAAAAGGGGGACGCCCCTGGGACGCCAGGCGGAAGTATATATCA
AGGGCGGGCGCCTGGTTCCTGATGAGGTAACTATTGGGTTGGTGCAGGAACGCCTGGTTCAACCTGATTGCCGGAATGGC
TTCCTCCTGGACGGCTTTCCCCGGACAGTAGCCCAGGCGGAAGCCCTGGATTCCTGGCTGTCGAGCCGGGGGGAGAGGTT
GGATGCCGTTATTGACATCGAGGTGCCCCGGGATGCTTTGCTGGAGCGCCTGACAGGGCGCCGGGTTTGCCGCCAGTGCG
GGGCCACCTATCATGTGCGCTATAACCCGCCTGCAGTACCGGGGAAGTGTGATGCCTGCGGTCAGGATCTGGTCCAGCGG
GCCGACGATACAGAAGCCACGGTGAACAAGCGCCTGGATGTTTATAACGAGCAGACGGCTCCCCTCGTTAACTACTACCG
GCAGCGCGGTCTTTTAAAGGAAATTGACGGCAGCCAGGCCATCCCGGCGGTAATCCTGGCTATAGGCAGGGCCCTGGGAA
GAGACTGGCAATGA

Upstream 100 bases:

>100_bases
TCGTGGGTGTGGCACTGGAAACCATGAAACAACTGGAATCCCACCTGTTGTTGCGGCACTACCAGGGCTTTATGAAATAA
CAACCGGGAGGCTTAAAGGC

Downstream 100 bases:

>100_bases
TTATTTTAAAATCGCGCCGGGAAATAGCCCTGATGCGGGAGGCAGGCCGGATAGTCGCCGGTGCCCTGGCCAAACTACAG
GAGCATATAGCTCCCGGCAT

Product: adenylate kinase

Products: NA

Alternate protein names: AK; ATP-AMP transphosphorylase

Number of amino acids: Translated: 217; Mature: 217

Protein sequence:

>217_residues
MRLVLLGPPGAGKGTQAREINQRLAIPHISTGDMFREAIKRGTPLGRQAEVYIKGGRLVPDEVTIGLVQERLVQPDCRNG
FLLDGFPRTVAQAEALDSWLSSRGERLDAVIDIEVPRDALLERLTGRRVCRQCGATYHVRYNPPAVPGKCDACGQDLVQR
ADDTEATVNKRLDVYNEQTAPLVNYYRQRGLLKEIDGSQAIPAVILAIGRALGRDWQ

Sequences:

>Translated_217_residues
MRLVLLGPPGAGKGTQAREINQRLAIPHISTGDMFREAIKRGTPLGRQAEVYIKGGRLVPDEVTIGLVQERLVQPDCRNG
FLLDGFPRTVAQAEALDSWLSSRGERLDAVIDIEVPRDALLERLTGRRVCRQCGATYHVRYNPPAVPGKCDACGQDLVQR
ADDTEATVNKRLDVYNEQTAPLVNYYRQRGLLKEIDGSQAIPAVILAIGRALGRDWQ
>Mature_217_residues
MRLVLLGPPGAGKGTQAREINQRLAIPHISTGDMFREAIKRGTPLGRQAEVYIKGGRLVPDEVTIGLVQERLVQPDCRNG
FLLDGFPRTVAQAEALDSWLSSRGERLDAVIDIEVPRDALLERLTGRRVCRQCGATYHVRYNPPAVPGKCDACGQDLVQR
ADDTEATVNKRLDVYNEQTAPLVNYYRQRGLLKEIDGSQAIPAVILAIGRALGRDWQ

Specific function: Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth

COG id: COG0563

COG function: function code F; Adenylate kinase and related kinases

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenylate kinase family

Homologues:

Organism=Homo sapiens, GI4502013, Length=214, Percent_Identity=44.8598130841121, Blast_Score=207, Evalue=6e-54,
Organism=Homo sapiens, GI7524346, Length=214, Percent_Identity=44.8598130841121, Blast_Score=207, Evalue=6e-54,
Organism=Homo sapiens, GI19923437, Length=200, Percent_Identity=39.5, Blast_Score=160, Evalue=6e-40,
Organism=Homo sapiens, GI310110345, Length=202, Percent_Identity=39.6039603960396, Blast_Score=144, Evalue=5e-35,
Organism=Homo sapiens, GI53832003, Length=202, Percent_Identity=39.6039603960396, Blast_Score=144, Evalue=5e-35,
Organism=Homo sapiens, GI8051579, Length=202, Percent_Identity=39.6039603960396, Blast_Score=144, Evalue=5e-35,
Organism=Homo sapiens, GI53832001, Length=202, Percent_Identity=39.6039603960396, Blast_Score=144, Evalue=5e-35,
Organism=Homo sapiens, GI4502011, Length=204, Percent_Identity=28.4313725490196, Blast_Score=96, Evalue=2e-20,
Organism=Homo sapiens, GI22749187, Length=186, Percent_Identity=31.1827956989247, Blast_Score=95, Evalue=5e-20,
Organism=Homo sapiens, GI7706497, Length=208, Percent_Identity=27.8846153846154, Blast_Score=90, Evalue=1e-18,
Organism=Homo sapiens, GI28144897, Length=213, Percent_Identity=28.6384976525822, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI28144899, Length=213, Percent_Identity=28.6384976525822, Blast_Score=83, Evalue=1e-16,
Organism=Escherichia coli, GI1786680, Length=218, Percent_Identity=47.2477064220183, Blast_Score=207, Evalue=4e-55,
Organism=Caenorhabditis elegans, GI17552384, Length=217, Percent_Identity=39.1705069124424, Blast_Score=185, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI17537943, Length=218, Percent_Identity=28.8990825688073, Blast_Score=109, Evalue=1e-24,
Organism=Caenorhabditis elegans, GI17567503, Length=210, Percent_Identity=31.9047619047619, Blast_Score=106, Evalue=8e-24,
Organism=Caenorhabditis elegans, GI17550688, Length=205, Percent_Identity=28.2926829268293, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17533833, Length=211, Percent_Identity=27.4881516587678, Blast_Score=97, Evalue=6e-21,
Organism=Saccharomyces cerevisiae, GI6320432, Length=216, Percent_Identity=42.5925925925926, Blast_Score=189, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6321018, Length=200, Percent_Identity=40.5, Blast_Score=155, Evalue=6e-39,
Organism=Saccharomyces cerevisiae, GI6322828, Length=192, Percent_Identity=27.6041666666667, Blast_Score=81, Evalue=1e-16,
Organism=Drosophila melanogaster, GI22026816, Length=211, Percent_Identity=42.1800947867299, Blast_Score=190, Evalue=6e-49,
Organism=Drosophila melanogaster, GI17737899, Length=200, Percent_Identity=39, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI24645822, Length=200, Percent_Identity=39, Blast_Score=155, Evalue=2e-38,
Organism=Drosophila melanogaster, GI221459597, Length=199, Percent_Identity=32.1608040201005, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI21356893, Length=199, Percent_Identity=32.1608040201005, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24663208, Length=209, Percent_Identity=23.9234449760766, Blast_Score=79, Evalue=3e-15,
Organism=Drosophila melanogaster, GI17647141, Length=209, Percent_Identity=23.9234449760766, Blast_Score=79, Evalue=3e-15,

Paralogues:

None

Copy number: 1640 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 847 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. [C]

Swissprot (AC and ID): KAD_MOOTA (Q2RFR8)

Other databases:

- EMBL:   CP000232
- RefSeq:   YP_431264.1
- HSSP:   P16304
- ProteinModelPortal:   Q2RFR8
- SMR:   Q2RFR8
- STRING:   Q2RFR8
- GeneID:   3831669
- GenomeReviews:   CP000232_GR
- KEGG:   mta:Moth_2439
- NMPDR:   fig|264732.9.peg.2471
- eggNOG:   COG0563
- HOGENOM:   HBG630208
- OMA:   RTYHVKY
- PhylomeDB:   Q2RFR8
- BioCyc:   MTHE264732:MOTH_2439-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00235
- InterPro:   IPR006259
- InterPro:   IPR000850
- InterPro:   IPR007862
- PANTHER:   PTHR23359
- PRINTS:   PR00094
- TIGRFAMs:   TIGR01351

Pfam domain/function: PF00406 ADK; PF05191 ADK_lid

EC number: =2.7.4.3

Molecular weight: Translated: 23982; Mature: 23982

Theoretical pI: Translated: 8.47; Mature: 8.47

Prosite motif: PS00113 ADENYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLVLLGPPGAGKGTQAREINQRLAIPHISTGDMFREAIKRGTPLGRQAEVYIKGGRLVP
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCEECC
DEVTIGLVQERLVQPDCRNGFLLDGFPRTVAQAEALDSWLSSRGERLDAVIDIEVPRDAL
HHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHH
LERLTGRRVCRQCGATYHVRYNPPAVPGKCDACGQDLVQRADDTEATVNKRLDVYNEQTA
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCH
PLVNYYRQRGLLKEIDGSQAIPAVILAIGRALGRDWQ
HHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MRLVLLGPPGAGKGTQAREINQRLAIPHISTGDMFREAIKRGTPLGRQAEVYIKGGRLVP
CEEEEECCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCEECC
DEVTIGLVQERLVQPDCRNGFLLDGFPRTVAQAEALDSWLSSRGERLDAVIDIEVPRDAL
HHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHCCCCEEEEEEEECCHHHH
LERLTGRRVCRQCGATYHVRYNPPAVPGKCDACGQDLVQRADDTEATVNKRLDVYNEQTA
HHHHHHHHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHCCCCCH
PLVNYYRQRGLLKEIDGSQAIPAVILAIGRALGRDWQ
HHHHHHHHCCHHHHCCCCCHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA